The highbush blueberry（Vaccinium corymbosum）,Duke,was used to construct a de novo transcriptome sequence library and to perform data statistical analysis.Mega 4,CLC Sequence Viewer 6 software,and quantitative PCR we...The highbush blueberry（Vaccinium corymbosum）,Duke,was used to construct a de novo transcriptome sequence library and to perform data statistical analysis.Mega 4,CLC Sequence Viewer 6 software,and quantitative PCR were employed for bioinformatics and expression analyses of the basic helix-loop-helix（BHLH）transcription factors of the sequencing library.The results showed that 28.38 gigabytes of valid data were obtained from transcriptome sequencing and were assembled into 108 033 unigenes.Functional annotation showed that 32 244 unigenes were annotated into Clusters of Orthologous Groups（COG）and Gene Ontology（GO）databases,whereas the rest of the 75 789 unigenes had no matching information.By using COG and GO classification tools,sequences with annotation information were divided into 25 and 52 categories,respectively,which involved transport and metabolism,transcriptional regulation,and signal transduction.Analysis of the transcriptome library identified a total of 59 BHLH genes.Sequence analysis revealed that 55 genes of that contained a complete BHLH domain.Furthermore,phylogenetic analysis showed that BHLH genes of blueberry（Duke）could be divided into 13 sub-groups.PCR results showed that 45 genes were expressed at various developmental stages of buds,stems,leaves,flowers,and fruits,suggesting that the function of BHLH was associated with the development of different tissues and organs of blueberry,Duke.The present study would provided a foundation for further investigations on the classification and functions of the blueberry BHLH family.展开更多
Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the fo...Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.展开更多
Basic helix−loop−helix(bHLH)domain-containing transcription factors are known for their roles in regulating various plant growth and developmental processes.Previously,we showed that MdbHLH3 from apple(Malus domestica...Basic helix−loop−helix(bHLH)domain-containing transcription factors are known for their roles in regulating various plant growth and developmental processes.Previously,we showed that MdbHLH3 from apple(Malus domestica)has multiple functions,modulating both anthocyanin biosynthesis and cell acidification.Here,we show that MdbHLH3 also regulates ethylene biosynthesis and leaf senescence by promoting the expression of dehydratase-enolasephosphatase complex 1(MdDEP1).Therefore,we propose a model whereby MdbHLH3 acts as a crucial factor that modulates anthocyanin biosynthesis and cell acidification in addition to fruit ripening and leaf senescence by regulating distinct target genes.展开更多
Genome-wide identification and comparative gene-famiy analyses have commonly been performed to investigate spedesspecif ic evolution Inked to various traits and molecular pathways.However,most previous studies have be...Genome-wide identification and comparative gene-famiy analyses have commonly been performed to investigate spedesspecif ic evolution Inked to various traits and molecular pathways.However,most previous studies have been Smited to gene screening h a single reference genome,faiing to account for the gene presence/absence variations(gPAVs)in a species.Here,we propose an innovative pangenome-based approach for gene-family analyses based on orthologous gene groups(OGGs).Usng the basic heix-bop-helix(bH_H)transcription factor family in barley as an example,we identified 161-176 bHLHs in 20 barley genomes,which can be classified into 201 OGGs.These 201 OGGs were further dassif jed into 140 core,12 softcore,29 shell,and 20 Ihe-spedfic/cloud bHLHs,reveaing the complete profile of bHLH genes in barley.Using a genome-scanning approach,we overcame the genome annotation bias and identified an average of 15 un-amotated core bHLHs per barley genome We found that whole-genome/segmental duplicates are predominant mechanisms contrixiting to the expansion of most core/softcore bHLHs,whereas dispensable bHLHs are more Ikely to result from small-scale dupication events.Interestingly,we noticed that the dispensable bHLHs tend to be enriched in the specific subfamiSes SF13,SF27,and SF28,rn plying the potentially based expansion of specific bHLHs h barley.We found that 50%of the bHLHs con tan at least 1 intact transposon element(TE)within the 2-kb upstream-to-downstream region.bHLHs with copy-number variations(CWs)have 1.48 TEs on average,sigrif icantiy more than core bhLHs without CNVs(1.36),supporting a potential role ofTEs in bHLH expansion.Analyses of selection pressure showed that dispensablebHLHs have experienced dearrelaxation of selection compared with core bHLHs,consistent with their conservation patterns.We also integrated the pangenome data with recently avaiable barley pantranscrip-tome data from 5 tissues and discovered apparent transcriptional divergence within and across bHLH sifofamiies.We conclude that pangenome-based gene-family analyses can better describe the previously untapped,genu'ne evolutionary status of bHLHs and provide novel insights into bHLH evolution in barley.We expect that this study wil inspire similar analyses in many other gene famiies and species.展开更多
Basic helix-loop-helix(bHLH)transcription factors play an important role in a wide range of metabolic and developmental processes in eukaryotes,and bHLH proteins also participate in immune responses,especially in plan...Basic helix-loop-helix(bHLH)transcription factors play an important role in a wide range of metabolic and developmental processes in eukaryotes,and bHLH proteins also participate in immune responses,especially in plants.However,their roles in insects upon entomopathogen infection are unknown.In this study,54 bHLH genes in 41 families were identified in a polyphagous pest,Spodoptera litura,including a new bHLH gene in group B,which is specifically present in Lepidoptera and was thus named Lep.The conserved amino acids in the bHLH domain,structural architecture,and chromosomal distribution of bHLH genes in S.litura were analyzed.The bHLH genes in Plutella xylostella and Apis mellifera were also updated,and genome-wide comparison and phylogenetic analysis of bHLH members in 5 holometabolous insects were performed.The expression profiles of S.litura bHLH(SlbHLH)genes in 3 tissues at different developmental stages and their responses to S.litura nucleopolyhedrovirus(SpltNPV),Nomuraea rileyi(Nr),and Bacillus thuringiensis(Bt)infection were investigated.More SlbHLHs in group B were expressed and differentially expressed during pathogen infections,and SlbHLHs tended to be downregulated in the midgut of S.litura larvae after B.thuringiensis treatment.Our study provides an overview of bHLH family members in S.litura and their responses to different pathogens used for pest biocontrol.These findings on bHLH members may contribute to uncovering the mechanism of host-pathogen interaction.展开更多
During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the mold.In which,the behavior of bubbles traversing the liquid slag serves as a rest...During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the mold.In which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid slag.In contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive information.Therefore,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding times.The results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles increases.In addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually decreases.In one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the large.These findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.展开更多
AIM:To compare refractive error and angle of deviation in patients with basic esotropia and basic exotropia.METHODS:A retrospective review was conducted on the medical records of patients with basic-type strabismus.De...AIM:To compare refractive error and angle of deviation in patients with basic esotropia and basic exotropia.METHODS:A retrospective review was conducted on the medical records of patients with basic-type strabismus.Demographic data,refractive error,best-corrected distance visual acuity(BCVA),and the horizontal and vertical angle of deviation between basic esotropia and exotropia patients were compared.RESULTS:Among the 7129 patients(mean age 22.98±14.81y)evaluated,44.7%(3185 cases,54.9%male)exhibited basic-type esotropia,while 55.3%(3944 cases,53.9%male)presented with basic-type exotropia.Basic esotropia cases exhibited more hyperopic spherical equivalent measurements in both eyes(right:0.53±3.07 vs left:0.56±2.98 D)than those with basic exotropia(right eye:-0.33±2.84 vs left eye:-0.24±2.68 D,P<0.001 for both eyes).Patients with basic esotropia had significantly greater horizontal deviation angles(near:36.08±18.87 PD and far:35.56±18.75 PD)compared to those with basic exotropia(near:33.75±16.11 PD and far:33.26±15.90 PD,P<0.001).Conversely,patients with basic exotropia had slightly higher vertical deviation angles(near:1.67±5.80 PD and far:1.72±5.89 PD)compared to those with basic esotropia(near:1.12±4.57 PD and far:1.12±4.58 PD,P<0.001).Patients with basic esotropia underwent surgical intervention at younger ages compared to basic exotropia individuals(19.68±15.99 vs 25.66±13.20,P<0.001).CONCLUSION:Basic esotropia patients present more hyperopic refractive errors,better visual acuity,larger horizontal yet smaller vertical ocular misalignments,and tend to undergo strabismus surgery at younger ages relative to basic exotropia cases.展开更多
The beauty in basic education is pure,simple and true.The beautiful works created by teachers,the beautiful works of teaching materials and the statues of model teachers were gathered in the palace of beauty-the Natio...The beauty in basic education is pure,simple and true.The beautiful works created by teachers,the beautiful works of teaching materials and the statues of model teachers were gathered in the palace of beauty-the National Art Museum of China,nourishing the heart of the public with the beauty in basic education.展开更多
The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate ne...The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.展开更多
Marxist and social science methodologies provide scientific conceptual tools and analytical perspectives for research across various disciplines.Among these,the methodology of quantitative and qualitative changes reve...Marxist and social science methodologies provide scientific conceptual tools and analytical perspectives for research across various disciplines.Among these,the methodology of quantitative and qualitative changes reveals the fundamental laws governing the development of things,offering significant guidance for exploring the relationship between Huimin Insurance and basic medical insurance,and for promoting the sustainable development of the medical security system.Based on this methodology and the practical context of the medical security field,this paper provides an in-depth analysis of the impact of Huimin Insurance on the sustainable development of basic medical insurance.展开更多
Background:Despite self-determination theory’s prominence,few studies examine BPN in China’s ethnic frontier regions.Therefore,this study investigates and analyzes the current situation of community residents with d...Background:Despite self-determination theory’s prominence,few studies examine BPN in China’s ethnic frontier regions.Therefore,this study investigates and analyzes the current situation of community residents with different demographic characteristics in Yanbian in the three basic psychological needs of competency needs,autonomy needs and attribution needs,so as to provide reference for the construction of community service in Yanbian area.Methods:A survey was conducted among 234 residents in four communities in Yanbian from September to October 2024.The equal probability random sampling method was used to collect data by using a general information questionnaire and basic psychological demand scale,and SPSS 28.0 was used for analysis.Through single factor analysis,Pearson correlation analysis and multiple linear regression analysis,the influencing factors and correlation of basic psychological needs of community residents in Yanbian area were discussed.Results:The basic psychological needs of residents were above the middle level;there is a significant positive correlation between economic status and the three dimensions of basic psychological needs(P<0.001).There is a significant positive correlation between the three dimensions of competence demand(β=2.028,P<0.001),autonomy demand(β=2.022,P<0.001),and attribution demand(β=2.693,P<0.001).Conclusion:The satisfaction degree of basic psychological needs of community residents in Yanbian is significantly affected by economic situation,which urges nurses to advocate for economic empowerment programs in community health and provides an empirical basis for the construction of a psychological service system in this area.At the same time,it is proposed that the region can respond by improving social support and improving employment results.展开更多
In this paper,we study the basic p-harmonic forms on the complete foliated Riemannian manifolds.By using the method in[1],we show that if the basic mean curvature form is bounded and co-closed,and the transversal curv...In this paper,we study the basic p-harmonic forms on the complete foliated Riemannian manifolds.By using the method in[1],we show that if the basic mean curvature form is bounded and co-closed,and the transversal curvature operator is nonnegative and positive at least one point,then we obtain a vanishing theorem for L^(p)-integrably p-harmonic r-forms.展开更多
As a by-product of the steelmaking process,steel slag has a large stock and poor stability,which has led to a gradual decline in its utilization.In order to enhance the utilization rate of steel slag,the preparation o...As a by-product of the steelmaking process,steel slag has a large stock and poor stability,which has led to a gradual decline in its utilization.In order to enhance the utilization rate of steel slag,the preparation of basic pellets by using steel slag as the flux was proposed,in consideration of the high basicity of steel slag.The incorporation of steel slag has been demonstrated to enhance the water-holding capacity and the decrepitation temperature of green pellets.The addition of steel slag increases the content of calcium oxide in the pellets,promotes the formation of a fusible phase in the pellets,and thus increases the liquid phase.With the increasing content of steel slag,the porosity of finished pellets gradually increases and the compressive strength decreases,but the compressive strength of finished pellets can all exceed 2500 N.The addition of steel slag can improve the reducibility index of pellets,with the maximum reducibility index increasing by 12.06%;the reduction swelling index is less than 10.9%,and the reduction degradation index is more than 58.4%.展开更多
This study investigated the mediating role of basic psychological needs satisfaction in relationship between teacher support and adolescents’personal growth initiative.A total of 493 adolescents(females=44.8%,mean ag...This study investigated the mediating role of basic psychological needs satisfaction in relationship between teacher support and adolescents’personal growth initiative.A total of 493 adolescents(females=44.8%,mean age=12.46,SD=0.57)completed the Teacher Support Scale,the Adolescents’Personal Growth Initiative Scale,and the Basic Psychological Needs Scale.The results,analyzed through a Mediation model analysis results indicated higher teacher support to be significantly associated with higher adolescents’personal growth initiative.Teacher support was also associated with higher basic psychological needs satisfaction.Basic psychological needs satisfaction mediated the relationship between teacher support and adolescents’personal growth initiative for higher personal growth initiative.Thus,enhancing students’perceptions of teacher support would support the student’s sense of proactive and resilient growth with basic psychological needs satisfaction.展开更多
With the transformation of medical models and the advancement of medical technology,the new era has put forward higher requirements for nursing talents.Nursing staff should not only master solid professional skills an...With the transformation of medical models and the advancement of medical technology,the new era has put forward higher requirements for nursing talents.Nursing staff should not only master solid professional skills and knowledge,but also possess innovative thinking and interdisciplinary cooperation capabilities.As an important place for cultivating nursing talents,higher vocational colleges should update the teaching content of experiment and training in a timely manner in combination with the needs of social changes.Based on this,this paper studies the experiment and training teaching of basic nursing in higher vocational nursing majors,analyzes the changes in the demand for nursing talents in the new era,expounds the existing problems in the current teaching,and puts forward corresponding implementation countermeasures,to cultivate high-quality nursing talents meeting the needs of the new era and provide reference for the teaching reform of higher vocational nursing majors.展开更多
基金supported by the National Natural Science Foundation of China (31301754)the Chinese Academy of Agricultural Sciences-Agricultural Science and Technology Innovation Program (CAAS-ASTIP)the Cultivation Plan for Youth Agricultural Science and Technology Innovative Talents of Liaoning Province, China (2015059)
文摘The highbush blueberry（Vaccinium corymbosum）,Duke,was used to construct a de novo transcriptome sequence library and to perform data statistical analysis.Mega 4,CLC Sequence Viewer 6 software,and quantitative PCR were employed for bioinformatics and expression analyses of the basic helix-loop-helix（BHLH）transcription factors of the sequencing library.The results showed that 28.38 gigabytes of valid data were obtained from transcriptome sequencing and were assembled into 108 033 unigenes.Functional annotation showed that 32 244 unigenes were annotated into Clusters of Orthologous Groups（COG）and Gene Ontology（GO）databases,whereas the rest of the 75 789 unigenes had no matching information.By using COG and GO classification tools,sequences with annotation information were divided into 25 and 52 categories,respectively,which involved transport and metabolism,transcriptional regulation,and signal transduction.Analysis of the transcriptome library identified a total of 59 BHLH genes.Sequence analysis revealed that 55 genes of that contained a complete BHLH domain.Furthermore,phylogenetic analysis showed that BHLH genes of blueberry（Duke）could be divided into 13 sub-groups.PCR results showed that 45 genes were expressed at various developmental stages of buds,stems,leaves,flowers,and fruits,suggesting that the function of BHLH was associated with the development of different tissues and organs of blueberry,Duke.The present study would provided a foundation for further investigations on the classification and functions of the blueberry BHLH family.
基金supported by grants from the Ministry of Education,Culture,Sports,Science and Technology in Japan and Naito Foundation to TCthe Japan Society for the Promotion of Science to MO and TC
文摘Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.
基金supported by grants from the National Key Research and Development Program of China(2018YFD1000200)the National Natural Science Foundation of China(31972375)+2 种基金the Ministry of Agriculture of China(CARS-28)Shandong Province(SDAIT-06-03)Nanjing Agricultural University(ZW201805).
文摘Basic helix−loop−helix(bHLH)domain-containing transcription factors are known for their roles in regulating various plant growth and developmental processes.Previously,we showed that MdbHLH3 from apple(Malus domestica)has multiple functions,modulating both anthocyanin biosynthesis and cell acidification.Here,we show that MdbHLH3 also regulates ethylene biosynthesis and leaf senescence by promoting the expression of dehydratase-enolasephosphatase complex 1(MdDEP1).Therefore,we propose a model whereby MdbHLH3 acts as a crucial factor that modulates anthocyanin biosynthesis and cell acidification in addition to fruit ripening and leaf senescence by regulating distinct target genes.
基金supported by the Australia Grain Research and Development Corporation(9176507).
文摘Genome-wide identification and comparative gene-famiy analyses have commonly been performed to investigate spedesspecif ic evolution Inked to various traits and molecular pathways.However,most previous studies have been Smited to gene screening h a single reference genome,faiing to account for the gene presence/absence variations(gPAVs)in a species.Here,we propose an innovative pangenome-based approach for gene-family analyses based on orthologous gene groups(OGGs).Usng the basic heix-bop-helix(bH_H)transcription factor family in barley as an example,we identified 161-176 bHLHs in 20 barley genomes,which can be classified into 201 OGGs.These 201 OGGs were further dassif jed into 140 core,12 softcore,29 shell,and 20 Ihe-spedfic/cloud bHLHs,reveaing the complete profile of bHLH genes in barley.Using a genome-scanning approach,we overcame the genome annotation bias and identified an average of 15 un-amotated core bHLHs per barley genome We found that whole-genome/segmental duplicates are predominant mechanisms contrixiting to the expansion of most core/softcore bHLHs,whereas dispensable bHLHs are more Ikely to result from small-scale dupication events.Interestingly,we noticed that the dispensable bHLHs tend to be enriched in the specific subfamiSes SF13,SF27,and SF28,rn plying the potentially based expansion of specific bHLHs h barley.We found that 50%of the bHLHs con tan at least 1 intact transposon element(TE)within the 2-kb upstream-to-downstream region.bHLHs with copy-number variations(CWs)have 1.48 TEs on average,sigrif icantiy more than core bhLHs without CNVs(1.36),supporting a potential role ofTEs in bHLH expansion.Analyses of selection pressure showed that dispensablebHLHs have experienced dearrelaxation of selection compared with core bHLHs,consistent with their conservation patterns.We also integrated the pangenome data with recently avaiable barley pantranscrip-tome data from 5 tissues and discovered apparent transcriptional divergence within and across bHLH sifofamiies.We conclude that pangenome-based gene-family analyses can better describe the previously untapped,genu'ne evolutionary status of bHLHs and provide novel insights into bHLH evolution in barley.We expect that this study wil inspire similar analyses in many other gene famiies and species.
基金This research was funded by grants from the National Key R&D Program of China(No,2019YFD1002100)National Natural Science Foundation of China(No.31901941 and No.31970474)+1 种基金Natural Science Foun-dation of Guangdong Province(No.202102020966)China Postdoctoral Science Foundation(No.2020M682752).The authors are grateful for the generous gift of S.litura nucleopolyhedrovirus(SpItNPV)from Professor Kai Yang at Sun Yat-Sen University,Nomuruea rileyi(Nr06)from Professor Xusheng Liu at Central China Normal University,and Bacillus thuringiensis(WB9)from Professor Xiong Guan at Fujian Agriculture and Forestry University.
文摘Basic helix-loop-helix(bHLH)transcription factors play an important role in a wide range of metabolic and developmental processes in eukaryotes,and bHLH proteins also participate in immune responses,especially in plants.However,their roles in insects upon entomopathogen infection are unknown.In this study,54 bHLH genes in 41 families were identified in a polyphagous pest,Spodoptera litura,including a new bHLH gene in group B,which is specifically present in Lepidoptera and was thus named Lep.The conserved amino acids in the bHLH domain,structural architecture,and chromosomal distribution of bHLH genes in S.litura were analyzed.The bHLH genes in Plutella xylostella and Apis mellifera were also updated,and genome-wide comparison and phylogenetic analysis of bHLH members in 5 holometabolous insects were performed.The expression profiles of S.litura bHLH(SlbHLH)genes in 3 tissues at different developmental stages and their responses to S.litura nucleopolyhedrovirus(SpltNPV),Nomuraea rileyi(Nr),and Bacillus thuringiensis(Bt)infection were investigated.More SlbHLHs in group B were expressed and differentially expressed during pathogen infections,and SlbHLHs tended to be downregulated in the midgut of S.litura larvae after B.thuringiensis treatment.Our study provides an overview of bHLH family members in S.litura and their responses to different pathogens used for pest biocontrol.These findings on bHLH members may contribute to uncovering the mechanism of host-pathogen interaction.
基金financially supported by the National Natural Science Foundation of China(Nos.52274315 and 52374320)the Fundamental Research Funds for the Central Universities(Nos.FRF-TP-22-011A1 and FRF-DF22-16)。
文摘During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the mold.In which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid slag.In contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive information.Therefore,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding times.The results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles increases.In addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually decreases.In one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the large.These findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.
文摘AIM:To compare refractive error and angle of deviation in patients with basic esotropia and basic exotropia.METHODS:A retrospective review was conducted on the medical records of patients with basic-type strabismus.Demographic data,refractive error,best-corrected distance visual acuity(BCVA),and the horizontal and vertical angle of deviation between basic esotropia and exotropia patients were compared.RESULTS:Among the 7129 patients(mean age 22.98±14.81y)evaluated,44.7%(3185 cases,54.9%male)exhibited basic-type esotropia,while 55.3%(3944 cases,53.9%male)presented with basic-type exotropia.Basic esotropia cases exhibited more hyperopic spherical equivalent measurements in both eyes(right:0.53±3.07 vs left:0.56±2.98 D)than those with basic exotropia(right eye:-0.33±2.84 vs left eye:-0.24±2.68 D,P<0.001 for both eyes).Patients with basic esotropia had significantly greater horizontal deviation angles(near:36.08±18.87 PD and far:35.56±18.75 PD)compared to those with basic exotropia(near:33.75±16.11 PD and far:33.26±15.90 PD,P<0.001).Conversely,patients with basic exotropia had slightly higher vertical deviation angles(near:1.67±5.80 PD and far:1.72±5.89 PD)compared to those with basic esotropia(near:1.12±4.57 PD and far:1.12±4.58 PD,P<0.001).Patients with basic esotropia underwent surgical intervention at younger ages compared to basic exotropia individuals(19.68±15.99 vs 25.66±13.20,P<0.001).CONCLUSION:Basic esotropia patients present more hyperopic refractive errors,better visual acuity,larger horizontal yet smaller vertical ocular misalignments,and tend to undergo strabismus surgery at younger ages relative to basic exotropia cases.
文摘The beauty in basic education is pure,simple and true.The beautiful works created by teachers,the beautiful works of teaching materials and the statues of model teachers were gathered in the palace of beauty-the National Art Museum of China,nourishing the heart of the public with the beauty in basic education.
基金supported by the National Natural Science Foundation of China,Nos.82272171(to ZY),82271403(to XL),81941011(to XL),31971279(to ZY),31730030(to XL)the Natural Science Foundation of Beijing,No.7222004(to HD).
文摘The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.
文摘Marxist and social science methodologies provide scientific conceptual tools and analytical perspectives for research across various disciplines.Among these,the methodology of quantitative and qualitative changes reveals the fundamental laws governing the development of things,offering significant guidance for exploring the relationship between Huimin Insurance and basic medical insurance,and for promoting the sustainable development of the medical security system.Based on this methodology and the practical context of the medical security field,this paper provides an in-depth analysis of the impact of Huimin Insurance on the sustainable development of basic medical insurance.
基金supported in part by the 2025 Yanbian University College Students’Innovation and Entrepreneurship Training Program.
文摘Background:Despite self-determination theory’s prominence,few studies examine BPN in China’s ethnic frontier regions.Therefore,this study investigates and analyzes the current situation of community residents with different demographic characteristics in Yanbian in the three basic psychological needs of competency needs,autonomy needs and attribution needs,so as to provide reference for the construction of community service in Yanbian area.Methods:A survey was conducted among 234 residents in four communities in Yanbian from September to October 2024.The equal probability random sampling method was used to collect data by using a general information questionnaire and basic psychological demand scale,and SPSS 28.0 was used for analysis.Through single factor analysis,Pearson correlation analysis and multiple linear regression analysis,the influencing factors and correlation of basic psychological needs of community residents in Yanbian area were discussed.Results:The basic psychological needs of residents were above the middle level;there is a significant positive correlation between economic status and the three dimensions of basic psychological needs(P<0.001).There is a significant positive correlation between the three dimensions of competence demand(β=2.028,P<0.001),autonomy demand(β=2.022,P<0.001),and attribution demand(β=2.693,P<0.001).Conclusion:The satisfaction degree of basic psychological needs of community residents in Yanbian is significantly affected by economic situation,which urges nurses to advocate for economic empowerment programs in community health and provides an empirical basis for the construction of a psychological service system in this area.At the same time,it is proposed that the region can respond by improving social support and improving employment results.
基金supported by Guangzhou Science and Technology Program(202102021174)Guangdong Basic and Applied Basic Research Foundation(2023A1515012121).The second author was supported by the Natural Science Foundation of Jiangsu Province(BK20230900)+1 种基金the Fundamental Research Funds for the Central Universities(30924010838)Both authors are partially supported by NSF in China(12141104).
文摘In this paper,we study the basic p-harmonic forms on the complete foliated Riemannian manifolds.By using the method in[1],we show that if the basic mean curvature form is bounded and co-closed,and the transversal curvature operator is nonnegative and positive at least one point,then we obtain a vanishing theorem for L^(p)-integrably p-harmonic r-forms.
基金financially supported by Key Research Project of Hubei Province(No.2022BCA062)China Baowu Low Carbon Metallurgy Innovation Foundation(No.BWLCF202107).
文摘As a by-product of the steelmaking process,steel slag has a large stock and poor stability,which has led to a gradual decline in its utilization.In order to enhance the utilization rate of steel slag,the preparation of basic pellets by using steel slag as the flux was proposed,in consideration of the high basicity of steel slag.The incorporation of steel slag has been demonstrated to enhance the water-holding capacity and the decrepitation temperature of green pellets.The addition of steel slag increases the content of calcium oxide in the pellets,promotes the formation of a fusible phase in the pellets,and thus increases the liquid phase.With the increasing content of steel slag,the porosity of finished pellets gradually increases and the compressive strength decreases,but the compressive strength of finished pellets can all exceed 2500 N.The addition of steel slag can improve the reducibility index of pellets,with the maximum reducibility index increasing by 12.06%;the reduction swelling index is less than 10.9%,and the reduction degradation index is more than 58.4%.
文摘This study investigated the mediating role of basic psychological needs satisfaction in relationship between teacher support and adolescents’personal growth initiative.A total of 493 adolescents(females=44.8%,mean age=12.46,SD=0.57)completed the Teacher Support Scale,the Adolescents’Personal Growth Initiative Scale,and the Basic Psychological Needs Scale.The results,analyzed through a Mediation model analysis results indicated higher teacher support to be significantly associated with higher adolescents’personal growth initiative.Teacher support was also associated with higher basic psychological needs satisfaction.Basic psychological needs satisfaction mediated the relationship between teacher support and adolescents’personal growth initiative for higher personal growth initiative.Thus,enhancing students’perceptions of teacher support would support the student’s sense of proactive and resilient growth with basic psychological needs satisfaction.
文摘With the transformation of medical models and the advancement of medical technology,the new era has put forward higher requirements for nursing talents.Nursing staff should not only master solid professional skills and knowledge,but also possess innovative thinking and interdisciplinary cooperation capabilities.As an important place for cultivating nursing talents,higher vocational colleges should update the teaching content of experiment and training in a timely manner in combination with the needs of social changes.Based on this,this paper studies the experiment and training teaching of basic nursing in higher vocational nursing majors,analyzes the changes in the demand for nursing talents in the new era,expounds the existing problems in the current teaching,and puts forward corresponding implementation countermeasures,to cultivate high-quality nursing talents meeting the needs of the new era and provide reference for the teaching reform of higher vocational nursing majors.
