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Prognostic value of hemoglobin-to-red cell distribution width ratio and inflammation markers in colorectal cancer
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作者 Esra Zeynelgil Yakup Duzkopru +1 位作者 Abdulkadir Kocanoglu Serdar Karakaya 《World Journal of Gastrointestinal Oncology》 2025年第6期243-252,共10页
BACKGROUND The hemoglobin-to-red cell distribution width ratio(HRR)is a recently intro-duced,easily accessible marker that provides insights into inflammation and the tumor vascular microenvironment.It has been sugges... BACKGROUND The hemoglobin-to-red cell distribution width ratio(HRR)is a recently intro-duced,easily accessible marker that provides insights into inflammation and the tumor vascular microenvironment.It has been suggested to have prognostic value for overall survival in various types of cancer,including urothelial carcinoma,lung cancer,and hepatocellular carcinoma.It has not yet been sufficiently invest-igated in colorectal cancers(CRC).AIM To investigate the prognostic significance of the HRR and other inflammation-based hematological markers in patients with metastatic CRC.Additionally,the study evaluated the impact of surgical interventions,particularly metastasectomy,and multiple clinical and laboratory parameters on overall survival.By iden-tifying low-cost,accessible prognostic indicators,this research seeks to support clinicians in optimizing treatment strategies and risk stratification for patients with CRC.METHODS In this retrospective study,patients diagnosed with CRC between January 2020 and December 2024 were analyzed.The impact of HRR in conjunction with inflammatory markers and a total of 22 different clinical and laboratory para-meters on overall survival were evaluated using univariate Cox regression and a multivariate model.Survival curves were visualized using Kaplan-Meier analysis.RESULTS A total of 155 patients with CRC were included in the study.The median age was 60 years,and 61.9%presented with de novo metastasis.In the receiver operating characteristic curve and area under the curve analysis performed to determine the optimal cutoff,the values were found to be 6.10 for carcinoembryonic antigen(CEA)(P=0.036),18.85 for platelet-to-red cell distribution width ratio(P=0.028),and 10.87 for platelet distribution width-to-lymphocyte ratio(P=0.028).For neutrophil-to-lymphocyte ratio,systemic immune-inflammation index(SII),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio,HRR,and carbohydrate antigen 19-9,an optimal cutoff could not be determined using the receiver operating characteristic-area under the curve analysis.Therefore,the median values were adopted as the cutoffs(3.09,835.96,177.50,0.380,0.824,and 21.6,respectively).Univariate analysis identified male gender(P=0.045),being under 65 years of age(P=0.001),history of metastas-ectomy(P=0.001),low serum CEA level(P=0.010),low PLR(P=0.024),low SII(P=0.010),and high HRR(P=0.025)as favorable prognostic factors for overall survival.In the multivariate model,being under 65 years of age[hazard ratio(HR)=1.59,95%confidence interval(CI):1.06-2.39,P=0.025],metastasectomy(HR=0.49,95%CI:0.29-0.85,P=0.011),CEA(HR=1.51,95%CI:1.0-2.28,P=0.048),and PLR(HR=1.63,95%CI:1.09-2.44,P=0.018)emerged as independent prognostic factors for overall survival,whereas gender,SII,and HRR did not retain statistical significance.CONCLUSION In conclusion,low HRR alone was a prognostic indicator.However,when modelled with other inflammatory and clinical parameters,it did not provide a sufficiently strong marker feature. 展开更多
关键词 Colon cancer Neutrophil-to-lymphocyte ratio Hemoglobin-to-red cell distribution width ratio Systemic immuneinflammation index Inflammation markers
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Combination of red blood cell distribution width and platelet-to-lymphocyte ratio for predicting severity of diabetic retinopathy
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作者 Zhi-Mei Wei Yu Zhao +7 位作者 Ran-Ran Ding Yu-Song Zeng Zheng Zeng Zi-Tong He Jing Hao Jing-Jing Hu Jin-Guo Yu Cai-Yun You 《International Journal of Ophthalmology(English edition)》 2025年第8期1506-1514,共9页
AIM:To assess and compare the utility of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),systemic inflammation index(SII),and red blood cell distribution width(RDW)as potential biomarkers to pred... AIM:To assess and compare the utility of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),systemic inflammation index(SII),and red blood cell distribution width(RDW)as potential biomarkers to predict the severity of diabetic retinopathy(DR)in the United States population.METHODS:The observational study enlisted patients diagnosed with DR from the National Health and Nutrition Examination Survey(NHANES)database,spanning the period from 2005 to 2008.The severity of DR was defined according to Early Treatment for Diabetic Retinopathy Study(ETDRs).The effect of NLR,PLR,SII,and RDW on proliferative diabetic retinopathy(PDR)were explored using multivariable logistic regression analysis model.Subgroup analysis and restricted cubic splines(RCS)were conducted to assess the robustness of the correlations across subgroups and to explore nonlinear relationships between four indices and PDR.The receiver operating characteristic(ROC)analysis was employed for the purpose of assessing and evaluating the predictive efficacy of NLR,PLR,SII,and RDW in determining the severity of DR.RESULTS:After adjusting for other confounders(age,gender,race,body mass index,diabetes duration,and HbA1c)in multivariable analysis,a unit increase of PLR×0.1,SII×0.01,and RDW would raise the risk for PDR by 15.6%,22.2%,and 33%,respectively.Particularly,there was a 2.208-fold greater risk of PDR in individuals with an elevated NLR(OR=2.208,95%CI,1.348-3.617,P<0.001).RCS analyses showed positive relationships of four indices and PDR after segmented regression based on their own turning points.The results of ROC analysis revealed that PLR+RDW[area under the curve(AUC)=0.772,95%CI:0.669-0.874]had the best predictive value for PDR,compared with NLR+PLR+SII(AUC=0.697,95%CI:0.570-0.825)or RDW alone(AUC=0.736,95%CI:0.646-0.826).CONCLUSION:The combination of RDW and NLR demonstrates a promising ability to predict the severity of DR across the United States population,and it could be promisingly used in clinics for monitoring the progress of DR. 展开更多
关键词 diabetic retinopathy red blood cell distribution width neutrophil-lymphocyte ratio platelet-to-lymphocyte ratio systemic inflammation index National Health and Nutrition Examination Survey(NHANES)database
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Red cell distribution width to platelet ratio: New and promising prognostic marker in acute pancreatitis 被引量:43
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作者 Erdin etinkaya Kazim Senol +1 位作者 Baris Saylam Mesut Tez 《World Journal of Gastroenterology》 SCIE CAS 2014年第39期14450-14454,共5页
AIM: To evaluate the accuracy of red cell distribution width (RDW) to platelet ratio (RPR) to predict in-hospital mortality in acute pancreatitis (AP).
关键词 Acute pancreatitis Red cell distribution width Red cell distribution width to platelet ratio
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Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic Dysfunction-Associated Steatotic Liver Disease-induced cirrhosis 被引量:3
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作者 Marcello Dallio Mario Romeo +8 位作者 Paolo Vaia Salvatore Auletta Simone Mammone Marina Cipullo Luigi Sapio Angela Ragone Marco Niosi Silvio Naviglio Alessandro Federico 《World Journal of Gastroenterology》 SCIE CAS 2024年第7期685-704,共20页
BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic event.Based on the first decompensation event(DE),the transition to deco... BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic event.Based on the first decompensation event(DE),the transition to decompensated advanced chronic liver disease(dACLD)can occur through two modalities referred to as acute decompensation(AD)and non-AD(NAD),respectively.Clinically Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these patients.However,due to its invasiveness and costs,CSPH is almost never evaluated in clinical practice.Therefore,recognizing noninvasively predicting tools still have more appeal across healthcare systems.The red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD).However,its predictive role for the decompensation has never been explored.AIM In this observational study,we investigated the clinical usage of RPR in predicting DEs in MASLD-related cACLD patients.METHODS Fourty controls and 150 MASLD-cACLD patients were consecutively enrolled and followed up(FUP)semiannually for 3 years.At baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver Disease(MELD),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were collected.During FUP,DEs(timing and modaities)were recorded.CSPH was assessed at the baseline and on DE occurrence according to the available Clinical Practice Guidelines.RESULTS Of 150 MASLD-related cACLD patients,43(28.6%)progressed to dACLD at a median time of 28.9 months(29 NAD and 14 AD).Baseline RPR values were significantly higher in cACLD in comparison to controls,as well as MELD,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLD-progressing compared to cACLD individuals[all P<0.0001,except for FIB-4(P:0.007)and ALBI(P:0.011)].Receiving operator curve analysis revealed RPR>0.472 and>0.894 as the best cut-offs in the prediction respectively of 3-year first DE,as well as its superiority compared to the other non-invasive tools examined.RPR(P:0.02)and the presence of baseline-CSPH(P:0.04)were significantly and independently associated with the DE.Patients presenting baseline-CSPH and RPR>0.472 showed higher risk of decompensation(P:0.0023).CONCLUSION Altogether these findings suggest the RPR as a valid and potentially applicable non-invasive tool in the prediction of timing and modalities of decompensation in MASLD-related cACLD patients. 展开更多
关键词 Liver cirrhosis Red blood cell distribution width Red blood cell distribution width to platelet ratio Translational Medicine Prognostic biomarker
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R/S ratio in lead Ⅱ, and the prognostic significance of red cell distribution width in acute coronary syndrome 被引量:1
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作者 Abuzer Coskun Sevki Hakan Eren 《World Journal of Clinical Cases》 SCIE 2019年第16期2217-2226,共10页
BACKGROUND In spite of developing medical technologies to discover the etiopathogenesis of diseases and developments in the treatment of coronary artery disease, acute coronary syndromes(ACS) continue to be the main c... BACKGROUND In spite of developing medical technologies to discover the etiopathogenesis of diseases and developments in the treatment of coronary artery disease, acute coronary syndromes(ACS) continue to be the main cause of mortality and morbidity worldwide. New cardiac biomarkers and techniques are needed to help provide rapid diagnosis in order to evaluate risk in coronary artery patients.AIM To evaluate the effects of R to S ratio(RSR) in the electrocardiograph of patients with ACS, from the point of the arising complication after myocardial infarction(MI), to three-vessel disease(TVD) and mortality.METHODS The data of 1,296 patients with ACS, who presented to the emergency department of our hospital with chest pain between January 2014 and December2018 and were admitted to the cardiology clinic, were retrospectively included in this cross-sectional cohort study. Patients with an RSR value less than I were assigned to group Ⅰ, while those with an RSR value greater than Ⅰ were assigned to group Ⅱ.RESULTS In our study, 466(35.9%) of the 1,296 patients, 357(38.3%) in group 1 and 109(29.9%) in group 2, were female, with a mean age of 61.56 ± 9.42. ST-elevation MI 573(44.2%), unstable angina(UA) 502(38.7%) and non ST-elevation MI 220(17%)were more prevalent in group Ⅰ. Acute anterior MI 263(20.3) in group Ⅰ, and acute inferior MI 184(14.2) in group Ⅱ was higher. Ischemic heart failure was the most common complication. In group Ⅱ, the red cell distribution width(RDW) was 15.42 ± 1.82, the gensini score was 48.39 ± 36.44, the left ventricular ejection fraction was 41.17 ± 10.41, the TVD was 111(8.5), and the mortality rate was 72(5.6), which was significantly higher than group Ⅰ RDW; in MI with ST and nonST-elevation, in TVD, mortality and complications were high and low in UA. In single and multivariate regression analyses, the variables were associated with ACS risk.CONCLUSION RSR levels may be an auxiliary predictive value in ACS in terms of complications developing after MI, TVD, and mortality. 展开更多
关键词 Acute CORONARY SYNDROME EMERGENCY DEPARTMENT R/S ratio Red cell distribution width
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Effects of process parameters on the depth-to-width ratio of flux-cored wire underwater wet welding 被引量:3
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作者 韩焱飞 郭宁 +2 位作者 王芳 袁新 冯吉才 《China Welding》 EI CAS 2013年第1期35-40,共6页
The effects of process parameters on the depth-to-width ratio (D/W) of flux-cored wire underwater wet welding with a certain type of homemade .flux-cored wire are studied. It is found that the welding .speed, wire f... The effects of process parameters on the depth-to-width ratio (D/W) of flux-cored wire underwater wet welding with a certain type of homemade .flux-cored wire are studied. It is found that the welding .speed, wire feeding speed and torch oscillating amplitude hare significant effects on the dopth-to-width ratio (D/W) of welds. The D/W ratio of welds increases significantly with the increase of welding speed without the oscillating of welding torch. It increased (from 0. 14 to 0. 26 ) with the increase of wire feeding speed while the torch oscillating. And it decreased linearly with the increase of torch oscillating amplitude. However, the influelwe of oscillating speed, wire extension and welding voltage on the D/W ratio of welds was not obvious. 展开更多
关键词 flux-cored wire underwater wet welding depth-to-width ratio
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Theoretical analyses on bed topography responses in large depth-to-width ratio river bends with constant curvatures 被引量:2
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作者 Shuxian GAO Haijue XU Yuchuan BAI 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2018年第5期747-766,共20页
Bed morphology is the result of a dynamic response to a complex meandering river system. It is an important factor for the further development of river. Based on the meandering river characterized by a large depth-to-... Bed morphology is the result of a dynamic response to a complex meandering river system. It is an important factor for the further development of river. Based on the meandering river characterized by a large depth-to-width ratio, a theoretical model is established with the coupling of Navier-Stokes (N-S)~ sediment transport, and bed deformation equations. The flow characteristics and bed response of river are obtained with the perturbation method. The research results show that, under the effect of two- dimensional flow disturbance, the bars and pools present the regular response. For a given sinuousness, the amplitude of the bed response can be used as a criterion to judge the bedform stability. The effects of the Reynolds number, disturbance wavenumber, sinuousness, and bed morphology gradient on the bed response development are described. 展开更多
关键词 meandering river large depth-to-width ratio channel disturbance wave bed response
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Effect of Width-to-Thickness Ratio and Thickness Profile Changing on the Critical Instable Shape During Cold Strip Rolling 被引量:1
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作者 宋蕾 沈明钢 +2 位作者 杨利坡 王军生 陈雪波 《Journal of Shanghai Jiaotong university(Science)》 EI 2016年第4期411-418,共8页
Based on the volume constancy with equal flow-per-second and elastic sheet stability theory, a coupling relationship among lateral thickness difference, width-to-thickness ratio of cold rolling strip steel under ideal... Based on the volume constancy with equal flow-per-second and elastic sheet stability theory, a coupling relationship among lateral thickness difference, width-to-thickness ratio of cold rolling strip steel under ideal and actual working conditions, and shape is concluded according to the comprehensive influence principle of various factors on the critical instable shape analyzed in-depth. Firstly, the influence model under actual working condition is developed by referring to the basic relationship between lateral thickness difference and shape under ideal condition. The test results prove that for thin strips with thickness below 0.3 mm, their lateral thickness differences have significant effect on the shape. After then, the combined influence of lateral thickness difference and width-to-thickness ratio on the critical instable shape is concluded according to the elastic sheet stability model, with the synthetic effect of these three factors analyzed. Test data indicate that for cold rolling strip steel with width-to-thickness ratio above 3 000, the critical instability stress difference decreases significantly. Actual measurements are conducted on the lateral thickness differences of two rolls of typical strip manufactured by a sixhigh cold mill, with the influence law of lateral thickness variation and width-to-thickness ratio comprehensively investigated. It is demonstrated that during the production of ultrathin strip steel with different width-to-thickness ratios, the loading roll shapes should be fine adjusted according to the lateral thickness difference of input strips.Therefore, the variation of lateral thickness difference of output strips can meet the requirement of shape stability,so as to obtain fine shape. 展开更多
关键词 cold rolling strip lateral thickness difference width-to-thickness ratio sec flow rate equal
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Effects of Lobe Peak-to-Trough Width Ratio on Mixing and Combustion Performance in ATR Combustors
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作者 ZHAO Qingjun ZHANG Yuankun +3 位作者 HU Bin WANG Zhonghao SHI Qiang ZHAO Wei 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2022年第6期637-650,共14页
The air-turbo-rocket(ATR)engine is a promising propulsion plant for achieving numerous surface and air launched missile missions.The application of lobed mixer in the ATR combustor can promote the mixing of the fuelri... The air-turbo-rocket(ATR)engine is a promising propulsion plant for achieving numerous surface and air launched missile missions.The application of lobed mixer in the ATR combustor can promote the mixing of the fuelrich gas and the air,thus improving the engine performance significantly.The numerical simulation method was conducted to explore the effects of lobe peak-to-trough width ratio on mixing and combustion performance in ATR combustors.Results show that:For a given peak lobe width b1,the combustion efficiency and total pressure loss decrease with the increase of trough lobe width b2;For a given b2,the combustion efficiency and total pressure loss decrease with the increase of b1;The fan-type lobed mixer with smaller b2has a better effect on promoting the combustion efficiency in the region near the ATR combustor center line than that with a pair of parallel side walls.The total pressure recovery coefficient reaches more than 0.99 at the exit of combustor in nonreactive combustion while the total pressure loss reaches more than 4%in the reacting combustion.Compared with the mixing process,more than80%of the total pressure loss is caused during combustion. 展开更多
关键词 ATR combustor lobed mixer lobe peak-to-trough width ratio MIXING combustion streamwise vortex
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Change of the mode of failure by interface friction and width-to-height ratio of coal specimens 被引量:3
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作者 Gamal Rashed Syd S.Peng 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2015年第3期256-265,共10页
Bumps in coal mines have been recognized as a major hazard for many years. These sudden and violent failures around mine openings have compromised safety, ventilation and access to mine workings.Previous studies showe... Bumps in coal mines have been recognized as a major hazard for many years. These sudden and violent failures around mine openings have compromised safety, ventilation and access to mine workings.Previous studies showed that the violence of coal specimen failure depends on both the interface friction and width-to-height(W/H) ratio of coal specimen. The mode of failure for a uniaxially loaded coal specimen or a coal pillar is a combination of both shear failure along the interface and compressive failure in the coal. The shear failure along the interface triggered the compressive failure in coal. The compressive failure of a coal specimen or a coal pillar can be controlled by changing its W/H ratio. As the W/H ratio increases, the ultimate strength increases. Hence, with a proper combination of interface friction and the W/H ratio of pillar or coal specimen, the mode of failure will change from sudden violent failure which is brittle failure to non-violent failure which is ductile failure. The main objective of this paper is to determine at what W/H ratio and interface friction the mode of failure changes from violent to non-violent. In this research, coal specimens of W/H ratio ranging from 1 to 10 were uniaxially tested under two interface frictions of 0.1 and 0.25, and the results are presented and discussed. 展开更多
关键词 Bump Burst Coal strength Violent failure width-to-height(W/H) ratio Interface friction Stressestrain curve
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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure
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作者 Jie Pang Lin-Yan Qian +1 位作者 Ping Lv Xiao-Ru Che 《World Journal of Diabetes》 SCIE 2024年第6期1226-1233,共8页
BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular events.AIM To explore the value of... BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular events.AIM To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December 2021.The NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were recorded.The receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of HF.The correlation between NLR and RDW with the presence or absence of cardiac events was also investigated.RESULTS Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of HF.Furthermore,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac events.CONCLUSION NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic efficiency.Additionally,NLR and RDW values were directly proportional to patient outcomes. 展开更多
关键词 Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis
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The Paradigm of Surgical Ellipse Dimensions: Are the Length-to-Width Ratio of 3 to 4 and a Vertex Angle of 30&ordm;Correct?
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作者 Tamara R. Tilleman M. M. Tilleman M. H. A. Neumann 《Surgical Science》 2013年第4期236-240,共5页
Background: It has been postulated that elliptical cutaneous excisions must possess a length-to-width ratio of 3 to 4 and a vertex angle of 30o or less in order to be closed primarily without creating a “dog ear”. T... Background: It has been postulated that elliptical cutaneous excisions must possess a length-to-width ratio of 3 to 4 and a vertex angle of 30o or less in order to be closed primarily without creating a “dog ear”. These dimensions became axiomatic in cutaneous surgery and have been taught in the apprenticeship model for years. The present article examines the validity of that paradigm. Methods: We collected data from two sources: ellipses described in the literature (57 cases);and elliptical excisions performed at the authors’ outpatient clinic (83 cases). The surgical ellipse lengths, widths, and vertex angles were analyzed, and the data were compared to a mathematical formula used to generate a fusiform ellipse. Results: The length-to-width ratio of 3 - 4 was found to be inconsistent with the recommended vertex angle of 30o. In fact, a length-to-width ratio of 3 - 4 determines a vertex angle of 48o - 63o. A 30o vertex angle is only feasible with long length-to-width ration of about 7.5. Conclusions: The paradigm that surgical ellipses should have a vertex angle of 30o with length-to-width ratio of 3 - 4 is incorrect. Evidence from actual surgical practice and from mathematical formulation shows that either the length-to-width ratio must be larger than 3 - 4 or the vertex angle must be larger than 30 degrees. 展开更多
关键词 Elliptical Excision Length-to-width ratio of 3 - 4 30o Vertex Angle
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术前血红蛋白与红细胞分布宽度比值与老年患者胃肠肿瘤术后谵妄及焦虑抑郁状态的相关性
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作者 张倬宁 郝新宇 +5 位作者 蔡辰 郭永馨 曹江北 刘艳红 仝黎 米卫东 《临床麻醉学杂志》 北大核心 2026年第1期3-9,共7页
目的探讨术前血红蛋白与红细胞分布宽度比值(HRR)与老年患者胃肠肿瘤术后谵妄(POD)、焦虑抑郁状态的相关性。方法选择2020年4月至2022年4月择期行胃肠肿瘤手术的老年患者,记录患者术前血常规指标血红蛋白(Hb)和红细胞分布宽度(RDW)。主... 目的探讨术前血红蛋白与红细胞分布宽度比值(HRR)与老年患者胃肠肿瘤术后谵妄(POD)、焦虑抑郁状态的相关性。方法选择2020年4月至2022年4月择期行胃肠肿瘤手术的老年患者,记录患者术前血常规指标血红蛋白(Hb)和红细胞分布宽度(RDW)。主要指标为术后7 d内POD发生情况,采用3分钟谵妄诊断量表(3D-CAM)进行评估。次要指标包括术后7 d内的焦虑、抑郁状态发生情况,分别采用广泛性焦虑障碍量表(GAD-7)以及患者健康问卷(PHQ-9)评估。采用Logistic回归分析HRR与结局的相关性,限制性立方样条(RCS)分析HRR与结局的非线性关联可能性,受试者工作特征(ROC)曲线分析HRR预测结局的效能。结果共纳入患者345例,其中60例(17.4%)患者发生POD,75例(21.4%)患者存在术后抑郁状态,91例(26.4%)患者存在术后焦虑状态。对年龄、BMI、术前焦虑抑郁状态、术前Hb、RDW、白细胞、白蛋白、术中出血量以及是否输血进行校正,多因素Logistic回归模型分析显示,HRR与POD(OR=0.62,95%CI 0.51~0.73,P<0.001)、抑郁状态(OR=0.76,95%CI 0.63~0.91,P=0.003)以及焦虑状态(OR=0.77,95%CI 0.66~0.92,P=0.003)均呈显著负相关。RCS分析验证了HRR与POD、抑郁状态以及焦虑状态风险的对数比值[Log(Odds)]之间存在线性负相关。ROC曲线分析显示,HRR预测POD的ROC曲线下面积(AUC)为0.702(95%CI 0.629~0.774)、预测抑郁状态的AUC为0.650(95%CI 0.584~0.715)、预测焦虑状态的AUC为0.611(95%CI 0.542~0.680)。结论术前HRR与老年患者胃肠肿瘤手术POD、焦虑以及抑郁状态的发生存在明显负相关,可作为潜在的辅助预测指标。 展开更多
关键词 老年 胃肠肿瘤手术 血红蛋白与红细胞分布宽度比值 术后谵妄 抑郁状态 焦虑状态
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Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease 被引量:9
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作者 Agata Michalak Małgorzata Guz +4 位作者 Joanna Kozicka Marek Cybulski Witold Jeleniewicz Tomasz Lach Halina Cichoż-Lach 《World Journal of Gastroenterology》 SCIE CAS 2022年第38期5636-5647,共12页
BACKGROUND Looking for undiscovered blood markers of liver fibrosis and steatosis still remains an issue worth exploring.There are still plenty of unresolved issues related to the actual role of hematological indices ... BACKGROUND Looking for undiscovered blood markers of liver fibrosis and steatosis still remains an issue worth exploring.There are still plenty of unresolved issues related to the actual role of hematological indices as potential markers of liver function.AIM To study red blood cell distribution width(RDW),RDW-to-platelet ratio(RPR)and RDW-to-lymphocyte ratio(RLR) in alcohol-related liver cirrhosis(ALC) and metabolic-associated fatty liver disease(MAFLD).METHODS The study group was composed of 302 people:142 patients with ALC and 92 with MAFLD;68 persons were included as controls.RDW,RPR and RLR were measured in each person.Indirect and direct parameters of liver fibrosis were also assessed [aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index(APRI),fibrosis-4(FIB-4),gamma-glutamyl transpeptidase to platelet ratio(GPR),procollagen I carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,plateletderived growth factor AB,laminin].MELD score in ALC patients and nonalcoholic fatty liver disease(NAFLD) fibrosis score together with BARD score were obtained in the MAFLD group.The achieved results were compared to controls.Then a correlation between assessed markers was done.Diagnostic value of each investigated parameter and its suggested cut-off in the research group RESULTS RDW,RPR and RLR values turned out to be significantly higher in ALC and MAFLD groups compared to controls(ALC:P<0.0001;NAFLD:P<0.05,P<0.0001 and P<0.0001,respectively).RPR correlated positively with MELD score(P<0.01) and indirect indices of liver fibrosis(FIB-4 and GPR;P<0.0001) in ALC patients;negative correlations were found between PDGF-AB and both:RDW and RPR(P<0.01 and P<0.0001,respectively).RPR correlated positively with NAFLD fibrosis score and APRI(P<0.0001) in the MAFLD group;a positive relationship was observed between RDW and FIB-4,too(P<0.05).AUC values and suggested cut-offs for RDW,RPR and RLR in ALC patients were:0.912(>14.2%),0.965(>0.075) and 0.914(>8.684),respectively.AUC values and suggested cut-offs for RDW,RPR and RLR in MAFLD patients were:0.606(>12.8%),0.724(>0.047) and 0.691(>6.25),respectively.CONCLUSION RDW with its derivatives appear to be valuable diagnostic markers in patients with ALC.They can also be associated with a deterioration of liver function in this group. 展开更多
关键词 Hematological indices Alcohol-related liver cirrhosis Metabolic-associated liver disease Red blood cell distribution width Red blood cell distribution width-to-platelet ratio Red blood cell distribution width-to-lymphocyte ratio
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Crack elongation and its width of large depth reinforced concrete beams 被引量:2
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作者 管俊峰 赵顺波 黄承逵 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2010年第5期631-635,共5页
In order to meet the requirement of structural inspection,the crack spacing and crack width at various heights in the tensile zone of six large depth reinforced concrete beams were measured under several loading level... In order to meet the requirement of structural inspection,the crack spacing and crack width at various heights in the tensile zone of six large depth reinforced concrete beams were measured under several loading levels of serviceability state.The effects of the depth of normal section beams on the crack spacing and crack width were analyzed,and the modified model is proposed for calculating the average crack spacing by thinking about the depth of normal section,the reinforcement arrangement and the effective reinforcement ratio.The relationships of crack widths at any position in the tensile zone and at the reinforcement level on the side surface of beam were studied.By theoretical and statistical analysis,a method is proposed to calculate the ratios of crack widths between any position and the reinforcement level on the side surface of large depth reinforced concrete beams. 展开更多
关键词 reinforced concrete beam large depth of normal section crack elongation average crack spacing ratio of crack width
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Experimental Study on Chloride Ion Penetration Resistance of Coal Gangue Concrete under Multi-Factor Comprehensive Action 被引量:1
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作者 Hongyu Chen Hongguang Zhu +1 位作者 Hongqiang Ma Mingyue Zhang 《World Journal of Engineering and Technology》 2019年第2期58-64,共7页
In order to investigate the chloride ion penetration resistance of coal gangue concrete under multi-factor comprehensive action, the non-steady-state accelerated chloride ion migration test was used to test the chlori... In order to investigate the chloride ion penetration resistance of coal gangue concrete under multi-factor comprehensive action, the non-steady-state accelerated chloride ion migration test was used to test the chloride diffusion law of coal gangue concrete specimens by crack width, curing temperature and water-cement ratio. Three groups of crack width (0 mm, 0.05 - 0.12 mm, 0.12 - 0.2 mm), three curing temperatures (high temperature 45, medium temperature 25, low temperature 10), three water cement ratios (0.3, 0.4, 0.5) were set in the experiment. The results show that when the curing temperature and water cement ratio are constant, the crack width less than 0.12 mm has little effect on the chloride content and chloride diffusion coefficient. When the crack width is larger than 0.12 mm, the chloride penetration depth increases with the crack width. The resistance to chloride ion penetration of gangue concrete is greatly influenced by the water cement ratio. The influ-ence degree of three factors on chloride ion migration coefficient of gangue concrete is as follows: water cement ratio > crack width > curing temperature. 展开更多
关键词 Coal GANGUE Concrete CHLORIDE Ion PENETratioN Water CEMENT ratio Crack width CURING Temperature
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Zokor activity promotes soil water infiltration in the Mu Us sandy land of northern Shaanxi,China 被引量:1
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作者 Miao GAN Xuchao ZHU +7 位作者 Xueqin YANG Xiaorong WEI Qingyin ZHANG Tongchuan LI Ming'an SHAO Meixia MI Xi YANG Mingyu CHEN 《Pedosphere》 SCIE CAS CSCD 2024年第1期136-145,共10页
Zokors are common subterranean rodents that inhabit agricultural fields, shrublands, and grasslands in the arid and semi-arid regions of China. Zokor burrowing activities can alter soil structure and affect soil hydro... Zokors are common subterranean rodents that inhabit agricultural fields, shrublands, and grasslands in the arid and semi-arid regions of China. Zokor burrowing activities can alter soil structure and affect soil hydrological processes;however, there are few studies regarding their effects on soil preferential flow in the Mu Us sandy land. An evaluation of the effects of zokor disturbance on their habitat and soil water is important for understanding the ecological role of zokors in the soil ecosystem of the Mu Us sandy land. A field dye-tracing experiment was conducted in the Gechougou watershed on the southeastern edge of the Mu Us sandy land to investigate the effect of zokor burrowing activity on soil preferential flow characteristics. Our results showed that the density of zokor tunnels was the highest(0.40–0.46 m m^(-2)) under 30%–50% vegetation coverage and that the tunnels were approximately 3 cm from the surface.Both stained area ratio and stained path number were higher at sites with zokors than without zokors. Stained path widths were 10–80 and > 80 mm at zokor-harboring sites exhibiting homogeneous flow and heterogeneous finger flow, respectively. In the absence of zokors, homogeneous flow and highly interacted macropore flow were predominant. Soil water content below the zokor tunnels was higher than that above the tunnels. Moderate disturbance of soil structure by zokor activity facilitated soil water infiltration. These results enabled a better understanding of the effect of soil fauna on soil structure and hydrological processes and provided recommendations for ecological construction and renovation in arid and semi-arid regions. 展开更多
关键词 eld dye-tracing experiment preferential flow soil fauna stained area ratio stained path number stained path width subterranean rodent surface tortoise crack
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Effect of Peak Power and Pulse Width on Coherent Doppler Wind Lidar’s SNR 被引量:4
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作者 REN Yong WU Xuefei +1 位作者 TAO Fa CAO Haishuai 《Instrumentation》 2022年第2期26-32,共7页
The laser device is the core component of coherent Doppler wind lidar.The peak power and pulse width of laser transmitting pulse have important effects on SNR.Based on coherent Doppler wind pulse lidar,the peak power ... The laser device is the core component of coherent Doppler wind lidar.The peak power and pulse width of laser transmitting pulse have important effects on SNR.Based on coherent Doppler wind pulse lidar,the peak power and pulse width influence on SNR is studied on the theoretical derivation and analysis,and the results show that the higher the peak power can realize the greater the signal-to-noise ratio of coherent Doppler wind lidar.But when the peak power is too large,the laser pulse may appear nonlinear phenomenon,which cause the damage of the laser.So,the peak power must be less than the stimulated brillouin scattering power threshold.Increasing the pulse width can make the laser device to output more energy,but it will also make the spatial resolution lower,and the influence of turbulence on SNR will be greater.After a series of simulation analyses,it can be concluded that when the peak power is 650W and the pulse width is 340ns,the SNR of the system can be maximized.In addition,the coherent Doppler wind lidar system is set up to carry out corresponding experimental verification.The experimental results are consistent with the theoretical analysis and simulation,which verifies the correctness of the theoretical analysis and simulation results.It provides theoretical basis and practical ex-perience for the design of laser transmitting pulse in coherent Doppler wind lidar system. 展开更多
关键词 Coherent Lidar Fiber Laser Peak Power Pulse width Signal-to-Noise ratio(SNR)
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OsDA1 positively regulates grain width in rice
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作者 Cong Li Jun Liu +4 位作者 Liya Zhang Tao Li Hongyu Li Bin Liu Tao Zhao 《The Crop Journal》 SCIE CSCD 2024年第1期92-101,共10页
The size and shape of rice grains influence their yield and commercial value.We investigated the role of OsDA1,a rice homolog of the Arabidopsis DA1 gene,in regulating grain size and shape.OsDA1 was highly expressed i... The size and shape of rice grains influence their yield and commercial value.We investigated the role of OsDA1,a rice homolog of the Arabidopsis DA1 gene,in regulating grain size and shape.OsDA1 was highly expressed in young spikelets and glumes.Its overexpression led to enlarged seeds with increased width and decreased length/width ratio(LWR)and knocking out OsDA1 reduced grain width and increased grain length and LWR.A R310K point mutation in the DA1-like domain is a potential target for breeding for increased grain width and length.OsDA1 interacted with TCP gene-family proteins to regulate grain size and shape.Our findings deepen our understanding of the molecular mechanisms underlying grain size regulation and provide useful information for improving grain yield. 展开更多
关键词 RICE Osda1 Grain size Grain shape Grain length/width ratio TCP
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Determination Multipole Mixing Ratios and Transition Strengths of Gamma Rays from Level Studies of 93Mo (p, nγ) Reaction
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作者 Mayyada M. Hamarashid 《Journal of Physical Science and Application》 2012年第7期253-257,共5页
The multipole mixing ratios have been calculated by a2-ratio method, from levels of 93Mo(p, nγ) reaction. The branching ratios of such γ-transitions are used to calculate the total gamma widths. Besides, the trans... The multipole mixing ratios have been calculated by a2-ratio method, from levels of 93Mo(p, nγ) reaction. The branching ratios of such γ-transitions are used to calculate the total gamma widths. Besides, the transition strengths and probabilities have been calculated for γ-transitions from excited states whose life times have been reported previously. The results are found to be in general in good agreement with the previous results populated from the previous work. 展开更多
关键词 Moltipole mixing ratio mean lifetime gamma widths transitions strength transitions probabilities.
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