在非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)中,弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的发生率最高,其异质性明显。利妥昔单抗的出现极大改善了患者的预后及生存,其联合CHOP成为经典一线治疗方案,50%~70%患...在非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)中,弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的发生率最高,其异质性明显。利妥昔单抗的出现极大改善了患者的预后及生存,其联合CHOP成为经典一线治疗方案,50%~70%患者可治愈,但仍有30%~50%因耐药等原因反应差或在缓解后复发。复发难治DLBCL,尤其是无法自体造血干细胞移植或移植后复发病人的治疗是目前亟待解决的问题。随着对靶向免疫治疗研究的不断深入,许多药物不断进入临床应用或正在开发中,该文主要就单克隆抗体、双特异性抗体、抗体药物偶联物、选择性核出口蛋白抑制剂、嵌合抗原受体T细胞、程序性死亡受体/配体1抑制剂等药物作一简要综述。展开更多
In this paper,we study anti-derivations and anti-left multipliers.For a class of algebras,which contains triangular algebras,matrix algebras,embedded algebras,Cuntz algebras,nest algebras,P-lattice algebras,and linear...In this paper,we study anti-derivations and anti-left multipliers.For a class of algebras,which contains triangular algebras,matrix algebras,embedded algebras,Cuntz algebras,nest algebras,P-lattice algebras,and linear transformation algebras L(X),we show that every anti-left multiplier on these algebras is zero.Furthermore,let A be a zero product determined algebra andδbe a linear mapping from A into itself,satisfying that for any a,b in A,ab=0 impliesδ(b)a+bδ(a)=0.We show thatδ(x)=D(x)+δ(1)x,where D is an anti-derivation andδ(1)∈Z(A).展开更多
文摘在非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)中,弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的发生率最高,其异质性明显。利妥昔单抗的出现极大改善了患者的预后及生存,其联合CHOP成为经典一线治疗方案,50%~70%患者可治愈,但仍有30%~50%因耐药等原因反应差或在缓解后复发。复发难治DLBCL,尤其是无法自体造血干细胞移植或移植后复发病人的治疗是目前亟待解决的问题。随着对靶向免疫治疗研究的不断深入,许多药物不断进入临床应用或正在开发中,该文主要就单克隆抗体、双特异性抗体、抗体药物偶联物、选择性核出口蛋白抑制剂、嵌合抗原受体T细胞、程序性死亡受体/配体1抑制剂等药物作一简要综述。
基金Supported by the General Program of Shanghai Natural Science Foundation(Grant No.24ZR1415600)the National Natural Science Foundation of China(Grant Nos.1232637412401157)。
文摘In this paper,we study anti-derivations and anti-left multipliers.For a class of algebras,which contains triangular algebras,matrix algebras,embedded algebras,Cuntz algebras,nest algebras,P-lattice algebras,and linear transformation algebras L(X),we show that every anti-left multiplier on these algebras is zero.Furthermore,let A be a zero product determined algebra andδbe a linear mapping from A into itself,satisfying that for any a,b in A,ab=0 impliesδ(b)a+bδ(a)=0.We show thatδ(x)=D(x)+δ(1)x,where D is an anti-derivation andδ(1)∈Z(A).
