Objective To evaluate whether the effects of HMG - CoA reductase inhibitors on patients with hyperlipidemia are closely related to baseline lipid levels. Methods The data analyzed originated from 3 separate multicente...Objective To evaluate whether the effects of HMG - CoA reductase inhibitors on patients with hyperlipidemia are closely related to baseline lipid levels. Methods The data analyzed originated from 3 separate multicenter clinical trials with similar designs during 1994 to 1999. 166 patients with mean age 58. 9±9. 2 years were involved in Simvastatin Clinical Trial with simvastatin 10 mg once daily for 8 weeks. 146 patients with mean age 57. 9±8. 7years were involved in Lovastatin Clinical Trial with lovastatin 20 mg once daily for 8 weeks. 105 patients with mean age 57. 8±9. 3 years were involved in Atorvastatin Clinical Trial with atorvastatin 10 mg once daily for 6 weeks. Baseline total cholesterol (TC) was more than 5. 98 mmol. L - 1, and baseline triglyceride (TG) was less than 4. 52 mmo. L - 1. The patients were grouped by baseline lipid levels. Results The higher the baseline TC, low density lipoprotein cholesterol (LDL - C) and TG levels were, the more effective the simvastatin, lovastatin, or atorvastatin was in reducing serum TC, LDL - C, and TG, respectively. A positive linear correlation was found between baseline values and effects of simvastatin, lovastatin, or atorvastatin in reducing serum TC, LDL - C, and TG, respectively. Conclusion The changes of reduction on serum lipid with HMG - CoA reductase inhibitors in patients with hyperlipidemia were influenced by baseline lipid levels.展开更多
Objective To investigate the relationship between baseline serum uric acid and the severity of coronary artery disease(CAD)in the first-degree relatives or nonfirst-degree relatives of men with type 2 diabetes.Methods...Objective To investigate the relationship between baseline serum uric acid and the severity of coronary artery disease(CAD)in the first-degree relatives or nonfirst-degree relatives of men with type 2 diabetes.Methods Three hundred and eighty-one men with negative coronary angiography for the first time were divided into diabetes and non-diabetes groups and followed-up for展开更多
Introduction:To establish baseline radioactivity levels and ensure the safety of drinking water quality in China,gross alpha and gross beta radioactivity levels in drinking water were surveyed from 2012 to 2024.Method...Introduction:To establish baseline radioactivity levels and ensure the safety of drinking water quality in China,gross alpha and gross beta radioactivity levels in drinking water were surveyed from 2012 to 2024.Methods:The surveillance was conducted through the national monitoring system for radioactivity in drinking water,organized by The National Institute for Radiological Protection(NIRP)during the period 2012–2024.Drinking water samples were collected and pretreated in accordance with a unified protocol,and radioactivity was determined using alpha/beta counting systems by local laboratories.Results:From 2012 to 2024,over 11,000 drinking water samples were collected and analyzed across 29 provinces,including areas surrounding nuclear power plants.The mean concentration ranges of gross alpha and gross beta radioactivity levels in all regions and various water bodies were 0.01–0.17 Bq/L and 0.05–0.38 Bq/L,respectively,all of which are below the guidance values specified in the national standard GB 5749(0.5 Bq/L for gross alpha and 1 Bq/L for gross beta).However,the gross alpha and gross beta activity levels in well water were higher than those in other water bodies.The results indicate that radioactivity in drinking water primarily originates from natural radionuclides.Conclusions:Drinking water in China maintains normal background levels of radioactivity.Nuclear power plant operations do not seem to have an impact on surrounding water sources.展开更多
文摘Objective To evaluate whether the effects of HMG - CoA reductase inhibitors on patients with hyperlipidemia are closely related to baseline lipid levels. Methods The data analyzed originated from 3 separate multicenter clinical trials with similar designs during 1994 to 1999. 166 patients with mean age 58. 9±9. 2 years were involved in Simvastatin Clinical Trial with simvastatin 10 mg once daily for 8 weeks. 146 patients with mean age 57. 9±8. 7years were involved in Lovastatin Clinical Trial with lovastatin 20 mg once daily for 8 weeks. 105 patients with mean age 57. 8±9. 3 years were involved in Atorvastatin Clinical Trial with atorvastatin 10 mg once daily for 6 weeks. Baseline total cholesterol (TC) was more than 5. 98 mmol. L - 1, and baseline triglyceride (TG) was less than 4. 52 mmo. L - 1. The patients were grouped by baseline lipid levels. Results The higher the baseline TC, low density lipoprotein cholesterol (LDL - C) and TG levels were, the more effective the simvastatin, lovastatin, or atorvastatin was in reducing serum TC, LDL - C, and TG, respectively. A positive linear correlation was found between baseline values and effects of simvastatin, lovastatin, or atorvastatin in reducing serum TC, LDL - C, and TG, respectively. Conclusion The changes of reduction on serum lipid with HMG - CoA reductase inhibitors in patients with hyperlipidemia were influenced by baseline lipid levels.
文摘Objective To investigate the relationship between baseline serum uric acid and the severity of coronary artery disease(CAD)in the first-degree relatives or nonfirst-degree relatives of men with type 2 diabetes.Methods Three hundred and eighty-one men with negative coronary angiography for the first time were divided into diabetes and non-diabetes groups and followed-up for
文摘Introduction:To establish baseline radioactivity levels and ensure the safety of drinking water quality in China,gross alpha and gross beta radioactivity levels in drinking water were surveyed from 2012 to 2024.Methods:The surveillance was conducted through the national monitoring system for radioactivity in drinking water,organized by The National Institute for Radiological Protection(NIRP)during the period 2012–2024.Drinking water samples were collected and pretreated in accordance with a unified protocol,and radioactivity was determined using alpha/beta counting systems by local laboratories.Results:From 2012 to 2024,over 11,000 drinking water samples were collected and analyzed across 29 provinces,including areas surrounding nuclear power plants.The mean concentration ranges of gross alpha and gross beta radioactivity levels in all regions and various water bodies were 0.01–0.17 Bq/L and 0.05–0.38 Bq/L,respectively,all of which are below the guidance values specified in the national standard GB 5749(0.5 Bq/L for gross alpha and 1 Bq/L for gross beta).However,the gross alpha and gross beta activity levels in well water were higher than those in other water bodies.The results indicate that radioactivity in drinking water primarily originates from natural radionuclides.Conclusions:Drinking water in China maintains normal background levels of radioactivity.Nuclear power plant operations do not seem to have an impact on surrounding water sources.
