The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′...The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′)^(p) on grand p-adic Herz spaces.展开更多
In this article,we prove the boundedness for commutators of fractional Hardy and Hardy-Littlewood-Pólya operators on grand p-adic variable Herz spaces,where the symbols of the commutators belong to Lipschitz spaces.
HIV infection continues to pose a significant global health challenge,with subSaharan Africa bearing a disproportionate burden.The replication cycle of HIV is fundamentally driven by intricate molecular interactions.T...HIV infection continues to pose a significant global health challenge,with subSaharan Africa bearing a disproportionate burden.The replication cycle of HIV is fundamentally driven by intricate molecular interactions.This study investigates the competitive biochemical interplay between reverse transcriptase(RT)and integrase(IN)enzymes,employing a fractional calculus framework to model their mutual inhibitory effects.Through the application of fixed-point theory and Picard stability analysis,the existence,uniqueness,and stability of the fractional-order system are rigorously established.The role of RT-IN enzymatic competition in influencing HIV replication dynamics is elucidated through global sensitivity analysis using Latin Hypercube Sampling.Furthermore,the model incorporates memory-dependent characteristics by examining three distinct fractional operators,namely,the Caputo,Caputo-Fabrizio,and Atangana-Baleanu operators in the Caputo sense,thereby elucidating their respective influences on system behavior.The Atangana-Baleanu operator,in particular,demonstrates an enhanced capacity to capture the complex,synergistic processes underpinning HIV progression.This research provides a critical nexus between molecular virology and applied mathematics,offering foundational insights for the advancement of more precise and targeted therapeutic strategies against HIV.展开更多
Lassa Fever(LF)is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa,causing thousands of deaths annually.This study develops a dynamic model of Lassa virus transmission,capturing the pr...Lassa Fever(LF)is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa,causing thousands of deaths annually.This study develops a dynamic model of Lassa virus transmission,capturing the progression of the disease through susceptible,exposed,infected,and recovered populations.The focus is on simulating this model using the fractional Caputo derivative,allowing both qualitative and quantitative analyses of boundedness,positivity,and solution uniqueness.Fixed-point theory and Lipschitz conditions are employed to confirm the existence and uniqueness of solutions,while Lyapunov functions establish the global stability of both disease-free and endemic equilibria.The study further examines the role of the Caputo operator by solving the generalized power-law kernel via a two-step Lagrange polynomial method.This approach offers practical advantages in handling additional data points in integral forms,though Newton polynomial-based schemes are generally more accurate and can outperform Lagrange-based Adams-Bashforth methods.Graphical simulations validate the proposed numerical approach for different fractional orders(ν)and illustrate the influence of model parameters on disease dynamics.Results indicate that increasing the fractional order accelerates the decline of Lassa fever in both human and rodent populations.Moreover,fractional-order modeling provides more nuanced insights than traditional integer-order models,suggesting potential improvements for medical intervention strategies.The study demonstrates that carefully chosen fractional orders can optimize convergence and enhance the predictive capacity of Lassa fever models,offering a promising direction for future research in epidemiological modeling.展开更多
Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value ...Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.展开更多
Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.Th...Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.The aim of this study was to assess impact of 15 diverse oils on groundwater quality and environmental forensics based on oil-water equilibrium experiments.Our results indicate that contamination of groundwater by gasoline and naphtha is primarily attributed to volatile hydrocarbons,while pollution from diesel,kerosene,and crude oil is predominantly from non-hydrocarbons.Rapid determination of the extent of non-hydrocarbon pollution in WSFs was achieved through a new quantitative index.Gasoline and naphtha exhibited the highest groundwater contamination potential while kerosene and light crude oils were also likely to cause groundwater contamina-tion.Although volatile hydrocarbons in the WSFs of diesel and jet fuel do not easily exceed current regulatory standards,unregulated non-hydrocarbons may pose a more severe contamination risk to groundwater.Notably,the presence of significant benzene and toluene,hydrogenation and alkylation products(e.g.,C4-C5 alkylben-zenes,alkylindenes,alkyltetralins,and dihydro-indenes),cycloalkanes in WSFs can effectively be utilized for preliminary source identification of light distillates,middle distillates,and crude oils,respectively.展开更多
Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral ...Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral techniques have achieved many exciting results in soil metal monitoring due to their advantages of being fast and non-destructive.However,insufficient attention has been paid to lithium in soil,and the feasibility of its estimation using hyperspectral techniques needs to be investigated.We studied 97 soil samples from claytype lithium mines in the Ertanggou area of the East Tianshan Mountains of Xinjiang to explore the effects of spectral resolution,fractional order derivatives(FOD),and characteristic band selection on the estimation accuracy of clay Li content,to obtain a fast and effective method for estimating clay Li content.Finally,we developed a new method for rapid and nondestructive estimation of soil lithium content.We have obtained some important results from the study.Spectral resolution exerts a significant impact on model performance,and its reduction usually leads to a decline in model performance.For the full band,the models constructed with low-order derivatives were superior to those with high-order derivatives,and the best model was obtained at the 0.4-order derivative(coefficient of determination(R^(2))and relative predictive deviation(RPD)of 0.777 and 2.118,respectively).In the characteristic bands,the lower order is sensitive to the visible-near-infrared range,and the higher order is sensitive to the short-wave infrared range,and the model constructed with the higher-order derivatives outperforms the lower-order derivatives.In this study,the combination of FOD and Random Forest(RF)can significantly improve the model performance,with R^(2),Relative Root Mean Squared Error(RRMSE),and RPD being 0.849,1.526,and 2.574,respectively.Therefore,this research provides a theoretical basis and technical reference for imaging hyperspectral exploration of anomalous areas of clay-type Li resources.展开更多
Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In ...Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its^(13)C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and^(13)C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions.展开更多
In this paper,we study a class of Linear Fractional Programming on a nonempty bounded set,called the Problem(LFP),and design a branch and bound algorithm to find the global optimal solution of the problem(LFP).First,w...In this paper,we study a class of Linear Fractional Programming on a nonempty bounded set,called the Problem(LFP),and design a branch and bound algorithm to find the global optimal solution of the problem(LFP).First,we convert the problem(LFP)to the equivalent problem(EP2).Secondly,by applying the linear relaxation technique to the problem(EP2),the linear relaxation programming problem(LRP2Y)was obtained.Then,the overall framework of the algorithm is given,and the convergence and complexity of the algorithm are analyzed.Finally,experimental results are listed to illustrate the effectiveness of the algorithm.展开更多
We investigate the constrained fractional Choquard equation■where m>0,N>2s with s∈(0,1)being the order of the fractional Laplacian operator and I_(α)forα∈(0,N)denotes the Riesz potential.The parameterμ∈ℝa...We investigate the constrained fractional Choquard equation■where m>0,N>2s with s∈(0,1)being the order of the fractional Laplacian operator and I_(α)forα∈(0,N)denotes the Riesz potential.The parameterμ∈ℝappears as a Lagrange multiplier.By imposing general mass-supercritical conditions on F,we confirm the existence of normalized solutions that characterize the global minimizer on the Pohozaev manifold.Our proof does not depend on the assumption that all weak solutions satisfy the Pohozaev identity,a challenge that remains unsolved for this doubly nonlocal equation.展开更多
SiCp-reinforced 6092Al composites with volume fractions of 25%and 60%were prepared using a powder metallurgy method.Their friction and wear characteristics were analyzed using a reciprocating friction and wear testing...SiCp-reinforced 6092Al composites with volume fractions of 25%and 60%were prepared using a powder metallurgy method.Their friction and wear characteristics were analyzed using a reciprocating friction and wear testing machine under loads of 20 to 50 N against YG6 cemented carbide.The experimental results show that the friction coefficients of all samples increase with increasing load.The 25vol%composite exhibits the lowest friction coefficient(0.1669-0.2716),while the 60vol%composite exhibits the highest(0.3237-0.3990),with the 6092 aluminum alloy falling between the two.The wear volume and specific wear rate also increase with load,but the composites with a higher Si C content demonstrate smaller increments,with the 60vol%composite exhibiting superior wear resistance.Under a 30 N load,the wear scars of the 60vol%composite show a significant increase in the contents of elements such as C,Co,W,and O,indicating more severe wear of the counterpart material.Scanning electron microscopy(SEM)reveals wear mechanisms including adhesive wear,two-body sliding and three-body rolling wear of particles,and delamination.展开更多
The fractional quantum Hall effect remains a captivating area in condensed matter physics,characterized by strongly correlated topological order,which manifests as fractionalized excitations and anyonic statistics.Num...The fractional quantum Hall effect remains a captivating area in condensed matter physics,characterized by strongly correlated topological order,which manifests as fractionalized excitations and anyonic statistics.Numerical simulations,such as exact diagonalization,density matrix renormalization groups,matrix product states,and Monte Carlo methods are essential for examining the properties of strongly correlated systems.Recently,density functional theory has been employed in this field within the framework of composite fermion theory.This paper systematically evaluates how density functional theory approaches have addressed fundamental challenges in fractional quantum Hall systems,including ground state and low-energy excitations.Special attention is given to the insights provided by density functional theory regarding composite fermion behavior,edge effects,and the nature of fractional charge and magnetoroton excitations.The discussion critically examines both the advantages and limitations of these approaches,while highlighting the productive interplay between numerical simulations and theoretical models.Future directions are explored,particularly the promising potential of time-dependent density functional theory for modeling non-equilibrium dynamics in quantum Hall systems.展开更多
This paper introduces a novel fractional-order model based on the Caputo-Fabrizio(CF)derivative for analyzing computer virus propagation in networked environments.The model partitions the computer population into four...This paper introduces a novel fractional-order model based on the Caputo-Fabrizio(CF)derivative for analyzing computer virus propagation in networked environments.The model partitions the computer population into four compartments:susceptible,latently infected,breaking-out,and antivirus-capable systems.By employing the CF derivative—which uses a nonsingular exponential kernel—the framework effectively captures memory-dependent and nonlocal characteristics intrinsic to cyber systems,aspects inadequately represented by traditional integer-order models.Under Lipschitz continuity and boundedness assumptions,the existence and uniqueness of solutions are rigorously established via fixed-point theory.We develop a tailored two-step Adams-Bashforth numerical scheme for the CF framework and prove its second-order accuracy.Extensive numerical simulations across various fractional orders reveal that memory effects significantly influence virus transmission and control dynamics;smaller fractional orders produce more pronounced memory effects,delaying both infection spread and antivirus activation.Further theoretical analysis,including Hyers-Ulam stability and sensitivity assessments,reinforces the model’s robustness and identifies key parameters governing virus dynamics.The study also extends the framework to incorporate stochastic effects through a stochastic CF formulation.These results underscore fractional-order modeling as a powerful analytical tool for developing robust and effective cybersecurity strategies.展开更多
Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical eff...Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical effects and mechanisms in immune enhancement,adjunctive anti-tumor activity,and regulation of glucose/lipid metabolism.Three clinical trials were conducted.In an immune study,120 healthy volunteers(CD4+T cell count 500–1000 cells/μL)received 150 mg/day GFP-D for 8 weeks,resulting in significant increases in CD4+T cells(from 632±95 to 812±108 cells/μL,28.5%increase,within the physiological activation range),CD4+/CD8+ratio,NK cell activity,IL-2,and IFN-γ(all P<0.001 vs.placebo).An anti-tumor study with 80 advanced cancer patients(stratified by age,tumor stage,and histotype)showed that adding 1000 mg/day GFP-D to chemotherapy improved objective response rate(52.5%vs.30.0%,P=0.036,95%CI:1.02–3.87),one-year progression-free survival(55.8%vs.33.3%,P=0.022),and preserved immune parameters versus chemotherapy alone.A metabolic study in 90 type 2 diabetes patients found that 400 mg/day GFP-D for 12 weeks significantly lowered fasting glucose,HbA1c,total cholesterol,triglycerides,and LDL-C,while raising HDL-C(from 1.0±0.2 to 1.2±0.2 mmol/L,20%increase,supported by increased AMPK phosphorylation).Mechanistically,immune enhancement involves macrophage/dendritic cell activation via Dectin-1/TLR4 receptors(confirmed by increased receptor expression and downstream signaling molecules),promoting cytokine-driven T/NK cell responses.Anti-tumor effects stem from immunomodulation,direct induction of cancer cell apoptosis(via mitochondrial/caspase pathways,verified by increased Bax/Bcl-2 ratio and caspase-3 activation),and angiogenesis inhibition by downregulating VEGF.Metabolic benefits are linked to AMPK pathway activation in liver/muscle(confirmed by increased p-AMPK/AMPK ratio),enhancing glucose uptake and inhibiting gluconeogenesis/lipogenesis,alongside modulation of gut microbiota(increased Bifidobacterium and Lactobacillus abundance).All trials reported no severe adverse events related to GFP-D;liver/kidney function parameters(ALT,AST,creatinine,urea nitrogen)remained within normal ranges throughout the intervention.Collectively,GFP-D emerges as a multi-functional bioactive agent with substantial therapeutic potential.展开更多
In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizh...In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizhong Zhou,Hongxia Liu and Yang Xu(2022).Then,an A_(α)-spectral condition is given to ensure that G is a fractional ID-[a,b]-factor-critical covered graph and an(a,b,k)-factor-critical graph,respectively.In fact,(a,b,k)-factor-critical graph is a graph which has an[a,b]-factor for k=0.Thus,these above results extend the results of Jia Wei and Shenggui Zhang(2023)and Ao Fan,Ruifang Liu and Guoyan Ao(2023)in some sense.展开更多
Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin f...Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps process.The key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene glycol.The utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling up.In the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.展开更多
Pitch produced by the lique-faction of coal was divided into two frac-tions:soluble in toluene(TS)and insol-uble in toluene but soluble in pyridine(TI-PS),and their differences in molecu-lar structure and oxidation ac...Pitch produced by the lique-faction of coal was divided into two frac-tions:soluble in toluene(TS)and insol-uble in toluene but soluble in pyridine(TI-PS),and their differences in molecu-lar structure and oxidation activity were studied.Several different carbon materi-als were produced from them by oxida-tion in air(350℃,300 mL/min)fol-lowed by carbonization(1000℃ in Ar),and the effect of the cross-linked structure on their structure and sodium storage properties was investigated.The results showed that the two pitch fractions were obviously different after the air oxidation.The TS fraction with a low degree of condensation and abundant side chains had a stronger oxidation activity and thus introduced more cross-linked oxygen-containing functional groups C(O)―O which prevented carbon layer rearrangement during the carbonization.As a result,a disordered hard carbon with more defects was formed,which improved the electrochemical performance.Therefore,the carbon materials derived from TS(O-TS-1000)had an obvious disordered structure and a larger layer spacing,giving them better sodium storage perform-ance than those derived from the TI-PS fraction(O-TI-PS-1000).The specific capacity of O-TS-1000 was about 250 mAh/g at 20 mA/g,which was 1.67 times higher than that of O-TI-PS-1000(150 mAh/g).展开更多
In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):104...In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):1045-1049]and Monrad and Rootzén[Probab.Theory Related Fields,1995,101(2):173-192].展开更多
Soil microorganisms and labile soil organic carbon(SOC)fractions are essential factors affecting greenhouse gas(GHG)emissions in paddy fields.However,the effects of labile SOC fractions and microorganisms on GHG emiss...Soil microorganisms and labile soil organic carbon(SOC)fractions are essential factors affecting greenhouse gas(GHG)emissions in paddy fields.However,the effects of labile SOC fractions and microorganisms on GHG emissions from flooding to drying after organic fertilizer replacing for chemical fertilizer remain unclear.Here,a long-term experiment was conducted with four treatments:chemical fertilization only(control),organic fertilizer substituting 25%of chemical N fertilizer(NM1),50%of chemical N fertilizer(NM2),and NM2combined with crop straw(NMS).GHG emissions were monitored,and soil samples were collected to determine labile SOC fractions and microorganisms.Results revealed the GHG emissions in the NM2 significantly increased by 196.88%from flooding to drying,mainly due to the higher CO_(2) emissions.The GHG emissions per kg of C input in NMS was the lowest with the value of 9.17.From flooding to drying,organic fertilizer application significantly increased the readily oxidizable organic carbon(ROC)contents and C lability;the NM2 and NMS dramatically increased the SOC and non-readily oxidizable organic carbon(NROC).The bacterial communities showed significant differences among different treatments in the flooding,while the significant difference was only found between the NMS and other treatments in the drying.From flooding to drying,changing soil moisture conditions causes C fractions and microbial communities to jointly affect carbon emissions,and the NMS promoted carbon sequestration and mitigated GHG emissions.Our findings highlight the importance of the labile SOC fractions and microorganisms linked to GHG emissions in paddy fields.展开更多
This article studies the existence and uniqueness of the mild solution of a family of control systems with a delay that are governed by the nonlinear fractional evolution differential equations in Banach spaces.Moreov...This article studies the existence and uniqueness of the mild solution of a family of control systems with a delay that are governed by the nonlinear fractional evolution differential equations in Banach spaces.Moreover,we establish the controllability of the considered system.To do so,first,we investigate the approximate controllability of the corresponding linear system.Subsequently,we prove the nonlinear system is approximately controllable if the corresponding linear system is approximately controllable.To reach the conclusions,the theory of resolvent operators,the Banach contraction mapping principle,and fixed point theorems are used.While concluding,some examples are given to demonstrate the efficacy of the proposed results.展开更多
基金Supported by Natural Science Foundation of China(12461021)。
文摘The goal of this paper is to establish the boundedness of the p-adic fractional integral operator with rough kernel I_(β,Ω′)^(p)and its commutators generated by b∈Λ_(γ)(Q_(p)^(n))(0<γ<1)and the I_(β,Ω′)^(p) on grand p-adic Herz spaces.
基金Supported by Chizhou University High Level Talent Research Start up Fund (No.CZ2025YJRC52)。
文摘In this article,we prove the boundedness for commutators of fractional Hardy and Hardy-Littlewood-Pólya operators on grand p-adic variable Herz spaces,where the symbols of the commutators belong to Lipschitz spaces.
基金Supported by the DST FIST Programme(SR/FST/MS-II/2021/101(C))UGC-JRF(21161010788)+1 种基金supported by NSFC(11831003,12171111)SFC(KZ202110005011)。
文摘HIV infection continues to pose a significant global health challenge,with subSaharan Africa bearing a disproportionate burden.The replication cycle of HIV is fundamentally driven by intricate molecular interactions.This study investigates the competitive biochemical interplay between reverse transcriptase(RT)and integrase(IN)enzymes,employing a fractional calculus framework to model their mutual inhibitory effects.Through the application of fixed-point theory and Picard stability analysis,the existence,uniqueness,and stability of the fractional-order system are rigorously established.The role of RT-IN enzymatic competition in influencing HIV replication dynamics is elucidated through global sensitivity analysis using Latin Hypercube Sampling.Furthermore,the model incorporates memory-dependent characteristics by examining three distinct fractional operators,namely,the Caputo,Caputo-Fabrizio,and Atangana-Baleanu operators in the Caputo sense,thereby elucidating their respective influences on system behavior.The Atangana-Baleanu operator,in particular,demonstrates an enhanced capacity to capture the complex,synergistic processes underpinning HIV progression.This research provides a critical nexus between molecular virology and applied mathematics,offering foundational insights for the advancement of more precise and targeted therapeutic strategies against HIV.
文摘Lassa Fever(LF)is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa,causing thousands of deaths annually.This study develops a dynamic model of Lassa virus transmission,capturing the progression of the disease through susceptible,exposed,infected,and recovered populations.The focus is on simulating this model using the fractional Caputo derivative,allowing both qualitative and quantitative analyses of boundedness,positivity,and solution uniqueness.Fixed-point theory and Lipschitz conditions are employed to confirm the existence and uniqueness of solutions,while Lyapunov functions establish the global stability of both disease-free and endemic equilibria.The study further examines the role of the Caputo operator by solving the generalized power-law kernel via a two-step Lagrange polynomial method.This approach offers practical advantages in handling additional data points in integral forms,though Newton polynomial-based schemes are generally more accurate and can outperform Lagrange-based Adams-Bashforth methods.Graphical simulations validate the proposed numerical approach for different fractional orders(ν)and illustrate the influence of model parameters on disease dynamics.Results indicate that increasing the fractional order accelerates the decline of Lassa fever in both human and rodent populations.Moreover,fractional-order modeling provides more nuanced insights than traditional integer-order models,suggesting potential improvements for medical intervention strategies.The study demonstrates that carefully chosen fractional orders can optimize convergence and enhance the predictive capacity of Lassa fever models,offering a promising direction for future research in epidemiological modeling.
文摘Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.
基金supported by the National Science Foundation of China(Nos.42177042,and 42477051)the National Key R&D Program of China(No.2023YFC3708700)the Science Foundation of China University of Petroleum-Beijing(No.2462022QNXZ006).
文摘Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.The aim of this study was to assess impact of 15 diverse oils on groundwater quality and environmental forensics based on oil-water equilibrium experiments.Our results indicate that contamination of groundwater by gasoline and naphtha is primarily attributed to volatile hydrocarbons,while pollution from diesel,kerosene,and crude oil is predominantly from non-hydrocarbons.Rapid determination of the extent of non-hydrocarbon pollution in WSFs was achieved through a new quantitative index.Gasoline and naphtha exhibited the highest groundwater contamination potential while kerosene and light crude oils were also likely to cause groundwater contamina-tion.Although volatile hydrocarbons in the WSFs of diesel and jet fuel do not easily exceed current regulatory standards,unregulated non-hydrocarbons may pose a more severe contamination risk to groundwater.Notably,the presence of significant benzene and toluene,hydrogenation and alkylation products(e.g.,C4-C5 alkylben-zenes,alkylindenes,alkyltetralins,and dihydro-indenes),cycloalkanes in WSFs can effectively be utilized for preliminary source identification of light distillates,middle distillates,and crude oils,respectively.
基金Sponsored the National Natural Science Foundation of China(42502088)the National Major Science and Technology Project of China(2025ZD1007504-1)+2 种基金the Special Research Fund of Natural Science(Special Post)of Guizhou University(X202402)the Guizhou Provincial Science and Technology Projects(QKHJC[2024]youth 153)the Xinjiang Uygur Autonomous Region Natural Science Foundation(2024D01A147)。
文摘Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral techniques have achieved many exciting results in soil metal monitoring due to their advantages of being fast and non-destructive.However,insufficient attention has been paid to lithium in soil,and the feasibility of its estimation using hyperspectral techniques needs to be investigated.We studied 97 soil samples from claytype lithium mines in the Ertanggou area of the East Tianshan Mountains of Xinjiang to explore the effects of spectral resolution,fractional order derivatives(FOD),and characteristic band selection on the estimation accuracy of clay Li content,to obtain a fast and effective method for estimating clay Li content.Finally,we developed a new method for rapid and nondestructive estimation of soil lithium content.We have obtained some important results from the study.Spectral resolution exerts a significant impact on model performance,and its reduction usually leads to a decline in model performance.For the full band,the models constructed with low-order derivatives were superior to those with high-order derivatives,and the best model was obtained at the 0.4-order derivative(coefficient of determination(R^(2))and relative predictive deviation(RPD)of 0.777 and 2.118,respectively).In the characteristic bands,the lower order is sensitive to the visible-near-infrared range,and the higher order is sensitive to the short-wave infrared range,and the model constructed with the higher-order derivatives outperforms the lower-order derivatives.In this study,the combination of FOD and Random Forest(RF)can significantly improve the model performance,with R^(2),Relative Root Mean Squared Error(RRMSE),and RPD being 0.849,1.526,and 2.574,respectively.Therefore,this research provides a theoretical basis and technical reference for imaging hyperspectral exploration of anomalous areas of clay-type Li resources.
基金financially supported by the National Natural Science Foundation of China(42477044,32171648 and U23A2017)the Hubei Provincial Science and Technology Program,China(2025AFD451 and 2022CFB030)。
文摘Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its^(13)C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and^(13)C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions.
基金Supported by the National Natural Science Foundation of China(Grant Nos.12571317 and 12071133).
文摘In this paper,we study a class of Linear Fractional Programming on a nonempty bounded set,called the Problem(LFP),and design a branch and bound algorithm to find the global optimal solution of the problem(LFP).First,we convert the problem(LFP)to the equivalent problem(EP2).Secondly,by applying the linear relaxation technique to the problem(EP2),the linear relaxation programming problem(LRP2Y)was obtained.Then,the overall framework of the algorithm is given,and the convergence and complexity of the algorithm are analyzed.Finally,experimental results are listed to illustrate the effectiveness of the algorithm.
基金supported by the Guangdong Basic and Applied Basic Research Foundation(2022A1515012138)the NSFC(12271436,12371119)supported by the Natural Science Basic Research Program of Shaanxi(2022JC-04).
文摘We investigate the constrained fractional Choquard equation■where m>0,N>2s with s∈(0,1)being the order of the fractional Laplacian operator and I_(α)forα∈(0,N)denotes the Riesz potential.The parameterμ∈ℝappears as a Lagrange multiplier.By imposing general mass-supercritical conditions on F,we confirm the existence of normalized solutions that characterize the global minimizer on the Pohozaev manifold.Our proof does not depend on the assumption that all weak solutions satisfy the Pohozaev identity,a challenge that remains unsolved for this doubly nonlocal equation.
基金Funded by the Provincial Talent Project of Gansu Province(No.2025QNGR18)the Natural Science Foundation of Gansu Province(No.23JRRA1647)+2 种基金the"Qizhi"Talent Cultivation Project of Lanzhou Institute of Technology(No.2025QZ-02)the Education Science and Technology Innovation Project of Gansu Province(No.2025A-229)the Lanzhou Science and Technology Development Guidance Plan Project(No.2024-9-307)。
文摘SiCp-reinforced 6092Al composites with volume fractions of 25%and 60%were prepared using a powder metallurgy method.Their friction and wear characteristics were analyzed using a reciprocating friction and wear testing machine under loads of 20 to 50 N against YG6 cemented carbide.The experimental results show that the friction coefficients of all samples increase with increasing load.The 25vol%composite exhibits the lowest friction coefficient(0.1669-0.2716),while the 60vol%composite exhibits the highest(0.3237-0.3990),with the 6092 aluminum alloy falling between the two.The wear volume and specific wear rate also increase with load,but the composites with a higher Si C content demonstrate smaller increments,with the 60vol%composite exhibiting superior wear resistance.Under a 30 N load,the wear scars of the 60vol%composite show a significant increase in the contents of elements such as C,Co,W,and O,indicating more severe wear of the counterpart material.Scanning electron microscopy(SEM)reveals wear mechanisms including adhesive wear,two-body sliding and three-body rolling wear of particles,and delamination.
基金supported by National Natural Science Foundation of China under Grant Nos.12474140 and 12347101supported by National Natural Science Foundation of China under Grant No.12204432+1 种基金supported by the graduate research and innovation foundation of Chongqing,China under Grant No.CYB25066the inaugural Doctoral Student Special Project of the China Association for Science and Technology Young Talents Lifting Program(2024)。
文摘The fractional quantum Hall effect remains a captivating area in condensed matter physics,characterized by strongly correlated topological order,which manifests as fractionalized excitations and anyonic statistics.Numerical simulations,such as exact diagonalization,density matrix renormalization groups,matrix product states,and Monte Carlo methods are essential for examining the properties of strongly correlated systems.Recently,density functional theory has been employed in this field within the framework of composite fermion theory.This paper systematically evaluates how density functional theory approaches have addressed fundamental challenges in fractional quantum Hall systems,including ground state and low-energy excitations.Special attention is given to the insights provided by density functional theory regarding composite fermion behavior,edge effects,and the nature of fractional charge and magnetoroton excitations.The discussion critically examines both the advantages and limitations of these approaches,while highlighting the productive interplay between numerical simulations and theoretical models.Future directions are explored,particularly the promising potential of time-dependent density functional theory for modeling non-equilibrium dynamics in quantum Hall systems.
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)(grant number IMSIU-DDRSP2601).
文摘This paper introduces a novel fractional-order model based on the Caputo-Fabrizio(CF)derivative for analyzing computer virus propagation in networked environments.The model partitions the computer population into four compartments:susceptible,latently infected,breaking-out,and antivirus-capable systems.By employing the CF derivative—which uses a nonsingular exponential kernel—the framework effectively captures memory-dependent and nonlocal characteristics intrinsic to cyber systems,aspects inadequately represented by traditional integer-order models.Under Lipschitz continuity and boundedness assumptions,the existence and uniqueness of solutions are rigorously established via fixed-point theory.We develop a tailored two-step Adams-Bashforth numerical scheme for the CF framework and prove its second-order accuracy.Extensive numerical simulations across various fractional orders reveal that memory effects significantly influence virus transmission and control dynamics;smaller fractional orders produce more pronounced memory effects,delaying both infection spread and antivirus activation.Further theoretical analysis,including Hyers-Ulam stability and sensitivity assessments,reinforces the model’s robustness and identifies key parameters governing virus dynamics.The study also extends the framework to incorporate stochastic effects through a stochastic CF formulation.These results underscore fractional-order modeling as a powerful analytical tool for developing robust and effective cybersecurity strategies.
文摘Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical effects and mechanisms in immune enhancement,adjunctive anti-tumor activity,and regulation of glucose/lipid metabolism.Three clinical trials were conducted.In an immune study,120 healthy volunteers(CD4+T cell count 500–1000 cells/μL)received 150 mg/day GFP-D for 8 weeks,resulting in significant increases in CD4+T cells(from 632±95 to 812±108 cells/μL,28.5%increase,within the physiological activation range),CD4+/CD8+ratio,NK cell activity,IL-2,and IFN-γ(all P<0.001 vs.placebo).An anti-tumor study with 80 advanced cancer patients(stratified by age,tumor stage,and histotype)showed that adding 1000 mg/day GFP-D to chemotherapy improved objective response rate(52.5%vs.30.0%,P=0.036,95%CI:1.02–3.87),one-year progression-free survival(55.8%vs.33.3%,P=0.022),and preserved immune parameters versus chemotherapy alone.A metabolic study in 90 type 2 diabetes patients found that 400 mg/day GFP-D for 12 weeks significantly lowered fasting glucose,HbA1c,total cholesterol,triglycerides,and LDL-C,while raising HDL-C(from 1.0±0.2 to 1.2±0.2 mmol/L,20%increase,supported by increased AMPK phosphorylation).Mechanistically,immune enhancement involves macrophage/dendritic cell activation via Dectin-1/TLR4 receptors(confirmed by increased receptor expression and downstream signaling molecules),promoting cytokine-driven T/NK cell responses.Anti-tumor effects stem from immunomodulation,direct induction of cancer cell apoptosis(via mitochondrial/caspase pathways,verified by increased Bax/Bcl-2 ratio and caspase-3 activation),and angiogenesis inhibition by downregulating VEGF.Metabolic benefits are linked to AMPK pathway activation in liver/muscle(confirmed by increased p-AMPK/AMPK ratio),enhancing glucose uptake and inhibiting gluconeogenesis/lipogenesis,alongside modulation of gut microbiota(increased Bifidobacterium and Lactobacillus abundance).All trials reported no severe adverse events related to GFP-D;liver/kidney function parameters(ALT,AST,creatinine,urea nitrogen)remained within normal ranges throughout the intervention.Collectively,GFP-D emerges as a multi-functional bioactive agent with substantial therapeutic potential.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11961041,12261055)the Key Project of Natural Science Foundation of Gansu Province(Grant No.24JRRA222)the Foundation for Innovative Fundamental Research Group Project of Gansu Province(Grant No.25JRRA805).
文摘In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizhong Zhou,Hongxia Liu and Yang Xu(2022).Then,an A_(α)-spectral condition is given to ensure that G is a fractional ID-[a,b]-factor-critical covered graph and an(a,b,k)-factor-critical graph,respectively.In fact,(a,b,k)-factor-critical graph is a graph which has an[a,b]-factor for k=0.Thus,these above results extend the results of Jia Wei and Shenggui Zhang(2023)and Ao Fan,Ruifang Liu and Guoyan Ao(2023)in some sense.
基金supported by the Fundamental Research Funds for the Central Universities(QNTD202302)National Natural Science Foundation of China(22378024)the Foreign expert program(G2022109001L).
文摘Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps process.The key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene glycol.The utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling up.In the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.
文摘Pitch produced by the lique-faction of coal was divided into two frac-tions:soluble in toluene(TS)and insol-uble in toluene but soluble in pyridine(TI-PS),and their differences in molecu-lar structure and oxidation activity were studied.Several different carbon materi-als were produced from them by oxida-tion in air(350℃,300 mL/min)fol-lowed by carbonization(1000℃ in Ar),and the effect of the cross-linked structure on their structure and sodium storage properties was investigated.The results showed that the two pitch fractions were obviously different after the air oxidation.The TS fraction with a low degree of condensation and abundant side chains had a stronger oxidation activity and thus introduced more cross-linked oxygen-containing functional groups C(O)―O which prevented carbon layer rearrangement during the carbonization.As a result,a disordered hard carbon with more defects was formed,which improved the electrochemical performance.Therefore,the carbon materials derived from TS(O-TS-1000)had an obvious disordered structure and a larger layer spacing,giving them better sodium storage perform-ance than those derived from the TI-PS fraction(O-TI-PS-1000).The specific capacity of O-TS-1000 was about 250 mAh/g at 20 mA/g,which was 1.67 times higher than that of O-TI-PS-1000(150 mAh/g).
基金Supported by NSFC(Nos.11661025,12161024)Natural Science Foundation of Guangxi(Nos.2020GXNSFAA159118,2021GXNSFAA196045)+2 种基金Guangxi Science and Technology Project(No.Guike AD20297006)Training Program for 1000 Young and Middle-aged Cadre Teachers in Universities of GuangxiNational College Student's Innovation and Entrepreneurship Training Program(No.202110595049)。
文摘In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):1045-1049]and Monrad and Rootzén[Probab.Theory Related Fields,1995,101(2):173-192].
基金the support of the National Natural Science Foundation of China(No.42107247)the National Key Research and Development Project(No.2022YFD1901605)+1 种基金the Natural Science Foundation of Sichuan Province(Nos.2025YFHZ0142 and 2024NSFSC0800)the Tobacco Science Foundation of Sichuan Province(No.SCYC202407)。
文摘Soil microorganisms and labile soil organic carbon(SOC)fractions are essential factors affecting greenhouse gas(GHG)emissions in paddy fields.However,the effects of labile SOC fractions and microorganisms on GHG emissions from flooding to drying after organic fertilizer replacing for chemical fertilizer remain unclear.Here,a long-term experiment was conducted with four treatments:chemical fertilization only(control),organic fertilizer substituting 25%of chemical N fertilizer(NM1),50%of chemical N fertilizer(NM2),and NM2combined with crop straw(NMS).GHG emissions were monitored,and soil samples were collected to determine labile SOC fractions and microorganisms.Results revealed the GHG emissions in the NM2 significantly increased by 196.88%from flooding to drying,mainly due to the higher CO_(2) emissions.The GHG emissions per kg of C input in NMS was the lowest with the value of 9.17.From flooding to drying,organic fertilizer application significantly increased the readily oxidizable organic carbon(ROC)contents and C lability;the NM2 and NMS dramatically increased the SOC and non-readily oxidizable organic carbon(NROC).The bacterial communities showed significant differences among different treatments in the flooding,while the significant difference was only found between the NMS and other treatments in the drying.From flooding to drying,changing soil moisture conditions causes C fractions and microbial communities to jointly affect carbon emissions,and the NMS promoted carbon sequestration and mitigated GHG emissions.Our findings highlight the importance of the labile SOC fractions and microorganisms linked to GHG emissions in paddy fields.
文摘This article studies the existence and uniqueness of the mild solution of a family of control systems with a delay that are governed by the nonlinear fractional evolution differential equations in Banach spaces.Moreover,we establish the controllability of the considered system.To do so,first,we investigate the approximate controllability of the corresponding linear system.Subsequently,we prove the nonlinear system is approximately controllable if the corresponding linear system is approximately controllable.To reach the conclusions,the theory of resolvent operators,the Banach contraction mapping principle,and fixed point theorems are used.While concluding,some examples are given to demonstrate the efficacy of the proposed results.
