Remodeling plant intracellular nucleotide-binding leucine-rich repeat immune receptors(NLRs)to engineer synthetic disease-resistance genes has emerged as a promising approach to achieving broad-spectrum disease resist...Remodeling plant intracellular nucleotide-binding leucine-rich repeat immune receptors(NLRs)to engineer synthetic disease-resistance genes has emerged as a promising approach to achieving broad-spectrum disease resistance.But strategies for expanding NLR recognition spectra[[1],[2],[3],[4],[5]]are often limited by the rapid evolution of pathogens and pests.In our recent study,we developed an innovative strategy to engineer broad-spectrum,durable and complete disease resistance in plants by remodeling autoactive NLRs into protease-activated switches[6].展开更多
Engineering durable,broad-spectrum,and complete disease resistance in crops is a holy grail of plant pathology.However,the engineering strategies to achieve this goal are extremely rare at present.In their recently pu...Engineering durable,broad-spectrum,and complete disease resistance in crops is a holy grail of plant pathology.However,the engineering strategies to achieve this goal are extremely rare at present.In their recently published work,Wang et al.(2025)report an ingenious strategy to remodel autoactive nucleotide-binding leucine-rich repeat receptors(aNLRs),creating a protease-activated "molecular switch" that unleashes potent,broad-spectrum,and potentially durable immunity against multiple devastating plant pathogens.展开更多
基金supported by the Biological Breeding-National Science and Technology Major Project(2024ZD04077).
文摘Remodeling plant intracellular nucleotide-binding leucine-rich repeat immune receptors(NLRs)to engineer synthetic disease-resistance genes has emerged as a promising approach to achieving broad-spectrum disease resistance.But strategies for expanding NLR recognition spectra[[1],[2],[3],[4],[5]]are often limited by the rapid evolution of pathogens and pests.In our recent study,we developed an innovative strategy to engineer broad-spectrum,durable and complete disease resistance in plants by remodeling autoactive NLRs into protease-activated switches[6].
基金supported by grants from the National Natural Science Foundation of China(nos.32025031 and 32170167)the National Key R&D Program of China(2023YFF1000500).
文摘Engineering durable,broad-spectrum,and complete disease resistance in crops is a holy grail of plant pathology.However,the engineering strategies to achieve this goal are extremely rare at present.In their recently published work,Wang et al.(2025)report an ingenious strategy to remodel autoactive nucleotide-binding leucine-rich repeat receptors(aNLRs),creating a protease-activated "molecular switch" that unleashes potent,broad-spectrum,and potentially durable immunity against multiple devastating plant pathogens.
