Small modular reactors have received widespread attention owing to their inherent safety,low investment,and flexibility.Small pressurized water reactors(SPWRs)have become important candidates for SMRs owing to their h...Small modular reactors have received widespread attention owing to their inherent safety,low investment,and flexibility.Small pressurized water reactors(SPWRs)have become important candidates for SMRs owing to their high technological maturity.Since the Fukushima accident,research on accident-tolerant fuels(ATFs),which are more resistant to serious accidents than conventional fuels,has gradually increased.This study analyzes the neutronics and thermal hydraulics of an SPWR(ACPR50S)for different ATFs,BeO+UO_(2)−SiC,BeO+UO_(2)−FeCrAl,U_(3)Si_(2)−SiC,and U_(3)Si_(2)−FeCrAl,based on a PWR fuel management code,the Bamboo-C deterministic code.In the steady state,the burnup calculations,reactivity coefficients,power and temperature distributions,and control rod reactivity worth were studied.The transients of the control rod ejection accident for the two control rods with the maximum and minimum reactivity worth were analyzed.The results showed that 5%B-10 enrichment in the wet annular burnable absorbers assembly can effectively reduce the initial reactivity and end-of-life reactivity penalty.The BeO+UO2−SiC core exhibited superior neutronic characteristics in terms of burnup and negative temperature reactivity compared with the other three cases owing to the strong moderation ability of BeO+UO_(2)and low neutron absorption of SiC.However,the U_(3)Si_(2)core had a marginally better power-flattening effect than BeO+UO_(2),and the differential worth of each control rod group was similar between different ATFs.During the transient of a control rod ejection,the changes in the fuel temperature,coolant temperature,and coolant density were similar.The maximum difference was less than 10℃ for the fuel temperature and 2℃ for the coolant temperature.展开更多
Purpose: This study aimed to explore the effects of a 10-week combined exercise regimen on immobilizationinduced muscle atrophy and elucidate the possible function of Protein arginine methyltransferase 1(Prmt1) in thi...Purpose: This study aimed to explore the effects of a 10-week combined exercise regimen on immobilizationinduced muscle atrophy and elucidate the possible function of Protein arginine methyltransferase 1(Prmt1) in this process.Methods: 8-week-old male C57BL/6J mice were carried out combined exercise for 10 weeks. One week before the end of the intervention, mice underwent cast immobilization. Additionally, to investigate the potential mechanism in exercise-induced protection of skeletal muscle, mice in the exercise preconditioning group were administered TC-E-5003(an inhibitor of Prmt1 enzymatic activity). Exercise performance, muscle mass, and the cross-sectional area(CSA) of muscle fibers were analyzed. Besides, Prmt1 and Sestrin1(Sesn1) were either overexpressed or inhibited in C2C12 myotubes to elucidate the underlying mechanism.Results: Exercise preconditioning not only significantly improved muscle mass and motor ability in immobilized mice but also inhibited excessive activation of degradation pathways and enhanced protein synthesis. Importantly, Prmt1 mediated the protective effects of exercise preconditioning on muscle atrophy. Mechanistically,Prmt1 regulated the p38 mitogen-activated protein kinase(p38)/activating transcription factor 2(ATF2)pathway, which modulates Sesn1 expression. Sesn1 acts as a downstream of Prmt1 and ATF2, contributing to the myoblast differentiation and skeletal muscle regeneration through AMP-Activated protein kinase α2(AMPKα2)/transcriptional co-activator PPAR-γ co-activator-1 α(PGC-1α) signaling pathway.Conclusions: Taken together, our results highlighted the effectiveness of exercise preconditioning in preventing muscle atrophy via the Prmt1-Sesn1 pathway.展开更多
The friction properties of wet clutches are highly dependent on the surface tribofilms formed by automatic transmission fluids (ATFs). Here, four commercial ATFs were evaluated with a disc-on-disc tribometer to study ...The friction properties of wet clutches are highly dependent on the surface tribofilms formed by automatic transmission fluids (ATFs). Here, four commercial ATFs were evaluated with a disc-on-disc tribometer to study tribofilm formation on steel surfaces and the effects of tribofilms on the friction properties. The chemical composition, stoichiometry, structure, and thickness of the tribofilms were investigated by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), secondary ion mass spectrometry (SIMS), and X-ray photoelectron spectroscopy (XPS). Calcium phosphate (CaP) tribofilms form on the friction surface with all ATFs, which contributes to their antishudder characteristics. The thickness and surface coverage of CaP tribofilms are positively correlated with their antishudder properties.展开更多
In this paper,the influence of oxidation of automatic transmission fluids(ATFs)and sliding distance on the friction coefficients of a wet clutch in approached running-in conditions was investigated.The ATFs were oxidi...In this paper,the influence of oxidation of automatic transmission fluids(ATFs)and sliding distance on the friction coefficients of a wet clutch in approached running-in conditions was investigated.The ATFs were oxidized by a laboratory process approaching oxidation occurred in actual ATFs.Oxidation was evaluated by means of increase in carbonyl compounds and depletion of zinc dialkyldithiophosphates(ZDDPs)additives.Also,the changes in kinematic viscosity and viscosity index were evaluated.Pin-ondisk tests were conducted to replicate the actual sliding contact in a wet clutch.The pin specimens were cut from friction material composite plates and the disks were actual steel separators both from an automotive wet clutch.Friction coefficient, μ,was measured at progressive sliding velocity,ν,to obtain μ–νcurves at 26 and 100°C.Three μ–νtests were consecutively run using the same pair of specimens and oil.The cumulative sliding distance for each μ–νtest generated surface flattening using the oils.The friction coefficients of the wet clutch increased due to the ATFs oxidation meanwhile the dm/dv values decreased in most cases.It suggests that ATF oxidation can enhance torque capacity of the wet clutch,but it could reduce anti-shudder property.Progressive sliding distance improved the slopes in the μ–νresults using fresh ATFs meanwhile it generated a slope decrease by using aged ATFs.展开更多
Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion injury.Autophagy occurs within hours after cereb...Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion injury.Autophagy occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains unclear.In this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion injury.We found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced autophagy.Furthermore,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating autophagy.Blocking autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion injury.Findings from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.展开更多
基金supported by the National Natural Science Foundation of China (No. 12205150)Natural Science Foundation of Jiangsu Province (No. BK20210304)+1 种基金China Postdoctoral Science Foundation (Nos. 2020M681594 and 2019TQ0148)Jiangsu Province Postdoctoral Science Foundation (Nos. 2020Z231)
文摘Small modular reactors have received widespread attention owing to their inherent safety,low investment,and flexibility.Small pressurized water reactors(SPWRs)have become important candidates for SMRs owing to their high technological maturity.Since the Fukushima accident,research on accident-tolerant fuels(ATFs),which are more resistant to serious accidents than conventional fuels,has gradually increased.This study analyzes the neutronics and thermal hydraulics of an SPWR(ACPR50S)for different ATFs,BeO+UO_(2)−SiC,BeO+UO_(2)−FeCrAl,U_(3)Si_(2)−SiC,and U_(3)Si_(2)−FeCrAl,based on a PWR fuel management code,the Bamboo-C deterministic code.In the steady state,the burnup calculations,reactivity coefficients,power and temperature distributions,and control rod reactivity worth were studied.The transients of the control rod ejection accident for the two control rods with the maximum and minimum reactivity worth were analyzed.The results showed that 5%B-10 enrichment in the wet annular burnable absorbers assembly can effectively reduce the initial reactivity and end-of-life reactivity penalty.The BeO+UO2−SiC core exhibited superior neutronic characteristics in terms of burnup and negative temperature reactivity compared with the other three cases owing to the strong moderation ability of BeO+UO_(2)and low neutron absorption of SiC.However,the U_(3)Si_(2)core had a marginally better power-flattening effect than BeO+UO_(2),and the differential worth of each control rod group was similar between different ATFs.During the transient of a control rod ejection,the changes in the fuel temperature,coolant temperature,and coolant density were similar.The maximum difference was less than 10℃ for the fuel temperature and 2℃ for the coolant temperature.
基金funded by research grants from the National Natural Science Foundation of China (32171135 and 32371168)。
文摘Purpose: This study aimed to explore the effects of a 10-week combined exercise regimen on immobilizationinduced muscle atrophy and elucidate the possible function of Protein arginine methyltransferase 1(Prmt1) in this process.Methods: 8-week-old male C57BL/6J mice were carried out combined exercise for 10 weeks. One week before the end of the intervention, mice underwent cast immobilization. Additionally, to investigate the potential mechanism in exercise-induced protection of skeletal muscle, mice in the exercise preconditioning group were administered TC-E-5003(an inhibitor of Prmt1 enzymatic activity). Exercise performance, muscle mass, and the cross-sectional area(CSA) of muscle fibers were analyzed. Besides, Prmt1 and Sestrin1(Sesn1) were either overexpressed or inhibited in C2C12 myotubes to elucidate the underlying mechanism.Results: Exercise preconditioning not only significantly improved muscle mass and motor ability in immobilized mice but also inhibited excessive activation of degradation pathways and enhanced protein synthesis. Importantly, Prmt1 mediated the protective effects of exercise preconditioning on muscle atrophy. Mechanistically,Prmt1 regulated the p38 mitogen-activated protein kinase(p38)/activating transcription factor 2(ATF2)pathway, which modulates Sesn1 expression. Sesn1 acts as a downstream of Prmt1 and ATF2, contributing to the myoblast differentiation and skeletal muscle regeneration through AMP-Activated protein kinase α2(AMPKα2)/transcriptional co-activator PPAR-γ co-activator-1 α(PGC-1α) signaling pathway.Conclusions: Taken together, our results highlighted the effectiveness of exercise preconditioning in preventing muscle atrophy via the Prmt1-Sesn1 pathway.
文摘The friction properties of wet clutches are highly dependent on the surface tribofilms formed by automatic transmission fluids (ATFs). Here, four commercial ATFs were evaluated with a disc-on-disc tribometer to study tribofilm formation on steel surfaces and the effects of tribofilms on the friction properties. The chemical composition, stoichiometry, structure, and thickness of the tribofilms were investigated by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), secondary ion mass spectrometry (SIMS), and X-ray photoelectron spectroscopy (XPS). Calcium phosphate (CaP) tribofilms form on the friction surface with all ATFs, which contributes to their antishudder characteristics. The thickness and surface coverage of CaP tribofilms are positively correlated with their antishudder properties.
基金The authors would like to acknowledge to CNMNIPN for the support in the spectroscopic analyses of our oil samplesWe also thank to“Laboratorio de Reología y Física de la Materia Blanda”from ESFM-Instituto Politécnico Nacional for the assistance and equipment support for the viscosity measurements of our oil samples.
文摘In this paper,the influence of oxidation of automatic transmission fluids(ATFs)and sliding distance on the friction coefficients of a wet clutch in approached running-in conditions was investigated.The ATFs were oxidized by a laboratory process approaching oxidation occurred in actual ATFs.Oxidation was evaluated by means of increase in carbonyl compounds and depletion of zinc dialkyldithiophosphates(ZDDPs)additives.Also,the changes in kinematic viscosity and viscosity index were evaluated.Pin-ondisk tests were conducted to replicate the actual sliding contact in a wet clutch.The pin specimens were cut from friction material composite plates and the disks were actual steel separators both from an automotive wet clutch.Friction coefficient, μ,was measured at progressive sliding velocity,ν,to obtain μ–νcurves at 26 and 100°C.Three μ–νtests were consecutively run using the same pair of specimens and oil.The cumulative sliding distance for each μ–νtest generated surface flattening using the oils.The friction coefficients of the wet clutch increased due to the ATFs oxidation meanwhile the dm/dv values decreased in most cases.It suggests that ATF oxidation can enhance torque capacity of the wet clutch,but it could reduce anti-shudder property.Progressive sliding distance improved the slopes in the μ–νresults using fresh ATFs meanwhile it generated a slope decrease by using aged ATFs.
基金supported by the National Natural Science Foundation of China,Nos.82260245(to YX),81660207(to YX),81960253(to YL),82160268(to YL),U1812403(to ZG)Science and Technology Projects of Guizhou Province,Nos.[2019]1440(to YX),[2020]1Z067(to WH)+1 种基金Cultivation Foundation of Guizhou Medical University,No.[20NSP069](to YX)Excellent Young Talents Plan of Guizhou Medical University,No.(2022)101(to WH)。
文摘Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion injury.Autophagy occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains unclear.In this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion injury.We found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced autophagy.Furthermore,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating autophagy.Blocking autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion injury.Findings from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.
