Stimuli-triggered drug delivery systems hold vast promise in local infection treatment for the site-specific targeting and shuttling of drugs.Herein,chitosan conjugates(SPCS)installed with sialic acid(SA)and phenylbor...Stimuli-triggered drug delivery systems hold vast promise in local infection treatment for the site-specific targeting and shuttling of drugs.Herein,chitosan conjugates(SPCS)installed with sialic acid(SA)and phenylboronic acid(PBA)were synthesized,of which SA served as targeting ligand for coccidium and reversible-binding bridge for PBA.The enhanced drug-loading capacity of SPCS micelles was attributed to a combination assembly from hydrophobicity-driving and reversible borate bridges.The drug-loaded SPCS micelles shared superior biostability in upper gastrointestinal tract.After reaching the lesions,the borate bridges were snipped by carbohydrates under a higher pH followed by accelerated drug release,while SA exposure on micellar surface facilitated drug cellular internalization to eliminate parasites inside.The drugmicelles revealed an enhanced anti-coccidial capacity with a higher index of 185.72 compared with commercial preparation.The dual-responsive combination of physicochemical assembly could provide an efficient strategy for the exploitation of stable,safe and flexible anti-infectious drug delivery systems.展开更多
Nanocarbon-based materials, such as carbon nanotubes(CNTs) and graphene have been attached much attention by scientific and industrial community. As two representative nanocarbon materials, one-dimensional CNTs and tw...Nanocarbon-based materials, such as carbon nanotubes(CNTs) and graphene have been attached much attention by scientific and industrial community. As two representative nanocarbon materials, one-dimensional CNTs and twodimensional graphene both possess remarkable mechanical properties. In the past years, a large amount of work have been done by using CNTs or graphene as building blocks for constructing novel, macroscopic, mechanically strong fibrous materials. In this review, we summarize the assembly approaches of CNT-based fibers and graphene-based fibers in chronological order, respectively. The mechanical performances of these fibrous materials are compared, and the critical influences on the mechanical properties are discussed. Personal perspectives on the fabrication methods of CNT-and graphene-based fibers are further presented.展开更多
Both morphology and composition have a great influence on the properties and functions of materials,however,how to rational modulate both of them to achieve their synergistic effects has been a longstanding expectatio...Both morphology and composition have a great influence on the properties and functions of materials,however,how to rational modulate both of them to achieve their synergistic effects has been a longstanding expectation.Herein,we demonstrate a competitive assembling strategy for the construction of metal-free graphite carbon nitride(CN)homojunctions in which morphology and composition can be easily controlled simultaneously by only changing the ratio of assembly raw materials.These homojunctions are comprised of porous nanotubular S-doped CN(SCN)grafted with CN nanovesicles,which are derived from thermal polycondensation of melamine-thiocyanuric acid(M-T)/melamine-cyanuric acid(M-C)supramolecular hybrid blocks.This unique architecture and component engineering endows the novel SCN-CN homojunction with abundant active sites,enhanced visible trapping ability,and intimate interface contact.As a result,the synthesized SCN-CN homojunctions demonstrate high photocatalytic activity for hydrogen evolution and pollutant degradation.This developed strategy opens up intriguing opportu-nities for the rational construction of intricate metal-free heterostructures with controllable architecture and interfacial contact for applications in energy-related fields.展开更多
Enzyme biosensors,despite their high specificity and sensitivity,are constrained by the inherent fragility of enzymes.Despite being considered ideal for enzyme protection by in-situ covalent organic frameworks(COFs)im...Enzyme biosensors,despite their high specificity and sensitivity,are constrained by the inherent fragility of enzymes.Despite being considered ideal for enzyme protection by in-situ covalent organic frameworks(COFs)immobilization,the harsh conditions of COFs synthesis often lead to enzyme inactivation.Herein,a strategy was developed to prepare robust enzyme@COFs microcapsules(enzyme@MCCOFs)by the interfacial assembly of hydrophobic COFs spheres to form stable Pickering emulsions,followed by COFs regrowth to reinforce the microcapsules.Compared with conventional methods,this approach confines the enzymes in a mild environ-ment,achievig an impressive encapsulation efficiency of 85.9%.Enzymes are protected from inhospitable conditions by the mechanical robustness of microcapsules COFs shell which also features adjustable pores to enhance substrate transport and exhibit size selectivity.The success of strategy was verified by the construction of enzyme@MCCOFs based on various hydrophobic COFs spheres(water contact angle>90◦)with different pore sizes and degrees of functionalization,and they can be pre-modified to meet specific application requirements.The strategy is simple yet effective.COFs employed in this strategy only requires a slight degree of hydropho-bicity,rather than specific functional groups.In addition,a formula was also proposed to predict and control the size of the enzyme@MCCOFs accurately.A cascade catalytic system based on enzyme@MCCOFs has been emulated for the construction of a colorimetric and electrochemical glucose biosensing platform.This study provides new insight into the construction of enzyme@MCCOFs and their biosensing applications.展开更多
Gold nanoclusters(AuNCs)have garnered significant attention due to their unique photoluminescent,catalytic,and therapeutic properties.Since the discovery of their ability to enhance emission through aggregation,resear...Gold nanoclusters(AuNCs)have garnered significant attention due to their unique photoluminescent,catalytic,and therapeutic properties.Since the discovery of their ability to enhance emission through aggregation,researchers have extensively studied hybrid nanomaterials formed by combining AuNCs with various components through assembly.Assembly can significantly improve the original performance of AuNCs and confer additional properties such as responsiveness and targeting.These assembly strategies greatly expand the potential applications of AuNCs and are regarded as essential means to improve the detection,imaging,and therapeutic capabilities.This review categorizes recent advancements in AuNC assembly methods,including self-assembly and co-assembly of AuNCs.In addition,the emerging directions in the in vivo assembly and disassembly of AuNCs are also being addressed.We also discuss the applications of AuNC assemblies in in vitro biodetection,in vivo bioimaging,and therapeutic platforms.Finally,we offer prospects for the future development of AuNC assemblies.With further exploration of assembly strategies,mechanisms,and application designs,AuNC assemblies are expected to play a more significant role in more fields.展开更多
The development of advanced materials and technologies in the field of sustainability is of vital importance for addressing environmental pollution.Covalent organic frameworks(COFs)show great potential in the field of...The development of advanced materials and technologies in the field of sustainability is of vital importance for addressing environmental pollution.Covalent organic frameworks(COFs)show great potential in the field of environmental remediation due to their ordered structure,high porosity,low density,large specific surface area,alongside excellent chemical stability.These features position COFs as promising candidates for environmental remediation.However,COFs usually exist in powder form with poor processability and recyclability.To overcome such challenges,the construction of COF-based aerogels with a unique three-dimensional interconnected pore structure and extremely low density is considered an important means to realize their device applications.The research on the development of advanced COF aerogel composites at the molecular level opens up a new way and provides a new choice of multifunctional materials for environmental governance.This review focuses on COF aerogels and systematically summarizes their synthesis methods and development in environmental applications.展开更多
基金financial support from National Key Research and Development Program(2017YFD0501403)National Natural Science Foundation of China(Nos.81872819)+4 种基金Natural Science Foundation of Jiangsu Province(No.BK20171390)supported by Double First-Rate construction plan of China Pharmaceutical University(CPU2018GY26)the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.SKLNMZZCX201816)the National Science and Technology Major Project(2017ZX09101001)the financial support from Development Funds for Priority Academic Programs in Jiangsu Higher Education Institutions-Young Talent Program。
文摘Stimuli-triggered drug delivery systems hold vast promise in local infection treatment for the site-specific targeting and shuttling of drugs.Herein,chitosan conjugates(SPCS)installed with sialic acid(SA)and phenylboronic acid(PBA)were synthesized,of which SA served as targeting ligand for coccidium and reversible-binding bridge for PBA.The enhanced drug-loading capacity of SPCS micelles was attributed to a combination assembly from hydrophobicity-driving and reversible borate bridges.The drug-loaded SPCS micelles shared superior biostability in upper gastrointestinal tract.After reaching the lesions,the borate bridges were snipped by carbohydrates under a higher pH followed by accelerated drug release,while SA exposure on micellar surface facilitated drug cellular internalization to eliminate parasites inside.The drugmicelles revealed an enhanced anti-coccidial capacity with a higher index of 185.72 compared with commercial preparation.The dual-responsive combination of physicochemical assembly could provide an efficient strategy for the exploitation of stable,safe and flexible anti-infectious drug delivery systems.
基金supported by the National Natural Science Foundation of China (Nos. 21325417, 51533008)the MOST National Key Research and Development Plan (2016YFA0200200)+1 种基金the National Postdoctoral Program for Innovative Talents (No. BX201700209)the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University (No. LK1403)
文摘Nanocarbon-based materials, such as carbon nanotubes(CNTs) and graphene have been attached much attention by scientific and industrial community. As two representative nanocarbon materials, one-dimensional CNTs and twodimensional graphene both possess remarkable mechanical properties. In the past years, a large amount of work have been done by using CNTs or graphene as building blocks for constructing novel, macroscopic, mechanically strong fibrous materials. In this review, we summarize the assembly approaches of CNT-based fibers and graphene-based fibers in chronological order, respectively. The mechanical performances of these fibrous materials are compared, and the critical influences on the mechanical properties are discussed. Personal perspectives on the fabrication methods of CNT-and graphene-based fibers are further presented.
基金the National Natural Science Foundation of China(Nos.51772085,12072110)the Natural Science Foundation of Hunan Province(No.2020JJ4190).
文摘Both morphology and composition have a great influence on the properties and functions of materials,however,how to rational modulate both of them to achieve their synergistic effects has been a longstanding expectation.Herein,we demonstrate a competitive assembling strategy for the construction of metal-free graphite carbon nitride(CN)homojunctions in which morphology and composition can be easily controlled simultaneously by only changing the ratio of assembly raw materials.These homojunctions are comprised of porous nanotubular S-doped CN(SCN)grafted with CN nanovesicles,which are derived from thermal polycondensation of melamine-thiocyanuric acid(M-T)/melamine-cyanuric acid(M-C)supramolecular hybrid blocks.This unique architecture and component engineering endows the novel SCN-CN homojunction with abundant active sites,enhanced visible trapping ability,and intimate interface contact.As a result,the synthesized SCN-CN homojunctions demonstrate high photocatalytic activity for hydrogen evolution and pollutant degradation.This developed strategy opens up intriguing opportu-nities for the rational construction of intricate metal-free heterostructures with controllable architecture and interfacial contact for applications in energy-related fields.
基金supported by the National Natural Science Foundation of China(22264016 and 22464013).
文摘Enzyme biosensors,despite their high specificity and sensitivity,are constrained by the inherent fragility of enzymes.Despite being considered ideal for enzyme protection by in-situ covalent organic frameworks(COFs)immobilization,the harsh conditions of COFs synthesis often lead to enzyme inactivation.Herein,a strategy was developed to prepare robust enzyme@COFs microcapsules(enzyme@MCCOFs)by the interfacial assembly of hydrophobic COFs spheres to form stable Pickering emulsions,followed by COFs regrowth to reinforce the microcapsules.Compared with conventional methods,this approach confines the enzymes in a mild environ-ment,achievig an impressive encapsulation efficiency of 85.9%.Enzymes are protected from inhospitable conditions by the mechanical robustness of microcapsules COFs shell which also features adjustable pores to enhance substrate transport and exhibit size selectivity.The success of strategy was verified by the construction of enzyme@MCCOFs based on various hydrophobic COFs spheres(water contact angle>90◦)with different pore sizes and degrees of functionalization,and they can be pre-modified to meet specific application requirements.The strategy is simple yet effective.COFs employed in this strategy only requires a slight degree of hydropho-bicity,rather than specific functional groups.In addition,a formula was also proposed to predict and control the size of the enzyme@MCCOFs accurately.A cascade catalytic system based on enzyme@MCCOFs has been emulated for the construction of a colorimetric and electrochemical glucose biosensing platform.This study provides new insight into the construction of enzyme@MCCOFs and their biosensing applications.
基金financially supported by the National Natural Science Foundation of China(Nos.52003097 and 52293474)the Shenzhen Science and Technology Program(No.CYJ20220530160603007).
文摘Gold nanoclusters(AuNCs)have garnered significant attention due to their unique photoluminescent,catalytic,and therapeutic properties.Since the discovery of their ability to enhance emission through aggregation,researchers have extensively studied hybrid nanomaterials formed by combining AuNCs with various components through assembly.Assembly can significantly improve the original performance of AuNCs and confer additional properties such as responsiveness and targeting.These assembly strategies greatly expand the potential applications of AuNCs and are regarded as essential means to improve the detection,imaging,and therapeutic capabilities.This review categorizes recent advancements in AuNC assembly methods,including self-assembly and co-assembly of AuNCs.In addition,the emerging directions in the in vivo assembly and disassembly of AuNCs are also being addressed.We also discuss the applications of AuNC assemblies in in vitro biodetection,in vivo bioimaging,and therapeutic platforms.Finally,we offer prospects for the future development of AuNC assemblies.With further exploration of assembly strategies,mechanisms,and application designs,AuNC assemblies are expected to play a more significant role in more fields.
基金supported by the National Natural Science Foundation of China(22175094,21971113)。
文摘The development of advanced materials and technologies in the field of sustainability is of vital importance for addressing environmental pollution.Covalent organic frameworks(COFs)show great potential in the field of environmental remediation due to their ordered structure,high porosity,low density,large specific surface area,alongside excellent chemical stability.These features position COFs as promising candidates for environmental remediation.However,COFs usually exist in powder form with poor processability and recyclability.To overcome such challenges,the construction of COF-based aerogels with a unique three-dimensional interconnected pore structure and extremely low density is considered an important means to realize their device applications.The research on the development of advanced COF aerogel composites at the molecular level opens up a new way and provides a new choice of multifunctional materials for environmental governance.This review focuses on COF aerogels and systematically summarizes their synthesis methods and development in environmental applications.
