This study was aimed to explore the associations between the combined effects of several polymorphisms in the PPAR-γ and RXR-α gene and environmental factors with the risk of metabolic syndrome by back-error propaga...This study was aimed to explore the associations between the combined effects of several polymorphisms in the PPAR-γ and RXR-α gene and environmental factors with the risk of metabolic syndrome by back-error propaga- tion artificial neural network （BPANN）. We established the model based on data gathered from metabolic syndrome patients （n = 1012） and normal controls （n = 1069） by BPANN. Mean impact value （MIV） for each input variable was calculated and the sequence of factors was sorted according to their absolute MIVs. Generalized multifactor dimensionality reduction （GMDR） confirmed a joint effect of PPAR-9＂ and RXR-a based on the results from BPANN. By BPANN analysis, the sequences according to the importance of metabolic syndrome risk fac- tors were in the order of body mass index （BMI）, serum adiponectin, rs4240711, gender, rs4842194, family history of type 2 diabetes, rs2920502, physical activity, alcohol drinking, rs3856806, family history of hypertension, rs1045570, rs6537944, age, rs17817276, family history of hyperlipidemia, smoking, rs1801282 and rs3132291. However, no polymorphism was statistically significant in multiple logistic regression analysis. After controlling for environmental factors, A1, A2, B1 and B2 （rs4240711, rs4842194, rs2920502 and rs3856806） models were the best models （cross-validation consistency 10/10, P = 0.0107） with the GMDR method. In conclusion, the interaction of the PPAR-γ and RXR-α gene could play a role in susceptibility to metabolic syndrome. A more realistic model is obtained by using BPANN to screen out determinants of diseases of multiple etiologies like metabolic syndrome.展开更多
目的利用360°全方向24和36声源测试设备,初步探讨健听中青年和健听老年前期-老年人水平声源定位特点。方法选取2021年4月至2021年9月中国人民解放军总医院耳鼻喉科收治的43例健听成年受试者为研究对象,其中男性22例,女性21例;根据...目的利用360°全方向24和36声源测试设备,初步探讨健听中青年和健听老年前期-老年人水平声源定位特点。方法选取2021年4月至2021年9月中国人民解放军总医院耳鼻喉科收治的43例健听成年受试者为研究对象,其中男性22例,女性21例;根据年龄分为中青年组(21~49岁)20例和老年前期-老年组(50~72岁)23例。两组分别给予纯音听阈测试、全方向24声源(间隔15°)和36声源(间隔10°)水平声源定位(sound localization,SL)能力评估。给声强度60 dB HL,给声刺激为1 kHz啭音,通过计算均方根误差(root mean square,RMS)、平均绝对误差(mean absolutely error,MAE)等评估受试者的声源定位能力。结果24声源老年前期-老年组MAE、RMS均值高于中青年组的MAE、RMS均值,差异有统计学意义(P<0.05);36声源老年前期-老年组MAE、RMS高于中青年组的MAE、RMS,差异无统计学意义(P>0.05)。24声源和36声源前场MAE和RMS均高于后场的MAE和RMS,前后场的MAE和RMS比较,差异有统计学意义(P<0.01);左右场的MAE、RMS比较,差异无统计学意义(P>0.05)。24声源前后混淆比例为7.73%,36声源前后混淆比例为15.42%;24声源和36声源均为正前方的声源定位准确度最差;老年前期-老年组前后混淆的比例高于中青年组,差异无统计学意义(P>0.05)。结论健听老年前期-老年人全方向24声源和36声源水平定位能力,相比健听中青年组有所下降。左右场的定位准确度高,前后场的定位准确度低,正前方定位准确度最低。全方向水平声源定位能力的测试结果与扬声器数量有关,且反应趋势具有一致性。展开更多
基金supported by the National Natural Science Foundation of China Grant No.30771858Jiangsu Provincial Natural Science Foundation Grant No.BK2007229Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘This study was aimed to explore the associations between the combined effects of several polymorphisms in the PPAR-γ and RXR-α gene and environmental factors with the risk of metabolic syndrome by back-error propaga- tion artificial neural network （BPANN）. We established the model based on data gathered from metabolic syndrome patients （n = 1012） and normal controls （n = 1069） by BPANN. Mean impact value （MIV） for each input variable was calculated and the sequence of factors was sorted according to their absolute MIVs. Generalized multifactor dimensionality reduction （GMDR） confirmed a joint effect of PPAR-9＂ and RXR-a based on the results from BPANN. By BPANN analysis, the sequences according to the importance of metabolic syndrome risk fac- tors were in the order of body mass index （BMI）, serum adiponectin, rs4240711, gender, rs4842194, family history of type 2 diabetes, rs2920502, physical activity, alcohol drinking, rs3856806, family history of hypertension, rs1045570, rs6537944, age, rs17817276, family history of hyperlipidemia, smoking, rs1801282 and rs3132291. However, no polymorphism was statistically significant in multiple logistic regression analysis. After controlling for environmental factors, A1, A2, B1 and B2 （rs4240711, rs4842194, rs2920502 and rs3856806） models were the best models （cross-validation consistency 10/10, P = 0.0107） with the GMDR method. In conclusion, the interaction of the PPAR-γ and RXR-α gene could play a role in susceptibility to metabolic syndrome. A more realistic model is obtained by using BPANN to screen out determinants of diseases of multiple etiologies like metabolic syndrome.
文摘目的利用360°全方向24和36声源测试设备,初步探讨健听中青年和健听老年前期-老年人水平声源定位特点。方法选取2021年4月至2021年9月中国人民解放军总医院耳鼻喉科收治的43例健听成年受试者为研究对象,其中男性22例,女性21例;根据年龄分为中青年组(21~49岁)20例和老年前期-老年组(50~72岁)23例。两组分别给予纯音听阈测试、全方向24声源(间隔15°)和36声源(间隔10°)水平声源定位(sound localization,SL)能力评估。给声强度60 dB HL,给声刺激为1 kHz啭音,通过计算均方根误差(root mean square,RMS)、平均绝对误差(mean absolutely error,MAE)等评估受试者的声源定位能力。结果24声源老年前期-老年组MAE、RMS均值高于中青年组的MAE、RMS均值,差异有统计学意义(P<0.05);36声源老年前期-老年组MAE、RMS高于中青年组的MAE、RMS,差异无统计学意义(P>0.05)。24声源和36声源前场MAE和RMS均高于后场的MAE和RMS,前后场的MAE和RMS比较,差异有统计学意义(P<0.01);左右场的MAE、RMS比较,差异无统计学意义(P>0.05)。24声源前后混淆比例为7.73%,36声源前后混淆比例为15.42%;24声源和36声源均为正前方的声源定位准确度最差;老年前期-老年组前后混淆的比例高于中青年组,差异无统计学意义(P>0.05)。结论健听老年前期-老年人全方向24声源和36声源水平定位能力,相比健听中青年组有所下降。左右场的定位准确度高,前后场的定位准确度低,正前方定位准确度最低。全方向水平声源定位能力的测试结果与扬声器数量有关,且反应趋势具有一致性。
