OBJECTIVE:To observe whether electroacupuncture stimulation of auricular concha region(EA-ACR)on behavior changes of depression by loss of control over stress model(LOC),and whether its effect is improved by regulatin...OBJECTIVE:To observe whether electroacupuncture stimulation of auricular concha region(EA-ACR)on behavior changes of depression by loss of control over stress model(LOC),and whether its effect is improved by regulating the expression levels of hydroxytryptamine(serotonin,5-HT)1A receptor(5-HT_(1A)R)/hydroxytryptamine(serotonin,5-HT)2A receptor(5-HT_(2A)R)in hippocampus.METHODS:LOC was prepared using a Skinner box,and EA-ACR to observe behavioral changes,and Western Blot was used to detect the changes of 5-HT_(1A)R/5-HT_(2A)R in the hippocampus,and then observe the changes of EA-ACR behavior after microinjection of 5-HT_(1A)R/5-HT_(2A)R antagonist into the hippocampus.RESULTS:EA-ACR improve depressive-like behavior,up-regulated 5-HT_(1A)R expression and down-regulated 5-HT_(2A)R expression in hippocampal brain area.EA-ACR did not improve depression-like behavior after hippocampal microinjection of 5-HT_(1A)R antagonist,while injection of 5-HT_(2A)R antagonists can improve depressionlike behaviors.CONCLUSION:EA-ACR can improve depressive-like behaviors.Loss of control over stress leads to upregulation of 5-HT_(1A)R and down-regulation of 5-HT_(2A)R in the hippocampus,while EA-ACR mainly improves depressive behavior by regulating 5-HT_(1A)R in Hip.展开更多
VEXAS(vacuoles,E1 enzyme,X-linked,autoinflammatory,somatic)syndrome is a severe and progressive disease,characterized by clinical features that bridge rheumatologic and hematologic conditions.[1]VEXAS syndrome is a ra...VEXAS(vacuoles,E1 enzyme,X-linked,autoinflammatory,somatic)syndrome is a severe and progressive disease,characterized by clinical features that bridge rheumatologic and hematologic conditions.[1]VEXAS syndrome is a rare condition that was not reported until 2020.[2]Since then,interest among dermatologists,hematologists,and rheumatologists with published works has increased,[3]but none of them reported in the emergency setting,nor have any cases arisen following COVID-19 infection.展开更多
Objective:To explore the effects of acupoint catgut embedding combined with auricular point pressing with beans on symptom management self-efficacy and quality of life in patients with nonalcoholic steatohepatitis(NAS...Objective:To explore the effects of acupoint catgut embedding combined with auricular point pressing with beans on symptom management self-efficacy and quality of life in patients with nonalcoholic steatohepatitis(NASH)of liver depression and spleen deficiency type.Methods:Sixty patients with NASH of liver depression and spleen deficiency type admitted to our hospital from January 2021 to December 2023 were selected and divided into an acupoint catgut embedding group(n=30)and a combined group(n=30)using the envelope lottery method.The acupoint catgut embedding group received acupoint catgut embedding intervention,while the combined group received auricular point pressing with beans on the basis of the acupoint catgut embedding group.The two groups were compared in terms of TCM syndrome scores,symptom management self-efficacy[Chronic Disease Self-Efficacy Scale(CDSES)],and quality of life[Chronic Liver Disease Questionnaire(CLDQ)].Results:After intervention,the combined group had lower TCM syndrome scores for both primary and secondary symptoms compared to the acupoint catgut embedding group(P<0.05).The combined group also had higher scores in all dimensions and total score of the CDSES compared to the acupoint catgut embedding group(P<0.05).Similarly,the combined group had higher scores in all dimensions and total score of the CLDQ compared to the acupoint catgut embedding group(P<0.05).Conclusion:Acupoint catgut embedding combined with auricular point pressing with beans can effectively improve TCM symptoms,enhance symptom management self-efficacy,and improve quality of life in patients with NASH of liver depression and spleen deficiency type.展开更多
Objective: This study aims to evaluate the efficacy and safety of using a strip-shaped cymba conchae orthosis for the nonsurgical correction of complex auricular deformities. Methods: Clinical data were collected from...Objective: This study aims to evaluate the efficacy and safety of using a strip-shaped cymba conchae orthosis for the nonsurgical correction of complex auricular deformities. Methods: Clinical data were collected from 2020 to 2021 for 6 patients who underwent correction using a stripshaped cymba conchae orthosis. The indications, corrective effects, and complications associated with use of the orthosis were analyzed. Results: There were four indications for treatment: cryptotia with helix adhesion;cryptotia with grade I microtia;cryptotia with excessive helix thickness;and auricular deformity beyond the treatment time window(≥6 months). Excellent corrective effects were observed in all 6 patients. Complications occurred in one patient, who recovered after symptomatic treatment. Conclusion: The use of a strip-shaped cymba conchae orthosis alone or combined with a U-shaped helix orthosis presents a feasible approach for correcting complex auricular deformities or deformities beyond the treatment time window in pediatric patients.展开更多
BACKGROUND This case report highlights a rare instance of concurrent keloid and epidermal cyst development at an ear cartilage harvest site following rhinoplasty in a 25-year-old woman.Both conditions,which typically ...BACKGROUND This case report highlights a rare instance of concurrent keloid and epidermal cyst development at an ear cartilage harvest site following rhinoplasty in a 25-year-old woman.Both conditions,which typically stem from skin trauma,seldom occur together,demonstrating the exceptional characteristics of this case.CASE SUMMARY The patient underwent successful surgical removal of both the keloid and the epidermal cyst.Postoperative treatment included the use of silicone sheets,gel,and oral tranilast to reduce scarring.No recurrence was observed over a 6-mo follow-up period,indicating effective management of the condition.CONCLUSION The effective management of complex skin trauma cases underscores the need for individualized treatment strategies in plastic surgery.展开更多
Preeclampsia is a serious obstetric complication.Currently,there is a lack of effective preventive approaches for this disease.Recent studies have identified transcutaneous auricular vagus nerve stimulation(taVNS)as a...Preeclampsia is a serious obstetric complication.Currently,there is a lack of effective preventive approaches for this disease.Recent studies have identified transcutaneous auricular vagus nerve stimulation(taVNS)as a potential novel non-pharmaceutical therapeutic modality for preeclampsia.In this study,we investigated whether taVNS inhibits apoptosis of placental trophoblastic cells through ROS-induced UPR^(mt).Our results showed that taVNS promoted the release of acetylcholine(ACh).ACh decreased the expression of UPR^(mt) by inhibiting the formation of mitochondrial ROS(mtROS),presumably through M3AChR.This reduced the release of pro-apoptotic proteins(cleaved caspase-3,NF-kB-p65,and cytochrome C)and helped preserve the morphological and functional integrity of mitochondria,thus reducing the apoptosis of placental trophoblasts,improving placental function,and relieving preeclampsia.Our study unravels the potential pathophysiological mechanism of preeclampsia.In-depth characterization of the UPR^(mt) is essential for developing more effective therapeutic strategies for preeclampsia targeting mitochondrial function.展开更多
Objective:This study aimed to evaluate the effectiveness and safety of combining low-frequency pulsed electrophysiological techniques with auricular acupuncture(a fusion of traditional Chinese and Western medicine)for...Objective:This study aimed to evaluate the effectiveness and safety of combining low-frequency pulsed electrophysiological techniques with auricular acupuncture(a fusion of traditional Chinese and Western medicine)for patients experiencing perioperative gastrointestinal dysfunction(POGD)following gynecological surgery.Methods:Eighty patients undergoing gynecological surgery were randomly assigned to an experimental group and a control group.Both groups received enhanced recovery after surgery(ERAS)care,with the experimental group receiving additional treatment combining electrophysiology and auricular acupuncture.Postoperative recovery indicators,including bowel sound recovery time,time to first exhaust and defecation,duration and incidence of abdominal pain and distension,nausea and vomiting,and specific gastrointestinal markers(HSP70,I-FABP,DAO,D-lactate),were monitored and compared between the two groups.Results:After treatment,the postoperative bowel sound recovery time,first postoperative exhaust time,duration of abdominal pain,and duration of abdominal distension were shorter in the experimental group than in the control group(P<0.05).The 6-hour and 48-hour integral values of the experimental group were significantly lower than those of the control group.In the experimental group,60%of the patients were completely cured of gastrointestinal function after surgery,whereas only 32.5%of the patients in the control group were cured.The main symptom scores(abdominal pain,abdominal distension,nausea and vomiting)on the third postoperative day and the total symptom scores on the third postoperative day were significantly lower in the experimental group than in the control group(P<0.05).The values of HSP70,I-FABP,DAO,and D-lactate in the experimental group on postoperative day one were significantly lower than those in the control group(P<0.05).Conclusion:The combination of the Chinese and Western medicine ERAS programs of low-frequency pulse electrophysiology technology plus auricular acupuncture can accelerate local gastrointestinal blood circulation during the perioperative period of gynecology,promote the recovery of gastrointestinal function,promote anal exhaustion,and prevent the occurrence of postoperative abdominal pain and bloating.The combination of Chinese and Western medicine ERAS can increase gastrointestinal fluid secretion,increase gastrointestinal hormone and blood flow values,increase gastrointestinal electrophysiological detection values,and change the indicators of gastrointestinal dysfunction.展开更多
Objective:To explore the efficacy of auricular acupuncture combined with transcutaneous electrical nerve stimulation(TENS)and nonsteroidal anti-inflammatory drugs(NSAIDs)in alleviating postpartum uterine pain.Methods:...Objective:To explore the efficacy of auricular acupuncture combined with transcutaneous electrical nerve stimulation(TENS)and nonsteroidal anti-inflammatory drugs(NSAIDs)in alleviating postpartum uterine pain.Methods:A total of 501 postpartum women with uterine pain were randomly divided into an experimental group(n=250)and a control group(n=251).The control group received oral NSAIDs(such as ibuprofen sustained-release capsules,diclofenac sodium suppositories,etc.),while the experimental group received auricular acupuncture and TENS in addition to the NSAIDs.The clinical efficacy,pain intensity,and vaginal bleeding volume of the two groups were observed.Results:The total effective rate in the experimental group(93.20%)was significantly higher than that in the control group(73.20%)(P<0.001).The NRS scores in the experimental group were lower than those in the control group after the intervention,and the bleeding volume within 24 h and 48 h after the intervention was also less than that in the control group,with significant differences(all P<0.001).Conclusion:Auricular acupuncture combined with TENS and NSAIDs for the treatment of postpartum uterine pain is safe and effective,can significantly reduce pain and vaginal bleeding,and is worthy of clinical promotion.展开更多
BACKGROUND The auricle,or auricula,defines the visible boundaries of the external ear and is essential in forensic investigations,including facial reconstruction and human remains identification.Beyond its forensic si...BACKGROUND The auricle,or auricula,defines the visible boundaries of the external ear and is essential in forensic investigations,including facial reconstruction and human remains identification.Beyond its forensic significance,auricular morphology attracts interest from various fields,such as medicine and industry.The size of the ears is culturally associated with health and longevity,while surgical techniques for ear reconstruction address both congenital and aesthetic concerns.AIM To determine whether known correlations with various measurements and observations regarding sex and age could also be established through computed tomography(CT).METHODS Computed tomography scans of the head from 342 females and 329 males aged 18 to 97 years(mean=60±19 years)were included in this study.Different auricular lengths,widths and perimeters were measured for both sides.Additionally,the preauricular area was assessed using three-dimensional volume rendering tech-nique images.RESULTS The measured auricular dimensions in centimeters are presented as mean values(right/left)for males(length 16.91±0.51/6.93±0.52;length 22.83±0.35/2.84±0.34;width 13.94±0.32/4.01±0.36;width 23.51±0.34/3.46±0.31;perimeter 17.66±1.25/17.71±1.28)and females(length 16.44±0.5/6.48±0.51;length 22.7±0.32/2.71±0.33;width 13.6±0.32/3.68±0.31;width 23.3±0.3/3.26±0.27;perimeter 16.36±1.2/16.46±1.2).A positive correlation with age was shown in all measurements,with the highest value for perimeter in both,males(r-value:right/left:0.49/0.47)and females(r-value:right/left:0.53/0.53).After confounding factors were excluded,the preauricular vertical line was first seen at 45 years.The mean age for males with preauricular vertical lines was 66.65±10.92 years(95%CI:63.99-69.3),while without vertical lines,it was 44.48±16.15 years(95%CI:41.21-47.74);for females,it was 70.18±12.44 years(95%CI:68.9-71.46)with and 47.87±17.09 years(95%CI:45.96-49.78)without vertical lines.CONCLUSION In this study,we pioneered the use of CT volumetric data to examine human auricle morphology and we achieved a precise 3D(pre-)auricular assessment.Sex-specific positive correlations between ear dimensions and age,as well as the mean age for the appearance of preauricular lines,were identified,providing valuable insights into the capabilities of modern CT devices.展开更多
Objective:To study the effect of head meridian massage combined with auricular acupoint plasters on patients with insomnia.Methods:The sample consisted of 50 cases,and all of them were admitted to Yixing Hospital of T...Objective:To study the effect of head meridian massage combined with auricular acupoint plasters on patients with insomnia.Methods:The sample consisted of 50 cases,and all of them were admitted to Yixing Hospital of Traditional Chinese Medicine from January 2022 to December 2023.The patients were divided into an observation group and a control group,with 25 cases in each group.The observation group was treated with a combination of head meridian massage and auricular acupoint plaster while the control group underwent conventional nursing care.The improvement of sleep quality and nursing effect were used as evaluation criteria to compare the clinical effects of the nursing programs.Results:After nursing intervention,the Pittsburgh sleep quality index(PSQI)score of the observation group,which was 7.17±1.41 points was lower than that of the control group(9.04±1.96 points),(t=3.8724,P<0.05).The total efficacy was 96.00%for the observation group and 76.00%for the control group(2=4.1528,P<0.05).Conclusion:Head meridian massage combined with auricular acupoint can improve the sleep quality of patients with insomnia.展开更多
Objective:To explore the efficacy of auricular acupoint pressure patch combined with modified Huangqi Decoction in treating diabetic nephropathy.Methods:60 patients with diabetic nephropathy treated in our hospital fr...Objective:To explore the efficacy of auricular acupoint pressure patch combined with modified Huangqi Decoction in treating diabetic nephropathy.Methods:60 patients with diabetic nephropathy treated in our hospital from January 2021 to December 2022 were selected for this study.The patients were randomly divided into two groups using the random number table method,with 30 patients in each group.Among them,the control group was treated with conventional Western medicine,while the experimental group was treated with auricular acupoint pressure patches combined with modified Huangqi Decoction.The patients’fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),glycated hemoglobin(HbA1c),urinary protein quantification,urea nitrogen(BUN),serum creatinine(SCr),and other indicators were detected and recorded before and after treatment.Results:Before treatment,there was no statistically significant difference in the FPG,the 2hPG,and the HbA1c between the two groups of patients(P>0.05);after treatment,the FPG,the 2hPG,and the HbA1c of the patients in the experimental group were significantly lower than those in the control group(P<0.05).Before treatment,there was no statistically significant difference in the urinary protein quantification,the BUN,and the SCr between the two groups of patients(P>0.05);after treatment,the urinary protein quantification,BUN,and SCr of the patients in the experimental group were significantly lower than those in the control group(P<0.05).The experimental group showed better improvement in symptoms such as fatigue,backache,and frequency of nocturia(P<0.05).Conclusion:Auricular acupoint pressure patch combined with modified Huangqi Decoction effectively treats diabetic nephropathy and it helps control blood sugar and renal function indicators and improve clinical symptoms,therefore improving the patients’quality of life.展开更多
Objective:To explore whether auricular concha eletroacupuncture(ACEA)is effective in regulating lipidlipoprotein metabolism in rats submitted to cold stress.Methods:Thirty-six adult male Sprague-Dawley rats were place...Objective:To explore whether auricular concha eletroacupuncture(ACEA)is effective in regulating lipidlipoprotein metabolism in rats submitted to cold stress.Methods:Thirty-six adult male Sprague-Dawley rats were placed in four groups(9 rats in each group),the rats in three groups of which were submitted to cold stress for fourteen days,the last one of which was a control group.After the cold stress process,in those three groups,the rats of one group were with no treatment(stress only),two were treated with either ACEA or auricular margin eletroacupuncture(AMEA)repeated for fourteen days.On the 14th day,all the rats were sacrificed after all experimental procedure for blood sampling.Blood glucose,triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)levels were tested by using the collected serum.Plasma lecithin-cholesterol acyltransferase(LCAT)was measured with ELISA kit.Results:ACEA down-regulated the TG level(P<0.05)and LDL-C level(P<0.05),and up-regulated HDL-C level(P<0.05)and LACT level(P<0.05).AMEA did not regulate the bio-markers.Conclusion:ACEA played an important role in regulating lipid-lipoprotein metabolism in rats submitted to cold stress.展开更多
As an external treatment technique of traditional Chinese medicine(TCM),auricular point sticking,which is rooted in holographic biology theory and TCM viscera and meridian theory,is a safe and effective treatment meth...As an external treatment technique of traditional Chinese medicine(TCM),auricular point sticking,which is rooted in holographic biology theory and TCM viscera and meridian theory,is a safe and effective treatment method.This article introduces the technology overview and development process.The auricular point sticking technique for constipation is taken as an example to specify the basic requirements,assessment,operational points,acupoint selection and matters needing attention during the implementation of the auricular acupressure technique,providing a reference for the operating procedures of this technique in the clinical treatment of other diseases such as insomnia,diarrhea,colds,hypertension,headache,and dysmenorrhea.展开更多
Polymorphism of nine strains （CF05, CF09, 29, 916, AU9, Chang10, Chang7, 8808 and AU. Japanese） of A. auricular cultivated in Heilongjiang Province were analyzed by RAPD （Random Amplication polymorphic DNA）. Thirt...Polymorphism of nine strains （CF05, CF09, 29, 916, AU9, Chang10, Chang7, 8808 and AU. Japanese） of A. auricular cultivated in Heilongjiang Province were analyzed by RAPD （Random Amplication polymorphic DNA）. Thirteen primers were selected from forty PCR primers with 10bp long random primer. The results showed that nine strains of A. auricular have a high level of genetic diversity and the percentage of DNA polymorphic was 96.05. The genotypes of 9 strains of Auricularia auricular were identified by the fingerprints from primer 27 and primer 46 by RAPD analysis. The results are helpful for quickly identifying strains of A. auricular in its early breeding time, and also provides a powerful theoretic basis to differentiate strains （Auricularia auricular） whose morphology is very similar in breeding programs of edible fungus.展开更多
To introduce the experience of professor JIA Chun-sheng in rapid analgesia and motor function rehabilitation by subcutaneous penetration needling of auricular acupuncture.Subcutaneous penetration needling of auricular...To introduce the experience of professor JIA Chun-sheng in rapid analgesia and motor function rehabilitation by subcutaneous penetration needling of auricular acupuncture.Subcutaneous penetration needling of auricular acupuncture plays a role in rapid analgesia and motor function rehabilitation in treatment of pain in limbs and trunk and/or limb dysfunction caused by migraine,cervical spondylosis,acute lumbar sprain,soft tissue injury,scapulohumeral periarthritis,lumbar disc herniation,sciatica,stroke or cerebral trauma,and it is worthy of being widely promoted and applied clinically.展开更多
Objective To observe and compare the difference of clinical therapeutic effect of electroacupuncture combined with auricular plaster therapy and electroacupuncture therapy on simple obesity. Methods sixty female patie...Objective To observe and compare the difference of clinical therapeutic effect of electroacupuncture combined with auricular plaster therapy and electroacupuncture therapy on simple obesity. Methods sixty female patients of simple obesity were randomly divided into two groups： an electroacupuncture group and a combined group. Each group had 30 patients treated respectively with electroacupuncture and electroacupuncture therapy combined with auricular point pressing therapy. The changes of the body mass index （BMI）, body fat percentage （F%）, and waist-hip ratio （WHR） were observed to evaluate the effect of loosing weight. Results Compared with the scores before treatment, the BMI, F%, WHR level in two groups dropped （ all P〈0.01 ） in all 60 patients. And compared with the electroacupuncture group, the combined group dropped more obviously （ P〈0.05, P〈0.01 ） . Conclusion The effects of electroacupuncture therapy and electroacupuncture combined with auricular plaster therapy on simple obesity were both remarkable, but more in the combined group, so it indicates that the combined therapy is better than single therapy.展开更多
Objective To observe the clinical efficacy of electroacupuncture combined with auricular acupressure in treatment of nervous tinnitus. Methods One hundred and four patients with nervous tinnitus were randomly divided ...Objective To observe the clinical efficacy of electroacupuncture combined with auricular acupressure in treatment of nervous tinnitus. Methods One hundred and four patients with nervous tinnitus were randomly divided into a group A and a group B according to the method of random number table, with 52 patients in each group. In the group A, acupuncture at Yìfēng（翳风 TE 17）, Tīnggōng（听宫 SI 19）, Tīnghuì（听会 GB 2）, ěrmén（耳门 TE 21） and Fēngchí（风池 GB 20） combined with auricular acupressure, such as Shènshàngxiàn（肾上腺 TG 2p）, Jiāog？n（交感 AH6a）, Nèifēnmì（内分泌 CO18）, Nèi？r（内耳 LO 6）, Wài？r（外耳 TG1u）, Shèn（肾 CO10） and Gān（肝 CO12） were applied; in the group B, intravenous injection with compound Dānshēn（丹参 Radix et Rhizoma Salviae Miltiorrhizae） dissolved in 250 m L of 0.9% Na Cl injection were applied, combined with oral administration of 10 mg of Vitamin B1 and 0.5 mg of mecobalamin tablets. After treatment for three courses in the two groups, efficacy was evaluated based on Reference Standards of Severity, Assessment and Efficacy Evaluation of Tinnitus. Results In the group A（75 ears with nervous tinnitus）, 30 ears were cured, markedly effective was seen in 21 ears, and effective in 22, and the total effective rate was 97.4%; in the group B（76 ears with nervous tinnitus）, 17 ears were cured, markedly effective was seen in 20 ears, and effective in 23, and the total effective rate was 79.0%. The total effective rate in the group A was obviously superior to that in the group B, and the difference between the two groups was statistically significant（P〈0.05）. Compared before the treatment, the score of tinnitus severity both reduced in two groups（both P〈0.05）, and the reducing amplitude of score in the group A was greater than that in the group B（P〈0.05）. Conclusion Electroacupuncture combined with auricular acupressure in treatment of nervous tinnitus is worthy of clinical promotion and application since it has significant efficacy, which is obviously superior to drug therapy, and without adverse effect.展开更多
Implantable cervical vagus nerve stimulation(i VNS) is a representative and promising neuromodulation.However,the invasive nature restricts its application.Traditional auricular acupuncture treatment has a long histor...Implantable cervical vagus nerve stimulation(i VNS) is a representative and promising neuromodulation.However,the invasive nature restricts its application.Traditional auricular acupuncture treatment has a long history.The auricular branch of the vagus nerve(ABVN) is a branch on the surface of the ear.Some studies demonstrates that transcutaneous auricular vagus nerve stimulation(ta VNS) would achieve similar effects as i VNS.Ta VNS and i VNS share a common anatomical basis and acting mechanism.In this article,we made a comparison between i VNS and ta VNS in indications and efficacy.The recent studies have revealed similar clinical efficacy of ta VNS,ta VNS would expand the indication of i VNS.Highquality clinical evidences are needed before ta VNS become be an alternative of i VNS.展开更多
Objectives:To observe the clinical long-term therapeutic effect on functional dyspepsia(FD) in the comparative study of transcutaneous auricular vagus nerve stimulation(taVNS) with transcutaneous auricular none-vagus ...Objectives:To observe the clinical long-term therapeutic effect on functional dyspepsia(FD) in the comparative study of transcutaneous auricular vagus nerve stimulation(taVNS) with transcutaneous auricular none-vagus nerve stimulation(tnVNS).Methods:A total of 90 FD patients were randomized into a taVNS group and a tnVNS group,45 cases in each one.The patients in both the taNVS group and the tnVNS group were treated 5 times a week,30 min each time,for 4 weeks totally.Before treatment,after treatment and in follow-up visit,overall symptom points,functional dyspepsia-related quality of life questionnaire(FDQOL),Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD) and self-rating depression scale(SDS) were adopted to evaluate the severity of the symptoms and observe the clinical therapeutic effect of patients.Results:Compared with the scores before treatment,the overall symptom points,FDDQL,HAMA,HAMD and SDS at each time point after treatment were all lower in the patients of the taVNS group.The scores of FDDQL after treatment were almost all higher than that before treatment in the self-comparison of each group.All of the above differences were significant statistically(all P <0.05).Compared with the tnVNS group,the overall symptom points,FDDQL, HAMA,HAMD and SDS at each time point after treatment were all lower in the taVNS group and the score of FDDQL was higher,indicating the statistical differences(all P<0.05).Conclusion:Transcutaneous auricular vagus nerve stimulation is applicable for the treatment of functional dyspepsia.Compared with the control group,taVNS obtains a better long-term effect.展开更多
A total of 30 students scoring between 12 and 20 on the Test Anxiety Scale who had been exhibiting an anxious state 〉 24 hours, and 30 normal control students were recruited. Indices of heart rate variability were re...A total of 30 students scoring between 12 and 20 on the Test Anxiety Scale who had been exhibiting an anxious state 〉 24 hours, and 30 normal control students were recruited. Indices of heart rate variability were recorded using an Actiheart electrocardiogram recorder at 10 minutes before auricular pressing, in the first half of stimulation and in the second half of stimulation. The results revealed that the standard deviation of all normal to normal intervals and the root mean square of standard deviation of normal to normal intervals were significantly increased after stimulation. The heart rate variability triangular index, very-low-frequency power, low-frequency power, and the ratio of low-frequency to high-frequency power were increased to different degrees after stimulation. Compared with normal controls, the root mean square of standard deviation of normal to normal intervals was significantly increased in anxious students following auricular pressing. These results indicated that auricular pressing can elevate heart rate variability, especially the root mean square of standard deviation of normal to normal intervals in students with pre-exam anxiety.展开更多
基金the Natural Science Foundation of Shaanxi Province:Acupuncture’s Anxiolytic Effects in Uncontrollable Stress:Modulation of the Median Raphe Nucleus to Ventral Hippocampus Serotonergic Pathway(No.2022JQ-949)the National Natural Science Foundation of China:Study on the Mechanisms of Learning and Memory Impairment induced by Chronic Pain and the Intervention Effects of Acupuncture(No.82004489)。
文摘OBJECTIVE:To observe whether electroacupuncture stimulation of auricular concha region(EA-ACR)on behavior changes of depression by loss of control over stress model(LOC),and whether its effect is improved by regulating the expression levels of hydroxytryptamine(serotonin,5-HT)1A receptor(5-HT_(1A)R)/hydroxytryptamine(serotonin,5-HT)2A receptor(5-HT_(2A)R)in hippocampus.METHODS:LOC was prepared using a Skinner box,and EA-ACR to observe behavioral changes,and Western Blot was used to detect the changes of 5-HT_(1A)R/5-HT_(2A)R in the hippocampus,and then observe the changes of EA-ACR behavior after microinjection of 5-HT_(1A)R/5-HT_(2A)R antagonist into the hippocampus.RESULTS:EA-ACR improve depressive-like behavior,up-regulated 5-HT_(1A)R expression and down-regulated 5-HT_(2A)R expression in hippocampal brain area.EA-ACR did not improve depression-like behavior after hippocampal microinjection of 5-HT_(1A)R antagonist,while injection of 5-HT_(2A)R antagonists can improve depressionlike behaviors.CONCLUSION:EA-ACR can improve depressive-like behaviors.Loss of control over stress leads to upregulation of 5-HT_(1A)R and down-regulation of 5-HT_(2A)R in the hippocampus,while EA-ACR mainly improves depressive behavior by regulating 5-HT_(1A)R in Hip.
基金National High Level Hospital Clinical Research Funding(Scientific Research Seed Fund of Peking University First Hospital).
文摘VEXAS(vacuoles,E1 enzyme,X-linked,autoinflammatory,somatic)syndrome is a severe and progressive disease,characterized by clinical features that bridge rheumatologic and hematologic conditions.[1]VEXAS syndrome is a rare condition that was not reported until 2020.[2]Since then,interest among dermatologists,hematologists,and rheumatologists with published works has increased,[3]but none of them reported in the emergency setting,nor have any cases arisen following COVID-19 infection.
文摘Objective:To explore the effects of acupoint catgut embedding combined with auricular point pressing with beans on symptom management self-efficacy and quality of life in patients with nonalcoholic steatohepatitis(NASH)of liver depression and spleen deficiency type.Methods:Sixty patients with NASH of liver depression and spleen deficiency type admitted to our hospital from January 2021 to December 2023 were selected and divided into an acupoint catgut embedding group(n=30)and a combined group(n=30)using the envelope lottery method.The acupoint catgut embedding group received acupoint catgut embedding intervention,while the combined group received auricular point pressing with beans on the basis of the acupoint catgut embedding group.The two groups were compared in terms of TCM syndrome scores,symptom management self-efficacy[Chronic Disease Self-Efficacy Scale(CDSES)],and quality of life[Chronic Liver Disease Questionnaire(CLDQ)].Results:After intervention,the combined group had lower TCM syndrome scores for both primary and secondary symptoms compared to the acupoint catgut embedding group(P<0.05).The combined group also had higher scores in all dimensions and total score of the CDSES compared to the acupoint catgut embedding group(P<0.05).Similarly,the combined group had higher scores in all dimensions and total score of the CLDQ compared to the acupoint catgut embedding group(P<0.05).Conclusion:Acupoint catgut embedding combined with auricular point pressing with beans can effectively improve TCM symptoms,enhance symptom management self-efficacy,and improve quality of life in patients with NASH of liver depression and spleen deficiency type.
文摘Objective: This study aims to evaluate the efficacy and safety of using a strip-shaped cymba conchae orthosis for the nonsurgical correction of complex auricular deformities. Methods: Clinical data were collected from 2020 to 2021 for 6 patients who underwent correction using a stripshaped cymba conchae orthosis. The indications, corrective effects, and complications associated with use of the orthosis were analyzed. Results: There were four indications for treatment: cryptotia with helix adhesion;cryptotia with grade I microtia;cryptotia with excessive helix thickness;and auricular deformity beyond the treatment time window(≥6 months). Excellent corrective effects were observed in all 6 patients. Complications occurred in one patient, who recovered after symptomatic treatment. Conclusion: The use of a strip-shaped cymba conchae orthosis alone or combined with a U-shaped helix orthosis presents a feasible approach for correcting complex auricular deformities or deformities beyond the treatment time window in pediatric patients.
文摘BACKGROUND This case report highlights a rare instance of concurrent keloid and epidermal cyst development at an ear cartilage harvest site following rhinoplasty in a 25-year-old woman.Both conditions,which typically stem from skin trauma,seldom occur together,demonstrating the exceptional characteristics of this case.CASE SUMMARY The patient underwent successful surgical removal of both the keloid and the epidermal cyst.Postoperative treatment included the use of silicone sheets,gel,and oral tranilast to reduce scarring.No recurrence was observed over a 6-mo follow-up period,indicating effective management of the condition.CONCLUSION The effective management of complex skin trauma cases underscores the need for individualized treatment strategies in plastic surgery.
基金supported by the National Natural Science Foundation of China (82105016)the Natural Science Foundation of Shaanxi Province (2022SF-318)+1 种基金the Scientific Research Fund Project of Shaanxi Province Department of Education (21JSO12)the National Training Program of Innovation and Entrepreneurship for Students of China (202210716017).
文摘Preeclampsia is a serious obstetric complication.Currently,there is a lack of effective preventive approaches for this disease.Recent studies have identified transcutaneous auricular vagus nerve stimulation(taVNS)as a potential novel non-pharmaceutical therapeutic modality for preeclampsia.In this study,we investigated whether taVNS inhibits apoptosis of placental trophoblastic cells through ROS-induced UPR^(mt).Our results showed that taVNS promoted the release of acetylcholine(ACh).ACh decreased the expression of UPR^(mt) by inhibiting the formation of mitochondrial ROS(mtROS),presumably through M3AChR.This reduced the release of pro-apoptotic proteins(cleaved caspase-3,NF-kB-p65,and cytochrome C)and helped preserve the morphological and functional integrity of mitochondria,thus reducing the apoptosis of placental trophoblasts,improving placental function,and relieving preeclampsia.Our study unravels the potential pathophysiological mechanism of preeclampsia.In-depth characterization of the UPR^(mt) is essential for developing more effective therapeutic strategies for preeclampsia targeting mitochondrial function.
基金Shenzhen Bao’an District of Traditional Chinese Medicine Clinical Research(2023ZYYLCZX-12,Shenzhen Bao’an District Chinese Medicine Association funded the special clinical research of Chinese medicine)Shenzhen“Medical and Health Three Projects”Project Grant(SZZYSM202106003)+1 种基金Shenzhen Bao’an District of Medical and Health Research Project(2023JD212)Scientific Research Project of Shandong Public Health Society(SGWXH202304).
文摘Objective:This study aimed to evaluate the effectiveness and safety of combining low-frequency pulsed electrophysiological techniques with auricular acupuncture(a fusion of traditional Chinese and Western medicine)for patients experiencing perioperative gastrointestinal dysfunction(POGD)following gynecological surgery.Methods:Eighty patients undergoing gynecological surgery were randomly assigned to an experimental group and a control group.Both groups received enhanced recovery after surgery(ERAS)care,with the experimental group receiving additional treatment combining electrophysiology and auricular acupuncture.Postoperative recovery indicators,including bowel sound recovery time,time to first exhaust and defecation,duration and incidence of abdominal pain and distension,nausea and vomiting,and specific gastrointestinal markers(HSP70,I-FABP,DAO,D-lactate),were monitored and compared between the two groups.Results:After treatment,the postoperative bowel sound recovery time,first postoperative exhaust time,duration of abdominal pain,and duration of abdominal distension were shorter in the experimental group than in the control group(P<0.05).The 6-hour and 48-hour integral values of the experimental group were significantly lower than those of the control group.In the experimental group,60%of the patients were completely cured of gastrointestinal function after surgery,whereas only 32.5%of the patients in the control group were cured.The main symptom scores(abdominal pain,abdominal distension,nausea and vomiting)on the third postoperative day and the total symptom scores on the third postoperative day were significantly lower in the experimental group than in the control group(P<0.05).The values of HSP70,I-FABP,DAO,and D-lactate in the experimental group on postoperative day one were significantly lower than those in the control group(P<0.05).Conclusion:The combination of the Chinese and Western medicine ERAS programs of low-frequency pulse electrophysiology technology plus auricular acupuncture can accelerate local gastrointestinal blood circulation during the perioperative period of gynecology,promote the recovery of gastrointestinal function,promote anal exhaustion,and prevent the occurrence of postoperative abdominal pain and bloating.The combination of Chinese and Western medicine ERAS can increase gastrointestinal fluid secretion,increase gastrointestinal hormone and blood flow values,increase gastrointestinal electrophysiological detection values,and change the indicators of gastrointestinal dysfunction.
基金Shaanxi Provincial Key Research and Development Program(Project No.2024SF-YBXM-242)。
文摘Objective:To explore the efficacy of auricular acupuncture combined with transcutaneous electrical nerve stimulation(TENS)and nonsteroidal anti-inflammatory drugs(NSAIDs)in alleviating postpartum uterine pain.Methods:A total of 501 postpartum women with uterine pain were randomly divided into an experimental group(n=250)and a control group(n=251).The control group received oral NSAIDs(such as ibuprofen sustained-release capsules,diclofenac sodium suppositories,etc.),while the experimental group received auricular acupuncture and TENS in addition to the NSAIDs.The clinical efficacy,pain intensity,and vaginal bleeding volume of the two groups were observed.Results:The total effective rate in the experimental group(93.20%)was significantly higher than that in the control group(73.20%)(P<0.001).The NRS scores in the experimental group were lower than those in the control group after the intervention,and the bleeding volume within 24 h and 48 h after the intervention was also less than that in the control group,with significant differences(all P<0.001).Conclusion:Auricular acupuncture combined with TENS and NSAIDs for the treatment of postpartum uterine pain is safe and effective,can significantly reduce pain and vaginal bleeding,and is worthy of clinical promotion.
基金Supported by Schulz B received funding from Guerbet AG,No.8050.
文摘BACKGROUND The auricle,or auricula,defines the visible boundaries of the external ear and is essential in forensic investigations,including facial reconstruction and human remains identification.Beyond its forensic significance,auricular morphology attracts interest from various fields,such as medicine and industry.The size of the ears is culturally associated with health and longevity,while surgical techniques for ear reconstruction address both congenital and aesthetic concerns.AIM To determine whether known correlations with various measurements and observations regarding sex and age could also be established through computed tomography(CT).METHODS Computed tomography scans of the head from 342 females and 329 males aged 18 to 97 years(mean=60±19 years)were included in this study.Different auricular lengths,widths and perimeters were measured for both sides.Additionally,the preauricular area was assessed using three-dimensional volume rendering tech-nique images.RESULTS The measured auricular dimensions in centimeters are presented as mean values(right/left)for males(length 16.91±0.51/6.93±0.52;length 22.83±0.35/2.84±0.34;width 13.94±0.32/4.01±0.36;width 23.51±0.34/3.46±0.31;perimeter 17.66±1.25/17.71±1.28)and females(length 16.44±0.5/6.48±0.51;length 22.7±0.32/2.71±0.33;width 13.6±0.32/3.68±0.31;width 23.3±0.3/3.26±0.27;perimeter 16.36±1.2/16.46±1.2).A positive correlation with age was shown in all measurements,with the highest value for perimeter in both,males(r-value:right/left:0.49/0.47)and females(r-value:right/left:0.53/0.53).After confounding factors were excluded,the preauricular vertical line was first seen at 45 years.The mean age for males with preauricular vertical lines was 66.65±10.92 years(95%CI:63.99-69.3),while without vertical lines,it was 44.48±16.15 years(95%CI:41.21-47.74);for females,it was 70.18±12.44 years(95%CI:68.9-71.46)with and 47.87±17.09 years(95%CI:45.96-49.78)without vertical lines.CONCLUSION In this study,we pioneered the use of CT volumetric data to examine human auricle morphology and we achieved a precise 3D(pre-)auricular assessment.Sex-specific positive correlations between ear dimensions and age,as well as the mean age for the appearance of preauricular lines,were identified,providing valuable insights into the capabilities of modern CT devices.
基金Wuxi Municipal Health Commission"Promotion of Meridian-Based Head Massage Combined with Auricular Acupressure for Insomnia Patients"(Project No.T202245)。
文摘Objective:To study the effect of head meridian massage combined with auricular acupoint plasters on patients with insomnia.Methods:The sample consisted of 50 cases,and all of them were admitted to Yixing Hospital of Traditional Chinese Medicine from January 2022 to December 2023.The patients were divided into an observation group and a control group,with 25 cases in each group.The observation group was treated with a combination of head meridian massage and auricular acupoint plaster while the control group underwent conventional nursing care.The improvement of sleep quality and nursing effect were used as evaluation criteria to compare the clinical effects of the nursing programs.Results:After nursing intervention,the Pittsburgh sleep quality index(PSQI)score of the observation group,which was 7.17±1.41 points was lower than that of the control group(9.04±1.96 points),(t=3.8724,P<0.05).The total efficacy was 96.00%for the observation group and 76.00%for the control group(2=4.1528,P<0.05).Conclusion:Head meridian massage combined with auricular acupoint can improve the sleep quality of patients with insomnia.
文摘Objective:To explore the efficacy of auricular acupoint pressure patch combined with modified Huangqi Decoction in treating diabetic nephropathy.Methods:60 patients with diabetic nephropathy treated in our hospital from January 2021 to December 2022 were selected for this study.The patients were randomly divided into two groups using the random number table method,with 30 patients in each group.Among them,the control group was treated with conventional Western medicine,while the experimental group was treated with auricular acupoint pressure patches combined with modified Huangqi Decoction.The patients’fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),glycated hemoglobin(HbA1c),urinary protein quantification,urea nitrogen(BUN),serum creatinine(SCr),and other indicators were detected and recorded before and after treatment.Results:Before treatment,there was no statistically significant difference in the FPG,the 2hPG,and the HbA1c between the two groups of patients(P>0.05);after treatment,the FPG,the 2hPG,and the HbA1c of the patients in the experimental group were significantly lower than those in the control group(P<0.05).Before treatment,there was no statistically significant difference in the urinary protein quantification,the BUN,and the SCr between the two groups of patients(P>0.05);after treatment,the urinary protein quantification,BUN,and SCr of the patients in the experimental group were significantly lower than those in the control group(P<0.05).The experimental group showed better improvement in symptoms such as fatigue,backache,and frequency of nocturia(P<0.05).Conclusion:Auricular acupoint pressure patch combined with modified Huangqi Decoction effectively treats diabetic nephropathy and it helps control blood sugar and renal function indicators and improve clinical symptoms,therefore improving the patients’quality of life.
基金Supported by Major National R&D Program of China:Z161100002616003Joint Sino-German-Project:GZ1236+2 种基金The Fundamental Research Funds for the Central Public Welfare Research Institutes:ZZ16012Chinese Postdoctoral Science Foundation:2016M590185Natural Science Foundation of Beijing:7111007。
文摘Objective:To explore whether auricular concha eletroacupuncture(ACEA)is effective in regulating lipidlipoprotein metabolism in rats submitted to cold stress.Methods:Thirty-six adult male Sprague-Dawley rats were placed in four groups(9 rats in each group),the rats in three groups of which were submitted to cold stress for fourteen days,the last one of which was a control group.After the cold stress process,in those three groups,the rats of one group were with no treatment(stress only),two were treated with either ACEA or auricular margin eletroacupuncture(AMEA)repeated for fourteen days.On the 14th day,all the rats were sacrificed after all experimental procedure for blood sampling.Blood glucose,triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)levels were tested by using the collected serum.Plasma lecithin-cholesterol acyltransferase(LCAT)was measured with ELISA kit.Results:ACEA down-regulated the TG level(P<0.05)and LDL-C level(P<0.05),and up-regulated HDL-C level(P<0.05)and LACT level(P<0.05).AMEA did not regulate the bio-markers.Conclusion:ACEA played an important role in regulating lipid-lipoprotein metabolism in rats submitted to cold stress.
文摘As an external treatment technique of traditional Chinese medicine(TCM),auricular point sticking,which is rooted in holographic biology theory and TCM viscera and meridian theory,is a safe and effective treatment method.This article introduces the technology overview and development process.The auricular point sticking technique for constipation is taken as an example to specify the basic requirements,assessment,operational points,acupoint selection and matters needing attention during the implementation of the auricular acupressure technique,providing a reference for the operating procedures of this technique in the clinical treatment of other diseases such as insomnia,diarrhea,colds,hypertension,headache,and dysmenorrhea.
基金The research was supported by Science Foundation of Northeast Forestry University (2004)
文摘Polymorphism of nine strains （CF05, CF09, 29, 916, AU9, Chang10, Chang7, 8808 and AU. Japanese） of A. auricular cultivated in Heilongjiang Province were analyzed by RAPD （Random Amplication polymorphic DNA）. Thirteen primers were selected from forty PCR primers with 10bp long random primer. The results showed that nine strains of A. auricular have a high level of genetic diversity and the percentage of DNA polymorphic was 96.05. The genotypes of 9 strains of Auricularia auricular were identified by the fingerprints from primer 27 and primer 46 by RAPD analysis. The results are helpful for quickly identifying strains of A. auricular in its early breeding time, and also provides a powerful theoretic basis to differentiate strains （Auricularia auricular） whose morphology is very similar in breeding programs of edible fungus.
文摘To introduce the experience of professor JIA Chun-sheng in rapid analgesia and motor function rehabilitation by subcutaneous penetration needling of auricular acupuncture.Subcutaneous penetration needling of auricular acupuncture plays a role in rapid analgesia and motor function rehabilitation in treatment of pain in limbs and trunk and/or limb dysfunction caused by migraine,cervical spondylosis,acute lumbar sprain,soft tissue injury,scapulohumeral periarthritis,lumbar disc herniation,sciatica,stroke or cerebral trauma,and it is worthy of being widely promoted and applied clinically.
文摘Objective To observe and compare the difference of clinical therapeutic effect of electroacupuncture combined with auricular plaster therapy and electroacupuncture therapy on simple obesity. Methods sixty female patients of simple obesity were randomly divided into two groups： an electroacupuncture group and a combined group. Each group had 30 patients treated respectively with electroacupuncture and electroacupuncture therapy combined with auricular point pressing therapy. The changes of the body mass index （BMI）, body fat percentage （F%）, and waist-hip ratio （WHR） were observed to evaluate the effect of loosing weight. Results Compared with the scores before treatment, the BMI, F%, WHR level in two groups dropped （ all P〈0.01 ） in all 60 patients. And compared with the electroacupuncture group, the combined group dropped more obviously （ P〈0.05, P〈0.01 ） . Conclusion The effects of electroacupuncture therapy and electroacupuncture combined with auricular plaster therapy on simple obesity were both remarkable, but more in the combined group, so it indicates that the combined therapy is better than single therapy.
文摘Objective To observe the clinical efficacy of electroacupuncture combined with auricular acupressure in treatment of nervous tinnitus. Methods One hundred and four patients with nervous tinnitus were randomly divided into a group A and a group B according to the method of random number table, with 52 patients in each group. In the group A, acupuncture at Yìfēng（翳风 TE 17）, Tīnggōng（听宫 SI 19）, Tīnghuì（听会 GB 2）, ěrmén（耳门 TE 21） and Fēngchí（风池 GB 20） combined with auricular acupressure, such as Shènshàngxiàn（肾上腺 TG 2p）, Jiāog？n（交感 AH6a）, Nèifēnmì（内分泌 CO18）, Nèi？r（内耳 LO 6）, Wài？r（外耳 TG1u）, Shèn（肾 CO10） and Gān（肝 CO12） were applied; in the group B, intravenous injection with compound Dānshēn（丹参 Radix et Rhizoma Salviae Miltiorrhizae） dissolved in 250 m L of 0.9% Na Cl injection were applied, combined with oral administration of 10 mg of Vitamin B1 and 0.5 mg of mecobalamin tablets. After treatment for three courses in the two groups, efficacy was evaluated based on Reference Standards of Severity, Assessment and Efficacy Evaluation of Tinnitus. Results In the group A（75 ears with nervous tinnitus）, 30 ears were cured, markedly effective was seen in 21 ears, and effective in 22, and the total effective rate was 97.4%; in the group B（76 ears with nervous tinnitus）, 17 ears were cured, markedly effective was seen in 20 ears, and effective in 23, and the total effective rate was 79.0%. The total effective rate in the group A was obviously superior to that in the group B, and the difference between the two groups was statistically significant（P〈0.05）. Compared before the treatment, the score of tinnitus severity both reduced in two groups（both P〈0.05）, and the reducing amplitude of score in the group A was greater than that in the group B（P〈0.05）. Conclusion Electroacupuncture combined with auricular acupressure in treatment of nervous tinnitus is worthy of clinical promotion and application since it has significant efficacy, which is obviously superior to drug therapy, and without adverse effect.
基金Supported by the China Academy of Chinese Medical Sciences Innovation Fund:Brain Effects and Multimodal Imaging Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in Patients with Disorder of Consciousness(CI2021A03305)the National Key Research and Development Program:Optimization and Effect Mechanism of Transcutaneous Electrical Cranial-auricular Acupoint Stimulation(TECAS) on Depression(No.2018YFC1705800)。
文摘Implantable cervical vagus nerve stimulation(i VNS) is a representative and promising neuromodulation.However,the invasive nature restricts its application.Traditional auricular acupuncture treatment has a long history.The auricular branch of the vagus nerve(ABVN) is a branch on the surface of the ear.Some studies demonstrates that transcutaneous auricular vagus nerve stimulation(ta VNS) would achieve similar effects as i VNS.Ta VNS and i VNS share a common anatomical basis and acting mechanism.In this article,we made a comparison between i VNS and ta VNS in indications and efficacy.The recent studies have revealed similar clinical efficacy of ta VNS,ta VNS would expand the indication of i VNS.Highquality clinical evidences are needed before ta VNS become be an alternative of i VNS.
基金Supported by National Natural Science Foundation:81674072Beijing Municipal Administration of Hospitals Incubating Program:PZ2021001。
文摘Objectives:To observe the clinical long-term therapeutic effect on functional dyspepsia(FD) in the comparative study of transcutaneous auricular vagus nerve stimulation(taVNS) with transcutaneous auricular none-vagus nerve stimulation(tnVNS).Methods:A total of 90 FD patients were randomized into a taVNS group and a tnVNS group,45 cases in each one.The patients in both the taNVS group and the tnVNS group were treated 5 times a week,30 min each time,for 4 weeks totally.Before treatment,after treatment and in follow-up visit,overall symptom points,functional dyspepsia-related quality of life questionnaire(FDQOL),Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD) and self-rating depression scale(SDS) were adopted to evaluate the severity of the symptoms and observe the clinical therapeutic effect of patients.Results:Compared with the scores before treatment,the overall symptom points,FDDQL,HAMA,HAMD and SDS at each time point after treatment were all lower in the patients of the taVNS group.The scores of FDDQL after treatment were almost all higher than that before treatment in the self-comparison of each group.All of the above differences were significant statistically(all P <0.05).Compared with the tnVNS group,the overall symptom points,FDDQL, HAMA,HAMD and SDS at each time point after treatment were all lower in the taVNS group and the score of FDDQL was higher,indicating the statistical differences(all P<0.05).Conclusion:Transcutaneous auricular vagus nerve stimulation is applicable for the treatment of functional dyspepsia.Compared with the control group,taVNS obtains a better long-term effect.
基金funded by the Undergraduate Innovation Experimental Design Program of Guangdong Province,No.1212110041the Extracurricular Scientific Research Project of Southern Medical University,No.2009kw034
文摘A total of 30 students scoring between 12 and 20 on the Test Anxiety Scale who had been exhibiting an anxious state 〉 24 hours, and 30 normal control students were recruited. Indices of heart rate variability were recorded using an Actiheart electrocardiogram recorder at 10 minutes before auricular pressing, in the first half of stimulation and in the second half of stimulation. The results revealed that the standard deviation of all normal to normal intervals and the root mean square of standard deviation of normal to normal intervals were significantly increased after stimulation. The heart rate variability triangular index, very-low-frequency power, low-frequency power, and the ratio of low-frequency to high-frequency power were increased to different degrees after stimulation. Compared with normal controls, the root mean square of standard deviation of normal to normal intervals was significantly increased in anxious students following auricular pressing. These results indicated that auricular pressing can elevate heart rate variability, especially the root mean square of standard deviation of normal to normal intervals in students with pre-exam anxiety.
