OBJECTIVE: To investigate the efficacy and potential mechanism of Bailing capsule( 百令胶囊, BL) antiautoimmune thyroiditis(AIT). METHODS: Based on the AIT rat model, the effect of BL in alleviating AIT was evaluated ...OBJECTIVE: To investigate the efficacy and potential mechanism of Bailing capsule( 百令胶囊, BL) antiautoimmune thyroiditis(AIT). METHODS: Based on the AIT rat model, the effect of BL in alleviating AIT was evaluated by detecting serum thyroid index free triiodothyronine(FT3), free thyroxine(FT4), thyroid-stimulating hormone(TSH), thyroglobulin antibody(TGAb), thyroid peroxidase antibody(TPOAb), and inflammatory factors Interferon-gamma(IFN-γ), Interleukin-4,-10, and-12(IL-4, IL-10, and IL-12) as well as thyroid tissue Hematoxylin-eosin(HE) staining and ultrastructure observation. The mechanism of BL was explored by combining transcriptome and proteome analysis, and further verified by Western blot(WB). RESULTS: BL effectively reduced serum FT3, FT4, TGAb, and TPOAb levels in AIT rats, restored TSH balance, inhibited the release of pro-inflammatory cytokines IFN-γ and IL-12, promoted the production of anti-inflammatory cytokines IL-4 and IL-10, and significantly reduced IFN-γ/IL-4 and IL-12/IL-10, improved thyroid follicular structure, and protected thyroid tissue from injury. Kyoto Encyclopedia of Genes and Genomes and protein interaction network analysis showed that BL affected the expression of fatty acidbinding protein 4, acyl-Co A synthetase long-chain family member 1, and acyl-Co A dehydrogenase long chain to regulate the peroxisome proliferator-activated receptor signaling pathway, thereby inhibiting the fatty acid metabolism and the inflammatory state of AIT rats.CONCLUSIONS: BL could effectively reduce thyroid inflammation in AIT model rats. The possible BL mechanism was to regulate the peroxisome proliferatoractivated receptor signaling pathway and inhibit fatty acid metabolism. This study suggested that BL has the potential to be used in clinical treatment of AIT.展开更多
Objective:To investigate the clinical efficacy and safety of alprostadil combined with Bailing Capsule in the treatment of chronic renal failure,and the influence of alprostadil combined with Bailing Capsule on residu...Objective:To investigate the clinical efficacy and safety of alprostadil combined with Bailing Capsule in the treatment of chronic renal failure,and the influence of alprostadil combined with Bailing Capsule on residual renal function,renal hemodynamics,immune indexes and nutritional status.Methods 86 patients with chronic renal failure(CRF)hospitalized in Wuhan integrated traditional Chinese and Western Medicine Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology from January 2018 to June 2019 were selected as the study objects.They were randomly divided into control group and case group with 43 cases in each group.Two groups were given peritoneal dialysis treatment,the control group was given bailing capsule,the case group was given alprostadil injection on the basis of the control group.To observe the clinical effect of the two groups before and after treatment,and the changes of residual renal function,renal hemodynamics,immune index and nutritional status.Results The total effective rate of the case group was 97.68%,higher than 83.73%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of bun,SCR,GFR,24h urinary protein quantity,resistance index,CRP,IL-6,TNF,CD8+and SGA in the two groups were lower than those before treatment;the levels of renal blood flow,RRF,CD3+,CD4+,ALB,PA,TRF and Hb were higher than those before treatment;moreover,the improvement of serum inflammatory cytokines,residual renal function and renal hemodynamic indexes,immune indexes and nutritional status in the case group were significant The difference was statistically significant(P<0.05).The incidence of adverse reactions in the control group was 16.28%,higher than 6.98%in the case group,with no significant difference(P>0.05).Conclusion Alprostadil combined with Bailing capsule can significantly improve the residual renal function,hemodynamics,immune index,reduce the degree of inflammatory response in patients with chronic renal failure.展开更多
Objective: To explore the effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy. Methods: 142 patients with diabetic n...Objective: To explore the effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy. Methods: 142 patients with diabetic nephropathy admitted to our hospital from April 2017 to July 2018 were selected as the study subjects. 71 cases in the control group and 71 cases in the observation group were randomly assigned. The renal function, oxidative stress, inflammation and immune indexes of two groups of patients with diabetic nephropathy were compared and analyzed. Results: After treatment, the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ of DN patients in both groups decreased significantly compared with those before the treatment, while the levels of SOD, CD4+, CD4+/CD8+ increased significantly compared with those before the treatment;and the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ in the observation group were significantly lower than those in the control group, while the levels of SOD, CD4+, CD4+/CD8+ in the observation group were significantly higher than those in the control group. Conclusions: Bailing capsule combined with irbesartan in the treatment of diabetic nephropathy can effectively improve the renal function, oxidize inflammatory reaction and enhance the immune function of patients, which has clinical significance.展开更多
Objective:To investigate the effect of Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin on lipid metabolism and insulin resistance in patients with polycystic ovary syndrome (PCOS)....Objective:To investigate the effect of Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin on lipid metabolism and insulin resistance in patients with polycystic ovary syndrome (PCOS).Methods: A total of 108 patients with PCOS who were treated in our hospital between November 2014 and April 2017 were reviewed and divided into routine group (n=67) who received routine therapy and Bailing capsule group (n=41) who received Bailing capsule combined with routine therapy. Routine group received ethinylestradiol and cyproterone acetate and metformin therapy, and Bailing capsule group were treated with Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy. The differences in the levels of lipid metabolism, insulin resistance indexes as well as inflammatory factors were compared between the two groups before and after treatment.Results: There was no statistically significant difference in serum levels of lipid metabolism, insulin resistance-related indexes and inflammatory factors between the two groups before treatment. After treatment, serum HDL-C content of Bailing capsule group was higher than that of routine group whereas LDL-C and TC contents were lower than those of routine group;serum insulin resistance-related indexes FINS and HOMA-IR levels were lower than those of routine group;serum inflammatory cytokines IL-6, TNF-α, APN and LEP contents were lower than those of routine group.Conclusion: Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy can effectively improve the lipid metabolism level and inhibit the insulin resistance in patients with PCOS.展开更多
Objective:To investigate the effects of Bailing capsule combined with edaravone on immune function, antioxidant function and related factors in patients with chronic obstructive pulmonary disease (COPD).Methods:160 pa...Objective:To investigate the effects of Bailing capsule combined with edaravone on immune function, antioxidant function and related factors in patients with chronic obstructive pulmonary disease (COPD).Methods:160 patients with COPD who received treatment in the department of respiratory medicine of our hospital from March 2016 to March 2018 were randomly divided into control group and observation group, 80 cases in each group. Patients in the control group received edaravone treatment, while patients in the observation group received bailing capsule combined with edaravone treatment. The levels of T lymphocyte, superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9) were measured and compared before and after treatment.Result: After treatment, the levels of CD3+, CD4+, CD4+ / CD8+, SOD and NO of patients in the control group and the observation group were significantly higher than those before treatment, while the levels of CD8+ and MDA were significantly lower than those before treatment. The change trend of the levels of T lymphocyte and antioxidant enzyme of patients in the observation group were significantly more obvious than that in the control group (P<0.05). After treatment, the serum levels of TGF-β1, TNF-α and MMP-9 of patients in the control group and the observation group decreased significantly, and the change trend of the above factors of patients in the observation group was more obvious than that in the control group (P<0.05).Conclusion: Bailing capsule combined with edaravone in the treatment of chronic obstructive pulmonary disease can significantly enhance the immune function and antioxidant function of patients and alleviate inflammation of the body. It has good clinical curative effect.展开更多
Prof. Yang Bailing is a research professor specializing in chemical lasers and aero-dynamics. Born in Shanghai in October 1943, he graduated from the Harbin Institute of Military Engineering in 1966 and was then assig...Prof. Yang Bailing is a research professor specializing in chemical lasers and aero-dynamics. Born in Shanghai in October 1943, he graduated from the Harbin Institute of Military Engineering in 1966 and was then assigned to work at the CAS-affiliated Dalian Institute of Chemical Physics. In 1980, he展开更多
On a hot summer day in August 2006, Lamao Cering crouched in a windy field in west China＇s Qinghai Province murmuring to herself. ＂I want to go to school,＂ she chanted quietly over and over in an almost mantra-like...On a hot summer day in August 2006, Lamao Cering crouched in a windy field in west China＇s Qinghai Province murmuring to herself. ＂I want to go to school,＂ she chanted quietly over and over in an almost mantra-like trance, oblivious to her father＇s call to come back and tend the sheep.展开更多
基金Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine:Studies on the Antimalarial and Drug Resistance Mechanisms of Artemisinin and the Expansion of New Indications (No. ZYYCXTD-C-202002)。
文摘OBJECTIVE: To investigate the efficacy and potential mechanism of Bailing capsule( 百令胶囊, BL) antiautoimmune thyroiditis(AIT). METHODS: Based on the AIT rat model, the effect of BL in alleviating AIT was evaluated by detecting serum thyroid index free triiodothyronine(FT3), free thyroxine(FT4), thyroid-stimulating hormone(TSH), thyroglobulin antibody(TGAb), thyroid peroxidase antibody(TPOAb), and inflammatory factors Interferon-gamma(IFN-γ), Interleukin-4,-10, and-12(IL-4, IL-10, and IL-12) as well as thyroid tissue Hematoxylin-eosin(HE) staining and ultrastructure observation. The mechanism of BL was explored by combining transcriptome and proteome analysis, and further verified by Western blot(WB). RESULTS: BL effectively reduced serum FT3, FT4, TGAb, and TPOAb levels in AIT rats, restored TSH balance, inhibited the release of pro-inflammatory cytokines IFN-γ and IL-12, promoted the production of anti-inflammatory cytokines IL-4 and IL-10, and significantly reduced IFN-γ/IL-4 and IL-12/IL-10, improved thyroid follicular structure, and protected thyroid tissue from injury. Kyoto Encyclopedia of Genes and Genomes and protein interaction network analysis showed that BL affected the expression of fatty acidbinding protein 4, acyl-Co A synthetase long-chain family member 1, and acyl-Co A dehydrogenase long chain to regulate the peroxisome proliferator-activated receptor signaling pathway, thereby inhibiting the fatty acid metabolism and the inflammatory state of AIT rats.CONCLUSIONS: BL could effectively reduce thyroid inflammation in AIT model rats. The possible BL mechanism was to regulate the peroxisome proliferatoractivated receptor signaling pathway and inhibit fatty acid metabolism. This study suggested that BL has the potential to be used in clinical treatment of AIT.
基金National Natural Science Foundation of China(No.81770679)
文摘Objective:To investigate the clinical efficacy and safety of alprostadil combined with Bailing Capsule in the treatment of chronic renal failure,and the influence of alprostadil combined with Bailing Capsule on residual renal function,renal hemodynamics,immune indexes and nutritional status.Methods 86 patients with chronic renal failure(CRF)hospitalized in Wuhan integrated traditional Chinese and Western Medicine Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology from January 2018 to June 2019 were selected as the study objects.They were randomly divided into control group and case group with 43 cases in each group.Two groups were given peritoneal dialysis treatment,the control group was given bailing capsule,the case group was given alprostadil injection on the basis of the control group.To observe the clinical effect of the two groups before and after treatment,and the changes of residual renal function,renal hemodynamics,immune index and nutritional status.Results The total effective rate of the case group was 97.68%,higher than 83.73%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of bun,SCR,GFR,24h urinary protein quantity,resistance index,CRP,IL-6,TNF,CD8+and SGA in the two groups were lower than those before treatment;the levels of renal blood flow,RRF,CD3+,CD4+,ALB,PA,TRF and Hb were higher than those before treatment;moreover,the improvement of serum inflammatory cytokines,residual renal function and renal hemodynamic indexes,immune indexes and nutritional status in the case group were significant The difference was statistically significant(P<0.05).The incidence of adverse reactions in the control group was 16.28%,higher than 6.98%in the case group,with no significant difference(P>0.05).Conclusion Alprostadil combined with Bailing capsule can significantly improve the residual renal function,hemodynamics,immune index,reduce the degree of inflammatory response in patients with chronic renal failure.
文摘Objective: To explore the effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy. Methods: 142 patients with diabetic nephropathy admitted to our hospital from April 2017 to July 2018 were selected as the study subjects. 71 cases in the control group and 71 cases in the observation group were randomly assigned. The renal function, oxidative stress, inflammation and immune indexes of two groups of patients with diabetic nephropathy were compared and analyzed. Results: After treatment, the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ of DN patients in both groups decreased significantly compared with those before the treatment, while the levels of SOD, CD4+, CD4+/CD8+ increased significantly compared with those before the treatment;and the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ in the observation group were significantly lower than those in the control group, while the levels of SOD, CD4+, CD4+/CD8+ in the observation group were significantly higher than those in the control group. Conclusions: Bailing capsule combined with irbesartan in the treatment of diabetic nephropathy can effectively improve the renal function, oxidize inflammatory reaction and enhance the immune function of patients, which has clinical significance.
文摘Objective:To investigate the effect of Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin on lipid metabolism and insulin resistance in patients with polycystic ovary syndrome (PCOS).Methods: A total of 108 patients with PCOS who were treated in our hospital between November 2014 and April 2017 were reviewed and divided into routine group (n=67) who received routine therapy and Bailing capsule group (n=41) who received Bailing capsule combined with routine therapy. Routine group received ethinylestradiol and cyproterone acetate and metformin therapy, and Bailing capsule group were treated with Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy. The differences in the levels of lipid metabolism, insulin resistance indexes as well as inflammatory factors were compared between the two groups before and after treatment.Results: There was no statistically significant difference in serum levels of lipid metabolism, insulin resistance-related indexes and inflammatory factors between the two groups before treatment. After treatment, serum HDL-C content of Bailing capsule group was higher than that of routine group whereas LDL-C and TC contents were lower than those of routine group;serum insulin resistance-related indexes FINS and HOMA-IR levels were lower than those of routine group;serum inflammatory cytokines IL-6, TNF-α, APN and LEP contents were lower than those of routine group.Conclusion: Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy can effectively improve the lipid metabolism level and inhibit the insulin resistance in patients with PCOS.
文摘Objective:To investigate the effects of Bailing capsule combined with edaravone on immune function, antioxidant function and related factors in patients with chronic obstructive pulmonary disease (COPD).Methods:160 patients with COPD who received treatment in the department of respiratory medicine of our hospital from March 2016 to March 2018 were randomly divided into control group and observation group, 80 cases in each group. Patients in the control group received edaravone treatment, while patients in the observation group received bailing capsule combined with edaravone treatment. The levels of T lymphocyte, superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9) were measured and compared before and after treatment.Result: After treatment, the levels of CD3+, CD4+, CD4+ / CD8+, SOD and NO of patients in the control group and the observation group were significantly higher than those before treatment, while the levels of CD8+ and MDA were significantly lower than those before treatment. The change trend of the levels of T lymphocyte and antioxidant enzyme of patients in the observation group were significantly more obvious than that in the control group (P<0.05). After treatment, the serum levels of TGF-β1, TNF-α and MMP-9 of patients in the control group and the observation group decreased significantly, and the change trend of the above factors of patients in the observation group was more obvious than that in the control group (P<0.05).Conclusion: Bailing capsule combined with edaravone in the treatment of chronic obstructive pulmonary disease can significantly enhance the immune function and antioxidant function of patients and alleviate inflammation of the body. It has good clinical curative effect.
文摘Prof. Yang Bailing is a research professor specializing in chemical lasers and aero-dynamics. Born in Shanghai in October 1943, he graduated from the Harbin Institute of Military Engineering in 1966 and was then assigned to work at the CAS-affiliated Dalian Institute of Chemical Physics. In 1980, he
文摘On a hot summer day in August 2006, Lamao Cering crouched in a windy field in west China＇s Qinghai Province murmuring to herself. ＂I want to go to school,＂ she chanted quietly over and over in an almost mantra-like trance, oblivious to her father＇s call to come back and tend the sheep.
