Recent geological study and survey on the scale of 1: 50000 in northern Guangxi have made some advancements: meta-basic-ultrabasic rocks which occured as bedding injection sheets in the Sanrnenjie formation of the Pro...Recent geological study and survey on the scale of 1: 50000 in northern Guangxi have made some advancements: meta-basic-ultrabasic rocks which occured as bedding injection sheets in the Sanrnenjie formation of the Proterozoic Danzhou group and caused contact metamorphism or hydrothermal alteration in adjacent wallrocks, were originated in extensional environment. Basic rocks belong to deep-sea tholeiite. TLe meta-basic -ultrabasic rocks sufferred intense deformation partitioning, resulting in lenticular network which was composed of mylonite zones in highly de formed field and lensoids in less- or non-deformed field. This structural pattern was explained as "melange" or "non-rooted cool intrusion " by previous workers. The deformation partitioning was mainly pure shearing in the early stage plus simple shearing in the later stage. This evolution was closely related to progressive deformation of the Guangxi orogeny.展开更多
目的探究毛兰素(Erianin)在特应性皮炎(atopic dermatitis,AD)中的作用及其在高迁移率族蛋白1(high mobility group box-1,HMGB1)/晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)-Ras同源基因家族成员A(Ra...目的探究毛兰素(Erianin)在特应性皮炎(atopic dermatitis,AD)中的作用及其在高迁移率族蛋白1(high mobility group box-1,HMGB1)/晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)-Ras同源基因家族成员A(Ras homolog gene family member A,RhoA)/Rho关联含卷曲螺旋结合蛋白激酶1(recombinant Rho associated coiled coil containing protein kinase 1,ROCK1)信号通路中的调控机制。方法1-氯-2,4-二硝基苯(1-Chloro-2,4-dinitrobenzene,DNCB)诱导BALB/c小鼠作为AD的模型,测量小鼠的皮肤厚度、脾和淋巴结的重量。甲苯胺蓝和HE染色检测小鼠的背部皮肤和耳朵的病理改变;ELISA检测炎症因子水平;肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)刺激HaCaT细胞建立AD体外模型;采用流式细胞术检测细胞活性氧(reactive oxygen species,ROS);免疫荧光法检测线粒体活性氧(mitochondrion reactive oxygen species,mtROS);TUNEL检测细胞凋亡情况;免疫蛋白印迹法检测HMGB1、RAGE、RhoA、ROCK1蛋白表达情况。结果在体内实验中毛兰素抑制皮肤厚度的增加,减轻脾和淋巴结重量,改善炎症细胞的浸润和肥大细胞脱颗粒,降低炎症因子水平(P<0.05)。在体外实验中,毛兰素减少TNF-α诱导的HaCaT细胞ROS、mtROS的产生(P<0.01)。毛兰素治疗后HMGB1、RAGE、RhoA及ROCK1的蛋白表达量下降(P<0.01);使用RAGE特异性阻断剂(TFA)处理r-HMGB1刺激的HaCaT细胞后,HMGB1的表达没有发生变化,RAGE、RhoA及ROCK1表达减少(P<0.01);在Rho激酶抑制剂Y-27632+r-HMGB1组中,除RAGE的表达没有降低,其余结果与TFA+r-HMGB1组相近。结论毛兰素可能通过调节HMGB1/RAGE-RhoA/ROCK1信号通路缓解特应性皮炎。展开更多
Rho/ROCK信号通路是细胞内一条重要的信号转导通路,其中Rho蛋白和ROCK(Rho-associated protein kinase)是其关键组成部分。Rho蛋白是一类小型GTP酶,参与调控细胞骨架的关键过程。ROCK作为Rho蛋白的下游效应蛋白激酶,能够调节细胞的形态...Rho/ROCK信号通路是细胞内一条重要的信号转导通路,其中Rho蛋白和ROCK(Rho-associated protein kinase)是其关键组成部分。Rho蛋白是一类小型GTP酶,参与调控细胞骨架的关键过程。ROCK作为Rho蛋白的下游效应蛋白激酶,能够调节细胞的形态、迁移和增殖等多种生物学过程。近年来,Rho/ROCK信号通路在各种病毒复制中的作用逐渐受到重视,研究发现一些病毒通过Rho/ROCK通路干扰细胞的收缩、黏附和迁移,参与调节病毒感染引发的免疫反应,并影响细胞间的紧密连接。现主要综述Rho/ROCK信号通路及其关键信号分子Rho和ROCK的活化与调控在病毒复制及细胞间紧密连接蛋白研究中的进展。展开更多
Based on systematic analyses of 72 samples of different basic-ultrabasic rocks, the present paper discusses the relationship between melt structure and Cu and Au mineralization. It is found that if the NBO/T, NBO, M2+...Based on systematic analyses of 72 samples of different basic-ultrabasic rocks, the present paper discusses the relationship between melt structure and Cu and Au mineralization. It is found that if the NBO/T, NBO, M2+, FeO and MgO values are relatively high and the T, M3+, Fe2O3 and CaO values are low the basic-ultrabasic melt will be favourable to Cu (Ni) mineralization, but if the former are low and the latter are high it is favourable to Au metallization. Cu ions occupy dominantly octahedra in basic-ultrabasic melt and the higher the NBO/T, NBO and M2+ values, the more the octahedra in the melt. Au element mainly takes the form of Au+ ions in basic-ultrabasic melt and the Au+ ions constitute tetrahedral sites together with Fe3+ ions. Therefore, low M2+ and high Fe3+, i.e. high oxygen fu-gacity, can promote the enrichment of Au+ ions and Au mineralization. Components NT (other than Au+), Al2O3 and SiO2 in basic-ultrabasic melt have no effect on metallogenetic species. As mentioned above, in relevant diagrams distribution areas of the characteristic values of ore-free melt and those of ore-forming melt are overlapped in different degrees, which possibly indicates that not all the magmas have mineralizing ability. It can be well distinguished whether basic-ultrabasic rocks are favourable to Cu or Au mineralization or they are just ore-free rocks by analysing integrated diagrams of the characteristic values of the magmatic melt structure.展开更多
Rockbursts, which mainly affect mining roadways, are dynamic disasters arising from the surrounding rock under high stress. Understanding the interaction between supports and the surrounding rock is necessary for effe...Rockbursts, which mainly affect mining roadways, are dynamic disasters arising from the surrounding rock under high stress. Understanding the interaction between supports and the surrounding rock is necessary for effective rockburst control. In this study, the squeezing behavior of the surrounding rock is analyzed in rockburst roadways, and a mechanical model of rockbursts is established considering the dynamic support stress, thus deriving formulas and providing characteristic curves for describing the interaction between the support and surrounding rock. Design principles and parameters of supports for rockburst control are proposed. The results show that only when the geostress magnitude exceeds a critical value can it drive the formation of rockburst conditions. The main factors influencing the convergence response and rockburst occurrence around roadways are geostress, rock brittleness, uniaxial compressive strength, and roadway excavation size. Roadway support devices can play a role in controlling rockburst by suppressing the squeezing evolution of the surrounding rock towards instability points of rockburst. Further, the higher the strength and the longer the impact stroke of support devices with constant resistance, the more easily multiple balance points can be formed with the surrounding rock to control rockburst occurrence. Supports with long impact stroke allow adaptation to varying geostress levels around the roadway, aiding in rockburst control. The results offer a quantitative method for designing support systems for rockburst-prone roadways. The design criterion of supports is determined by the intersection between the convergence curve of the surrounding rock and the squeezing deformation curve of the support devices.展开更多
文摘Recent geological study and survey on the scale of 1: 50000 in northern Guangxi have made some advancements: meta-basic-ultrabasic rocks which occured as bedding injection sheets in the Sanrnenjie formation of the Proterozoic Danzhou group and caused contact metamorphism or hydrothermal alteration in adjacent wallrocks, were originated in extensional environment. Basic rocks belong to deep-sea tholeiite. TLe meta-basic -ultrabasic rocks sufferred intense deformation partitioning, resulting in lenticular network which was composed of mylonite zones in highly de formed field and lensoids in less- or non-deformed field. This structural pattern was explained as "melange" or "non-rooted cool intrusion " by previous workers. The deformation partitioning was mainly pure shearing in the early stage plus simple shearing in the later stage. This evolution was closely related to progressive deformation of the Guangxi orogeny.
文摘目的探究毛兰素(Erianin)在特应性皮炎(atopic dermatitis,AD)中的作用及其在高迁移率族蛋白1(high mobility group box-1,HMGB1)/晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)-Ras同源基因家族成员A(Ras homolog gene family member A,RhoA)/Rho关联含卷曲螺旋结合蛋白激酶1(recombinant Rho associated coiled coil containing protein kinase 1,ROCK1)信号通路中的调控机制。方法1-氯-2,4-二硝基苯(1-Chloro-2,4-dinitrobenzene,DNCB)诱导BALB/c小鼠作为AD的模型,测量小鼠的皮肤厚度、脾和淋巴结的重量。甲苯胺蓝和HE染色检测小鼠的背部皮肤和耳朵的病理改变;ELISA检测炎症因子水平;肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)刺激HaCaT细胞建立AD体外模型;采用流式细胞术检测细胞活性氧(reactive oxygen species,ROS);免疫荧光法检测线粒体活性氧(mitochondrion reactive oxygen species,mtROS);TUNEL检测细胞凋亡情况;免疫蛋白印迹法检测HMGB1、RAGE、RhoA、ROCK1蛋白表达情况。结果在体内实验中毛兰素抑制皮肤厚度的增加,减轻脾和淋巴结重量,改善炎症细胞的浸润和肥大细胞脱颗粒,降低炎症因子水平(P<0.05)。在体外实验中,毛兰素减少TNF-α诱导的HaCaT细胞ROS、mtROS的产生(P<0.01)。毛兰素治疗后HMGB1、RAGE、RhoA及ROCK1的蛋白表达量下降(P<0.01);使用RAGE特异性阻断剂(TFA)处理r-HMGB1刺激的HaCaT细胞后,HMGB1的表达没有发生变化,RAGE、RhoA及ROCK1表达减少(P<0.01);在Rho激酶抑制剂Y-27632+r-HMGB1组中,除RAGE的表达没有降低,其余结果与TFA+r-HMGB1组相近。结论毛兰素可能通过调节HMGB1/RAGE-RhoA/ROCK1信号通路缓解特应性皮炎。
文摘Rho/ROCK信号通路是细胞内一条重要的信号转导通路,其中Rho蛋白和ROCK(Rho-associated protein kinase)是其关键组成部分。Rho蛋白是一类小型GTP酶,参与调控细胞骨架的关键过程。ROCK作为Rho蛋白的下游效应蛋白激酶,能够调节细胞的形态、迁移和增殖等多种生物学过程。近年来,Rho/ROCK信号通路在各种病毒复制中的作用逐渐受到重视,研究发现一些病毒通过Rho/ROCK通路干扰细胞的收缩、黏附和迁移,参与调节病毒感染引发的免疫反应,并影响细胞间的紧密连接。现主要综述Rho/ROCK信号通路及其关键信号分子Rho和ROCK的活化与调控在病毒复制及细胞间紧密连接蛋白研究中的进展。
文摘Based on systematic analyses of 72 samples of different basic-ultrabasic rocks, the present paper discusses the relationship between melt structure and Cu and Au mineralization. It is found that if the NBO/T, NBO, M2+, FeO and MgO values are relatively high and the T, M3+, Fe2O3 and CaO values are low the basic-ultrabasic melt will be favourable to Cu (Ni) mineralization, but if the former are low and the latter are high it is favourable to Au metallization. Cu ions occupy dominantly octahedra in basic-ultrabasic melt and the higher the NBO/T, NBO and M2+ values, the more the octahedra in the melt. Au element mainly takes the form of Au+ ions in basic-ultrabasic melt and the Au+ ions constitute tetrahedral sites together with Fe3+ ions. Therefore, low M2+ and high Fe3+, i.e. high oxygen fu-gacity, can promote the enrichment of Au+ ions and Au mineralization. Components NT (other than Au+), Al2O3 and SiO2 in basic-ultrabasic melt have no effect on metallogenetic species. As mentioned above, in relevant diagrams distribution areas of the characteristic values of ore-free melt and those of ore-forming melt are overlapped in different degrees, which possibly indicates that not all the magmas have mineralizing ability. It can be well distinguished whether basic-ultrabasic rocks are favourable to Cu or Au mineralization or they are just ore-free rocks by analysing integrated diagrams of the characteristic values of the magmatic melt structure.
基金funded by the National Natural Science Foundation of China (No. 52304133)the National Key R&D Program of China (No. 2022YFC3004605)the Department of Science and Technology of Liaoning Province (No. 2023-BS-083)。
文摘Rockbursts, which mainly affect mining roadways, are dynamic disasters arising from the surrounding rock under high stress. Understanding the interaction between supports and the surrounding rock is necessary for effective rockburst control. In this study, the squeezing behavior of the surrounding rock is analyzed in rockburst roadways, and a mechanical model of rockbursts is established considering the dynamic support stress, thus deriving formulas and providing characteristic curves for describing the interaction between the support and surrounding rock. Design principles and parameters of supports for rockburst control are proposed. The results show that only when the geostress magnitude exceeds a critical value can it drive the formation of rockburst conditions. The main factors influencing the convergence response and rockburst occurrence around roadways are geostress, rock brittleness, uniaxial compressive strength, and roadway excavation size. Roadway support devices can play a role in controlling rockburst by suppressing the squeezing evolution of the surrounding rock towards instability points of rockburst. Further, the higher the strength and the longer the impact stroke of support devices with constant resistance, the more easily multiple balance points can be formed with the surrounding rock to control rockburst occurrence. Supports with long impact stroke allow adaptation to varying geostress levels around the roadway, aiding in rockburst control. The results offer a quantitative method for designing support systems for rockburst-prone roadways. The design criterion of supports is determined by the intersection between the convergence curve of the surrounding rock and the squeezing deformation curve of the support devices.
