The overview shows that the scientific interest in social behaviour in mice has exponentially grown in the last two decades in parallel with advances in biotechnology and the emergence of genetically engineered mice. ...The overview shows that the scientific interest in social behaviour in mice has exponentially grown in the last two decades in parallel with advances in biotechnology and the emergence of genetically engineered mice. Most of the studies are psychopharmacological or look for the neurochemical bases of social behaviour and its alterations. However, the rol of social behaviour per se is increasing mainly in those research works aimed to model neuropsychiatric and neurode-generative diseases. In fact, at the translational level, the study of social behaviour in murine models is relevant because changes in social behaviour are present in most neuropsychiatric and neurodegenerative disorders as well as in other diseases that, directly or indirectly, affect the sphere of social relationships. The consideration of social behaviour in the experimental design of basic and translational research works using murine models may improve the predictive validity of new preventive and/or therapeutic strategies. The present work provides conceptual description of social behaviour in mice, the tests used to measure it and analyzes its increasing interest, mostly in the area of neuroscience. It reviews the 821 scientific studies (in English) included in the MEDLINE database from 1930 to December 2012. Keywords used for the search where those related to the different kinds of social behaviour (spontaneous or induced) in mice and took into account the diversity of experimental paradigms (dyads, groups, parental relationships, isolation) and the wide spectrum of behavioural tests available.展开更多
Nowaday more and more R&D policy makers are concerning the resource allocationpattern on Basic Research,haowever answers satisfing to the utmost degree have not been gotten. By the thought of coordinative developm...Nowaday more and more R&D policy makers are concerning the resource allocationpattern on Basic Research,haowever answers satisfing to the utmost degree have not been gotten. By the thought of coordinative development between Science & Technology, economy, education and environment, this paper tries to deal with the problems facing China on the resource allocation of Basic Research. A comparative study on both developed and developing countries is made. In the meantime, the mechanism of the coordinative development between Science & Technology, economy, education and environment as well as the coordinative development between Basic Research, Applied Research & Development are explored. Based on the comparative study and mechanism analysis, a system dynamic model is constructed, and several policy tests are made, focusing on the analysis of scale & speed of resource allocation policy of Basic Research in China.展开更多
文摘The overview shows that the scientific interest in social behaviour in mice has exponentially grown in the last two decades in parallel with advances in biotechnology and the emergence of genetically engineered mice. Most of the studies are psychopharmacological or look for the neurochemical bases of social behaviour and its alterations. However, the rol of social behaviour per se is increasing mainly in those research works aimed to model neuropsychiatric and neurode-generative diseases. In fact, at the translational level, the study of social behaviour in murine models is relevant because changes in social behaviour are present in most neuropsychiatric and neurodegenerative disorders as well as in other diseases that, directly or indirectly, affect the sphere of social relationships. The consideration of social behaviour in the experimental design of basic and translational research works using murine models may improve the predictive validity of new preventive and/or therapeutic strategies. The present work provides conceptual description of social behaviour in mice, the tests used to measure it and analyzes its increasing interest, mostly in the area of neuroscience. It reviews the 821 scientific studies (in English) included in the MEDLINE database from 1930 to December 2012. Keywords used for the search where those related to the different kinds of social behaviour (spontaneous or induced) in mice and took into account the diversity of experimental paradigms (dyads, groups, parental relationships, isolation) and the wide spectrum of behavioural tests available.
文摘Nowaday more and more R&D policy makers are concerning the resource allocationpattern on Basic Research,haowever answers satisfing to the utmost degree have not been gotten. By the thought of coordinative development between Science & Technology, economy, education and environment, this paper tries to deal with the problems facing China on the resource allocation of Basic Research. A comparative study on both developed and developing countries is made. In the meantime, the mechanism of the coordinative development between Science & Technology, economy, education and environment as well as the coordinative development between Basic Research, Applied Research & Development are explored. Based on the comparative study and mechanism analysis, a system dynamic model is constructed, and several policy tests are made, focusing on the analysis of scale & speed of resource allocation policy of Basic Research in China.
