With the increasing accumulation of plastic pollutants in various environments,research on microorganisms(including bacteria,fungi,and algae)with plastic degradation capabilities has gained significant attention.Howev...With the increasing accumulation of plastic pollutants in various environments,research on microorganisms(including bacteria,fungi,and algae)with plastic degradation capabilities has gained significant attention.However,only a limited number of microbial plastic-degrading enzymes have been identified to date.This highlights that the degradation mechanisms employed by many plastic-degrading microorganisms,particularly filamentous fungi,remain insufficiently explored.In this study,we utilized a versatile fungal plasmid(pCT74)to express green fluorescent protein(GFP)in a marine-derived fungus Alternaria alternata strain FB1 with plastic degradation capabilities.Upon evaluating the degradation effect of polyester-type polyurethane(PU)film,we observed that different transformants exhibited three kinds of activities(the same,reduced,or enhanced degradation capability)compared to the FB1 wild-type strain.Further analysis of the plasmid fragment insertion sites in different transformants revealed that pCT74 integrates randomly into the genome of the host fungus.Notably,a direct correlation was found between the plasmid insertion site and the degradation capability of the corresponding transformant.Our findings not only redefine the potential applications of plasmid pCT74 in filamentous fungi but also show a novel research approach to identifying key enzymes involved in plastic degradation by fungi.展开更多
This article identifies the role of library and information science (LIS) education in the development of community health information services for people living with HIV/AIDS (PLWHA). Preliminary findings are present...This article identifies the role of library and information science (LIS) education in the development of community health information services for people living with HIV/AIDS (PLWHA). Preliminary findings are presented from semi- structured qualitative interviews that were conducted with eleven directors and managers of local branches in the Knox County Public Library (KCPL) System that is located in the East Tennessee region in the United States. Select feedback reported by research participants is summarized in the article about strategies in LIS education that can help local public librarians and others in their efforts to become more responsive information providers to PLWHA. Research findings help better understand the issues and concerns regarding the development of digital and non-digital health information services for PLWHA in local public library institutions.展开更多
Virtual Home Library (VHL) is an integrated IT system that utilizes virtual reality technology and an IPTV set-top box (STB) to virtually construct a ‘library’ and the relevant reading environment on televisions in ...Virtual Home Library (VHL) is an integrated IT system that utilizes virtual reality technology and an IPTV set-top box (STB) to virtually construct a ‘library’ and the relevant reading environment on televisions in people’s home. Unlike the online e-book reading applications, Virtual Home Library can be applied on televisions – the world’s most convenient and most efficient communication tool. Providing extended digital library services, it will be a perfect group reading utility for family readers. The system has been investigated by a joint research team formed by the National Library of China and the Communication University of China, collaborating with a Chinese IPTV equipment manufacturer. This paper presents some preliminary investigations of the VHL system performed by the research team.展开更多
Statistics show that, in 2016, the National Central Library had has more than 1.27 million books, 36.46million volumes of documents, 1323 TB of digital resources, nearly 5.64 million visitors, nearly 25 million copies...Statistics show that, in 2016, the National Central Library had has more than 1.27 million books, 36.46million volumes of documents, 1323 TB of digital resources, nearly 5.64 million visitors, nearly 25 million copies of literature and held 4,400 social education activities including exhibitions, lectures, training,universal reading and art popularization, benefiting more than 1.73 million people. All these figures reveal the achievements of the National Central Library in enriching the collection resources and providing public cultural services in the past five years.展开更多
This article introduces several of the more significant service delivery innovations and their resulting accomplishments instigated by Dongguan Library(thereafter abbreviated as DGL) in recent years. The textual expos...This article introduces several of the more significant service delivery innovations and their resulting accomplishments instigated by Dongguan Library(thereafter abbreviated as DGL) in recent years. The textual exposition of this paper is based on a case study of DGL by this author about its user-centered vision, mission, immediate objectives and the exhibited service performance within a contextual environment of collegial support from its professional peers. After a five-year period of intensive efforts on such focused professional development and practice, DGL has completed its information service mapping and information delivery for the entire municipality of Dongguan on a 7-day and twentyfour-hour(7/24) basis. This singular feast of accomplishment seems to suggest the moral that any significant development of scale of a municipal library has to be in keeping pace closely with the progress of the society at large in general and with the changing information demands of its local clientele in particular.展开更多
Many modern Chinese libraries have established distribution agencies in other cities to distribute books published or sold on consignment.Huating Bookstore,which was once the Shanghai General Distribution Office of Zh...Many modern Chinese libraries have established distribution agencies in other cities to distribute books published or sold on consignment.Huating Bookstore,which was once the Shanghai General Distribution Office of Zhejiang Library in modern times,is one of them.On the basis of a brief description of modern Zhejiang Library and its book publishing,as well as the overview of Huating Bookstore,the paper introduces and analyzes the ZPL Publishing Book Catalogue sent by Huating Bookstore,and the ZPL publishing and selling consignment books issued by Huating Bookstore.It points out that Huating Bookstore is a bridge between the ZPL located in Hangzhou and various retail ZPL publishing bookstores in Shanghai.Their production and sales relationship is a mutually beneficial one.展开更多
Abstract ： Interlibrary Loan and Document Delivery Service is the major form for libraries to share resources.The librairies of universities or colleges can better guarantee the supply of document information ,accomm...Abstract ： Interlibrary Loan and Document Delivery Service is the major form for libraries to share resources.The librairies of universities or colleges can better guarantee the supply of document information ,accommodating to users＇ need for documents to the greatest extent.This article elaborates on the definition of Interlibrary Loan and Document Delivery as well as their significance with a key focus on the Interlibrary Loan and Document Delivery practice of Oriental Vocational and Technical College in Zhejiang, meanwhile it also puts forward some suggestions on how to better practisee the service of lnterlibrary Loan and Document Delivery.展开更多
Through investigating both users' and librarians' perceptions of the relative importance of the major criteria governing the selection of digital resources, we attempted to develop a criterion weight framework...Through investigating both users' and librarians' perceptions of the relative importance of the major criteria governing the selection of digital resources, we attempted to develop a criterion weight framework for a library's selection of digital resources, which can meet both the users' requirements and the library's goal of developing digital collections. The respective weight of each specific criterion is decided through the Analytic Hierarchy Process(AHP) Method. The findings of this study indicate that, when assigning weights to the selection criteria, it is important to consult the opinions of a wide crosssection of people, especially the views of different users. As a result, the digital resource selection system characterized by the criteria weights can reflect more comprehensively the users' requirements, and meanwhile it enables librarians' more rational selection of digital resources.展开更多
Purpose:Centralized on the construction of a personalized knowledge environment that can better meet the need of Chinese agricultural researchers,this paper presents the practice conducted by the National Agricultural...Purpose:Centralized on the construction of a personalized knowledge environment that can better meet the need of Chinese agricultural researchers,this paper presents the practice conducted by the National Agricultural Library(NAL)of Chinese Academy of Agricultural Sciences(CAAS)in the digital research environment.Based on the analysis of information needs of Chinese agricultural researchers,CAAS constructed digital research environments for its researchers at different levels,by means of providing more professional knowledge services for targeted researcher users.Design/methodology/approach:On the basis of the construction of public service platform—National Agriculture Information System of the Library of CAAS(i.e.NAL),local resources were integrated with public open resources by using key technologies,such as Web 2.0,knowledge navigation,linked data and intelligent retrieval,to construct an institutional personalized digital repository for CAAS researchers.Findings:By using the construction tool CAASPKE,knowledge environment platforms have been constructed for 10 CAAS institutes,taking roughly 33%of CAAS institutes.In addition,16 discipline information environment platforms have been set up for CAAS research teams,and 5 professional digital libraries for provincial agricultural academies,which spread in Beijing,Shanxi,Sichuan,and the Xinjiang and Tibet Autonomous Regions.Research limitations:User’s local collections ought to be integrated with IR resources of the CAAS platform constantly.Due to the lack of overall knowledge resources,functions of the platform have not been fully explored,so the effect need be evaluated with the time being.Practical implications:The construction of research knowledge environment in CAAS has not only contributed to the development of its personalized knowledge service system,but also made the functions of libraries transformed into the information service system.In this case,CAAS libraries are now playing more and more important roles in the innovation process of Chinese agricultural researchers.Originality/value:The innovative practice is the first endeavor that ever implemented in the agricultural information service area across China’s mainland.The construction tool developed for the knowledge environment of personalization could customize resources flexibly according to the need of different CAAS users,and it can organize the knowledge resources of CAAS institutes effectively.展开更多
Ferroptosis of chondrocytes is a significant contributor to osteoarthritis(OA),for which there is still a lack of safe and effective therapeutic drugs targeting ferroptosis.Here,we screen for anti-ferroptotic drugs in...Ferroptosis of chondrocytes is a significant contributor to osteoarthritis(OA),for which there is still a lack of safe and effective therapeutic drugs targeting ferroptosis.Here,we screen for anti-ferroptotic drugs in Food and Drug Administration(FDA)-approved drug library via a high-throughput manner in chondrocytes.We identified a group of FDA-approved anti-ferroptotic drugs,among which vitamin K showed the most powerful protective effect.Further study demonstrated that vitamin K effectively inhibited ferroptosis and alleviated the extracellular matrix(ECM)degradation in chondrocytes.Intra-articular injection of vitamin K inhibited ferroptosis and alleviated OA phenotype in destabilization of the medial meniscus(DMM)mouse model.Mechanistically,transcriptome sequencing and knockdown experiments revealed that the anti-ferroptotic effects of vitamin K depended on growth arrest-specific 6(Gas6).Furthermore,exogenous expression of Gas6 was found to inhibit ferroptosis through the AXL receptor tyrosine kinase(AXL)/phosphatidylinositol 3-kinase(PI3K)/AKT serine/threonine kinase(AKT)axis.Together,we demonstrate that vitamin K inhibits ferroptosis and alleviates OA progression via enhancing Gas6 expression and its downstream pathway of AXL/PI3K/AKT axis,indicating vitamin K as well as Gas6 to serve as a potential therapeutic target for OA and other ferroptosis-related diseases.展开更多
1 In a world filled with more“stuff”than we need,sharing libraries are emerging as a solution to both environmental and economic concerns.Unlike traditional libraries,these“libraries of things”offer a variety of i...1 In a world filled with more“stuff”than we need,sharing libraries are emerging as a solution to both environmental and economic concerns.Unlike traditional libraries,these“libraries of things”offer a variety of items for borrowing,often for free or at a low cost.2 For example,the Oxford Maternity Clothes Library provides expectant mothers with free maternity wear,while the Warwick Toy Library allows locals to borrow toys and even reserve them online.The Tool Library in Wolverhampton offers gardening and DIY equipment,and the Share Shed in Devon has over 350 items available.Nappy libraries also provide parents with reusable cloth nappies(尿布),reducing costs and waste.展开更多
Purpose:This study aims to analyze academic research on Artificial Intelligence(AI)applications and tools in academic libraries,focusing on publications from the Scopus database between 2014 and 2024.Design/methodolog...Purpose:This study aims to analyze academic research on Artificial Intelligence(AI)applications and tools in academic libraries,focusing on publications from the Scopus database between 2014 and 2024.Design/methodology/approach:The study adheres to the PRISMA protocol,using VOSviewer,Bibliometrix,and Rstudio’s Biblioshiny function for bibliographic analysis and visualization.Findings:The study highlights how the potential of AI in academic libraries may be increased by changing user needs and technical advancements.It comprises four thematic clusters:foundational technologies(machine learning,natural language processing,and automation),emerging innovations(generative AI),user-centric applications(chatbots),and the importance of AI literacy.It also reveals research gaps in automation and strategic AI integration,providing recommendations for improving library services.Research limitations:The study is limited to articles published between 2014 and 2024 in the Scopus database,potentially excluding previous foundational work and research from other sources.Practical implications:The study offers policymakers and library practitioners insightful information on effectively utilizing AI tools.This may result in overlooking earlier foundational work and research from multiple sources.Originality/value:The study discovers the role of artificial intelligence(AI)in modernizing academic libraries,identifying research gaps,and providing strategic insights to improve technology and user experience.展开更多
With rapid technological advancements,academic libraries are compelled to reevaluate their mission statements and to reinmagine their roles in higher education institutions.The integration of innovative technologies i...With rapid technological advancements,academic libraries are compelled to reevaluate their mission statements and to reinmagine their roles in higher education institutions.The integration of innovative technologies in the learning and academic work has transformed user relationships with academic libraries in many ways.The paper examines the initiatives that a school-based library has undertaken to accommodate students’needs in light of emerging technologies.These initiatives involve space allocation,campus-wide programs and activities,and the provision of information-related services.The resulting benefits for academic user engagement and the current challenges and opportunities for academic libraries are discussed in the paper.展开更多
Under the background of accelerated global cultural exchange and information dissemination,reading has become a crucial component of public cultural services.Public libraries in Nordic countries(Denmark,Sweden,Norway,...Under the background of accelerated global cultural exchange and information dissemination,reading has become a crucial component of public cultural services.Public libraries in Nordic countries(Denmark,Sweden,Norway,Finland,Iceland)stand out by adhering to the core philosophy of“universal sharing and equal reading”,integrating reading promotion into national strategies,and constructing extensive service networks through sound legal guarantees and adequate financial support.This study identifies four key strategies for universality and equality in Nordic public libraries:covering all age groups,eliminating group differences,integrating digital and physical resources,and ensuring the right to read through legislative,financial,and other institutional support.These provide a reference for global public cultural services.展开更多
In the new era,university libraries have become the main front for universities to promote reading and have an important influence on the quality of talent cultivation in universities.It has become an important missio...In the new era,university libraries have become the main front for universities to promote reading and have an important influence on the quality of talent cultivation in universities.It has become an important mission for universities to do a good job in promoting reading in libraries in the new era and provide better reading services.Based on this,this article briefly summarizes the importance of reading promotion innovation in university libraries and the characteristics of reading behavior among university teachers and students.On this basis,it explores the reading promotion model of university libraries in the new era,hoping to provide useful references for the reading promotion work in university libraries.展开更多
The aim of this article is to present a unique interpretation of the holistic worldview,both in theory and in practice.It explores how this approach,along with a planning process fundamentally different from conventio...The aim of this article is to present a unique interpretation of the holistic worldview,both in theory and in practice.It explores how this approach,along with a planning process fundamentally different from conventional methods,was implemented in the design and construction of the Music Center and Library in the city of Tel Aviv.This process forms a coherent representation of a complete worldview:a humanistic,holistic worldview developed and adopted through more than five decades of architectural practice across all scales of design.In this approach,a building is not regarded as a collection of isolated design elements,but as one hierarchical language,in which the building,its interior,and its ornamented details down to the handle of the door is one continuous system.Within this system,the building,its interior spaces,and even the smallest ornamental details,down to the door handles,are conceived as parts of a single,continuous whole.This worldview aligns with contemporary scientific discourse in fields such as cosmology,neurobiology,psychology,complexity theory,and Buddhist philosophy,disciplines with which this body of work is closely associated.展开更多
This paper conducts topic mining and analysis of research literature in the domestic smart library field based on the BERTopic model,aiming to reveal its topic development context and evolution trends.Journal literatu...This paper conducts topic mining and analysis of research literature in the domestic smart library field based on the BERTopic model,aiming to reveal its topic development context and evolution trends.Journal literature in the smart library field collected by CNKI(China National Knowledge Infrastructure)from 2015 to 2024 was analyzed using the BERTopic model and dynamic topic modeling for topic mining and evolution trend analysis.The study found that the domestic smart library field involves multiple core topics,identifying a diversified topic structure centered around“data”,“user”,“5g”,etc.The research results provide data support and practical reference for libraries to accurately identify key points of technology integration during smart transformation and to optimize smart service models.展开更多
Data factors are becoming the core driving force in the intelligent transformation of libraries.Based on a systematic review of the progress in data governance practices in libraries both domestically and internationa...Data factors are becoming the core driving force in the intelligent transformation of libraries.Based on a systematic review of the progress in data governance practices in libraries both domestically and internationally,this study delves into the mechanism by which data governance promotes data factorization and proposes implementation paths for data governance oriented toward data factorization.The aim is to facilitate the intelligent transformation and high-quality development of libraries.展开更多
基金Supported by the Science and Technology Innovation Project of Laoshan Laboratory(Nos.2022QNLM030004-3,LSKJ202203103)the NSFC Innovative Group Grant(No.42221005)+5 种基金the Key Collaborative Research Program of the Alliance of International Science Organizations(No.ANSO-CR-KP-2022-08)the Shandong Provincial Natural Science Foundation(No.ZR2021ZD28)the Major Research Plan of the National Natural Science Foundation(No.92351301)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA22050301)the Taishan Scholars Program(No.tstp20230637)the Qingdao Natural Science Foundation(No.23-2-1-182-zyyd-jch)。
文摘With the increasing accumulation of plastic pollutants in various environments,research on microorganisms(including bacteria,fungi,and algae)with plastic degradation capabilities has gained significant attention.However,only a limited number of microbial plastic-degrading enzymes have been identified to date.This highlights that the degradation mechanisms employed by many plastic-degrading microorganisms,particularly filamentous fungi,remain insufficiently explored.In this study,we utilized a versatile fungal plasmid(pCT74)to express green fluorescent protein(GFP)in a marine-derived fungus Alternaria alternata strain FB1 with plastic degradation capabilities.Upon evaluating the degradation effect of polyester-type polyurethane(PU)film,we observed that different transformants exhibited three kinds of activities(the same,reduced,or enhanced degradation capability)compared to the FB1 wild-type strain.Further analysis of the plasmid fragment insertion sites in different transformants revealed that pCT74 integrates randomly into the genome of the host fungus.Notably,a direct correlation was found between the plasmid insertion site and the degradation capability of the corresponding transformant.Our findings not only redefine the potential applications of plasmid pCT74 in filamentous fungi but also show a novel research approach to identifying key enzymes involved in plastic degradation by fungi.
文摘This article identifies the role of library and information science (LIS) education in the development of community health information services for people living with HIV/AIDS (PLWHA). Preliminary findings are presented from semi- structured qualitative interviews that were conducted with eleven directors and managers of local branches in the Knox County Public Library (KCPL) System that is located in the East Tennessee region in the United States. Select feedback reported by research participants is summarized in the article about strategies in LIS education that can help local public librarians and others in their efforts to become more responsive information providers to PLWHA. Research findings help better understand the issues and concerns regarding the development of digital and non-digital health information services for PLWHA in local public library institutions.
文摘Virtual Home Library (VHL) is an integrated IT system that utilizes virtual reality technology and an IPTV set-top box (STB) to virtually construct a ‘library’ and the relevant reading environment on televisions in people’s home. Unlike the online e-book reading applications, Virtual Home Library can be applied on televisions – the world’s most convenient and most efficient communication tool. Providing extended digital library services, it will be a perfect group reading utility for family readers. The system has been investigated by a joint research team formed by the National Library of China and the Communication University of China, collaborating with a Chinese IPTV equipment manufacturer. This paper presents some preliminary investigations of the VHL system performed by the research team.
文摘Statistics show that, in 2016, the National Central Library had has more than 1.27 million books, 36.46million volumes of documents, 1323 TB of digital resources, nearly 5.64 million visitors, nearly 25 million copies of literature and held 4,400 social education activities including exhibitions, lectures, training,universal reading and art popularization, benefiting more than 1.73 million people. All these figures reveal the achievements of the National Central Library in enriching the collection resources and providing public cultural services in the past five years.
文摘This article introduces several of the more significant service delivery innovations and their resulting accomplishments instigated by Dongguan Library(thereafter abbreviated as DGL) in recent years. The textual exposition of this paper is based on a case study of DGL by this author about its user-centered vision, mission, immediate objectives and the exhibited service performance within a contextual environment of collegial support from its professional peers. After a five-year period of intensive efforts on such focused professional development and practice, DGL has completed its information service mapping and information delivery for the entire municipality of Dongguan on a 7-day and twentyfour-hour(7/24) basis. This singular feast of accomplishment seems to suggest the moral that any significant development of scale of a municipal library has to be in keeping pace closely with the progress of the society at large in general and with the changing information demands of its local clientele in particular.
基金the research results of Humanities and Social Science Planning Fund Project of the Ministry of Education of P.R.China,titled“Research on the Books Publishing of Modern Chinese Library from the Perspective of Generalized Technology”(Project number:19YJA870014).
文摘Many modern Chinese libraries have established distribution agencies in other cities to distribute books published or sold on consignment.Huating Bookstore,which was once the Shanghai General Distribution Office of Zhejiang Library in modern times,is one of them.On the basis of a brief description of modern Zhejiang Library and its book publishing,as well as the overview of Huating Bookstore,the paper introduces and analyzes the ZPL Publishing Book Catalogue sent by Huating Bookstore,and the ZPL publishing and selling consignment books issued by Huating Bookstore.It points out that Huating Bookstore is a bridge between the ZPL located in Hangzhou and various retail ZPL publishing bookstores in Shanghai.Their production and sales relationship is a mutually beneficial one.
文摘Abstract ： Interlibrary Loan and Document Delivery Service is the major form for libraries to share resources.The librairies of universities or colleges can better guarantee the supply of document information ,accommodating to users＇ need for documents to the greatest extent.This article elaborates on the definition of Interlibrary Loan and Document Delivery as well as their significance with a key focus on the Interlibrary Loan and Document Delivery practice of Oriental Vocational and Technical College in Zhejiang, meanwhile it also puts forward some suggestions on how to better practisee the service of lnterlibrary Loan and Document Delivery.
基金the Foundation for Humanities and Social Sciences of the Chinese Ministry of Education(Grant No.:10CTQ011)China Postdoctoral Science Foundation(Grant No.:20100470971)
文摘Through investigating both users' and librarians' perceptions of the relative importance of the major criteria governing the selection of digital resources, we attempted to develop a criterion weight framework for a library's selection of digital resources, which can meet both the users' requirements and the library's goal of developing digital collections. The respective weight of each specific criterion is decided through the Analytic Hierarchy Process(AHP) Method. The findings of this study indicate that, when assigning weights to the selection criteria, it is important to consult the opinions of a wide crosssection of people, especially the views of different users. As a result, the digital resource selection system characterized by the criteria weights can reflect more comprehensively the users' requirements, and meanwhile it enables librarians' more rational selection of digital resources.
基金supported by the National Science & Technology Pillar Program During the Twelfth Five-year Period Plan of China(Grant No.2011BAH10B06)
文摘Purpose:Centralized on the construction of a personalized knowledge environment that can better meet the need of Chinese agricultural researchers,this paper presents the practice conducted by the National Agricultural Library(NAL)of Chinese Academy of Agricultural Sciences(CAAS)in the digital research environment.Based on the analysis of information needs of Chinese agricultural researchers,CAAS constructed digital research environments for its researchers at different levels,by means of providing more professional knowledge services for targeted researcher users.Design/methodology/approach:On the basis of the construction of public service platform—National Agriculture Information System of the Library of CAAS(i.e.NAL),local resources were integrated with public open resources by using key technologies,such as Web 2.0,knowledge navigation,linked data and intelligent retrieval,to construct an institutional personalized digital repository for CAAS researchers.Findings:By using the construction tool CAASPKE,knowledge environment platforms have been constructed for 10 CAAS institutes,taking roughly 33%of CAAS institutes.In addition,16 discipline information environment platforms have been set up for CAAS research teams,and 5 professional digital libraries for provincial agricultural academies,which spread in Beijing,Shanxi,Sichuan,and the Xinjiang and Tibet Autonomous Regions.Research limitations:User’s local collections ought to be integrated with IR resources of the CAAS platform constantly.Due to the lack of overall knowledge resources,functions of the platform have not been fully explored,so the effect need be evaluated with the time being.Practical implications:The construction of research knowledge environment in CAAS has not only contributed to the development of its personalized knowledge service system,but also made the functions of libraries transformed into the information service system.In this case,CAAS libraries are now playing more and more important roles in the innovation process of Chinese agricultural researchers.Originality/value:The innovative practice is the first endeavor that ever implemented in the agricultural information service area across China’s mainland.The construction tool developed for the knowledge environment of personalization could customize resources flexibly according to the need of different CAAS users,and it can organize the knowledge resources of CAAS institutes effectively.
基金supported by grants from the Wenzhou Science and Technology Bureau Foundation,China(Grant No.:ZY2019014)“Pioneer”and“Leading Goose”R&D Program of Zhejiang,China(Grant No.:2022C03144)National Natural Science Foundation of China(Grant Nos.:82172494,and 82372461).
文摘Ferroptosis of chondrocytes is a significant contributor to osteoarthritis(OA),for which there is still a lack of safe and effective therapeutic drugs targeting ferroptosis.Here,we screen for anti-ferroptotic drugs in Food and Drug Administration(FDA)-approved drug library via a high-throughput manner in chondrocytes.We identified a group of FDA-approved anti-ferroptotic drugs,among which vitamin K showed the most powerful protective effect.Further study demonstrated that vitamin K effectively inhibited ferroptosis and alleviated the extracellular matrix(ECM)degradation in chondrocytes.Intra-articular injection of vitamin K inhibited ferroptosis and alleviated OA phenotype in destabilization of the medial meniscus(DMM)mouse model.Mechanistically,transcriptome sequencing and knockdown experiments revealed that the anti-ferroptotic effects of vitamin K depended on growth arrest-specific 6(Gas6).Furthermore,exogenous expression of Gas6 was found to inhibit ferroptosis through the AXL receptor tyrosine kinase(AXL)/phosphatidylinositol 3-kinase(PI3K)/AKT serine/threonine kinase(AKT)axis.Together,we demonstrate that vitamin K inhibits ferroptosis and alleviates OA progression via enhancing Gas6 expression and its downstream pathway of AXL/PI3K/AKT axis,indicating vitamin K as well as Gas6 to serve as a potential therapeutic target for OA and other ferroptosis-related diseases.
文摘1 In a world filled with more“stuff”than we need,sharing libraries are emerging as a solution to both environmental and economic concerns.Unlike traditional libraries,these“libraries of things”offer a variety of items for borrowing,often for free or at a low cost.2 For example,the Oxford Maternity Clothes Library provides expectant mothers with free maternity wear,while the Warwick Toy Library allows locals to borrow toys and even reserve them online.The Tool Library in Wolverhampton offers gardening and DIY equipment,and the Share Shed in Devon has over 350 items available.Nappy libraries also provide parents with reusable cloth nappies(尿布),reducing costs and waste.
文摘Purpose:This study aims to analyze academic research on Artificial Intelligence(AI)applications and tools in academic libraries,focusing on publications from the Scopus database between 2014 and 2024.Design/methodology/approach:The study adheres to the PRISMA protocol,using VOSviewer,Bibliometrix,and Rstudio’s Biblioshiny function for bibliographic analysis and visualization.Findings:The study highlights how the potential of AI in academic libraries may be increased by changing user needs and technical advancements.It comprises four thematic clusters:foundational technologies(machine learning,natural language processing,and automation),emerging innovations(generative AI),user-centric applications(chatbots),and the importance of AI literacy.It also reveals research gaps in automation and strategic AI integration,providing recommendations for improving library services.Research limitations:The study is limited to articles published between 2014 and 2024 in the Scopus database,potentially excluding previous foundational work and research from other sources.Practical implications:The study offers policymakers and library practitioners insightful information on effectively utilizing AI tools.This may result in overlooking earlier foundational work and research from multiple sources.Originality/value:The study discovers the role of artificial intelligence(AI)in modernizing academic libraries,identifying research gaps,and providing strategic insights to improve technology and user experience.
文摘With rapid technological advancements,academic libraries are compelled to reevaluate their mission statements and to reinmagine their roles in higher education institutions.The integration of innovative technologies in the learning and academic work has transformed user relationships with academic libraries in many ways.The paper examines the initiatives that a school-based library has undertaken to accommodate students’needs in light of emerging technologies.These initiatives involve space allocation,campus-wide programs and activities,and the provision of information-related services.The resulting benefits for academic user engagement and the current challenges and opportunities for academic libraries are discussed in the paper.
基金This paper is a phased research outcome of the 2023 Beijing International Studies University Regional and Country Studies Special Research Project titled“Reading Promotion in Nordic Public Libraries and Its Implications for China’s National Reading Development”(Project No.QYGB23A003).
文摘Under the background of accelerated global cultural exchange and information dissemination,reading has become a crucial component of public cultural services.Public libraries in Nordic countries(Denmark,Sweden,Norway,Finland,Iceland)stand out by adhering to the core philosophy of“universal sharing and equal reading”,integrating reading promotion into national strategies,and constructing extensive service networks through sound legal guarantees and adequate financial support.This study identifies four key strategies for universality and equality in Nordic public libraries:covering all age groups,eliminating group differences,integrating digital and physical resources,and ensuring the right to read through legislative,financial,and other institutional support.These provide a reference for global public cultural services.
文摘In the new era,university libraries have become the main front for universities to promote reading and have an important influence on the quality of talent cultivation in universities.It has become an important mission for universities to do a good job in promoting reading in libraries in the new era and provide better reading services.Based on this,this article briefly summarizes the importance of reading promotion innovation in university libraries and the characteristics of reading behavior among university teachers and students.On this basis,it explores the reading promotion model of university libraries in the new era,hoping to provide useful references for the reading promotion work in university libraries.
文摘The aim of this article is to present a unique interpretation of the holistic worldview,both in theory and in practice.It explores how this approach,along with a planning process fundamentally different from conventional methods,was implemented in the design and construction of the Music Center and Library in the city of Tel Aviv.This process forms a coherent representation of a complete worldview:a humanistic,holistic worldview developed and adopted through more than five decades of architectural practice across all scales of design.In this approach,a building is not regarded as a collection of isolated design elements,but as one hierarchical language,in which the building,its interior,and its ornamented details down to the handle of the door is one continuous system.Within this system,the building,its interior spaces,and even the smallest ornamental details,down to the door handles,are conceived as parts of a single,continuous whole.This worldview aligns with contemporary scientific discourse in fields such as cosmology,neurobiology,psychology,complexity theory,and Buddhist philosophy,disciplines with which this body of work is closely associated.
文摘This paper conducts topic mining and analysis of research literature in the domestic smart library field based on the BERTopic model,aiming to reveal its topic development context and evolution trends.Journal literature in the smart library field collected by CNKI(China National Knowledge Infrastructure)from 2015 to 2024 was analyzed using the BERTopic model and dynamic topic modeling for topic mining and evolution trend analysis.The study found that the domestic smart library field involves multiple core topics,identifying a diversified topic structure centered around“data”,“user”,“5g”,etc.The research results provide data support and practical reference for libraries to accurately identify key points of technology integration during smart transformation and to optimize smart service models.
文摘Data factors are becoming the core driving force in the intelligent transformation of libraries.Based on a systematic review of the progress in data governance practices in libraries both domestically and internationally,this study delves into the mechanism by which data governance promotes data factorization and proposes implementation paths for data governance oriented toward data factorization.The aim is to facilitate the intelligent transformation and high-quality development of libraries.
