Prior to his initial diagnosis, a 21-year-old male had been experiencing facial acne for two years and had been treated by a doctor in private practice. The patient visited our department because the clinical manifest...Prior to his initial diagnosis, a 21-year-old male had been experiencing facial acne for two years and had been treated by a doctor in private practice. The patient visited our department because the clinical manifestations of mandibular acne did not improve. At the time of initial examination, telangiectasia (TE), post-inflammatory erythema (PIE), post-inflammatory hyperpigmentation (PIH), atrophic scars (ASs), and a hypertrophic scar (HS) with induration were observed on the right neck. We diagnosed this as an acne vulgaris complication. HS lesions were topically treated by injecting triamcinolone acetonide, and the patient was prescribed 8.1 g/day of oral Saireito (Japanese herb). Adapalene benzoyl peroxide gel and topical tacrolimus hydrate ointment were used to treat PIE and TE. Both HSs and PIE improved;however, TE and AS did not improve. Currently, the patient is under observation. We consider this to be a very rare concurrent occurrence of diverse complications of acne vulgaris, and present the following case study.展开更多
A 19-year-old man had atrophic scars on bilateral temple for several years. The atrophic scars were composed of rolling scars (three depressions, 8 × 4 mm in diameter), ice pick scars and boxcar scar. The patient...A 19-year-old man had atrophic scars on bilateral temple for several years. The atrophic scars were composed of rolling scars (three depressions, 8 × 4 mm in diameter), ice pick scars and boxcar scar. The patient was treated with chemical peeling (CP) using 20% glycolic acid (GA) (pH 3.2) and subsequent iontophoresis with vitamin C derivative at one month’s interval twice. Remarkable improvement was observed;the rolling scars almost disappeared with traces of hypopigmented macule. However, the ice pick scars and boxcar scar did not improve. CP and subsequent vitamin C iontophoresis can be an alternative non-surgical and non-invasive treatment for rolling scar in acne.展开更多
Objective:Current treatments for atrophic acne scars such as microneedling radiofrequency(MNRF)and fractional carbon dioxide(FCO_(2))laser have shown individual efficacy,but their combined effectiveness remains lackin...Objective:Current treatments for atrophic acne scars such as microneedling radiofrequency(MNRF)and fractional carbon dioxide(FCO_(2))laser have shown individual efficacy,but their combined effectiveness remains lacking.This study aimed to determine the effectiveness and safety of a sequential combination therapy with MNRF followed by FCO_(2) laser compared with each therapy administered alone for the treatment of atrophic acne scars.Methods:An open randomized trial was conducted on 45 patients with atrophic acne scars at Al-Salam Teaching Hospital,Mosul,Iraq,from January 2022 to July 2023.The patients were randomized into 3 groups,with 15 patients in each group:FCO_(2) group(6 sessions of FCO_(2) laser treatment),MNRF group(6 sessions of MNRF treatment),and combined group(3 sessions of MNRF treatment followed by 3 sessions of FCO_(2) laser treatment).The Goodman and Baron Global Quantitative Acne Scar Grading System(GBGQASGS)was used to assess the treatment effectiveness.Adverse effects of treatment were monitored.The pre-treatment and post-treatment GBGQASGS scores and the percentage reductions in the GBGQASGS scores in the 3 groups were assessed by analysis of variance.The effect size of each treatment regimen was assessed using the Cohen d effect size.Results:The 45 patients enrolled comprised 20(44.4%)men and 25(55.6%)women,with a mean age of 25.10±2.80 years and a GBGQASGS score of 28.93±6.19.All 3 types of treatment significantly reduced the GBGQASGS scores after 6 sessions(all P<0.05)as following:FCO_(2) group,from 28.66±5.71 to 11.66±2.71(59.3%reduction;Cohen d=3.80);MNRF group,from 27.26±6.93 to 11.66±3.09(57.2%reduction;Cohen d=2.90);Combined group,from 30.87±5.73 to 9.01±2.03(70.8%reduction;Cohen d=5.08).There was no difference in the GBGQASGS score of post-treatment among 3 groups(P=0.300),however,the combined group exhibited a significant reduction in the GBGQASGS score from pre-treatment to post-treatment(P<0.001).Post-inflammatory hyperpigmentation was reported in FCO_(2) and MNRF groups,tram-track scarring was found in FCO_(2) group,while no serious adverse effects were reported in the combined group.Conclusion:Sequential combination therapy with MNRF followed by FCO_(2) laser was as effective as each monotherapy for the treatment of atrophic acne scars with fewer adverse effects.The results may provide evidence for treatment choice.展开更多
Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insuffici...Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insufficient.This study was aimed to assess the impact of 30.0%supramolecular salicylic acid(SSA)combined with ultra-pulse carbon dioxide(CO_(2))fractional laser therapy on facial atrophic acne scars.Methods:This retrospective study included data from patients with atrophic acne scars treated from June 2020 to June 2022 in Mylike Cosmetology Hospital of Yunnan.The patients were divided into the combination group(SSA combined with ultra-pulse CO_(2)fractional laser therapy)and the laser group(ultra-pulse CO_(2)fractional laser therapy alone)depending on the treatments received.Four treatment sessions were conducted for each group.Follow-up visits were performed every 2 months after each treatment and included assessments of theÉchelle d’Évaluation clinique des cicatrices d’acnéscore,effective rate,and visual analog scale score.Continuous data were analyzed using Student t test.Dichotomous or unordered categorical data were compared using the Chi-square(χ2)test,and ordered categorical data were compared using the Mann-Whitney U test.Results:The combination and laser groups comprised 72 and 61 patients,respectively,and there were no significant differences in sex,age,or baselineÉchelle d’Évaluation clinique des cicatrices d’acnéscore between the 2 groups.The effective rate(95.8%vs.67.2%,P<0.001)was higher and the pain scores(during and after the intervention)were lower in the combination group than in the laser group(all P<0.001).The severity of erythema,edema,and crusting was milder in the combination group(P<0.001).The proportion of highly satisfied patients was higher(73.6%vs.31.2%,P<0.001)and the Dermatology Life Quality Index showed greater improvement(0.15±0.40 vs.1.39±1.53,P<0.001)in the combination group than that in the laser group.Conclusion:The combination of ultra-pulse CO_(2)fractional laser therapy and 30.0%SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing serious adverse reactions.展开更多
Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study...Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study”by Liu et al.1,the study was incorrectly described as a“retrospective case-control study”in the title,while the study was designed to compare outcomes between groups receiving different interventions,meeting the definition of a cohort study,not a case-control study.展开更多
文摘Prior to his initial diagnosis, a 21-year-old male had been experiencing facial acne for two years and had been treated by a doctor in private practice. The patient visited our department because the clinical manifestations of mandibular acne did not improve. At the time of initial examination, telangiectasia (TE), post-inflammatory erythema (PIE), post-inflammatory hyperpigmentation (PIH), atrophic scars (ASs), and a hypertrophic scar (HS) with induration were observed on the right neck. We diagnosed this as an acne vulgaris complication. HS lesions were topically treated by injecting triamcinolone acetonide, and the patient was prescribed 8.1 g/day of oral Saireito (Japanese herb). Adapalene benzoyl peroxide gel and topical tacrolimus hydrate ointment were used to treat PIE and TE. Both HSs and PIE improved;however, TE and AS did not improve. Currently, the patient is under observation. We consider this to be a very rare concurrent occurrence of diverse complications of acne vulgaris, and present the following case study.
文摘A 19-year-old man had atrophic scars on bilateral temple for several years. The atrophic scars were composed of rolling scars (three depressions, 8 × 4 mm in diameter), ice pick scars and boxcar scar. The patient was treated with chemical peeling (CP) using 20% glycolic acid (GA) (pH 3.2) and subsequent iontophoresis with vitamin C derivative at one month’s interval twice. Remarkable improvement was observed;the rolling scars almost disappeared with traces of hypopigmented macule. However, the ice pick scars and boxcar scar did not improve. CP and subsequent vitamin C iontophoresis can be an alternative non-surgical and non-invasive treatment for rolling scar in acne.
文摘Objective:Current treatments for atrophic acne scars such as microneedling radiofrequency(MNRF)and fractional carbon dioxide(FCO_(2))laser have shown individual efficacy,but their combined effectiveness remains lacking.This study aimed to determine the effectiveness and safety of a sequential combination therapy with MNRF followed by FCO_(2) laser compared with each therapy administered alone for the treatment of atrophic acne scars.Methods:An open randomized trial was conducted on 45 patients with atrophic acne scars at Al-Salam Teaching Hospital,Mosul,Iraq,from January 2022 to July 2023.The patients were randomized into 3 groups,with 15 patients in each group:FCO_(2) group(6 sessions of FCO_(2) laser treatment),MNRF group(6 sessions of MNRF treatment),and combined group(3 sessions of MNRF treatment followed by 3 sessions of FCO_(2) laser treatment).The Goodman and Baron Global Quantitative Acne Scar Grading System(GBGQASGS)was used to assess the treatment effectiveness.Adverse effects of treatment were monitored.The pre-treatment and post-treatment GBGQASGS scores and the percentage reductions in the GBGQASGS scores in the 3 groups were assessed by analysis of variance.The effect size of each treatment regimen was assessed using the Cohen d effect size.Results:The 45 patients enrolled comprised 20(44.4%)men and 25(55.6%)women,with a mean age of 25.10±2.80 years and a GBGQASGS score of 28.93±6.19.All 3 types of treatment significantly reduced the GBGQASGS scores after 6 sessions(all P<0.05)as following:FCO_(2) group,from 28.66±5.71 to 11.66±2.71(59.3%reduction;Cohen d=3.80);MNRF group,from 27.26±6.93 to 11.66±3.09(57.2%reduction;Cohen d=2.90);Combined group,from 30.87±5.73 to 9.01±2.03(70.8%reduction;Cohen d=5.08).There was no difference in the GBGQASGS score of post-treatment among 3 groups(P=0.300),however,the combined group exhibited a significant reduction in the GBGQASGS score from pre-treatment to post-treatment(P<0.001).Post-inflammatory hyperpigmentation was reported in FCO_(2) and MNRF groups,tram-track scarring was found in FCO_(2) group,while no serious adverse effects were reported in the combined group.Conclusion:Sequential combination therapy with MNRF followed by FCO_(2) laser was as effective as each monotherapy for the treatment of atrophic acne scars with fewer adverse effects.The results may provide evidence for treatment choice.
文摘Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insufficient.This study was aimed to assess the impact of 30.0%supramolecular salicylic acid(SSA)combined with ultra-pulse carbon dioxide(CO_(2))fractional laser therapy on facial atrophic acne scars.Methods:This retrospective study included data from patients with atrophic acne scars treated from June 2020 to June 2022 in Mylike Cosmetology Hospital of Yunnan.The patients were divided into the combination group(SSA combined with ultra-pulse CO_(2)fractional laser therapy)and the laser group(ultra-pulse CO_(2)fractional laser therapy alone)depending on the treatments received.Four treatment sessions were conducted for each group.Follow-up visits were performed every 2 months after each treatment and included assessments of theÉchelle d’Évaluation clinique des cicatrices d’acnéscore,effective rate,and visual analog scale score.Continuous data were analyzed using Student t test.Dichotomous or unordered categorical data were compared using the Chi-square(χ2)test,and ordered categorical data were compared using the Mann-Whitney U test.Results:The combination and laser groups comprised 72 and 61 patients,respectively,and there were no significant differences in sex,age,or baselineÉchelle d’Évaluation clinique des cicatrices d’acnéscore between the 2 groups.The effective rate(95.8%vs.67.2%,P<0.001)was higher and the pain scores(during and after the intervention)were lower in the combination group than in the laser group(all P<0.001).The severity of erythema,edema,and crusting was milder in the combination group(P<0.001).The proportion of highly satisfied patients was higher(73.6%vs.31.2%,P<0.001)and the Dermatology Life Quality Index showed greater improvement(0.15±0.40 vs.1.39±1.53,P<0.001)in the combination group than that in the laser group.Conclusion:The combination of ultra-pulse CO_(2)fractional laser therapy and 30.0%SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing serious adverse reactions.
文摘Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study”by Liu et al.1,the study was incorrectly described as a“retrospective case-control study”in the title,while the study was designed to compare outcomes between groups receiving different interventions,meeting the definition of a cohort study,not a case-control study.
