Simulation code for a model of the adaptive immune response seen in flavivirus infections is used to explain the immunopathological consequences seen in West Nile Virus virus (WNV) infections. We use a model that spec...Simulation code for a model of the adaptive immune response seen in flavivirus infections is used to explain the immunopathological consequences seen in West Nile Virus virus (WNV) infections. We use a model that specifically handles the differences in how the virus infects resting cells, the G0 state, versus dividing cells, the G1 state, which includes vastly increased MHC-I upregulation for resting cells over dividing cells. The simulation suggests how the infection progresses in a one host model and the results shed insight into the unusual survival curve data obtained for this infection: there is an increase in health even though viral load has increased.展开更多
To the Editor,Systemic lupus erythematosus(SLE)is a chronic auto immune disorder characterized by multiple organs and systems damage.1,2 Single-nucleotide polymorphism(SNP)studies have identified a host of loci associ...To the Editor,Systemic lupus erythematosus(SLE)is a chronic auto immune disorder characterized by multiple organs and systems damage.1,2 Single-nucleotide polymorphism(SNP)studies have identified a host of loci associated with susceptibility and clinical manifestations of SLE.展开更多
文摘Simulation code for a model of the adaptive immune response seen in flavivirus infections is used to explain the immunopathological consequences seen in West Nile Virus virus (WNV) infections. We use a model that specifically handles the differences in how the virus infects resting cells, the G0 state, versus dividing cells, the G1 state, which includes vastly increased MHC-I upregulation for resting cells over dividing cells. The simulation suggests how the infection progresses in a one host model and the results shed insight into the unusual survival curve data obtained for this infection: there is an increase in health even though viral load has increased.
基金supported by the Natural Science Foundation of Hunan Province,China,Grant/Award Numbers:2021JJ40856,2023JJ40827。
文摘To the Editor,Systemic lupus erythematosus(SLE)is a chronic auto immune disorder characterized by multiple organs and systems damage.1,2 Single-nucleotide polymorphism(SNP)studies have identified a host of loci associated with susceptibility and clinical manifestations of SLE.
