Ramsey oscillations typically exhibit an exponential decay envelope due to environmental noise. However,recent experiments have observed nonmonotonic Ramsey fringes characterized by beating patterns, which deviate fro...Ramsey oscillations typically exhibit an exponential decay envelope due to environmental noise. However,recent experiments have observed nonmonotonic Ramsey fringes characterized by beating patterns, which deviate from the standard behavior. These beating patterns have primarily been attributed to charge-noise fluctuations.In this paper, we have experimentally observed Ramsey fringe with beating pattern for transmon qubits, and traced the origin to electric instruments induced flux noise.展开更多
Background: Brainwave entrainment using binaural beats has shown potential in treating tinnitus, but most studies have focused on one-month treatment durations. Objective: This study aimed to evaluate the time-bound e...Background: Brainwave entrainment using binaural beats has shown potential in treating tinnitus, but most studies have focused on one-month treatment durations. Objective: This study aimed to evaluate the time-bound efficacy of brainwave entrainment using binaural beats, comparing it to a standard tinnitus masker over a three-month duration. Method: Sixty-three individuals having tinnitus with normal hearing sensitivity were enrolled in the study. The participants were categorized into groups Ⅰ, Ⅱ, and Ⅲ. They were provided with delta(4 Hz) and alpha(10 Hz) frequency binaural beats and standard tinnitus masker, respectively, for a duration of three months. The tinnitus handicap inventory(THI) scores, Visual analogue scale(VAS) rating for tinnitus distress, and quality of life parameters were measured. The reductions obtained for each measure during the end of the first, second and third month were measured and compared across the groups. Results: All three groups showed considerable reductions in THI and VAS scores and improvements in the quality of life domains, focusing on physical and psychological health. However, groups Ⅰ and Ⅱ, who received binaural beats stimuli, showed higher benefits than those who received standard tinnitus masker. Conclusion: The results of the current study indicated that binaural beats can be an effective treatment technique for individuals with tinnitus having normal hearing sensitivity. Clinicians and otology/audiology practitioners shall adopt this innovative treatment after further validating these findings.展开更多
Objective:To explore the correlation between night ECG parameters and sleep quality in elderly patients with atrial premature beat(PAC).Methods:A total of 307 elderly patients with PAC were selected from March 2022 to...Objective:To explore the correlation between night ECG parameters and sleep quality in elderly patients with atrial premature beat(PAC).Methods:A total of 307 elderly patients with PAC were selected from March 2022 to March 2024.The parameters of room morning load and heart rate variability(HRV)at night(22:00-6:00)were collected by 24h holter electrocardiogram,and the sleep quality of PAC patients was evaluated by Pittsburgh Sleep Quality Index(PSQI).Multiple regression analysis was used to explore the correlation between night ECG parameters and sleep quality.Results:The incidence of sleep disorder in 307 elderly PAC patients was 62.54%.Univariate analysis showed that there were no statistically significant differences in gender,BMI and education level(P>0.05),but there were statistically significant differences in age,disease course,underlying diseases,atrial morning load,SDNN,RMSSD,LF,HF,LF/HF and TP(P<0.05).Multivariate Logistic regression analysis showed that atrial morning load,SDNN,RMSSD,LF and LF/HF were independent influencing factors of sleep disorder in elderly PAC patients(P<0.05).Patients with sleep disorders were divided into mild group,moderate group and severe group according to PSQI score,and there were statistically significant differences in the indexes of atrial morning load,SDNN,LF,LF/HF and TP among the three groups(all P<0.05).Spearman correlation analysis showed that room morning load,LF,LF/HF and TP were positively correlated with the degree of sleep disorder,while SDNN parameters were negatively correlated with the degree of sleep disorder(all P<0.05).Conclusion:There is a significant correlation between night ECG parameters and sleep disorders in elderly patients with PAC.It is possible to prevent and treat sleep disorders by monitoring ECG abnormalities and improve the reliability of treatment.展开更多
BACKGROUND: Although the use of non-heart beating donors (NHBDs) could bridge the widening gap between organ demand and supply, its application to liver transplantation is limited due to the high incidence of primary ...BACKGROUND: Although the use of non-heart beating donors (NHBDs) could bridge the widening gap between organ demand and supply, its application to liver transplantation is limited due to the high incidence of primary graft loss. Prevention of liver injury in NHBDs will benefit the results of transplantation. This study was conducted to evaluate the protective effects of L-arginine on liver grafts from NHBDs. METHODS: One hundred and four Wistar rats were randomly divided into 7 groups: normal control (n=8) controls 1, 2 and 3 (C-1, C-2, C-3, n=16), and experimental 1, 2 and 3 (E-1, E-2, E-3, n=16). For groups C-1 and E-1, C-2 and E-2, and C-3 and E-3, the warm ischemia time was 0, 30, and 45 minutes, respectively. Liver grafts were flushed with and preserved in 4 degrees C Euro-collins solution containing 1 mmol/L L-arginine for 1 hour in each experimental group. Recipients of each experimental group were injected with L-arginine (10 mg/kg body weight) by tail vein 10 minutes before portal vein reperfusion. Donors and recipients of each experimental control group were treated with normal saline. Then transplantation was performed. At 1, 3, and 24 hours after portal vein reperfusion, blood samples were obtained to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide (NO) and plasma endothelin (ET). At 3 hours after portal vein reperfusion, grafts samples were fixed in 2.5% glutaraldehyde for electron microscopic observation. RESULTS: At I hour after portal vein reperfusion, the levels of NO in groups E-1, E-2, E-3 and C-1, C-2, C-3 were lower, while the levels of plasma ET, serum ALT and AST were higher than those in the normal control group (P<0.05). At 1, 3, and 24 hours, the levels of NO in groups E-1, E-2, E-3 were higher, while the levels of plasma ET, serum ALT and AST were lower than those in the corresponding control groups (C-1, C-2, C-3) (P<0.05). The levels of NO in groups C-2 and C-3 were lower than in group C-1 (P<0.05), and the level of NO in group C-3 was lower than in group C-2 (P<0.05). At 1, 3 and 24 hours, the levels of plasma ET, serum ALT, and AST in groups E-1, E-2, E-3 were lower than those in the corresponding control groups (C-1, C-2, C-3) (P<0.05). The levels of plasma ET, serum ALT, and AST were lower in group C-3 than in groups C-1 and C-2 (P<0.05). Pathological changes in groups E-1, E-2, E-3 were milder than those in the corresponding experimental control groups (C-1, C-2, C-3). CONCLUSIONS: The imbalance between NO and ET plays an important role in the development of ischemia-reperfusion injury of liver grafts from NHBDs. L-arginine can attenuate injury in liver grafts from NHBDs by improving the balance between NO and ET.展开更多
The present research on involute spline cold roll-beating forming is mainly about the principles and motion relations of cold roll-beating,the theory of roller design,and the stress and strain field analysis of cold r...The present research on involute spline cold roll-beating forming is mainly about the principles and motion relations of cold roll-beating,the theory of roller design,and the stress and strain field analysis of cold roll-beating,etc.However,the research on law of metal flow in the forming process of involute spline cold roll-beating is rare.According to the principle of involute spline cold roll-beating,the contact model between the rollers and the spline shaft blank in the process of cold roll-beating forming is established,and the theoretical analysis of metal flow in the cold roll-beating deforming region is proceeded.A finite element model of the spline cold roll-beating process is established,the formation mechanism of the involute spline tooth profile in cold roll-beating forming process is studied,and the node flow tracks of the deformation area are analyzed.The experimental research on the metal flow of cold roll-beating spline is conducted,and the metallographic structure variation,grain characteristics and metal flow line of the different tooth profile area are analyzed.The experimental results show that the particle flow directions of the deformable bodies in cold roll-beating deformation area are determined by the minimum moving resistance.There are five types of metal flow rules of the deforming region in the process of cold roll-beating forming.The characteristics of involute spline cold roll-beating forming are given,and the forming mechanism of involute spline cold roll-beating is revealed.This paper researches the law of metal flow in the forming process of involute spline cold roll-beating,which provides theoretical supports for solving the tooth profile forming quality problem.展开更多
The present research of cold-beating formation mainly focused on roller design and manufacture, kinematics, constitutive relation, metal flow law, thermo-mechanical coupling, surface micro-topography and microstructur...The present research of cold-beating formation mainly focused on roller design and manufacture, kinematics, constitutive relation, metal flow law, thermo-mechanical coupling, surface micro-topography and microstructure evolution. However, the research on surface quality and performance of workpieces in the process of cold-beating is rare. Cold-beating simulation experiment of 1020 steel is conducted at room temperature and strain rates ranging from 2000 to 4000 s^-1 base on the law of plastic forming. According to the experimental data, the model of strain hardening of 1020 steel is established, Scanning Electron Microscopy（SEM） is conducted, the mechanism of the work hardening of 1020 steel is clarified by analyzing microstructure variation of 1020 steel. It is found that the strain rate hardening effect of 1020 steel is stronger than the softening effect induced by increasing temperatures, the process of simulation cold-beating cause the grain shape of 1020 steel significant change and microstructure elongate significantly to form a fibrous tis- sue parallel to the direction of deformation, the higher strain rate, the more obvious grain refinement and the more hardening effect. Additionally, the change law of the work hardening rate is investigated, the relationship between dislocation density and strain, the relationship between work hardening rate and dislocation density is obtained. Results show that the change trend of the work hardening rate of 1020 steel is divided into two stages, the work hardening rate decreases dramatically in the first stage and slowly decreases in the second stage, finally tending toward zero. Dislocation density increases with increasing strain and strain rate, work hardening rate decreases with increasing dislocation density. The research results provide the basis for solving the problem of improving the surface quality and performance of workpieces under cold-beating formation of 1020 steel.展开更多
In the pump-controlled motor hydraulic transmission system,when the pressure pulsation frequencies seperately generated by the pump and the motor are close to each other,the hydraulic system will generate a strong pre...In the pump-controlled motor hydraulic transmission system,when the pressure pulsation frequencies seperately generated by the pump and the motor are close to each other,the hydraulic system will generate a strong pressure beat vibration phenomenon,which will seriously affect the smooth running of the hydraulic system.However,the modulated pressure signal also carries information related to the operating state of the hydraulic system,and a accurate extraction of pressure vibration characteristics is the key to obtain the operating state information of the hydraulic system.In order to extract the pressure beat vibration signal component effectively from the multi-component time-varying aliasing pressure signal and reconstruct the time domain characteristics,an extraction method of the pressure beat vibration characteristics of the hydraulic transmission system based on variational mode decomposition(VMD)is proposed.The experimental results show that the VMD method can accurately extract the pressure beat vibration characteristics from the high-pressure oil pressure signal of the hydraulic system,and the extraction effect is preferable to that of the traditional signal processing methods such as empirical mode decomposition(EMD).展开更多
文摘Ramsey oscillations typically exhibit an exponential decay envelope due to environmental noise. However,recent experiments have observed nonmonotonic Ramsey fringes characterized by beating patterns, which deviate from the standard behavior. These beating patterns have primarily been attributed to charge-noise fluctuations.In this paper, we have experimentally observed Ramsey fringe with beating pattern for transmon qubits, and traced the origin to electric instruments induced flux noise.
文摘Background: Brainwave entrainment using binaural beats has shown potential in treating tinnitus, but most studies have focused on one-month treatment durations. Objective: This study aimed to evaluate the time-bound efficacy of brainwave entrainment using binaural beats, comparing it to a standard tinnitus masker over a three-month duration. Method: Sixty-three individuals having tinnitus with normal hearing sensitivity were enrolled in the study. The participants were categorized into groups Ⅰ, Ⅱ, and Ⅲ. They were provided with delta(4 Hz) and alpha(10 Hz) frequency binaural beats and standard tinnitus masker, respectively, for a duration of three months. The tinnitus handicap inventory(THI) scores, Visual analogue scale(VAS) rating for tinnitus distress, and quality of life parameters were measured. The reductions obtained for each measure during the end of the first, second and third month were measured and compared across the groups. Results: All three groups showed considerable reductions in THI and VAS scores and improvements in the quality of life domains, focusing on physical and psychological health. However, groups Ⅰ and Ⅱ, who received binaural beats stimuli, showed higher benefits than those who received standard tinnitus masker. Conclusion: The results of the current study indicated that binaural beats can be an effective treatment technique for individuals with tinnitus having normal hearing sensitivity. Clinicians and otology/audiology practitioners shall adopt this innovative treatment after further validating these findings.
文摘Objective:To explore the correlation between night ECG parameters and sleep quality in elderly patients with atrial premature beat(PAC).Methods:A total of 307 elderly patients with PAC were selected from March 2022 to March 2024.The parameters of room morning load and heart rate variability(HRV)at night(22:00-6:00)were collected by 24h holter electrocardiogram,and the sleep quality of PAC patients was evaluated by Pittsburgh Sleep Quality Index(PSQI).Multiple regression analysis was used to explore the correlation between night ECG parameters and sleep quality.Results:The incidence of sleep disorder in 307 elderly PAC patients was 62.54%.Univariate analysis showed that there were no statistically significant differences in gender,BMI and education level(P>0.05),but there were statistically significant differences in age,disease course,underlying diseases,atrial morning load,SDNN,RMSSD,LF,HF,LF/HF and TP(P<0.05).Multivariate Logistic regression analysis showed that atrial morning load,SDNN,RMSSD,LF and LF/HF were independent influencing factors of sleep disorder in elderly PAC patients(P<0.05).Patients with sleep disorders were divided into mild group,moderate group and severe group according to PSQI score,and there were statistically significant differences in the indexes of atrial morning load,SDNN,LF,LF/HF and TP among the three groups(all P<0.05).Spearman correlation analysis showed that room morning load,LF,LF/HF and TP were positively correlated with the degree of sleep disorder,while SDNN parameters were negatively correlated with the degree of sleep disorder(all P<0.05).Conclusion:There is a significant correlation between night ECG parameters and sleep disorders in elderly patients with PAC.It is possible to prevent and treat sleep disorders by monitoring ECG abnormalities and improve the reliability of treatment.
基金a grant from the Science & Technology Development Foundation of Guangdong Health Bureau(No.2006345).
文摘BACKGROUND: Although the use of non-heart beating donors (NHBDs) could bridge the widening gap between organ demand and supply, its application to liver transplantation is limited due to the high incidence of primary graft loss. Prevention of liver injury in NHBDs will benefit the results of transplantation. This study was conducted to evaluate the protective effects of L-arginine on liver grafts from NHBDs. METHODS: One hundred and four Wistar rats were randomly divided into 7 groups: normal control (n=8) controls 1, 2 and 3 (C-1, C-2, C-3, n=16), and experimental 1, 2 and 3 (E-1, E-2, E-3, n=16). For groups C-1 and E-1, C-2 and E-2, and C-3 and E-3, the warm ischemia time was 0, 30, and 45 minutes, respectively. Liver grafts were flushed with and preserved in 4 degrees C Euro-collins solution containing 1 mmol/L L-arginine for 1 hour in each experimental group. Recipients of each experimental group were injected with L-arginine (10 mg/kg body weight) by tail vein 10 minutes before portal vein reperfusion. Donors and recipients of each experimental control group were treated with normal saline. Then transplantation was performed. At 1, 3, and 24 hours after portal vein reperfusion, blood samples were obtained to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide (NO) and plasma endothelin (ET). At 3 hours after portal vein reperfusion, grafts samples were fixed in 2.5% glutaraldehyde for electron microscopic observation. RESULTS: At I hour after portal vein reperfusion, the levels of NO in groups E-1, E-2, E-3 and C-1, C-2, C-3 were lower, while the levels of plasma ET, serum ALT and AST were higher than those in the normal control group (P<0.05). At 1, 3, and 24 hours, the levels of NO in groups E-1, E-2, E-3 were higher, while the levels of plasma ET, serum ALT and AST were lower than those in the corresponding control groups (C-1, C-2, C-3) (P<0.05). The levels of NO in groups C-2 and C-3 were lower than in group C-1 (P<0.05), and the level of NO in group C-3 was lower than in group C-2 (P<0.05). At 1, 3 and 24 hours, the levels of plasma ET, serum ALT, and AST in groups E-1, E-2, E-3 were lower than those in the corresponding control groups (C-1, C-2, C-3) (P<0.05). The levels of plasma ET, serum ALT, and AST were lower in group C-3 than in groups C-1 and C-2 (P<0.05). Pathological changes in groups E-1, E-2, E-3 were milder than those in the corresponding experimental control groups (C-1, C-2, C-3). CONCLUSIONS: The imbalance between NO and ET plays an important role in the development of ischemia-reperfusion injury of liver grafts from NHBDs. L-arginine can attenuate injury in liver grafts from NHBDs by improving the balance between NO and ET.
基金supported by National Natural Science Foundation of China(Grant Nos.5107512450975229)Doctoral Foundation of Henan University of Science and Technology of China(Grant No.09001331)
文摘The present research on involute spline cold roll-beating forming is mainly about the principles and motion relations of cold roll-beating,the theory of roller design,and the stress and strain field analysis of cold roll-beating,etc.However,the research on law of metal flow in the forming process of involute spline cold roll-beating is rare.According to the principle of involute spline cold roll-beating,the contact model between the rollers and the spline shaft blank in the process of cold roll-beating forming is established,and the theoretical analysis of metal flow in the cold roll-beating deforming region is proceeded.A finite element model of the spline cold roll-beating process is established,the formation mechanism of the involute spline tooth profile in cold roll-beating forming process is studied,and the node flow tracks of the deformation area are analyzed.The experimental research on the metal flow of cold roll-beating spline is conducted,and the metallographic structure variation,grain characteristics and metal flow line of the different tooth profile area are analyzed.The experimental results show that the particle flow directions of the deformable bodies in cold roll-beating deformation area are determined by the minimum moving resistance.There are five types of metal flow rules of the deforming region in the process of cold roll-beating forming.The characteristics of involute spline cold roll-beating forming are given,and the forming mechanism of involute spline cold roll-beating is revealed.This paper researches the law of metal flow in the forming process of involute spline cold roll-beating,which provides theoretical supports for solving the tooth profile forming quality problem.
基金Supported by National Natural Science Foundation of China(Grant Nos.551475146,51475366,51075124)
文摘The present research of cold-beating formation mainly focused on roller design and manufacture, kinematics, constitutive relation, metal flow law, thermo-mechanical coupling, surface micro-topography and microstructure evolution. However, the research on surface quality and performance of workpieces in the process of cold-beating is rare. Cold-beating simulation experiment of 1020 steel is conducted at room temperature and strain rates ranging from 2000 to 4000 s^-1 base on the law of plastic forming. According to the experimental data, the model of strain hardening of 1020 steel is established, Scanning Electron Microscopy（SEM） is conducted, the mechanism of the work hardening of 1020 steel is clarified by analyzing microstructure variation of 1020 steel. It is found that the strain rate hardening effect of 1020 steel is stronger than the softening effect induced by increasing temperatures, the process of simulation cold-beating cause the grain shape of 1020 steel significant change and microstructure elongate significantly to form a fibrous tis- sue parallel to the direction of deformation, the higher strain rate, the more obvious grain refinement and the more hardening effect. Additionally, the change law of the work hardening rate is investigated, the relationship between dislocation density and strain, the relationship between work hardening rate and dislocation density is obtained. Results show that the change trend of the work hardening rate of 1020 steel is divided into two stages, the work hardening rate decreases dramatically in the first stage and slowly decreases in the second stage, finally tending toward zero. Dislocation density increases with increasing strain and strain rate, work hardening rate decreases with increasing dislocation density. The research results provide the basis for solving the problem of improving the surface quality and performance of workpieces under cold-beating formation of 1020 steel.
基金National Natural Science Foundation of China(No.51675399)。
文摘In the pump-controlled motor hydraulic transmission system,when the pressure pulsation frequencies seperately generated by the pump and the motor are close to each other,the hydraulic system will generate a strong pressure beat vibration phenomenon,which will seriously affect the smooth running of the hydraulic system.However,the modulated pressure signal also carries information related to the operating state of the hydraulic system,and a accurate extraction of pressure vibration characteristics is the key to obtain the operating state information of the hydraulic system.In order to extract the pressure beat vibration signal component effectively from the multi-component time-varying aliasing pressure signal and reconstruct the time domain characteristics,an extraction method of the pressure beat vibration characteristics of the hydraulic transmission system based on variational mode decomposition(VMD)is proposed.The experimental results show that the VMD method can accurately extract the pressure beat vibration characteristics from the high-pressure oil pressure signal of the hydraulic system,and the extraction effect is preferable to that of the traditional signal processing methods such as empirical mode decomposition(EMD).
