Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebr...Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood flow and perfusion in the posterior circulation after interventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic reso- nance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery orifice stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treat- ment only. The intervention group received vertebral artery orifice angioplasty and stenting ＋ identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent functional magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy for severe vertebral artery orifice stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.展开更多
Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclero...Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods In this single-center,retrospective cross-sectional study,379 patients with T2DM were enrolled and categorized into two groups:259 T2DM patients with CAS(T2DM-CAS)and 120 T2DM patients without CAS(T2DM-WCAS).Carotid intima‒media thickness(CIMT)and carotid atheromatous plaques(CAPs)were assessed via Doppler ultrasound.UHR values were compared between the groups,and receiver operating characteristic(ROC)curve analysis was employed to evaluate their diagnostic performance.Results The UHR was significantly greater in the T2DM-CAS group than in the T2DM-WCAS group(P<0.001).Multivariate logistic regression analysis identified the UHR as an independent risk factor for T2DM-CAS(P<0.001).The area under the ROC curve(AUC)for UHR to detect CAS was 0.750,with an optimal cut-off value of 0.35.Conclusion The UHR is an independent risk factor for CAS in patients with T2DM and may serve as a valuable biomarker for predicting CAS in this population.展开更多
基金supported by the Natural Science Foundation of Yongchuan District of Chongqing in China,No.Ycstc,2013nc8031the Foundation of Chongqing Municipal Health Bureau in China,No.2010-2-250+1 种基金the Foundation of Chongqing Health and Family Planning Commission in China,No.20143001the Soft Science Foundation of Yongchuan District of Chongqing in China,No.Ycstc,2011BE5004
文摘Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood flow and perfusion in the posterior circulation after interventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic reso- nance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery orifice stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treat- ment only. The intervention group received vertebral artery orifice angioplasty and stenting ＋ identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent functional magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy for severe vertebral artery orifice stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.
基金supported by the National Natural Science Foundation of China(Grant No.82070862 and 82370840)the National Key R&D Program of China(Grant No.2020YFC2008900).
文摘Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods In this single-center,retrospective cross-sectional study,379 patients with T2DM were enrolled and categorized into two groups:259 T2DM patients with CAS(T2DM-CAS)and 120 T2DM patients without CAS(T2DM-WCAS).Carotid intima‒media thickness(CIMT)and carotid atheromatous plaques(CAPs)were assessed via Doppler ultrasound.UHR values were compared between the groups,and receiver operating characteristic(ROC)curve analysis was employed to evaluate their diagnostic performance.Results The UHR was significantly greater in the T2DM-CAS group than in the T2DM-WCAS group(P<0.001).Multivariate logistic regression analysis identified the UHR as an independent risk factor for T2DM-CAS(P<0.001).The area under the ROC curve(AUC)for UHR to detect CAS was 0.750,with an optimal cut-off value of 0.35.Conclusion The UHR is an independent risk factor for CAS in patients with T2DM and may serve as a valuable biomarker for predicting CAS in this population.
