Objective: to observe the oral mucosa reaction of nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy after ultrasonic atomization inhalation. Methods: in order to protect oral mucosa,...Objective: to observe the oral mucosa reaction of nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy after ultrasonic atomization inhalation. Methods: in order to protect oral mucosa, the patients were randomly divided into two groups: the control group was given 0.9% sodium chloride injection and the observation group was given ultrasonic atomization inhalation. Results: the incidence of oral mucosa reaction in the observation group was lower than that in the control group. The difference was statistically significant (P < 0.05). Conclusion: intensity-modulated radiotherapy for nasopharyngeal carcinoma using ultrasonic atomization inhalation is beneficial to protect oral mucosa and promote the improvement of patients' oral mucosa reaction.展开更多
Objective: to study and analyze the clinical application effect of comprehensive nursing in the treatment of acute and chronic pharyngitis by spray inhalation. Methods: 120 patients with acute and chronic pharyngitis ...Objective: to study and analyze the clinical application effect of comprehensive nursing in the treatment of acute and chronic pharyngitis by spray inhalation. Methods: 120 patients with acute and chronic pharyngitis who were admitted to our hospital from January 2020 to May 2021 were all treated by atomization inhalation. The patients were divided into two groups according to the admission time. 60 patients in the experimental group received comprehensive nursing intervention and 60 patients in the control group received daily nursing intervention. The effect of nursing intervention was compared between the two groups. Results: after the intervention, 3.33% of the patients in the experimental group did not reach the effective standard, 30.00% of the patients reached the effective standard, and 66.67% of the patients reached the significant effective standard. the total effective rate in the experimental group was higher than that in the control group by 96.67%, with a significant difference between the two groups (P0.05). There was no side reaction in the experimental group, and the incidence of side reaction in the experimental group was significantly lower than that in the control group, with a significant difference between the two groups (P0.05). Conclusion: the application of comprehensive nursing intervention to patients with acute and chronic pharyngolaryngitis treated by atomization inhalation can reduce the occurrence of adverse reactions and further improve the treatment effect, which has important clinical value.展开更多
Objective: to analyze the application and symptom improvement of atomized inhalation budesonide (BUD) in the treatment of bronchiolitis (RSV). Methods: a total of 100 patients with RSV in our hospital from January 201...Objective: to analyze the application and symptom improvement of atomized inhalation budesonide (BUD) in the treatment of bronchiolitis (RSV). Methods: a total of 100 patients with RSV in our hospital from January 2019 to January 2021 were selected, and the number table was randomly divided into 2 groups with 50 patients in each group. The patients in the reference group were given conventional drug treatment, and the atomized group was given atomized inhalation BUD treatment on the basis of this. Compare the relative efficacy. Results: before treatment, the lung function and RSV inflammation indexes of the two groups were compared, P > 0.05, but after treatment, the lung function of the two groups was improved, while RSV inflammation indexes were decreased, and the decrease degree of RSV inflammation indexes of the atomization group was greater than that of the reference group, and the improvement degree of lung function was greater than that of the reference group, P < 0.05. The improvement rate of atomization group was higher than that of reference group, P < 0.05. Conclusion: the therapeutic mode of nebulized inhalation of BUD is very effective in the clinical intervention of children with RSV, and can promote the improvement of pulmonary function, which is worth promoting.展开更多
Objective: to discuss and analyze the application and research of atomization inhalation therapy in pediatric respiratory diseases. Methods: from February 2019 to May 2020, 70 children with respiratory diseases were s...Objective: to discuss and analyze the application and research of atomization inhalation therapy in pediatric respiratory diseases. Methods: from February 2019 to May 2020, 70 children with respiratory diseases were selected as the research object. The 70 children were divided into two groups, A and B, with 35 children in each group. Patients in group A were given routine clinical medication, while patients in group B were given aerosol inhalation therapy. Finally, the therapeutic effects and the remission time of clinical symptoms of the two groups were compared. Results: after implementing the corresponding treatment measures in the two groups, it can be seen that the therapeutic effect of group B on children reached 96.24%, while that of group A only reached 79.23%. Comparing the data obtained from the two groups of children's therapeutic effects, it has statistical significance (P < 0.05). In addition, the time for the clinical symptoms of the two groups of children to disappear was significantly shorter in group B than in group A, and the two groups also had statistical significance (P < 0.05). After treatment, the data of blood oxygen saturation and maximal respiratory flow rate in group B were all better than those in group A, and the two groups also had statistical significance (P < 0.05). Conclusion: through this study, it can be seen that atomization inhalation therapy is more effective in the treatment of pediatric respiratory diseases, and it can also relieve various clinical symptoms of children in the shortest time. Atomization inhalation therapy is also safer in clinic, so it can be seen that atomization inhalation therapy is more effective.展开更多
Objective: to analyze the effect of nursing intervention for inhalation of aerosolized acute chronic pharyngitis. Methods: 73 patients with acute and chronic pharyngitis were randomly divided into two groups, 36 cases...Objective: to analyze the effect of nursing intervention for inhalation of aerosolized acute chronic pharyngitis. Methods: 73 patients with acute and chronic pharyngitis were randomly divided into two groups, 36 cases in the control group and 37 cases in the study group. Results: the total efficiency of the study group was significantly higher than that of the control group (P<0.05). Conclusion: the reasonable nursing intervention can accelerate the recovery of patients with acute and chronic pharyngitis by atomizing inhalation, which is worth popularizing.展开更多
Objective: the experiment will implement different treatment plans for patients with moderate and severe bronchial asthma, and further compare the clinical efficacy of budesonide and formoterol powder inhalation and b...Objective: the experiment will implement different treatment plans for patients with moderate and severe bronchial asthma, and further compare the clinical efficacy of budesonide and formoterol powder inhalation and budesonide suspension atomization inhalation. Methods: 100 patients with moderate to severe bronchial asthma admitted to our hospital were randomly selected as the subjects of this study. The diagnosis and treatment time range was from July 2020 to August 2021, and they were divided into groups by random design. The control group received budesonide suspension inhalation, while the observation group received budesonide formoterol powder inhalation, and the situation after four weeks of treatment was compared. Results: from the perspective of nursing quality, the lung function indexes of patients in the observation group were better than those in the control group. After treatment, FEV1 and FEV1/FVC in the observation group were (1.69±0.26) L and (65.77±0.28) %, respectively, while those in the control group were (1.13±0.19) L and (56.92±0.17) %. The comparison was statistically significant (P < 0.05). At the same time, the negative rate of bronchial dilation test in the observation group was higher than that in the control group (76.0% and 56.0%, respectively), and the difference was statistically significant. In addition, we compared the asthma control scores of patients before and after treatment, and the scores of the observation group were more advantageous after treatment, indicating that asthma symptoms were better controlled. Finally, the incidence of adverse reactions in patients was compared. There was no significant difference between the two groups, and both groups had safety guarantee. Conclusion: inhalation of Budesonide formoterol powder in the treatment of moderate and severe bronchial asthma has good efficacy, can improve the lung function index of patients, strengthen the control of asthma symptoms, and has the value of clinical promotion.展开更多
BACKGROUND： Latest researches at home and abroad indicate that glycerol trinitrate plays its function because it can metabolize into nitrogen monoxide （NO） in vivo. OBJECTIVE： To study the therapeutic effects of N...BACKGROUND： Latest researches at home and abroad indicate that glycerol trinitrate plays its function because it can metabolize into nitrogen monoxide （NO） in vivo. OBJECTIVE： To study the therapeutic effects of NO vector of ultrasonic atomizing inhalation on vertebro-basilar artery insufficiency （VBI） through transcranial Doppler （TCD） detection and serum NO content and indirect effect of TCD on cerebral blood flow changes. DESIGN： Randomized grouping and controlled clinical study. SETTING： Department of Neurology, the Fourth People＇s Hospital of Jinan. PARTICIPANTS： A total of 130 patients who were diagnosed as VBI were selected from Department of Neurology, the Fourth People＇s Hospital of Jinan from December 2001 to December 2005. The involved inpatients were checked by CT and MRI, and met the VBI diagnostic standard enacted by the Fourth National Academic Meeting of Cerebrovascular Disease in 1995. All patients and their relatives provided the confumed consent. They were randomly divided into low-dose treatment group （n =60）, high-lose treatment group （n =30） and control group （n =40）. METHODS： Patients in the low-dose and high-dose treatment groups were given ultrasonic atomizing inhalation of 3 mg and 5 mg glycerol trinitrate, respectively, for 20 minutes, once a day. In addition, ligustrazine and energy mixture were used once a day for three days in a course. Cases in the control group were only given ligustrazine and energy mixture. All selected cases accepted TCD, blood NO content was checked at the time of beginning, after the first time and after a period of treatment. According to the TCD test, VBI patients were divided into two groups （high-low flow velocity）. The vertebral artery （VA） and basal artery （BA） of left or right sides were detected by 2 Hz detector via occipital window. MAIN OUTCOME MEASURES： ①Blood flow velocity of systolic phase, blood flow velocity of diastole phase and vascular resistance in left and right VA and BA detected by using TCD before treatment, after treatment for one course; ②content of serum NO indirectly measured by using nitric acid disoxidation technique. RESULTS： All 130 VBI patients were involved in the final analysis. ①Changes of hemodynamic indexes： Systolic phase of VA and diastole phase of BA were higher in low-dose treatment group than that in the control group after first treatment, and there was significant difference （P 〈 0.05）; meanwhile, systolic phase and diastole phase of VA and systolic phase of BA were also higher in treatment group than that in the control group after one course （P 〈 0.05）. However, both systolic phase and diastole phase of VA and BA were lower in high-dose treatment group than that in the control group after first treatment and one course, and there was significant difference （P 〈 0.05）. ②Content of serum NO： After first treatment, there was no significant difference between low-dose treatment group and high-dose treatment group （P 〉 0.05）; but both groups were higher than control group, and there was significant difference （P 〈 0.05, 0.01）. CONCLUSION： NO vector of ultrasonic atomizing inhalation can improve VBI so as to improve cerebral blood-supply state.展开更多
Purpose:To evaluate the effectiveness of oxygen nebulization at preventing radiotherapyinduced mucositis in patients with nasopharyngeal cancer.Methods:Sixty patients with nasopharyngeal cancer treated with simultaneo...Purpose:To evaluate the effectiveness of oxygen nebulization at preventing radiotherapyinduced mucositis in patients with nasopharyngeal cancer.Methods:Sixty patients with nasopharyngeal cancer treated with simultaneous integrated boost intensity-modulated radiotherapy were randomly assigned to oxygen nebulization or ultrasonic nebulization groups;treatment was once daily for 20 minutes.All patients received routine oral care.We compared saliva pH and volume,food intake,and change in oral mucosa during radiotherapy,and dry mouth and sore throat after radiotherapy between the two groups.Results:There were significant differences in the incidence of grade III or IV mucositis,saliva volume and pH,and dry mouth and sore throat between the two groups when the total dose was 33 Gy(p<0.05 or p<0.01).Conclusion:Oxygen nebulization reduces radiotherapy-induced mucositis and relieves symptoms such as dry mouth and sore throat in patients with nasopharyngeal cancer.展开更多
Objective:To observe the effect of Elephantopus scaber Linn on community-acquired pneumonia and its relationship with the expression of TLR4/NF-κB pathway and the downstream inflammatory cytokines IL-6,IL-8,TNF-α.an...Objective:To observe the effect of Elephantopus scaber Linn on community-acquired pneumonia and its relationship with the expression of TLR4/NF-κB pathway and the downstream inflammatory cytokines IL-6,IL-8,TNF-α.and to explore its molecular mechanism for the treatment of community-acquired pneumonia,so as to provide new ideas and theoretical basis for the treatment of community-acquired pneumonia.Methods:140 patients with community-acquired pneumonia were randomly divided into observation group and control group,with 70 cases in each group.Observation group:Elephantopus scaber Linn+NS atomized inhalation+intravenous injection of ceftazidine;Control group:intravenous injection of ceftazidine;Meanwhile,70 healthy subjects were selected as the healthy control group.The expressions of TLR4,NF-kB,IL-6,IL-8 and TNF-αin serum of observation group,control group before and after treatment and healthy control group were detected by enzyme linked immunosorbent assay(ELISA),and the efficacy of Elephantopus scaber Linn in the treatment of community acquired pneumonia was observed.Results:Compared with the control group,the observation group was significantly better than the control group in recovery rate,total effective rate,number of days for the disappearance of symptoms such as fever,cough,expectoration,with statistical significance(P<0.05);Compared with the healthy control group,the serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere significantly different(P<0.05)between the observation group and the control group;Serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere significantly different(P<0.05)in the observation group before and after treatment with Elephantopus scaber Linn;Compared with the control group after treatment,there were significantly different(P<0.05)in serum TLR4,NF-κB,IL-6,IL-8 and TNF-αin the observation group after treatment.Conclusion:Serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere highly expressed in patients with community-acquired pneumonia,Elephantopus scaber Linn can decreased the expression of TLR4 and NF-κB in blood,and its downstream inflammatory factors also decreased significantly.There were significantly different(P<0.05)in blood TLR4 and NF-κB between the observation group and the control group after treatment.It is suggested that Elephantopus scaber Linn may inhibit TLR4/NF-kB signal pathway to exert anti-inflammatory effect.Elephantopus scaber Linn has a definite effect and can significantly improve the clinical symptoms,and effectively shorten the treatment cycle.展开更多
Objective: focusing on the effective nursing scheme of outpatient children, this paper analyzes the value of humanized nursing in improving their nursing compliance. Methods: the enrolled children were selected from M...Objective: focusing on the effective nursing scheme of outpatient children, this paper analyzes the value of humanized nursing in improving their nursing compliance. Methods: the enrolled children were selected from March 2019 to December 2020. The enrolled children were divided into control group and observation group by random number grouping method, with 60 cases in each group. Routine nursing and personalized nursing were implemented respectively, and the quality of nursing was evaluated. Results: there was no significant difference in lung function indexes between groups before nursing (P > 0.05). After nursing, FVC (3.42±0.38) L, FEV1 (83.61±6.36) L and PEF (3.48±1.26) s/L in observation group were significantly higher than those in control group (P < 0.05). The excellent and good rate of compliance in the observation group was higher than that in the control group (98.33%: 80.00%), that is, P < 0.05. Conclusion: the implementation of humanized nursing can improve the lung function and blood gas index of asthma patients, improve the patient's compliance and satisfaction, which is worthy of promotion and application.展开更多
Inhaled preparation is a common drug type in modern clinical practice. Because of its unique nature, it can be used by inhalation. It has the advantages that conventional oral or injection drugs do not have, and has b...Inhaled preparation is a common drug type in modern clinical practice. Because of its unique nature, it can be used by inhalation. It has the advantages that conventional oral or injection drugs do not have, and has been paid more attention in medical research. This paper analyzes the common classification of inhalation preparations, and analyzes the future development direction of inhalation preparations.展开更多
文摘Objective: to observe the oral mucosa reaction of nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy after ultrasonic atomization inhalation. Methods: in order to protect oral mucosa, the patients were randomly divided into two groups: the control group was given 0.9% sodium chloride injection and the observation group was given ultrasonic atomization inhalation. Results: the incidence of oral mucosa reaction in the observation group was lower than that in the control group. The difference was statistically significant (P < 0.05). Conclusion: intensity-modulated radiotherapy for nasopharyngeal carcinoma using ultrasonic atomization inhalation is beneficial to protect oral mucosa and promote the improvement of patients' oral mucosa reaction.
文摘Objective: to study and analyze the clinical application effect of comprehensive nursing in the treatment of acute and chronic pharyngitis by spray inhalation. Methods: 120 patients with acute and chronic pharyngitis who were admitted to our hospital from January 2020 to May 2021 were all treated by atomization inhalation. The patients were divided into two groups according to the admission time. 60 patients in the experimental group received comprehensive nursing intervention and 60 patients in the control group received daily nursing intervention. The effect of nursing intervention was compared between the two groups. Results: after the intervention, 3.33% of the patients in the experimental group did not reach the effective standard, 30.00% of the patients reached the effective standard, and 66.67% of the patients reached the significant effective standard. the total effective rate in the experimental group was higher than that in the control group by 96.67%, with a significant difference between the two groups (P0.05). There was no side reaction in the experimental group, and the incidence of side reaction in the experimental group was significantly lower than that in the control group, with a significant difference between the two groups (P0.05). Conclusion: the application of comprehensive nursing intervention to patients with acute and chronic pharyngolaryngitis treated by atomization inhalation can reduce the occurrence of adverse reactions and further improve the treatment effect, which has important clinical value.
文摘Objective: to analyze the application and symptom improvement of atomized inhalation budesonide (BUD) in the treatment of bronchiolitis (RSV). Methods: a total of 100 patients with RSV in our hospital from January 2019 to January 2021 were selected, and the number table was randomly divided into 2 groups with 50 patients in each group. The patients in the reference group were given conventional drug treatment, and the atomized group was given atomized inhalation BUD treatment on the basis of this. Compare the relative efficacy. Results: before treatment, the lung function and RSV inflammation indexes of the two groups were compared, P > 0.05, but after treatment, the lung function of the two groups was improved, while RSV inflammation indexes were decreased, and the decrease degree of RSV inflammation indexes of the atomization group was greater than that of the reference group, and the improvement degree of lung function was greater than that of the reference group, P < 0.05. The improvement rate of atomization group was higher than that of reference group, P < 0.05. Conclusion: the therapeutic mode of nebulized inhalation of BUD is very effective in the clinical intervention of children with RSV, and can promote the improvement of pulmonary function, which is worth promoting.
文摘Objective: to discuss and analyze the application and research of atomization inhalation therapy in pediatric respiratory diseases. Methods: from February 2019 to May 2020, 70 children with respiratory diseases were selected as the research object. The 70 children were divided into two groups, A and B, with 35 children in each group. Patients in group A were given routine clinical medication, while patients in group B were given aerosol inhalation therapy. Finally, the therapeutic effects and the remission time of clinical symptoms of the two groups were compared. Results: after implementing the corresponding treatment measures in the two groups, it can be seen that the therapeutic effect of group B on children reached 96.24%, while that of group A only reached 79.23%. Comparing the data obtained from the two groups of children's therapeutic effects, it has statistical significance (P < 0.05). In addition, the time for the clinical symptoms of the two groups of children to disappear was significantly shorter in group B than in group A, and the two groups also had statistical significance (P < 0.05). After treatment, the data of blood oxygen saturation and maximal respiratory flow rate in group B were all better than those in group A, and the two groups also had statistical significance (P < 0.05). Conclusion: through this study, it can be seen that atomization inhalation therapy is more effective in the treatment of pediatric respiratory diseases, and it can also relieve various clinical symptoms of children in the shortest time. Atomization inhalation therapy is also safer in clinic, so it can be seen that atomization inhalation therapy is more effective.
文摘Objective: to analyze the effect of nursing intervention for inhalation of aerosolized acute chronic pharyngitis. Methods: 73 patients with acute and chronic pharyngitis were randomly divided into two groups, 36 cases in the control group and 37 cases in the study group. Results: the total efficiency of the study group was significantly higher than that of the control group (P<0.05). Conclusion: the reasonable nursing intervention can accelerate the recovery of patients with acute and chronic pharyngitis by atomizing inhalation, which is worth popularizing.
文摘Objective: the experiment will implement different treatment plans for patients with moderate and severe bronchial asthma, and further compare the clinical efficacy of budesonide and formoterol powder inhalation and budesonide suspension atomization inhalation. Methods: 100 patients with moderate to severe bronchial asthma admitted to our hospital were randomly selected as the subjects of this study. The diagnosis and treatment time range was from July 2020 to August 2021, and they were divided into groups by random design. The control group received budesonide suspension inhalation, while the observation group received budesonide formoterol powder inhalation, and the situation after four weeks of treatment was compared. Results: from the perspective of nursing quality, the lung function indexes of patients in the observation group were better than those in the control group. After treatment, FEV1 and FEV1/FVC in the observation group were (1.69±0.26) L and (65.77±0.28) %, respectively, while those in the control group were (1.13±0.19) L and (56.92±0.17) %. The comparison was statistically significant (P < 0.05). At the same time, the negative rate of bronchial dilation test in the observation group was higher than that in the control group (76.0% and 56.0%, respectively), and the difference was statistically significant. In addition, we compared the asthma control scores of patients before and after treatment, and the scores of the observation group were more advantageous after treatment, indicating that asthma symptoms were better controlled. Finally, the incidence of adverse reactions in patients was compared. There was no significant difference between the two groups, and both groups had safety guarantee. Conclusion: inhalation of Budesonide formoterol powder in the treatment of moderate and severe bronchial asthma has good efficacy, can improve the lung function index of patients, strengthen the control of asthma symptoms, and has the value of clinical promotion.
文摘BACKGROUND： Latest researches at home and abroad indicate that glycerol trinitrate plays its function because it can metabolize into nitrogen monoxide （NO） in vivo. OBJECTIVE： To study the therapeutic effects of NO vector of ultrasonic atomizing inhalation on vertebro-basilar artery insufficiency （VBI） through transcranial Doppler （TCD） detection and serum NO content and indirect effect of TCD on cerebral blood flow changes. DESIGN： Randomized grouping and controlled clinical study. SETTING： Department of Neurology, the Fourth People＇s Hospital of Jinan. PARTICIPANTS： A total of 130 patients who were diagnosed as VBI were selected from Department of Neurology, the Fourth People＇s Hospital of Jinan from December 2001 to December 2005. The involved inpatients were checked by CT and MRI, and met the VBI diagnostic standard enacted by the Fourth National Academic Meeting of Cerebrovascular Disease in 1995. All patients and their relatives provided the confumed consent. They were randomly divided into low-dose treatment group （n =60）, high-lose treatment group （n =30） and control group （n =40）. METHODS： Patients in the low-dose and high-dose treatment groups were given ultrasonic atomizing inhalation of 3 mg and 5 mg glycerol trinitrate, respectively, for 20 minutes, once a day. In addition, ligustrazine and energy mixture were used once a day for three days in a course. Cases in the control group were only given ligustrazine and energy mixture. All selected cases accepted TCD, blood NO content was checked at the time of beginning, after the first time and after a period of treatment. According to the TCD test, VBI patients were divided into two groups （high-low flow velocity）. The vertebral artery （VA） and basal artery （BA） of left or right sides were detected by 2 Hz detector via occipital window. MAIN OUTCOME MEASURES： ①Blood flow velocity of systolic phase, blood flow velocity of diastole phase and vascular resistance in left and right VA and BA detected by using TCD before treatment, after treatment for one course; ②content of serum NO indirectly measured by using nitric acid disoxidation technique. RESULTS： All 130 VBI patients were involved in the final analysis. ①Changes of hemodynamic indexes： Systolic phase of VA and diastole phase of BA were higher in low-dose treatment group than that in the control group after first treatment, and there was significant difference （P 〈 0.05）; meanwhile, systolic phase and diastole phase of VA and systolic phase of BA were also higher in treatment group than that in the control group after one course （P 〈 0.05）. However, both systolic phase and diastole phase of VA and BA were lower in high-dose treatment group than that in the control group after first treatment and one course, and there was significant difference （P 〈 0.05）. ②Content of serum NO： After first treatment, there was no significant difference between low-dose treatment group and high-dose treatment group （P 〉 0.05）; but both groups were higher than control group, and there was significant difference （P 〈 0.05, 0.01）. CONCLUSION： NO vector of ultrasonic atomizing inhalation can improve VBI so as to improve cerebral blood-supply state.
文摘Purpose:To evaluate the effectiveness of oxygen nebulization at preventing radiotherapyinduced mucositis in patients with nasopharyngeal cancer.Methods:Sixty patients with nasopharyngeal cancer treated with simultaneous integrated boost intensity-modulated radiotherapy were randomly assigned to oxygen nebulization or ultrasonic nebulization groups;treatment was once daily for 20 minutes.All patients received routine oral care.We compared saliva pH and volume,food intake,and change in oral mucosa during radiotherapy,and dry mouth and sore throat after radiotherapy between the two groups.Results:There were significant differences in the incidence of grade III or IV mucositis,saliva volume and pH,and dry mouth and sore throat between the two groups when the total dose was 33 Gy(p<0.05 or p<0.01).Conclusion:Oxygen nebulization reduces radiotherapy-induced mucositis and relieves symptoms such as dry mouth and sore throat in patients with nasopharyngeal cancer.
文摘Objective:To observe the effect of Elephantopus scaber Linn on community-acquired pneumonia and its relationship with the expression of TLR4/NF-κB pathway and the downstream inflammatory cytokines IL-6,IL-8,TNF-α.and to explore its molecular mechanism for the treatment of community-acquired pneumonia,so as to provide new ideas and theoretical basis for the treatment of community-acquired pneumonia.Methods:140 patients with community-acquired pneumonia were randomly divided into observation group and control group,with 70 cases in each group.Observation group:Elephantopus scaber Linn+NS atomized inhalation+intravenous injection of ceftazidine;Control group:intravenous injection of ceftazidine;Meanwhile,70 healthy subjects were selected as the healthy control group.The expressions of TLR4,NF-kB,IL-6,IL-8 and TNF-αin serum of observation group,control group before and after treatment and healthy control group were detected by enzyme linked immunosorbent assay(ELISA),and the efficacy of Elephantopus scaber Linn in the treatment of community acquired pneumonia was observed.Results:Compared with the control group,the observation group was significantly better than the control group in recovery rate,total effective rate,number of days for the disappearance of symptoms such as fever,cough,expectoration,with statistical significance(P<0.05);Compared with the healthy control group,the serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere significantly different(P<0.05)between the observation group and the control group;Serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere significantly different(P<0.05)in the observation group before and after treatment with Elephantopus scaber Linn;Compared with the control group after treatment,there were significantly different(P<0.05)in serum TLR4,NF-κB,IL-6,IL-8 and TNF-αin the observation group after treatment.Conclusion:Serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere highly expressed in patients with community-acquired pneumonia,Elephantopus scaber Linn can decreased the expression of TLR4 and NF-κB in blood,and its downstream inflammatory factors also decreased significantly.There were significantly different(P<0.05)in blood TLR4 and NF-κB between the observation group and the control group after treatment.It is suggested that Elephantopus scaber Linn may inhibit TLR4/NF-kB signal pathway to exert anti-inflammatory effect.Elephantopus scaber Linn has a definite effect and can significantly improve the clinical symptoms,and effectively shorten the treatment cycle.
文摘Objective: focusing on the effective nursing scheme of outpatient children, this paper analyzes the value of humanized nursing in improving their nursing compliance. Methods: the enrolled children were selected from March 2019 to December 2020. The enrolled children were divided into control group and observation group by random number grouping method, with 60 cases in each group. Routine nursing and personalized nursing were implemented respectively, and the quality of nursing was evaluated. Results: there was no significant difference in lung function indexes between groups before nursing (P > 0.05). After nursing, FVC (3.42±0.38) L, FEV1 (83.61±6.36) L and PEF (3.48±1.26) s/L in observation group were significantly higher than those in control group (P < 0.05). The excellent and good rate of compliance in the observation group was higher than that in the control group (98.33%: 80.00%), that is, P < 0.05. Conclusion: the implementation of humanized nursing can improve the lung function and blood gas index of asthma patients, improve the patient's compliance and satisfaction, which is worthy of promotion and application.
文摘Inhaled preparation is a common drug type in modern clinical practice. Because of its unique nature, it can be used by inhalation. It has the advantages that conventional oral or injection drugs do not have, and has been paid more attention in medical research. This paper analyzes the common classification of inhalation preparations, and analyzes the future development direction of inhalation preparations.
