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UCA1和ITGA2在胰腺癌中的作用及调控机制
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作者 卫丽娟 许建 《实用医院临床杂志》 2025年第5期210-214,共5页
胰腺癌是一种高度致死的恶性肿瘤。长链非编码RNA UCA1在多种癌症中均表现出较高的表达水平,特别是在胰腺癌中,通过MAPK/ERK等信号通路推动癌细胞的迁移与侵袭,因此被视为有潜力的预后标志物和治疗靶点。同时,整合素家族成员ITGA2的高... 胰腺癌是一种高度致死的恶性肿瘤。长链非编码RNA UCA1在多种癌症中均表现出较高的表达水平,特别是在胰腺癌中,通过MAPK/ERK等信号通路推动癌细胞的迁移与侵袭,因此被视为有潜力的预后标志物和治疗靶点。同时,整合素家族成员ITGA2的高表达也与胰腺癌细胞的侵袭性及转移能力密切相关,其通过黏着斑信号途径调控癌症进展。此外,UCA1和ITGA2之间可能通过miR-107作为中介,协同影响胰腺癌的恶性生物学行为,表明UCA1和ITGA2有望作为胰腺癌诊断和治疗的新靶点。本文综述了UCA1和ITGA2在胰腺癌中的功能及其调控机制,未来研究应深入探索它们在胰腺癌中的具体机制及潜在的临床应用前景。 展开更多
关键词 uca1 ITGA2 miR-107 胰腺癌
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Structural Color Dynamic Graphics Display Based on Microlens Array 被引量:1
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作者 LI Xue-han LIU Ling-zhi +1 位作者 HUANG Min LI Xiu 《印刷与数字媒体技术研究》 北大核心 2025年第2期162-168,共7页
It is of great scientific significance to construct a 3D dynamic structural color with a special color effect based on the microlens array.However,the problems of imperfect mechanisms and poor color quality need to be... It is of great scientific significance to construct a 3D dynamic structural color with a special color effect based on the microlens array.However,the problems of imperfect mechanisms and poor color quality need to be solved.A method of 3D structural color turning on periodic metasurfaces fabricated by the microlens array and self-assembly technology was proposed in this study.In the experiment,Polydimethylsiloxane(PDMS)flexible film was used as a substrate,and SiO2 microspheres were scraped into grooves of the PDMS film to form 3D photonic crystal structures.By adjusting the number of blade-coated times and microsphere concentrations,high-saturation structural color micropatterns were obtained.These films were then matched with microlens arrays to produce dynamic graphics with iridescent effects.The results showed that by blade-coated two times and SiO2 microsphere concentrations of 50%are the best conditions.This method demonstrates the potential for being widely applied in the anticounterfeiting printing and ultra-high-resolution display. 展开更多
关键词 Structural color Microlens array Dynamic graphics display Moirémagnification Optical anti-counterfeiting
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HBV相关肝细胞癌患者血清UCA1、WRAP53表达水平及其临床意义
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作者 杨斌 王勇刚 +1 位作者 曹洪刚 高建勇 《肝脏》 2025年第7期943-947,共5页
目的探究乙型肝炎病毒(HBV)相关肝细胞癌患者血清尿路上皮癌相关1(UCA1)和含TP53反义的WD重复序列(WRAP53)水平与肝癌的关系。方法选取2022年6月至2024年3月于乐至县人民医院肿瘤内科接受治疗的HBV相关肝细胞癌患者82例作为观察组,选择... 目的探究乙型肝炎病毒(HBV)相关肝细胞癌患者血清尿路上皮癌相关1(UCA1)和含TP53反义的WD重复序列(WRAP53)水平与肝癌的关系。方法选取2022年6月至2024年3月于乐至县人民医院肿瘤内科接受治疗的HBV相关肝细胞癌患者82例作为观察组,选择同期慢性HBV感染者80例作为对照组。实时荧光定量PCR测定患者血清UCA1和WRAP53水平,应用二元logistic回归模型分析慢性HBV感染者肝癌发生的危险因素。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)评估UCA1和WRAP53对HBV相关肝细胞癌的诊断效能。结果观察组血清UCA1和WRAP53的表达水平分别为(2.42±0.72)和(3.16±1.07),高于对照组的(1.25±0.37)和(1.18±0.31),差异有统计学意义(t=13.054、16.079,均P<0.05)。Logistic回归分析表明,UCA1和WRAP53水平升高是慢性HBV感染者肝癌发生的独立危险因素。ROC曲线分析显示,UCA1和WRAP53诊断慢性HBV感染者肝癌发生的灵敏度分别为84.1%和90.2%;特异度分别为88.7%和96.3%;AUC分别为0.921和0.930,显示了两者在诊断慢性HBV感染者肝癌发生的高准确性。而当UCA1和WRAP53联合预测时,灵敏度和特异度分别为93.9%和98.8%,AUC值则达到0.980,表明联合检测具有更高的预测效能。结论HBV相关肝细胞癌患者的血清UCA1和WRAP53水平显著升高,这些标志物可作为HBV相关肝细胞癌的潜在诊断工具,具有较高的诊断价值。 展开更多
关键词 乙型肝炎病毒 肝细胞癌 uca1 WRAP53 生物标志物
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Integrated Optical True Time Delay Phased Array Antenna Systems 被引量:1
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作者 Qi Zihang Yang Linhui +1 位作者 Zhao Wenyu Li Xiuping 《China Communications》 2025年第5期152-172,共21页
The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled p... The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed. 展开更多
关键词 microwave photonics optical switch optical true time delay phased array antenna siliconbased integration
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Low-profile,low sidelobe array antenna with ultrawide beam coverage for UAV communication 被引量:1
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作者 Mei LI Zhiliang SHANG +2 位作者 Lin PU Ming-Chun TANG Lei ZHU 《Chinese Journal of Aeronautics》 2025年第1期444-454,共11页
This paper presents a design method to implement an antenna array characterized by ultra-wide beam coverage,low profile,and low Sidelobe Level(SLL)for the application of Unmanned Aerial Vehicle(UAV)air-to-ground commu... This paper presents a design method to implement an antenna array characterized by ultra-wide beam coverage,low profile,and low Sidelobe Level(SLL)for the application of Unmanned Aerial Vehicle(UAV)air-to-ground communication.The array consists of ten broadside-radiating,ultrawide-beamwidth elements that are cascaded by a central-symmetry series-fed network with tapered currents following Dolph-Chebyshev distribution to provide low SLL.First,an innovative design of end-fire Huygens source antenna that is compatible with metal ground is presented.A low-profile,half-mode Microstrip Patch Antenna(MPA)is utilized to serve as the magnetic dipole and a monopole is utilized to serves as the electric dipole,constructing the compact,end-fire,grounded Huygens source antenna.Then,two opposite-oriented end-fire Huygens source antennas are seamlessly integrated into a single antenna element in the form of monopole-loaded MPA to accomplish the ultrawide,broadside-radiating beam.Particular consideration has been applied into the design of series-fed network as well as antenna element to compensate the adverse coupling effects between elements on the radiation performance.Experiment indicates an ultrawide Half-Power Beamwidth(HPBW)of 161°and a low SLL of-25 dB with a high gain of 12 d Bi under a single-layer configuration.The concurrent ultrawide beamwidth and low SLL make it particularly attractive for applications of UAV air-to-ground communication. 展开更多
关键词 array antenna Broad beam Fan beam Low sidelobe level Chebyshev synthesis UAV communication
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Improving DOA estimation of GNSS interference through sparse non-uniform array reconfiguration 被引量:1
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作者 Rongling LANG Hao XU +3 位作者 Fei GAO Zewen TANG Zhipeng WANG Amir HUSSAIN 《Chinese Journal of Aeronautics》 2025年第8期104-118,共15页
Interference significantly impacts the performance of the Global Navigation Satellite Systems(GNSS),highlighting the need for advanced interference localization technology to bolster anti-interference and defense capa... Interference significantly impacts the performance of the Global Navigation Satellite Systems(GNSS),highlighting the need for advanced interference localization technology to bolster anti-interference and defense capabilities.The Uniform Circular Array(UCA)enables concurrent estimation of the Direction of Arrival(DOA)in both azimuth and elevation.Given the paramount importance of stability and real-time performance in interference localization,this work proposes an innovative approach to reduce the complexity and increase the robustness of the DOA estimation.The proposed method reduces computational complexity by selecting a reduced number of array elements to reconstruct a non-uniform sparse array from a UCA.To ensure DOA estimation accuracy,minimizing the Cramér-Rao Bound(CRB)is the objective,and the Spatial Correlation Coefficient(SCC)is incorporated as a constraint to mitigate side-lobe.The optimization model is a quadratic fractional model,which is solved by Semi-Definite Relaxation(SDR).When the array has perturbations,the mathematical expressions for CRB and SCC are re-derived to enhance the robustness of the reconstructed array.Simulation and hardware experiments validate the effectiveness of the proposed method in estimating interference DOA,showing high robustness and reductions in hardware and computational costs associated with DOA estimation. 展开更多
关键词 GNSS interference location Direction of arrival estimation Adaptive reconfigurable array Cramér-Raobound Quadratic fractional programming
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Arbitrary azimuthal optical field manipulation by dual-spiral arrays
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作者 MA Li WANG Ying +2 位作者 LI Min ZHANG Ying ZHAO Bo 《中国光学(中英文)》 北大核心 2025年第4期921-930,共10页
Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of curr... Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems. 展开更多
关键词 optical manipulation topological charge spiral array
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Ultrafast Self-powered Near-infrared Photodetectors and Imaging Array Based on Tin-lead Mixed Perovskites
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作者 LIU Jingjing YANG Zhichun +7 位作者 BAO Haotian MENG Xinqin QI Minru YANG Changgang ZHANG Guofeng QIN Chengbing XIAO Liantuan JIA Suotang 《发光学报》 北大核心 2025年第6期1037-1047,共11页
Tin-lead(Sn-Pb)mixed perovskites are extensively investigated in near-infrared(NIR)photodetectors(PDs)owing to their excellent photoelectric performance.However,achieving high-performance Sn-Pb mixed PDs remains chall... Tin-lead(Sn-Pb)mixed perovskites are extensively investigated in near-infrared(NIR)photodetectors(PDs)owing to their excellent photoelectric performance.However,achieving high-performance Sn-Pb mixed PDs remains challenging,primarily because of the rapid crystallization and the susceptibility of Sn^(2+) to oxidation.To ad⁃dress these issues,this study introduces the multifunctional molecules 2,3-difluorobenzenamine(DBM)to modulate the crystallization of Sn-Pb mixed perovskites and retard the oxidation of Sn^(2+),thereby significantly enhancing film quality.Compared with the pristine film,Sn-Pb mixed perovskite films modulated by DBM molecules exhibit a high⁃ly homogeneous morphology,reduced roughness and defect density.The self-powered NIR PDs fabricated with the improved films have a spectral response range from 300 nm to 1100 nm,a peak responsivity of 0.51 A·W^(-1),a spe⁃cific detectivity as high as 2.46×10^(11)Jones within the NIR region(780 nm to 1100 nm),a linear dynamic range ex⁃ceeding 152 dB,and ultrafast rise/fall time of 123/464 ns.Thanks to the outstanding performance of PDs,the fabri⁃cated 5×5 PDs array demonstrates superior imaging ability in the NIR region up to 980 nm.This work advances the development of Sn-Pb mixed perovskites for NIR detection and paves the way for their commercialization. 展开更多
关键词 tin-lead mixed perovskites near-infrared photodetectors imaging array oxidation crystallization modulation
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Retraction: UCA1 Regulates the Growth and Metastasis of Pancreatic Cancer by Sponging miR-135a
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作者 Oncology Research Editorial Office 《Oncology Research》 2025年第9期2596-2596,共1页
The published article titled“UCA1 Regulates the Growth and Metastasis of Pancreatic Cancer by Sponging miR-135a”has been retracted from Oncology Research,Vol.25,No.9,2017,pp.1529–1541.DOI:10.3727/096504017X14888987... The published article titled“UCA1 Regulates the Growth and Metastasis of Pancreatic Cancer by Sponging miR-135a”has been retracted from Oncology Research,Vol.25,No.9,2017,pp.1529–1541.DOI:10.3727/096504017X14888987683152 URL:https://www.techscience.com/or/v25n9/56938 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells. 展开更多
关键词 cellular datawhere pancreatic cancer cellular data similarity uca MIR RETRACTION
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Programmable array antenna based on nematic liquid crystals for the Ka-band
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作者 WANG Qiang KE Junchen BAI Lin 《Journal of Southeast University(English Edition)》 2025年第1期78-83,共6页
A programmable low-profile array antenna based on nematic liquid crystals(NLCs)is proposed.Each antenna unit comprises a square patch radiating structure and a tunable NLC-based phase shifter capable of achieving a ph... A programmable low-profile array antenna based on nematic liquid crystals(NLCs)is proposed.Each antenna unit comprises a square patch radiating structure and a tunable NLC-based phase shifter capable of achieving a phase shift exceeding 360°with high linearity.First,the above 64 antenna units are periodically arranged into an 8×8 NLC-based antenna array,and the bias voltage of the NLC-based phase shifter loaded on the antenna unit is adjusted through the control of the field-programmable gate array(FPGA)programming sequences.This configuration enables precise phase changes for all 64 channels.Numerical simulation,sample processing,and experimental measurements of the antenna array are conducted to validate the performance of the antenna.The numerical and experimental results demonstrate that the proposed antenna performs well within the frequency range of 19.5-20.5 GHz,with a 3 dB relative bandwidth of 10%and a maximum main lobe gain of 14.1 dBi.A maximum scanning angle of±34°is achieved through the adjustment of the FPGA programming sequence.This NLC-based programmable array antenna shows promising potential for applications in satellite communication. 展开更多
关键词 array antenna nematic liquid crystals electronically beam scanning field programmable gate array(FPGA)
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Extended Nested Array with a Filled Sensor for DOA Estimation of Non-circular Signals
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作者 LI Xiaolong ZHANG Xiaofei SHEN Zihan 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第1期90-100,共11页
Sparse array design has significant implications for improving the accuracy of direction of arrival(DOA)estimation of non-circular(NC)signals.We propose an extended nested array with a filled sensor(ENAFS)based on the... Sparse array design has significant implications for improving the accuracy of direction of arrival(DOA)estimation of non-circular(NC)signals.We propose an extended nested array with a filled sensor(ENAFS)based on the hole-filling strategy.Specifically,we first introduce the improved nested array(INA)and prove its properties.Subsequently,we extend the sum-difference coarray(SDCA)by adding an additional sensor to fill the holes.Thus the larger uniform degrees of freedom(uDOFs)and virtual array aperture(VAA)can be abtained,and the ENAFS is designed.Finally,the simulation results are given to verify the superiority of the proposed ENAFS in terms of DOF,mutual coupling and estimation performance. 展开更多
关键词 non-circular signal extended nested array sparse array direction of arrival(DOA)estimation sum-difference coarray
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lncRNA UCA1调控miR-135b-5p对子痫前期滋养细胞增殖和侵袭的影响
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作者 谢依欣 李小倩 张志慧 《中国优生与遗传杂志》 2025年第5期1062-1068,共7页
目的探讨长链非编码RNA尿路上皮癌胚抗原1(lncRNA UCA1)靶向微小RNA-135b-5p(miR-135b-5p)对子痫前期(PE)滋养细胞增殖和侵袭的影响。方法:利用HTR-8/SVneo细胞构建体外PE模型,并检测细胞中lncRNA UCA1和miR-135b-5p的表达量。将构建PE... 目的探讨长链非编码RNA尿路上皮癌胚抗原1(lncRNA UCA1)靶向微小RNA-135b-5p(miR-135b-5p)对子痫前期(PE)滋养细胞增殖和侵袭的影响。方法:利用HTR-8/SVneo细胞构建体外PE模型,并检测细胞中lncRNA UCA1和miR-135b-5p的表达量。将构建PE模型的HTR-8/SVneo细胞分为NC组、sh-NC组、sh-lncRNA UCA1组、sh-lncRNA UCA1+anti-miR-NC组、sh-lncRNA UCA1+anti-miR-135b-5p组。通过克隆形成实验和EdU染色检测各组细胞增殖能力;Transwell实验检测各组细胞侵袭能力;qRT-PCR实验检测各组细胞中lncRNA UCA1、miR-135b-5p以及细胞增殖、侵袭相关基因的表达量;Western blot实验检测细胞增殖和侵袭相关蛋白的表达量;双荧光素酶报告基因实验检测lncRNA UCA1和miR-135b-5p靶向关系。结果与Control组相比,Sham组lncRNA UCA1表达量上升(P<0.05),miR-135b-5p表达量下降(P<0.05);与sh-NC组相比,sh-lncRNA UCA1组细胞增殖能力、侵袭能力、lncRNA UCA1、增殖细胞核抗原(PCNA)、周期蛋白依赖性激酶(CDK1)、基质金属蛋白酶(MMP)2、MMP14 mRNA表达量和蛋白表达量都明显下降(P<0.05),miR-135b-5p表达量明显上升(P<0.05);而上述指标变化趋势在sh-lncRNA UCA1+anti-miR-135b-5p组中均被逆转(P<0.05)。结论干扰lncRNA UCA1表达可通过靶向上调miR-135b-5p表达抑制PE滋养细胞增殖和侵袭。 展开更多
关键词 lncRNA uca1 miR-135b-5p 子痫前期 增殖 侵袭
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Progress in metalenses:from single to array
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作者 Chang Peng Jin Yao Din Ping Tsai 《Opto-Electronic Technology》 2025年第1期34-56,共23页
As one of the most promising branches of metasurfaces,metalenses overcome the functional limits of conventional lenses and enable versatile control over light.Their compactness facilitates integration into miniatur-iz... As one of the most promising branches of metasurfaces,metalenses overcome the functional limits of conventional lenses and enable versatile control over light.Their compactness facilitates integration into miniatur-ized optical systems without significantly increasing the footprint.Recent advances in the field are unfolding along two parallel directions:performance enhancement and functional expansion of single metalenses,and architectural development of multi-metalens systems.In this review,we systematically summarize representative progress in both areas,aiming to clarify major unresolved challenges and highlight the most promising directions for future exploration. 展开更多
关键词 metasurface metalens metalens array planar optics
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Coherence CLEAN-SC(C-CLEAN-SC) phased array processing for coherent sound source localization
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作者 Ce ZHANG Wei MA 《Chinese Journal of Aeronautics》 2025年第7期140-146,共7页
Deconvolution methods are commonly used to improve the performance of phased array beamforming for sound source localization. However, for coherent sources localization, existing deconvolution methods are either highl... Deconvolution methods are commonly used to improve the performance of phased array beamforming for sound source localization. However, for coherent sources localization, existing deconvolution methods are either highly computationally demanding or sensitive to parameters.A deconvolution method, based on modifications of Clean based on Source Coherence(CLEAN-SC), is proposed for coherent sources localization. This method is called Coherence CLEAN-SC(C–CLEAN-SC). C–CLEAN-SC is able to locate coherent and incoherent sources in simulation and experimental cases. It has a high computational efficiency and does not require pre-set parameters. 展开更多
关键词 Coherent source localization Phased array BEAMFORMING CLEAN-SC DECONVOLUTION
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An Efficient Synthesizing Method for Super-Massive Sparse Phased Array in Non-Terrestrial Network Applications
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作者 Yin Haoyu Zhao Haiyan +2 位作者 Li Weidong Hao Zhangcheng Hong Wei 《China Communications》 2025年第10期1-11,共11页
In this paper,a method for designing supermassive sparse phased arrays(SMSPAs)known as the unitary modified matrix enhancement and matrix pencil(UMMEMP)method is proposed.In this method,an eigenvalue pairing method,wh... In this paper,a method for designing supermassive sparse phased arrays(SMSPAs)known as the unitary modified matrix enhancement and matrix pencil(UMMEMP)method is proposed.In this method,an eigenvalue pairing method,which is inspired by the modified MEMP,effectively pairs the repeated eigenvalues intractable in the unitary matrix pencil method,and it is more effective in determining the locations of elements in the sparse array.Three numerical examples and a full-wave validation are presented to demonstrate the effectiveness of the method,implemented via SMSPA,in achieving low sidelobe level wide-angle scanning radiation patterns,circular flattop radiation patterns,and ultra wide-angle scanning radiation patterns. 展开更多
关键词 Chebyshev array circular flat-top pattern pairing method super-massive sparse phased array ultra wide-angle scanning unitary modified matrix enhancement and matrix pencil
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Analysis and optimization of microchannel array precision grinding processes with micro-structured micro-grinding tool
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作者 Jianfei JIA Qinghe ZHANG +7 位作者 Wei YANG Honghui YAO Guicheng WU Huan ZHAO Jianhui ZHU Kenan LI Bing GUO Jun QIN 《Chinese Journal of Aeronautics》 2025年第7期669-683,共15页
Micro-grinding has been widely used in aerospace and other industry.However,the small diameter of the micro-grinding tool has limited its machining performance and efficiency.In order to solve the above problems,micro... Micro-grinding has been widely used in aerospace and other industry.However,the small diameter of the micro-grinding tool has limited its machining performance and efficiency.In order to solve the above problems,micro-structure has been applied on the micro-grinding tool.A morphology modeling has been established in this study to characterize the surface of microstructured micro-grinding tool,and the grinding performance of micro-structured micro-grinding tool has been analyzed through undeformed chip thickness,abrasive edge width,and effective distance between abrasives.Then deviation analysis,path optimization and parameter optimization of microchannel array precision grinding have been finished to improve processing quality and efficiency,and the deflection angle has the most obvious effects on the rectangular slot depth,micro-structured micro-grinding tool could reduce 10%surface roughness and 20%grinding force compared to original micro-grinding tool.Finally,the microchannel array has been machined with a size deviation of 2μm and surface roughness of 0.2μm. 展开更多
关键词 GRINDING Precision grinding Microchannel array MICRO-STRUCTURE Micro-grinding tool
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Design of a Pressure Sensor Array System Based on Minecraft
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作者 Ximing Luo 《Journal of Electronic Research and Application》 2025年第5期117-131,共15页
Multimodal information sensing becomes increasingly critical under the rapid development of automation and information technology.With the ability to provide high-density and high-sensitivity pressure detection,pressu... Multimodal information sensing becomes increasingly critical under the rapid development of automation and information technology.With the ability to provide high-density and high-sensitivity pressure detection,pressure sensor arrays have been applied to a variety of fields,including intelligent robotics,medical monitoring,and industrial automation.This study proposes a pressure sensor array system based on the Minecraft game platform.The simulation and testing of the pressure sensor arrays system have been conducted using redstone circuits and pressure plates in Minecraft to simulate real-world piezoelectric pressure sensor arrays.A series of experiments verified the feasibility and effectiveness of the system. 展开更多
关键词 Pressure sensor array Minecraft Redstone circuits
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lncRNA UCA1在口腔鳞状细胞癌中的研究进展
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作者 陈玥 孙雪倩 陈敏敏 《口腔医学》 2025年第4期317-320,共4页
口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是最高发的头颈部恶性肿瘤,其发病率和死亡率仍然较高。长链非编码RNA(long non-coding RNA,lncRNA)是一类重要的非编码RNA分子,在OSCC的发生和发展中发挥着重要作用。尿路上皮癌抗原... 口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是最高发的头颈部恶性肿瘤,其发病率和死亡率仍然较高。长链非编码RNA(long non-coding RNA,lncRNA)是一类重要的非编码RNA分子,在OSCC的发生和发展中发挥着重要作用。尿路上皮癌抗原1(urothelial carcinoma associated 1,UCA1)在OSCC中高水平表达,通过miRNA的海绵作用以及激活下游信号通路调节肿瘤细胞的生物学行为。本文综述了UCA1在OSCC中的作用机制及其在肿瘤增殖、侵袭转移、耐药、诊断、治疗及预后等方面的研究进展,这有望为UCA1在OSCC的潜在临床应用提供理论基础。 展开更多
关键词 口腔鳞状细胞癌 lncRNA uca1 致癌作用 诊断和预后 肿瘤治疗
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Experimental Demonstration of Multiport Magnetron Units with Specific Power Distribution toward Phased Array Applications
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作者 Da-gui SHEN Liang-jie BI +7 位作者 Yu QIN Pan CUI Xin-yu JIANG Rui GUO Hai-long LI Bin WANG Lin MENG Yong YIN 《真空电子技术》 2025年第3期26-35,共10页
In this paper,three magnetrons with each of them having specifically designed multiple coupling ports,which deliver specific power distribution for developing a magnetron array based on efficient phase locking between... In this paper,three magnetrons with each of them having specifically designed multiple coupling ports,which deliver specific power distribution for developing a magnetron array based on efficient phase locking between them,are proposed to produce high powerμs-level pulses.To demonstrate the effectiveness of the magnetron with one and two coupling ports as a unit for efficient phase locking,we designed experimentally the coupling ports delivering~10%(the power distribution ratio)of the output power of the magnetron for coupling with other magnetron units.The effect of one and two coupling ports on the operating capability,including the power distribution ratio,anode current and frequency,is demonstrated by establishing an equivalent experimental model which can characterize an ideal operation of the array.The experimental results show that the power distribution ratio is~9%for the magnetron with one coupling port,and~12.5%(coupling port 1,2)for the magnetron with two coupling ports.This shows good uniformity of the coupling capability of the two coupling ports and provides guidance for optimizing the power distribution ratio of multiport magnetron units,which are critical for efficient phase locking in the proposed array in future and higher power arrays. 展开更多
关键词 MAGNETRONS phased array high power phase locking vacuum electronics
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Bioinspired interface-mediated multichannel sensor array for rapid and robust identification of bacteria
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作者 Ting Huang Xiaohua Zhu +4 位作者 Meiling Liu Haitao Li Youyu Zhang Yang Liu Shouzhuo Yao 《Chinese Chemical Letters》 2025年第8期613-617,共5页
Rapid and robust identification of bacteria is crucial for environmental monitoring and clinical diagnosis.Herein,a bioinspired interface-mediated multichannel sensor array was developed based on three-coloremitting a... Rapid and robust identification of bacteria is crucial for environmental monitoring and clinical diagnosis.Herein,a bioinspired interface-mediated multichannel sensor array was developed based on three-coloremitting antimicrobial functional carbon dots(FCDs)and concanavalin A doped polydopamine nanoparticles(Con A-PDA)for identification of bacteria.In this sensor,the fluorescence intensity of the three FCDs was quenched by the Con A-PDA.Upon addition different types of bacteria,the fluorescence intensity of the three FCDs was restored or further quenched.Recur to statistical analysis methods,it is employed to accurately discriminate 10 types of bacteria(including three probiotics and seven pathogenic bacteria)in natural water samples and human urine samples.The discrimination ability of the sensor array was highly enhanced via different competing binding of the FCDs and the bacteria toward Con A-PDA.The proposed array-based method offers a rapid,high-throughput,and reliable sensing platform for pathogen diagnosis in the field of environmental monitoring and clinical diagnosis. 展开更多
关键词 BACTERIA Sensor array Bioinspired interface Carbon dots Polydopamine nanoparticles
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