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基于Preferential Attachment-VIKOR算法的阿尔茨海默病中药处方“方证”关系预测与处方综合评价
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作者 金博文 王豫骞 +3 位作者 樊薛津 张兆玮 张艳军 庄朋伟 《中草药》 北大核心 2025年第22期8273-8282,共10页
目的基于Preferential Attachment-VIKOR算法对中药配伍关系进行挖掘,实现对阿尔茨海默病(Alzheimer’s disease,AD)中药处方与证候对应关系的预测与处方综合评价。方法通过检索中国知网、维普、万方数据库,筛选2005年8月—2025年8月所... 目的基于Preferential Attachment-VIKOR算法对中药配伍关系进行挖掘,实现对阿尔茨海默病(Alzheimer’s disease,AD)中药处方与证候对应关系的预测与处方综合评价。方法通过检索中国知网、维普、万方数据库,筛选2005年8月—2025年8月所有中药治疗AD非重复的经验选方,整理中药处方的证候、组成,导入Neo4j图数据库,加载Graph Data Science插件,使用Preferential Attachment算法结合VIKOR算法进行网络挖掘,分析证候与处方的关系并进行处方综合评价,并基于经典名方对构建的算法准确性进行验证。结果筛选AD相中医证候51个,中药处方113个,中药171味,形成336个节点,1297条边的“疾病-证候-处方-中药”网络,网络中处方节点与证候节点间的Preferential Attachment评分即证候评分可以反映证候-处方的相关性,实现“方-证关系”的有效预测,其结果受处方药味数与处方组成影响,借由证候评分、药味数获得的配伍评分可以有效反映处方的配伍合理性。基于VIKOR算法综合证候评分、配伍评分、药味数对处方进行的评价,可以从证候与配伍2个维度实现对处方在具体证候下的综合评价。结论基于Neo4j图数据库建立了AD的“疾病-证候-处方-中药”网络,并基于Preferential Attachment-VIKOR算法实现对中药处方与证候对应关系的预测与处方证候与配伍的综合评价。 展开更多
关键词 阿尔茨海默病 中药配伍 证候 图数据库 Preferential attachment VIKOR算法
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Self-Esteem as a Mediator:Analyzing Its Impact on Parental Attachment and Adolescent Delinquency
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作者 Mahshid Manouchehri Musheer A.Aljaberi +3 位作者 Yi-Ching Lin Aiche Sabah Amira Mohammed Ali Chung-Ying Lin 《International Journal of Mental Health Promotion》 2025年第7期1013-1028,共16页
Background:While various factors contributing to delinquency have been explored,the role of selfesteem in this specific context has received little attention.Hence,this study aims to investigate the complex issue of a... Background:While various factors contributing to delinquency have been explored,the role of selfesteem in this specific context has received little attention.Hence,this study aims to investigate the complex issue of adolescent delinquency in Iran by focusing on the mediating role of self-esteem in the relationship between parental attachment and delinquent behavior.Methods:Using the multistage cluster random sampling method,the research involved 528 high school students in Tehran.Each student completed validated scales assessing their parental attachment,self-esteem,and delinquency at school.Multiple regression analyses with the Sobel test and bootstrappingmethod were used to examine mediated effects.Results:Thefindings reveal that self-esteem significantly mediates the relationship betweenmaternal attachment and delinquency(standardized coefficient=−0.0292;p=0.04).Adolescents with secure maternal attachments tend to exhibit higher self-esteem,which reduces the likelihood of delinquent behavior.In contrast,paternal attachment did not show a significant mediating effect in this study.These results underscore the importance of cultivating secure maternal relationships and fostering positive self-esteem to address adolescent delinquency.Conclusion:The study suggests that targeted interventions that strengthen maternal attachment and boost self-esteem could effectively mitigate delinquent behaviors among Iranian adolescents.These interventions should prioritize the emotional support and value of secure maternal bonds as key factors in promoting healthy adolescent development. 展开更多
关键词 ADOLESCENT DELINQUENCY maternal attachments parental influence paternal attachments SELF-ESTEEM
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Profiles of Parent-Child Attachment and Peer Attachment among Adolescents and Associations with Internalizing Problems
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作者 Chao Qu Xiaoshan Jia Haidong Zhu 《International Journal of Mental Health Promotion》 2025年第3期401-420,共20页
Objectives:Attachment is a profound and enduring connection to the emotion children progressively form with their parents as they mature.It significantly impacts the social and psychological development of kids and te... Objectives:Attachment is a profound and enduring connection to the emotion children progressively form with their parents as they mature.It significantly impacts the social and psychological development of kids and teenagers.This study aimed to explore the latent profiles and longitudinal transition patterns of parent-child and peer attachments among adolescents.Methods:A cohort of 914 participants from China completed the measures with a twelve-month interval.There were 46.8%boys and 53.2%girls in this survey.Latent profile analysis(LPA)was adopted to explore the distinct profiles reflecting different parent-child and peer attachment response patterns at each time point.Latent transition analysis(LTA)was used to examine the membership of distinct latent profiles and how individuals move between profiles over time.Results:Three latent profiles were found:the poor parent-child communication profile,the moderate attachment profile,and the good attachment profile.It was shown that the transition probability from the poor parent-child communication and good attachment profiles to the moderate attachment profile was higher than the transition probability between the poor parent-child communication and good attachment profiles.Patterns of parent-child and peer attachments were associated with depression and anxiety.Conclusion:This study demonstrates differences in adolescents’attachment to fathers,mothers,and peers and the need for targeted interventions for groups of adolescents with moderate levels of parent-child and peer attachment. 展开更多
关键词 Parent-child attachment peer attachment ADOLESCENCE latent profile analysis latent transition analysis
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Determining Dynamic Influence of Human and Machine System on Live-Streaming Addiction:Critical Mediating Mechanisms of Emotional and Functional Attachment
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作者 Hua Pang Xiaoyi Jin 《International Journal of Mental Health Promotion》 2025年第11期1709-1728,共20页
Background:Live streaming has become a globally prevalent form of digital entertainment,particularly among young audiences,fostering new modes of online engagement through real-time interaction.However,excessive use m... Background:Live streaming has become a globally prevalent form of digital entertainment,particularly among young audiences,fostering new modes of online engagement through real-time interaction.However,excessive use may lead to addictive behaviors in certain users.Current research on live-streaming addiction remains limited,with prior studies focusing primarily on socio-psychological drivers rather than the role of technological affordances.To address this gap,this study develops a conceptual model based on socio-technical systems and attachment theory to investigate how emotional and functional attachment mediate the relationship between platform features and addictive behavior.Methods:A total of 533 valid responses were collected in a cross-sectional survey(mean age=26.4 years,standard deviation[SD]=4.7;53.8%female).Data were analyzed using structural equation modeling(SEM)to test the hypothesized relationships.Additionally,the potential mediating effects of emotional and functional attachment between the platform features and live-streaming addiction were examined using the Bootstrap method.Results:Social factors(perceived interactivity,β=0.204,p<0.001;perceived confirmation,β=0.379,p<0.001)and technical factors(perceived customization,β=0.227,p<0.001;perceived amusement,β=0.252,p<0.001;vicarious expression,β=0.352,p<0.001)significantly strengthen both emotional and functional attachment,which in turn positively predict live-streaming addiction(emotional attachment:β=0.468,p<0.001;functional attachment:β=0.393,p<0.001).Furthermore,emotional attachment exerted a stronger influence on addiction than functional attachment.Conclusions:These findings deepen the understanding of live-streaming addiction by integrating socio-technical perspectives and offer practical implications for stakeholders to mitigate negative outcomes through effective strategies. 展开更多
关键词 Perceived interactivity perceived confirmation emotional attachment functional attachment live-streaming addiction
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Comparative evaluation of retentive capacity of three different attachment systems for implant retained overdentures:An in vitro study
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作者 Radha Chauhan Narendra Padiyar +2 位作者 Pragati Kaurani Ajay Gupta Sachin Chauhan 《World Journal of Methodology》 2025年第3期114-123,共10页
BACKGROUND The primary issue in managing edentulous patients is the severely resorbed mandibular ridge,particularly in older individuals with diminished adaptive capacities.This compromised situation leads to the fabr... BACKGROUND The primary issue in managing edentulous patients is the severely resorbed mandibular ridge,particularly in older individuals with diminished adaptive capacities.This compromised situation leads to the fabrication of inadequate dentures that lack retention and stability,potentially causing psychosocial issues.AIM To determine the difference in retentive capacity between three attachment systems in implant-retained overdentures.METHODS Three edentulous mandibular models were fabricated using heat-cured polymethacrylate resin,with two implant replicas placed in the intra-foraminal region of each model.30 acrylic resin mandibular overdentures were fabricated with provisions for three different overdenture attachment systems:A prefabricated ball/O-ring attachment,a locator attachment system,and an equator attachment system.Each model was subjected to 15000 pulls using a universal testing machine to remove the overdenture from the acrylic model and the force data were recorded.RESULTS The ball/O-ring attachment system demonstrated superior retentive capacity for 15 years,while the locator and equator attachment systems maintained excellent retentive capacity for 5 years.CONCLUSION The ball/O-ring attachment system outperformed better than the other two attachment systems regarding retentive capacity.The locator and equator attachment systems presented sufficient retentive abilities until 15000 cycles.After 7500 cycles,significant differences in retentive force between the systems evolved. 展开更多
关键词 DENTURES Overdenture attachment systems EQUATOR Dislodging cycles Retentive capacity
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Childhood Environmental Unpredictability and Psychopathy:Mediating Roles of Insecure Attachment and Life History Strategy
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作者 Fengbo Guo Leru Zhong +2 位作者 Xingru Huang Zewei Chen Xiaoyuan Sun 《International Journal of Mental Health Promotion》 2025年第2期111-124,共14页
Background:Childhood environmental unpredictability(CEU)is crucial to personal development,profoundly influence physical and psychological growth particularly,and psychopathy is recognized as a dark personality trait.... Background:Childhood environmental unpredictability(CEU)is crucial to personal development,profoundly influence physical and psychological growth particularly,and psychopathy is recognized as a dark personality trait.The aim of this study is to investigate the effects of insecure attachment and life history strategy(LHS)on the relationship between CEU and psychopathy by establishing a sequential mediation model based on evolutionary life history theory and cognitive-affective personality system.Methods:A group of 532 undergraduates completed the measurements for CEU,insecure attachment,LHS,and psychopathy,and Bootstrap mediation test through SPSS 25.0 and PROCESS macro tool was used to examine the relationship among these variables.Results:The results revealed positive relations between CEU and insecure attachment(β=0.87,p<0.001),CEU and LHS(β=0.11,p<0.001),and CEU and psychopathy(β=0.14,p<0.001).Insecure attachment was also positively associated with LHS(β=0.62,p<0.001)and psychopathy(β=0.04,p<0.001).In addition,LHS was significantly associated with psychopathy(β=0.08,p<0.001).The relationship between CEU and psychopathy is mediated independently and sequentially by insecure attachment and LHS.Conclusion:The current research shows the relationship between CEU and psychopathy,as well as the mechanism of insecure attachment and life history strategy as mediators. 展开更多
关键词 Childhood environmental unpredictability PSYCHOPATHY insecure attachment life history strategy mediating effect
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Antigenic and structural insights into Langya henipavirus attachment glycoprotein
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作者 Yaohui Li Xiaoyan Huang +7 位作者 Xiaodong Zai Chenfeng Mao Ruihua Li Yamei Feng Yue Zhang Zhang Zhang Jun Zhang Junjie Xu 《Virologica Sinica》 2025年第5期769-777,共9页
The invasion of host cells by the henipavirus is facilitated through the interaction between viral attachment(G)and fusion(F)glycoproteins with receptors on the cell surface.Langya henipavirus(LayV)was newly identifie... The invasion of host cells by the henipavirus is facilitated through the interaction between viral attachment(G)and fusion(F)glycoproteins with receptors on the cell surface.Langya henipavirus(LayV)was newly identified in China in 2022.The G proteins of LayV and Mojiang virus(MojV)exhibit high amino acid homology(86%),while they are located in a unique evolutionary clade within the Henipavirus genus.In this study,the crystal structure of the LayV G protein was resolved at a 3.37Åresolution,revealing a head domain with sixβ-propeller-like domains distinct from other henipavirus G proteins,such as those of Nipah virus(NiV)and Hendra virus(HeV).Furthermore,the prominent loop in the center cavity of the LayV G protein showed unique structural features.In the ELISA and SPR assays,the LayV G protein was unable to bind to the existing henipavirus-neutralizing antibodies or the ephrin-B2 receptor.Immunogenicity studies in mice demonstrated robust antibody responses elicited by the LayV G protein.These antibodies exhibited strong reactivity against both LayV and MojV G proteins.However,only weak cross-reactivity was observed with other henipaviruses.Moreover,eight monoclonal antibodies targeting the LayV G protein were generated,two of which exhibited broad binding activity across different henipavirus G proteins.These findings underscore the need for tailored vaccines and therapeutics for LayV and related novel henipaviruses. 展开更多
关键词 Langya henipavirus(LayV) attachment glycoprotein Crystal structure GLYCOSYLATION IMMUNOGENICITY Monoclonal antibodies
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Perceived value,awe,and place attachment:Influencing tourists'environmentally responsible behavior in desert tourism
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作者 Shan Huang LiJuan Shi +3 位作者 DanHua Sheng TianTian He Xing Guo JianHua Xiao 《Research in Cold and Arid Regions》 2025年第4期261-268,共8页
This study explores the impact of perceived value,awe,and place attachment on tourists'environmentally responsible behavior(ERB)in desert tourism contexts,using the Singing Sands Mountain and Crescent Spring sceni... This study explores the impact of perceived value,awe,and place attachment on tourists'environmentally responsible behavior(ERB)in desert tourism contexts,using the Singing Sands Mountain and Crescent Spring scenic area in Dunhuang,China as a case study.Data were collected from 315 tourists using a structured questionnaire and analyzed through a structural equation model.Results show that perceived value and awe significantly influence ERB both directly and indirectly via place attachment.Specifically,perceived value has a stronger direct effect on ERB compared to awe,highlighting the importance of tourists'overall evaluation of the destination in promoting sustainable behaviors.The mediating role of place attachment underscores the significance of emotional connections to the environment in fostering ERB.These findings provide valuable insights for sustainable tourism management in fragile desert ecosystems.The study also highlights the importance of enhancing perceived value through high-quality services and leveraging awe-inspiring experiences to promote sustainable behaviors. 展开更多
关键词 Perceived value AWE Place attachment Tourists'environmentally responsible behavior Desert tourism
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Numerical Modeling of Bubble-Particle Attachment in a Volume-of-Fluid Framework
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作者 Hojun Moon Donghyun You 《Computer Modeling in Engineering & Sciences》 2025年第10期367-390,共24页
A numerical method is presented to simulate bubble–particle interaction phenomena in particle-laden flows.The bubble surface is represented in an Eulerian framework by a volume-of-fluid(VOF)method,while particle moti... A numerical method is presented to simulate bubble–particle interaction phenomena in particle-laden flows.The bubble surface is represented in an Eulerian framework by a volume-of-fluid(VOF)method,while particle motions are predicted in a Lagrangian framework.Different frameworks for describing bubble surfaces and particles make it difficult to predict the exact locations of collisions between bubbles and particles.An effective bubble,defined as having a larger diameter than the actual bubble represented by the VOFmethod,is introduced to predict the collision locations.Once the collision locations are determined,the attachment of particles to the bubble surface is determined using a novel numerical algorithm based on collision/induction times.The proposed numerical method is validated through simulations of a rising bubble moving through a layer of particles.The validity of the collision detection algorithm is examined by comparing the collision probability predicted by the present numerical method with that predicted from a theoretical relationship based on bubble/particle diameters.The attachment probability predicted by the present algorithm is found to agree well with that of an experiment. 展开更多
关键词 Bubble-particle interaction VOLUME-OF-FLUID gas-liquid-solid flows attachment probability
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Role of attachment style in the association between childhood adversities and non-suicidal self-injury among young adults:a multigroup structural equation study
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作者 Rodolfo Rossi Tommaso B Jannini +3 位作者 Valentina Socci Francesca Pacitti Alessandro Rossi Giorgio Di Lorenzo 《General Psychiatry》 2025年第2期103-112,共10页
Background Non-suicidal self-injury(NSSI)is a significant health concern among adolescents and young adults,often resulting from adverse childhood experiences(ACEs).Dissociation,post-traumatic symptoms and attachment ... Background Non-suicidal self-injury(NSSI)is a significant health concern among adolescents and young adults,often resulting from adverse childhood experiences(ACEs).Dissociation,post-traumatic symptoms and attachment style may have a role in shaping such associations.Aims This study aims to provide a unified model of the impact of ACEs on NSSI,exploring complex post-traumatic stress disorder(cPTSD)symptoms and dissociation as potential mediators and the role of the predominant attachment style in affecting such associations.Methods 1010 young individuals attending the last year of high school participated in this cross-sectional study.ACEs,cPTSD,dissociation and NSSI were evaluated using self-report questionnaires.We fitted a path model of NSSI,with ACEs as exogenous variables and cPTSD and dissociation as sequential mediators.Secure,fearful and preoccupied attachment styles were modelled as grouping variables.Results Our findings showed that dissociation mediated the impact of ACEs on NSSI in subjects with a fearful attachment style,as opposed to those with a preoccupied attachment for whom cPTSD symptoms mediated the ACEs-NSSI association.Conclusions Attachment styles moderate the relationship between ACEs and NSSI,with either dissociation or post-traumatic symptomatology mediating the impact of ACEs on NSSI,depending on the predominant attachment style.Our results highlight the importance of attachment as a pathway modifier in the relationships between different psychopathology dimensions,providing a useful framework to better conceptualise the ACEs-NSSI association. 展开更多
关键词 adverse childhood experiences aces dissociationpost traumatic non suicidal self injury childhood adversities complex post traumatic stress disorder attachment style DISSOCIATION unified model impact MEDIATION
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Collision and attachment behavior between fine cassiterite particles and H_2 bubbles 被引量:17
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作者 任浏祎 张一敏 +2 位作者 覃文庆 包申旭 王军 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第2期520-527,共8页
Particle-bubble interaction during electro-flotation of cassiterite was investigated by determining the recovery of cassiterite and the collision mechanism of cassiterite particle and H2 bubble. Flotation tests at dif... Particle-bubble interaction during electro-flotation of cassiterite was investigated by determining the recovery of cassiterite and the collision mechanism of cassiterite particle and H2 bubble. Flotation tests at different conditions were conducted in a single bubble flotation cell. The recovery of cassiterite was found to be affected by cassiterite particle and bubble size. A matching range, in which the best recovery can be obtained, was found between particle and bubble size. Collision, attachment, and detachment of the particle-bubble were observed and captured by a high-speed camera. Particle-bubble collision and attachment were analyzed with the use of particle-bubble interaction theory to obtain the experimental results. An attachment model was introduced and verified through the photos captured by the high-speed camera. A bridge role was observed between the bubbles and particles. Particle-bubble interaction was found to be affected by bubble size and particle size, which significantly influenced not only the collision and attachment behavior of the particles and bubbles but also the flotation recovery of fine cassiterite particles. 展开更多
关键词 CASSITERITE fine particle flotation particle-bubble interaction collision and attachment
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基于IPA的春满街历史文化街区地方依恋研究
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作者 苗力 刘思源 +2 位作者 候嘉怡 朱莉·凯贝 李冰 《城市建筑》 2026年第1期33-36,共4页
历史文化街区更新中普遍存在大规模拆除或冻结保护的做法,导致街区活力衰退与情感联结断裂。文章以城子坦镇春满街历史文化街区为例,基于地方依恋理论构建情感、认知、行为与物质空间四维测度体系,运用问卷调查与IPA分析法,揭示当地居... 历史文化街区更新中普遍存在大规模拆除或冻结保护的做法,导致街区活力衰退与情感联结断裂。文章以城子坦镇春满街历史文化街区为例,基于地方依恋理论构建情感、认知、行为与物质空间四维测度体系,运用问卷调查与IPA分析法,揭示当地居民地方依恋特征。得出居民情感依恋强度较高,但对居住环境满意度和政策参与度显著偏低的结论。提出通过优化物质空间品质、增强居民参与机制等策略,提升春满街居民的地方依恋水平,为历史文化街区的地方依恋研究及保护更新实践提供参考。 展开更多
关键词 春满街历史文化街区 问卷调查 地方依恋 IPA模型 保护更新策略
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Anchor Attachment蛋白在结直肠癌中表达增强 被引量:1
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作者 左富义 李世拥 +2 位作者 于波 安萍 杨梅 《基础医学与临床》 CSCD 北大核心 2008年第12期1248-1250,共3页
目的探讨Anchor Attachment蛋白(AAP)的表达与结直肠癌浸润、转移的关系及临床意义。方法免疫组织化学法检测AAP的表达,分析AAP表达水平与肿瘤临床病理特征之间的关系;并用酶联免疫吸附(ELISA)法检测血清中AAP表达水平。结果结直肠正常... 目的探讨Anchor Attachment蛋白(AAP)的表达与结直肠癌浸润、转移的关系及临床意义。方法免疫组织化学法检测AAP的表达,分析AAP表达水平与肿瘤临床病理特征之间的关系;并用酶联免疫吸附(ELISA)法检测血清中AAP表达水平。结果结直肠正常肠黏膜、癌原发灶、淋巴结和肝转移灶中AAP的表达阳性率分别为20.5%、53.0%、69.8%和80.0%;癌原发灶、转移淋巴结和肝转移灶中AAP表达阳性率均显著高于正常肠黏膜组织(P<0.01),转移淋巴结和肝转移灶中AAP阳性率高于癌原发灶(P<0.05);淋巴结转移患者和肝转移患者的原发灶AAP阳性率显著高于无转移者(P<0.01);Dukes分期A、B、C、D期患者AAP阳性率逐渐增高,各分期之间差异显著(P<0.01)。83例结直肠癌患者血清AAP水平为(6.3±2.8)μg/L,显著高于30例健康志愿者的(2.2±0.9)μg/L,(t=6.976,P<0.01);Dukes分期A、B期患者血清AAP水平为(5.2±2.6)μg/L,显著低于C、D期患者的(7.1±2.9)μg/L(P<0.05)。结论检测外周静脉血AAP水平对预测和判断结直肠癌病情和肝转移有重要意义。 展开更多
关键词 结直肠肿瘤 ANCHOR attachment蛋白 肿瘤浸润 转移
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场所依赖(place attachment):一种游憩行为现象的研究框架 被引量:226
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作者 黄向 保继刚 Wall Geoffrey 《旅游学刊》 CSSCI 北大核心 2006年第9期19-24,共6页
“场所依赖”理论是解释“某些地方与人之间似乎存在着一种特殊的依赖关系”这个客观现象的有效理论工具,并已成为西方休闲和游憩研究的一个热点,而在我国仍然处于空白状态。本文讨论了场所和场所依赖的概念及其发展,介绍了西方场所依... “场所依赖”理论是解释“某些地方与人之间似乎存在着一种特殊的依赖关系”这个客观现象的有效理论工具,并已成为西方休闲和游憩研究的一个热点,而在我国仍然处于空白状态。本文讨论了场所和场所依赖的概念及其发展,介绍了西方场所依赖研究的最新进展。文章的主要贡献包括:(1)首次将以游憩为角度开展研究的场所依赖理论引进我国;(2)用数学方法示意理解场所依赖的结构;(3)构建了场所依赖理论的CDEEM研究框架。文章还探讨了场所依赖理论的应用前景。 展开更多
关键词 场所依赖 游憩行为 理论框架
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Electron Attachment Studies for CHCl3 Using Ion Mobility Spectrometry
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作者 韩海燕 冯鸿涛 +3 位作者 李虎 王鸿梅 江海河 储焰南 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2011年第2期218-224,I0004,共8页
The dissociative electron attachment process for CHCl3 at different electric field have been studied with nitrogen as drift and carrier gas using corona discharge ionization source ion mobility spectrometry (CD-IMS)... The dissociative electron attachment process for CHCl3 at different electric field have been studied with nitrogen as drift and carrier gas using corona discharge ionization source ion mobility spectrometry (CD-IMS). The corresponding electron attachment rate constants varied from 1.26×10-8 cm3/(molecules s) to 8.24×10-9 cm3/(molecules s) as the electric field changed from 200 V/cm to 500 V/cm. At a fixed electric field in the drift region, the attachment rate constants are also detected at different sample concentration. The ionmolecule reaction rate constants for the further reaction between Cl^- and CHCl3 are also detected, which indicates that the technique maybe becomes a new method to research the rate constants between ions and neural molecules. And the reaction rate constants between Cl- and CHCl3 are the first time detected using CD-IMS. 展开更多
关键词 Ion mobility spectrometry Dissociative electron attachment Ion-molecule reaction rate constant CHLOROFORM
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Influence of Matrix Attachment Regions from Maize on Transgene Expression Level in Tobacco
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作者 李旭刚 曾千春 +3 位作者 陈松彪 徐军望 常团结 朱祯 《Acta Botanica Sinica》 CSCD 2002年第7期804-808,共5页
The effect of matrix attachment regions (MARs) on foreign gene expression in transgenic plants was studied, The beta-glucuronidase (GUS) gene (uidA) was flanked by the MARs isolated from the genome of maize to form pl... The effect of matrix attachment regions (MARs) on foreign gene expression in transgenic plants was studied, The beta-glucuronidase (GUS) gene (uidA) was flanked by the MARs isolated from the genome of maize to form plant expression vector. The vectors with and without MARs were transferred into tobacco ( Nicotiana tabacum L.) through Agrobacterium-mediated transformation procedure. GUS activity assays indicated that MARs could increase expression level of uidA gene. The mean GUS activity could be increased twofold as compared to that of transformants without MARs, and the highest GUS activity of transformant could reach tenfold. The correspondence between GUS activity and mRNA accumulation was positive and indicated that MARs could improve transcription of foreign gene. 展开更多
关键词 matrix attachment region beta-glueuronidase TRANSGENE gene expression
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无托槽隐形矫治器近中移动下颌第二磨牙的三维有限元分析
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作者 邱生磊 李道堃 +1 位作者 王春娟 李娜 《中国组织工程研究》 北大核心 2026年第4期832-840,共9页
背景:正畸移动下颌第二磨牙替代缺失的第一磨牙是一种保留天然牙的良好办法,然而使用无托槽矫治器近中移动磨牙时磨牙会发生近中倾斜移动,附件和过矫治的应用对磨牙近中移动的影响尚不明确。目的:探究附件及过矫治对下颌第二磨牙近中移... 背景:正畸移动下颌第二磨牙替代缺失的第一磨牙是一种保留天然牙的良好办法,然而使用无托槽矫治器近中移动磨牙时磨牙会发生近中倾斜移动,附件和过矫治的应用对磨牙近中移动的影响尚不明确。目的:探究附件及过矫治对下颌第二磨牙近中移动位移和生物力学的影响。方法:使用1名志愿者的锥形束CT及口内扫描数据构建左侧下第一磨牙缺失的有限元模型。实验根据左下颌第二磨牙附件位置分为无附件组、颊侧附件组、舌侧附件组和颊舌附件组,4组均设计0°,1°,2°,3°,4°过矫治,总共20组模型。在Abaqus软件中分析计算牙齿位移趋势和应力。结果与结论:(1)无托槽隐形矫治器近中移动左下颌第二磨牙时,磨牙发生近中倾斜和压低,尖牙和前磨牙发生远中倾斜,切牙发生舌侧倾斜;(2)附件应用使第二磨牙位移量增加,使用颊舌附件时位移量最大,在单侧应用附件时磨牙会向无附件侧倾斜,而附件的应用对第二磨牙近中倾斜度无改善;(3)应用过矫治后,磨牙近中倾斜和压低趋势改善,磨牙更接近整体移动,牙周膜应力降低且分布更均匀,且随着过矫治程度增加更显著;(4)附件可以增强过矫治的作用效果,使用颊舌附件时作用效果最强,两者联合应用有利于控制磨牙近中倾斜和压低,但仍无法实现磨牙整体移动。 展开更多
关键词 无托槽隐形矫治器 有限元 磨牙 近中移动 附件 过矫治
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Octopus-Inspired Self-Adaptive Hydrogel Gripper Capable of Manipulating Ultra-Soft Objects
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作者 Yixian Wang Desheng Liu +9 位作者 Danli Hu Chao Wang Zonggang Li Jiayu Wu Pan Jiang Xingxing Yang Changcheng Bai Zhongying Ji Xin Jia Xiaolong Wang 《Nano-Micro Letters》 2026年第1期896-913,共18页
Octopuses,due to their flexible arms,marvelous adaptability,and powerful suckers,are able to effortlessly grasp and disengage various objects in the marine surrounding without causing devastation.However,manipulating ... Octopuses,due to their flexible arms,marvelous adaptability,and powerful suckers,are able to effortlessly grasp and disengage various objects in the marine surrounding without causing devastation.However,manipulating delicate objects such as soft and fragile foods underwater require gentle contact and stable adhesion,which poses a serious challenge to now available soft grippers.Inspired by the sucker infundibulum structure and flexible tentacles of octopus,herein we developed a hydraulically actuated hydrogel soft gripper with adaptive maneuverability by coupling multiple hydrogen bond-mediated supramolecular hydrogels and vat polymerization three-dimensional printing,in which hydrogel bionic sucker is composed of a tunable curvature membrane,a negative pressure cavity,and a pneumatic chamber.The design of the sucker structure with the alterable curvature membrane is conducive to realize the reliable and gentle switchable adhesion of the hydrogel soft gripper.As a proof-of-concept,the adaptive hydrogel soft gripper is capable of implement diversified underwater tasks,including gingerly grasping fragile foods like egg yolks and tofu,as well as underwater robots and vehicles that station-keeping and crawling based on switchable adhesion.This study therefore provides a transformative strategy for the design of novel soft grippers that will render promising utilities for underwater exploration soft robotics. 展开更多
关键词 Octopus sucker structure Self-adaptive gripper Supramolecular hydrogel Underwater switchable attachment Nondestructive manipulating
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中医“魄”概念的本质研究及应用探讨
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作者 刘朋 李丽 +2 位作者 田露 蔡卓昊 吴俊哲 《天津中医药》 2026年第1期58-61,共4页
文章立足于中医“魄”概念,系统挖掘古今文献,尝试从“阴气化魄”“附形之灵”及“五神之魄”3个层面系统阐述中医“魄”概念的本质内涵,总结“魄”概念的本质要点为:魄源于阴气,有主静、向内的生理功能;魄为“附形之灵”,以“形体”为... 文章立足于中医“魄”概念,系统挖掘古今文献,尝试从“阴气化魄”“附形之灵”及“五神之魄”3个层面系统阐述中医“魄”概念的本质内涵,总结“魄”概念的本质要点为:魄源于阴气,有主静、向内的生理功能;魄为“附形之灵”,以“形体”为用,可“并精而出入”。“五神之魄”藏于肺,不仅是“肺主气,司呼吸,主治节”生理的高度概括,也是低级神经中枢精神思维活动调控的密码。由此,总结出“魄”的生理功能,即参与维持生物本能、参与调节肺之生理、主持人具有“向下、向内与安静”特点的精神心理活动。从3个层面,魄用过度、魄衰阴弱、魄机惑乱,简要阐述了“魄”用失常的病理状态、临床表现及治法用药,为“以魄为枢,从魄论治”疾病提供临床思路与方法。 展开更多
关键词 阴气 附形之灵 五神 生理功能 病理状态
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