期刊文献+
共找到710篇文章
< 1 2 36 >
每页显示 20 50 100
Relief From Hunger
1
作者 DERRICK SILIMINA 《ChinAfrica》 2026年第3期42-43,共2页
Chinese food aid nourishes over 188,000 Zambians In the arid terrain of Shang’ombo District,approximately 850 km west of Lusaka,Zambia’s capital,Charity Imbuwa received a Chinese food-aid pack and shared it with her... Chinese food aid nourishes over 188,000 Zambians In the arid terrain of Shang’ombo District,approximately 850 km west of Lusaka,Zambia’s capital,Charity Imbuwa received a Chinese food-aid pack and shared it with her children at their home near the Angola border. 展开更多
关键词 HUNGER shangombo district arid terrain lusaka CAPITAL zambians RELIEF chinese food aid
原文传递
Soil temperature and water content as determinants of non-structural carbohydrates concentrations in Picea crassifolia under continuous drought
2
作者 Quanyan Tian Zhibin He +5 位作者 Shengchun Xiao Xiangyan Feng Huma Batool Xiaomei Peng Pengfei Lin Xi Zhu 《Journal of Forestry Research》 2026年第1期188-200,共13页
Non-structural carbohydrates(NSCs)are critical for plant drought adaptation,but their environmental drivers under prolonged drought remains unclear.We investigated seasonal NSCs dynamics in the leaf,stem and root of P... Non-structural carbohydrates(NSCs)are critical for plant drought adaptation,but their environmental drivers under prolonged drought remains unclear.We investigated seasonal NSCs dynamics in the leaf,stem and root of Picea crass ifolia(Qinghai spruce)during the growing seasons of2021-2023 under intensifying drought at three altitudes in Qilian Mountains,Northwest China.Our results revealed synchronous seasonal patterns in soluble sugar,starch,and total non-structural carbohydrate within the same year,contrasting with marked altitudinal disparities.As drought progressed(from 2021 to 2023),soluble sugars initially increased(2022)then declined(2023),while starch showed consistent reduction(except leaves).Moreover,the altitude of peak NSCs concentrations shifted from 3200 m in 2021to 2700 m in 2023.In particular,prolonged drought alters the environmental factors affecting NSCs.NSCs demonstrated significant positive correlations with soil temperature during humid 2021,then negatively with air temperature,vapor pressure deficit,and precipitation during 2022's initial drought,whereas under 2023's persistent drought conditions,soil temperature and water content emerged as dominant drivers.Concurrently,the ratio of soluble sugar to starch transitioned from air temperature and precipitation associations(2021-2022)to soil parameter dependence in2023.These findings provide new insights into the seasonal carbon dynamics of Qinghai spruce and the environmental response mechanisms under increasing drought stress,contributing to a better understanding of tree physiological adaptations in drought stress. 展开更多
关键词 Non-structural carbohydrates Evergreen conifer Environmental factors DROUGHT Arid mountains
在线阅读 下载PDF
Climate and human drivers of surface water changes in the Zavkhan River-Khyargas Lake Basin,western Mongolia
3
作者 BATSUREN Dorjsuren VALERY A.Zemtsov +4 位作者 ERDENEBAYAR Bavuu SANDELGER Dorligjav YAN Denghua GAO Hongkai ALTANBOLD Enkhbold 《Journal of Geographical Sciences》 2026年第1期255-280,共26页
This study investigates climate-and human-induced hydrological changes in the Zavkhan River-Khyargas Lake Basin,a highly sensitive arid and semi-arid region of Central Asia.Using Mann-Kendall,innovative trend analysis... This study investigates climate-and human-induced hydrological changes in the Zavkhan River-Khyargas Lake Basin,a highly sensitive arid and semi-arid region of Central Asia.Using Mann-Kendall,innovative trend analysis,and Sen's slope estimation methods,historical climate trends(1980-2100)were analyzed,while land cover changes represented human impacts.Future projections were simulated using the MIROC model with Shared Socioeconomic Pathways(SSPs)and the Tank model.Results show that during the past 40 years,air temperature significantly increased(Z=3.93^(***)),while precipitation(Z=-1.54^(*))and river flow(Z=-1.73^(*))both declined.The Khyargas Lake water level dropped markedly(Z=-5.57***).Land cover analysis reveals expanded cropland and impervious areas due to human activity.Under the SSP1.26 scenario,which assumes minimal climate change,air temperature is projected to rise by 2.0℃,precipitation by 21.8 mm,and river discharge by 1.61 m^(3)/s between 2000 and 2100.These findings indicate that both global warming and intensified land use have substantially altered hydrological and climatic processes in the basin,highlighting the vulnerability of western Mongolia's water resources to combined climatic and anthropogenic influence. 展开更多
关键词 arid zone semi-arid zone climate change land cover trend analysis western Mongolia
原文传递
Spatial Variation in Grain Size of Riparian Dunes in Typical Cold and Arid Deserts of China and Its Implications for Identifying Sediment Sources
4
作者 LI Xiaomei YAN Ping +3 位作者 CAO Liguo WANG Xiaoxu LIU Xiaokang CHEN Hao 《Chinese Geographical Science》 2026年第2期291-305,共15页
Riparian dunes in deserts exhibit unique geographic features due to aeolian-fluvial interactions.In this study,we collected 510 surface sediment samples from eight drainage basins and conducted a systematic analysis t... Riparian dunes in deserts exhibit unique geographic features due to aeolian-fluvial interactions.In this study,we collected 510 surface sediment samples from eight drainage basins and conducted a systematic analysis to examine the grain size characteristics of major riparian dunes in the typical cold and arid deserts of China.The results indicate that major riparian dunes of deserts in study area can be classified into three types based on their grain size characteristics.The Bartlett test of sphericity and the Kaiser-Meyer-Olkin(KMO)test were also performed,and their significance values were found to be 0.000 and 0.584,respectively.The results of the principal component analysis revealed that the cumulative contribution rate of the total variance reached 85.9%for the two principal components with characteristic roots greater than 1.0.The primary principal component included medium sand,whereas the secondary principal component included fine sand.We conducted a cluster analysis and classified the samples into three major types.Type I rivers include the Keriya River,Langqu River,Tora River and Heihe River,which are characterized by by fine particle size,and well-sorted.Type II includes Mu Bulag River,Kuye River,and the Xar Moron River,Compared with type I,it has a relatively coarser mean grain size and relatively poor sorting for this type.Type III includes the Maquan River,which is characterized mainly by fine sand and medium sand,accounting for more than 90%,and the sorting coefficient(0.52)suggests relatively well sorting in this pattern.Moreover,principal component analysis was applied to determine the particle sizes of samples from different watersheds.Moreover,these sediments exhibit both hydromorphic and aeolian features.At the drainage basin scale,the mode and intensity of aeolian-fluvial interactions depend on climatic conditions.In arid and semi-arid climate regions,wind is the dominant force,and the grain size exhibits significant aeolian features.Conversely,in the semi-humid region,flowing water is the dominant force,and riparian dunes in this region are formed by aeolian-fluvial interaction.The angle between the wind direction and flow direction in different reaches influences both the supply of sediment sources and the development of riparian dunes.This study will provide a new perspective for evaluating aeolian-fluvial interactions on riparian dunes in the deserts of China’s cold and arid regions. 展开更多
关键词 riparian dune grain size aeolian-fluvial interaction cold and arid deserts China
在线阅读 下载PDF
Multi-physical modeling of climate-driven elasto-plastic deformation,stress redistribution,and water potential in desiccation-cracked soils of arid regions
5
作者 Milad Jabbarzadeh Hamed Sadeghi 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期772-791,共20页
This study presents a multi-physical modeling approach to analyze the dynamics of moisture potential and stress-deformation features near deep desiccation cracks in clayey soils under three consecutive years’climate ... This study presents a multi-physical modeling approach to analyze the dynamics of moisture potential and stress-deformation features near deep desiccation cracks in clayey soils under three consecutive years’climate variability in an arid region.A triple research approach of statistical analysis,analytical framework,and numerical modeling was used to investigate the complex thermo-hydro-mechanical behavior of desiccation-cracked soil,incorporating realistic climatic data of Qom,Iran.The results revealed the interplay between stress,strain,and pore water pressure over time,demonstrating that soil experiences significant swelling and shrinkage due to cyclic wetting and drying.The horizontal stress distribution shows compressive stress concentration at crack tips during wetting,transitioning to tensile stresses uniformly across the soil surface during drying paths.Similarly,vertical stress distributions exhibit localized compressive stresses along crack boundaries during wetting and tensile stresses during drying,highlighting the critical stress conditions at crack tips.The model differentiates between microstructural and macrostructural changes in porosity.Annual trends in micro-porosity revealed cyclic-dependent behavior,with significant volumetric changes occurring in the first year,stabilizing with successive cycles.The results also indicated that part of the volumetric changes are irreversible,with volumetric plastic strain increasing exponentially but at a decreasing rate over three years.Principal stress analysis indicates a shift from compressive to tensile stress states around cracks,driven by climate-induced wetting and drying cycles.These findings underscore the critical role of climate variability in shaping cracked soil behavior in arid regions,providing insights into the heterogeneous behavior of cracked soil surfFicial layers. 展开更多
关键词 Soil-atmosphere interaction Moisture potential dynamics Stress-deformation characteristics Desiccation cracks Arid climate
在线阅读 下载PDF
Flammability of plant communities in arid and semi-arid ecosystems: Identifying key drivers and management implications
6
作者 Mosayeb HOJATI Azam KHOSRAVI MASHIZI 《Journal of Arid Land》 2026年第2期304-321,共18页
Arid and semi-arid ecosystems are prone to extensive fires due to specific climatic conditions,sparse vegetation cover,and high density of fine fuels.Understanding the flammability characteristics of land covers is es... Arid and semi-arid ecosystems are prone to extensive fires due to specific climatic conditions,sparse vegetation cover,and high density of fine fuels.Understanding the flammability characteristics of land covers is essential for fire management and designing land restoration programs in arid and semi-arid ecosystems.This study provided a new approach to evaluate the flammability of shrublands and woodlands using flammability indices(FIs)including time to ignition(TI),duration of combustion(DC),and flame height(FH)of plant species and their relative frequencies in the Dalfard Basin of southeastern Iran.The results showed that there was a significant difference in FIs between land covers.Shrublands had higher flammability potential compared with woodlands.Plant moisture content had a negative relationship with TI(P<0.010)and no significant relationship with DC and FH(P>0.050).Artemisia spp.,Astragalus gossypinus Fischer,Amygdalus scoparia Spach,and Cymbopogon jwarancusa(Jones)Schult.had the highest FI.Tree species such as Rhazya stricta Decne.,and Pistacia atlantica Desf.showed greater resistance to fire.Using principal component analysis,the relationship between species and FIs was examined,and TI of wet fuel was the most important FI in relation to species.Structural equation model showed that life form(P<0.001)was the most important flammability driver.Precipitation(P<0.010)and legume species(P<0.010)were significantly related to the flammability in arid land.This study emphasizes the importance of managing high-risk species and using resistant species in vegetation restoration and shows that combining species FIs with their abundance is an effective tool for assessing fire risk and fuel management at the plant community scale. 展开更多
关键词 duration of combustion plant moisture fire management structural equation model arid ecosystems
在线阅读 下载PDF
Thermal Performance and Design Optimization of a High-Concentration Photovoltaic System for Arid Environments
7
作者 Taher Maatallah Nagmeldeen A.M.Hassanain +6 位作者 GaydaaAl Zohbi Farooq Saeed Muhammad Saleem Nassir Hariri Mohamed Elsharawy Tapas Kumar Mallick Fahad Gallab Al-Amri 《Frontiers in Heat and Mass Transfer》 2026年第1期140-169,共30页
High-concentration photovoltaic(HCPV)systems present significant thermal management challenges due to the intense heat fluxes generated under concentrated solar irradiation,especially in arid environments.Effective he... High-concentration photovoltaic(HCPV)systems present significant thermal management challenges due to the intense heat fluxes generated under concentrated solar irradiation,especially in arid environments.Effective heat dissipation is critical to prevent performance degradation and structural failure.This study investigates the thermal performance and design optimization of an enhanced HCPV module,integrating numerical,analytical,and experimental methods.A coupled optical-thermal-electrical model was developed to simulate ray tracing,heat transfer,and temperature-dependent electrical behaviour,with predictions validated under real-world desert conditions.Compared to a baseline commercial module operating at 106℃,the optimized design achieved a peak temperature reduction of 16℃,lowering the cell temperature to 90℃under a concentration ratio of 961×and direct normal irradiance(DNI)of 950 W/m^(2).The total thermal resistance was reduced from 0.25 to 0.15 K/W(a 40%improvement),and the electrical efficiency increased from 37.5%to 38.6%,representing a relative gain of approximately 3.1%.The system consistently maintained a fill factor exceeding 78%,underscoring stable performance under high thermal load.These findings demonstrate that targeted thermal design,informed by integrated modeling,is essential for unlocking the reliability and efficiency of high-flux solar energy systems. 展开更多
关键词 Arid climate applications convective cooling heat transfer enhancement high-concentration photovoltaics(HCPV) heat sink optimization numerical thermal analysis thermal management thermal resistance
在线阅读 下载PDF
Effect of drought and elevated temperature on the physiological and biochemical properties of C_(3)and C_(4)halophytes in Amaranthaceae
8
作者 Zulfira RAKHMANKULOVA Elena SHUYSKAYA +3 位作者 Maria PROKOFIEVA Kristina TODERICH Luizat SAIDOVA ZHANG Yuanming 《Journal of Arid Land》 2026年第1期131-149,共19页
Rising temperatures and increased droughts caused by climate change significantly reduce crop yields.Halophytes with different photosynthetic metabolism types have specific mechanisms for resistance to climatic factor... Rising temperatures and increased droughts caused by climate change significantly reduce crop yields.Halophytes with different photosynthetic metabolism types have specific mechanisms for resistance to climatic factors.This study analyzed the morphophysiological,biochemical,and molecular-genetic mechanisms of tolerance and adaptation in halophytes,promising candidates for the restoration of salt affected lands in arid and semi-arid areas.Experiments under drought(D)and elevated temperature(eT),as well as their combined action(eT+D),were performed on Atriplex verrucifera M.Bied.(C_(3)plant)and Climacoptera crassa(M.Bieb.)Botsch.(C_(4)-NAD-ME plant)with different types of photosynthesis.The activity of photosystem I(PSI)and the efficiency of photosystem II(PSII)were measured,along with the expression of genes involved in the light(psaA,psaB,psbA,CAB,Fd1,PGR5,and ndhH)and dark(rbcL,Ppc2,and PPDK)reactions of photosynthesis.The content of key carboxylating enzymes ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)and phosphoenolpyruvate carboxylase(PEPC),as well as the photorespiration enzyme glycine decarboxylase(GDC),were assessed.Plant growth and water-salt balance parameters,and activity of enzymes in the malate dehydrogenase(MDH)system nicotinamide adenine dinucleotide(phosphate)(NAD(P))-MDH and NAD(P)-malic enzyme(ME)were also examined.A multivariate analysis of the experimental results revealed that A.verrucifera and C.crassa were both resistant to the effects of these climatic stressors.The tolerance mechanisms of both species were significantly influenced by a high level of photosynthetic plasticity.Nevertheless,differences were observed in the protective mechanisms underlying tolerance.In the C_(3)species,dissipative processes associated with non-photochemical quenching(NPQ)of PSII and MDH system enzymes(malate valves)were activated,particularly under osmotic stress.The negative effects in the C_(3)plants were caused by the combined action of eT+D,which was compensated by an increased expression of rbcL,psaA,CAB,and especially PGR5,i.e.,genes encoding Rubisco large subunit and PSI components:apoproteins A,chlorophyll a/b-associated protein(CAB)of light-harvesting complex,and proton gradient regulation 5(PGR5)protein of the main pathway of cyclic electron transport(CET)around PSI.In C_(4)species,the protective MDH complex was expressed to a lesser extent,but activation of the C_(4)carbon-concentrating mechanism(CCM)and upregulation of PGR5 expression were observed,particularly under the individual action of the factors.Under the combined stress of eT+D,C.crassa exhibited a synergistic effect,where the increase in NPQ level and NAD-ME activity,as well as decrease in NADP-ME activity was less pronounced compared with the effect of singular factors.Comparative physiological,biochemical,and molecular analyses of how C_(3)and C_(4)species response to individual and combined climatic factors provide new insights into sustainable plant adaptation strategies in the face of global climate change.Considering the high nutritional value of these two fodder species,a technological approach could be developed to improve the productivity of salt affected lands. 展开更多
关键词 Atriplex verrucifera M.Bied. Climacoptera crassa(M.Bieb.)Botsch. CHENOPODIACEAE photosynthesis cyclic electron transport(CET) malate valves arid land
在线阅读 下载PDF
Projection and reclassification of land use types in Lanzhou,Northwest China
9
作者 ZHU Rong JIANG Youyan LEI Runzhi 《Journal of Arid Land》 2026年第1期17-33,共17页
Land use in arid and semi-arid regions has a substantial effect on climate,environment,and biodiversity,thereby projecting the spatiotemporal changes in land use and the subsequent effects.This study employed the loca... Land use in arid and semi-arid regions has a substantial effect on climate,environment,and biodiversity,thereby projecting the spatiotemporal changes in land use and the subsequent effects.This study employed the locally calibrated Future Land Use Simulation(FLUS)model,which coupled system dynamics with cellular automata and integrated an artificial neural network algorithm and a roulette wheel selection mechanism.We projected future land use(2020–2100)dynamics of Lanzhou,a typical river valley city in Northwest China,under three different Shared Socioeconomic Pathway(SSP)scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5).The simulation results were validated and subsequently reclassified using the International Geosphere Biosphere Programme(IGBP)system to produce a dataset suitable for driving climatic and environmental models.Under the SSP1-2.6 scenario,urban and built-up land expanded consistently,whereas irrigated cropland and pasture as well as grassland contracted continuously.Conversely,the SSP5-8.5 scenario was characterized by a contraction of urban and built-up land,and relative stability of irrigated cropland and pasture as well as grassland.The SSP2-4.5 scenario presented a more complex trade-off,where urban and built-up land and grassland increased first and then decreased,whereas irrigated cropland and pasture followed an opposite trajectory.A significant inverse relationship between urban and built-up land and irrigated cropland and pasture was observed under all scenarios,underscoring the fundamental spatial competition that prevailed in this land-constrained valley city.Furthermore,the negative correlation of grassland with urban and built-up land,coupled with the positive correlation of grassland with irrigated cropland and pasture under both the SSP1-2.6 and SSP5-8.5 scenarios,indicated an evolution from broad confrontation to intricate internal trade-offs within the urban–agricultural–ecological system.This study underscored the critical influence of regional topographic and hydrological constraints on land-use evolution in arid regions,providing guidance for water resource management and ecosystem protection in Lanzhou,with applications for sustainable land-use planning in other arid and semi-arid river valley cities. 展开更多
关键词 land use changes Future Land Use Simulation(FLUS)model International Geosphere Biosphere Programme(IGBP) Shared Socioeconomic Pathways(SSPs) arid and semi-arid regions Northwest China
在线阅读 下载PDF
ARID1B基因缺失促进NSCLC细胞的增殖、迁移和侵袭能力的研究
10
作者 朱琳琳 张绪超 《中国肺癌杂志》 北大核心 2025年第3期165-175,共11页
背景与目的SWI/SNF染色质重塑复合物(switch/sucrose nonfermentable chromatin-remodeling complex)的异常与多种癌症密切相关,ARID1B(AT-rich interaction domain 1B)是SWI/SNF复合物的核心亚基之一。ARID1B基因突变或拷贝数缺失与DN... 背景与目的SWI/SNF染色质重塑复合物(switch/sucrose nonfermentable chromatin-remodeling complex)的异常与多种癌症密切相关,ARID1B(AT-rich interaction domain 1B)是SWI/SNF复合物的核心亚基之一。ARID1B基因突变或拷贝数缺失与DNA损伤反应受损、染色质可及性改变有关。然而,ARID1B缺失是否影响非小细胞肺癌(non-small cell lung cancer,NSCLC)细胞的增殖、迁移和侵袭能力及其分子机制仍缺乏系统研究。本研究旨在揭示ARID1B基因缺失对NSCLC细胞恶性表型的调控作用及其分子机制。方法通过公共数据库分析ARID1B基因与肺癌患者预后之间的相关性以及其在肺癌组织中的表达水平。CRISPR/Cas9(clustered regularly interspaced short palindromic repeat)技术构建ARID1B基因稳定敲除(knockout,KO)的细胞株。采用平板克隆实验检测细胞增殖情况,Transwell细胞迁移、侵袭实验检测细胞迁移能力变化。RNA-Seq进行差异基因的表达、富集分析。利用蛋白印迹(Western blot,WB)验证ARID1B基因敲除效果,检测上皮间充质转化(epithelial-mesenchymal transition,EMT)标志物、促分裂素原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号通路相关蛋白变化。构建裸鼠成瘤模型,并比较对照和ARID1B缺失细胞的成瘤能力。结果低ARID1B表达与肺癌患者不良预后有显著关联,其总生存期较短。ARID1B在肺癌细胞中的表达水平较正常细胞显著降低。ARID1B缺失型细胞增殖、迁移和侵袭能力增强。动物实验中,ARID1B基因缺失组成瘤速度加快。RNA-Seq结果进行富集分析可见差异基因主要在MAPK、磷脂酰肌醇3-激酶/蛋白激酶B(phosphoinositide 3-kinase/protein kinase B,PI3K/Akt)等信号通路富集。WB证明ARID1B基因缺失细胞E-cadherin、N-cadherin、Vimentin表达发生变化,MAPK、p-MAPK表达增加。结论成功建立A549-ARID1B KO和PC9-ARID1B KO细胞株,ARID1B缺失细胞株在体外、体内生物学行为水平和转录组测序水平均提示具有高迁移、侵袭、增殖潜能。EMT标志物表达的变化、MAPK信号通路的激活提示ARID1B缺失型NSCLC可能的转移机制。 展开更多
关键词 ARID1B 肺肿瘤 增殖 迁移 MAPK 转录组学分析
暂未订购
ARID5B基因多态性与儿童急性淋巴细胞白血病风险及微小残留病的关系研究
11
作者 马钰 高雅黛 +2 位作者 郭静 郑晓敏 张晓春 《中国实验血液学杂志》 北大核心 2025年第5期1269-1273,共5页
目的:探讨ARID5B基因单核苷酸多态性与宁夏地区回、汉族儿童急性淋巴细胞白血病(ALL)风险及微小残留病(MRD)的相关性。方法:采用病例对照研究,使用荧光共振能量转移技术,对54例ALL患儿及年龄、性别、民族相匹配的对照人群的ARID5B基因... 目的:探讨ARID5B基因单核苷酸多态性与宁夏地区回、汉族儿童急性淋巴细胞白血病(ALL)风险及微小残留病(MRD)的相关性。方法:采用病例对照研究,使用荧光共振能量转移技术,对54例ALL患儿及年龄、性别、民族相匹配的对照人群的ARID5B基因多态性位点进行检测,分析不同基因型ALL的易感性及其与MRD的相关性。结果:两组患儿rs10994982、rs7089424、rs10740055、rs7073837、rs4245595、rs7090445位点基因型及等位基因频率比较差异均无统计学意义(P>0.05)。在rs10821936位点上,ALL组T/T基因型和T等位基因频率均显著高于对照组(均P<0.05),ARID5B基因rs10821936的C/C基因型是ALL患儿MRD早期阳性的危险因素(P<0.05)。结论:ARID5B基因rs10821936与儿童ALL发生及MRD有一定相关性。 展开更多
关键词 儿童 急性淋巴细胞白血病 ARID5B基因 单核苷酸多态性 微小残留病
原文传递
ARID1B基因变异所致Coffin-Siris综合征合并孤独症谱系障碍2例报道并文献复习
12
作者 李梦月 李慧慧 +6 位作者 黄永 王甘雨 韩惠惠 孙爽 史晓依 王阳阳 王亚哲 《中国儿童保健杂志》 北大核心 2025年第1期112-116,共5页
Coffin-Siris 综合征(Coffin-Siris syndrome, CSS)是罕见的遗传性综合征,为常染色体显性遗传,其临床表现为不同程度的智力障碍、言语障碍、面部粗糙、生长障碍、发育迟缓伴第五指指甲或指骨缺如、胼胝体发育不全[1]。其他临床表型特征... Coffin-Siris 综合征(Coffin-Siris syndrome, CSS)是罕见的遗传性综合征,为常染色体显性遗传,其临床表现为不同程度的智力障碍、言语障碍、面部粗糙、生长障碍、发育迟缓伴第五指指甲或指骨缺如、胼胝体发育不全[1]。其他临床表型特征,如喂养困难、行为异常、听力障碍、癫痫发作及反复感染等症状。当前,已报道多个基因和CSS疾病相关,如SMARCA4、ARID1A、SMARCB1、ARID1B和SMARCE1等[2]。 展开更多
关键词 Coffin-Siris综合征 孤独症谱系障碍 ARID1B基因 基因突变
原文传递
ARID1A与PIK3CA突变在卵巢子宫内膜异位症恶变中的研究进展 被引量:2
13
作者 张云凤 张宛玥 +4 位作者 卢悦 王阳阳 井佳雨 牟婧祎 王悦(审校) 《国际妇产科学杂志》 2025年第1期19-22,共4页
子宫内膜异位症是一种常见的妇科疾病,育龄期女性的发病率为6%~10%。虽然子宫内膜异位症在形态学上呈良性表现,但易发生种植、侵袭及远处转移。卵巢子宫内膜异位症是最常见的子宫内膜异位症之一,治疗后易复发,严重威胁女性生殖健康。近... 子宫内膜异位症是一种常见的妇科疾病,育龄期女性的发病率为6%~10%。虽然子宫内膜异位症在形态学上呈良性表现,但易发生种植、侵袭及远处转移。卵巢子宫内膜异位症是最常见的子宫内膜异位症之一,治疗后易复发,严重威胁女性生殖健康。近年来大量研究发现,卵巢子宫内膜异位症具有恶变为卵巢癌的潜力。卵巢子宫内膜异位症恶变过程中最常见的是AT丰富结合域1A(AT-rich interaction domain 1A,ARID1A)与磷脂酰肌醇3激酶催化亚单位α(phosphatidylinositol 3-kinase catalytic subunit alpha,PIK3CA)基因突变,且发生在恶变早期。综述了ARID1A与PIK3CA突变在卵巢子宫内膜异位症恶变中的研究现状。 展开更多
关键词 子宫内膜异位症 卵巢肿瘤 基因 突变 ARID1A PIK3CA
暂未订购
Variations of soil moisture and its influencing factors in arid and semi-arid areas,China 被引量:2
14
作者 NIU Jiqiang LIU Zijian +5 位作者 CHEN Feiyan LIU Gangjun ZHOU Junli ZHOU Peng LI Hongrui LI Mengyang 《Journal of Arid Land》 2025年第5期624-643,共20页
Soil moisture(SM)is a critical variable in terrestrial ecosystems,especially in arid and semi-arid areas where water sources are limited.Despite its importance,understanding the spatiotemporal variations and influenci... Soil moisture(SM)is a critical variable in terrestrial ecosystems,especially in arid and semi-arid areas where water sources are limited.Despite its importance,understanding the spatiotemporal variations and influencing factors of SM in these areas remains insufficient.This study investigated the spatiotemporal variations and influencing factors of SM in arid and semi-arid areas of China by utilizing the extended triple collation(ETC),Mann-Kendall test,Theil-Sen estimator,ridge regression analysis,and other relevant methods.The following findings were obtained:(1)at the pixel scale,the long-term monthly SM data from the European Space Agency Climate Change Initiative(ESA CCI)exhibited the highest correlation coefficient of 0.794 and the lowest root mean square error(RMSE)of 0.014 m^(3)/m^(3);(2)from 2000 to 2022,the study area experienced significant increase in annual average SM,with a rate of 0.408×10^(-3)m^(3)/(m^(3)•a).Moreover,higher altitudes showed a notable upward trend,with SM increasing rates at 0.210×10^(-3)m^(3)/(m^(3)•a)between 1000 and 2000 m,0.530×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m,and 0.760×10^(-3)m^(3)/(m^(3)•a)at altitudes above 4000 m;(3)land surface temperature(LST),root zone soil moisture(RSM)(10-40 cm depth),and normalized difference vegetation index(NDVI)were identified as the primary factors influencing annual average SM,which accounted for 34.37%,24.16%,and 22.64%relative contributions,respectively;and(4)absolute contribution of LST was more significant in subareas at higher altitudes,with average absolute contributions of 0.800×10^(-3)m^(3)/(m^(3)•a)between 2000 and 4000 m and 0.500×10^(-2) m^(3)/(m^(3)•a)above 4000 m.This study reveals the spatiotemporal variations and main influencing factors of SM in Chinese arid and semi-arid areas,highlighting the more pronounced absolute contribution of LST to SM in high-altitude areas,providing valuable insights for ecological research and water resource management in these areas. 展开更多
关键词 soil moisture arid and semi-arid areas remote sensing extended triple collation ridge regression analysis
在线阅读 下载PDF
Performance of stabilized copper mine tailings with freeze-thaw and wet-dry seasonal cycles 被引量:2
15
作者 Uddav Ghimire Tejo V.Bheemasetti Hee-Jeong Kim 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1418-1428,共11页
Approximately 3.44 billion tons of copper mine tailings(MT)were produced globally in 2018 with an increase of 45%from 2010.Significant efforts are being made to manage these tailings through storage facilities,recycli... Approximately 3.44 billion tons of copper mine tailings(MT)were produced globally in 2018 with an increase of 45%from 2010.Significant efforts are being made to manage these tailings through storage facilities,recycling,and reuse in different industries.Currently,a large portion of tailings are managed through the tailing storage facilities(TSF)where these tailings undergo hydro-thermal-mechanical stresses with seasonal cycles which are not comprehensively understood.This study presents an investigative study to evaluate the performance of control and cement-stabilized copper MT under the influence of seasonal cycles,freeze-thaw(F-T)and wet-dry(W-D)conditions,representing the seasonal variability in the cold and arid regions.The control and cement-stabilized MT samples were subjected to a maximum of 12 F-T and 12 W-D cycles and corresponding micro-and-macro behavior was investigated through scanning electron microscope(SEM),volumetric strain(εvT,wet density(r),moisture content loss,and unconfined compressive strength(UCS)tests.The results indicated the vulnerability of Copper MT to 67%and 75%strength loss reaching residual states with 12 F-T and 8 W-D cycles,respectively.Whereas the stabilized MT retained 39%-55%and 16%-34%strength with F-T and W-D cycles,demonstrating increased durability.This research highlights the impact of seasonal cycles and corresponding strength-deformation characteristics of control and stabilized Copper MT in cold and arid regions. 展开更多
关键词 Copper mine tailings(MT) Stabilization Seasonal cycles Cold and arid region
在线阅读 下载PDF
Water–Heat Synergy Shapes Evapotranspiration–Precipitation Coupling Patterns across Northern China 被引量:1
16
作者 Zesu YANG Qiang ZHANG +4 位作者 Yu ZHANG Ping YUE Jian ZENG Lixia MENG Yulei QI 《Advances in Atmospheric Sciences》 2025年第6期1167-1178,共12页
Northern China is a prominent “hotspot” for land–atmosphere interactions, with substantial gradients in both moisture and thermal conditions. Previous studies have identified a link between land–atmosphere couplin... Northern China is a prominent “hotspot” for land–atmosphere interactions, with substantial gradients in both moisture and thermal conditions. Previous studies have identified a link between land–atmosphere coupling and the individual roles of each factor, but the synergistic effect of the two factors remains unclear. This study considers the covariation of evapotranspiration and precipitation to assess evapotranspiration–precipitation(ET–P) coupling across northern China,exploring its spatial variations and their linkage to water and heat factors. Our findings reveal a transition from strongly positive coupling in the northwest to weakly negative coupling in the southeast, peaking in spring. These spatial variations are attributable to water(soil moisture) and heat(air temperature), which explain 39% and 25% of the variability,respectively. The aridity index(AI), a water–heat synergy factor, is the dominant factor, explaining 66% of the spatial variation in ET–P coupling. As the AI increases, ET–P coupling shifts from strongly positive to weakly negative, with an AI around 0.7. This shift is determined by a shift in the evapotranspiration–lifting condensation level(LCL) coupling under an AI change. Regions with an AI below 0.7 experience water-limited evapotranspiration, where increased soil moisture enhances evapotranspiration, reduces sensible heat(H), and lowers the LCL, resulting in a negative ET–LCL coupling.Conversely, regions with an AI above 0.7 experience energy-limited evapotranspiration, where the positive ET–LCL coupling reflects a positive H–LCL coupling or a positive impact of the LCL on evapotranspiration. This analysis advances our understanding of the intricate influences of multifactor surface interactions on the spatial variations of land–atmosphere coupling. 展开更多
关键词 land–atmosphere interaction EVAPOTRANSPIRATION PRECIPITATION aridity index climate transition zone
在线阅读 下载PDF
Applicability of Different Indices for Delineating the Boundary of Arid Region:A Case Study in Northwestern China 被引量:1
17
作者 Xue Peng Xiang Li +3 位作者 Yingyibing Shen Xuehua Che Shipei Dong Zhuolun Li 《Journal of Earth Science》 2025年第1期212-222,共11页
Arid regions are vital components of Earth’s land surface.Clarifying the area/boundary of arid region is crucial for comprehending area changes and potential mechanisms.However,the accuracy and applicability of arid ... Arid regions are vital components of Earth’s land surface.Clarifying the area/boundary of arid region is crucial for comprehending area changes and potential mechanisms.However,the accuracy and applicability of arid region boundary delineated by different indices remain unclear.In this study,the annual precipitation(AP),humidity index(H),and aridity index(K)were calculated for delineating arid region of China using 106 meteorological stations during 1990–2019.The results suggest that AP and H can accurately delineate arid region,because they are consistent with the distribution of typical soil and vegetation in arid region,whereas K is not.Moreover,AP is the best index for delineating arid region in regions with limited meteorological data,especially in studying long-term patterns and mechanisms of area changes.The accuracy of delineating arid region using H is enhanced in regions with abundant meteorological data.Over the past 30 years,influenced by the increase of atmospheric moisture influx and precipitation,the area in arid region of northwestern China decreased by 70×10^(3)–90×10^(3)km^(2),resulting in the present area of approximately 1.55×10^(6)km^(2).This study provides appropriate indices for delineating arid region,contributing to improving our knowledge of regional responses difference to climate change. 展开更多
关键词 climate regionalization arid region climate change northwestern China Earth Science
原文传递
ARID1A通过AKT信号通路调控肺腺癌细胞增殖能力
18
作者 刘智荣 赵淑芳 王龙飞 《沈阳医学院学报》 2025年第3期244-249,共6页
目的:探讨肿瘤抑癌基因ARID1A(AT-rich interaction domain 1A)对肺腺癌细胞增殖的调控作用,及其与蛋白激酶B(protein kinase B,AKT)信号通路的分子机制的关联。方法:采用慢病毒转染技术构建ARID1A稳定过表达的A549/H1299细胞模型,通过R... 目的:探讨肿瘤抑癌基因ARID1A(AT-rich interaction domain 1A)对肺腺癌细胞增殖的调控作用,及其与蛋白激酶B(protein kinase B,AKT)信号通路的分子机制的关联。方法:采用慢病毒转染技术构建ARID1A稳定过表达的A549/H1299细胞模型,通过RT-PCR和Western blot验证转染效率;利用CCK-8检测细胞活力、EdU染色法评估细胞增殖率;划痕实验分析细胞迁移能力;活/死双染(Calcein/PI染色)与台盼蓝染色检测细胞死亡;Western blot检测AKT磷酸化水平;通过AKT抑制剂MK-2206(1μmol/L)处理过表达细胞,验证AKT通路在增殖调控中的作用。结果:ARID1A过表达显著抑制A549/H1299细胞增殖及迁移能力,并上调p-AKT水平;MK-2206处理后,过表达ARID1A组细胞增殖率被明显抑制;细胞死亡实验显示,过表达ARID1A对A549/H1299细胞死亡率无显著影响。结论:ARID1A通过激活AKT信号通路特异性抑制肺腺癌细胞增殖及迁移,提示靶向AKT通路可能为ARID1A缺失型肺腺癌患者的精准治疗提供潜在靶点。 展开更多
关键词 ARID1A 肺腺癌 AKT 细胞增殖
暂未订购
ARID1A蛋白表达缺失与胃腺癌组织学分化及淋巴结转移的临床病理学分析
19
作者 王晨曦 王龙飞 王耀辉 《川北医学院学报》 2025年第12期1511-1515,共5页
目的:探讨ARID1A蛋白表达缺失与胃腺癌组织学分化及淋巴结转移的关系,并分析其潜在的临床病理学意义。方法:回顾性分析行根治性切除的96例胃腺癌患者的临床资料。所有病例均保存有完整的石蜡包埋组织标本及临床病理学资料。肿瘤组织采... 目的:探讨ARID1A蛋白表达缺失与胃腺癌组织学分化及淋巴结转移的关系,并分析其潜在的临床病理学意义。方法:回顾性分析行根治性切除的96例胃腺癌患者的临床资料。所有病例均保存有完整的石蜡包埋组织标本及临床病理学资料。肿瘤组织采用苏木精-伊红(HE)染色评估组织学分化程度、Lauren分型、淋巴结转移、脉管侵犯(LVI)、神经侵犯(PNI)、浸润深度(pT分期)等病理特征。免疫组织化学(IHC)检测ARID1A蛋白的表达状态,判定标准为细胞核完全缺失染色定义为“缺失表达”。同时收集患者的性别、年龄、肿瘤部位、EB病毒(EBV)状态、微卫星不稳定性(MSI)状态等临床病理参数。分析ARID1A缺失与各临床病理学特征的关系,并进一步应用多因素Logistic回归模型评估胃腺癌淋巴结转移的独立危险因素。结果:96例患者中,ARID1A蛋白缺失表达率为35.4%(34/96)。单因素分析显示,ARID1A缺失与组织学分化程度、Lauren分型、淋巴结转移、pT分期及EBV状态均相关(P<0.05),而与性别、年龄、LVI、PNI及MSI状态均无相关性(P>0.05)。多因素Logistic回归分析表明,pT分期(HR=2.631,95%CI:1.122~6.169,P=0.026)是胃腺癌淋巴结转移的独立危险因素,而ARID1A缺失不是独立危险因素。结论:ARID1A蛋白缺失与胃腺癌的不良病理学特征(低分化、弥漫型Lauren分型及淋巴结转移)存在相关性,但未被证实为淋巴结转移的独立危险因素。提示ARID1A可能通过影响肿瘤的分化状态和浸润深度间接参与转移过程。ARID1A缺失有望作为胃腺癌分子分层和预后评估的潜在生物标志物。 展开更多
关键词 ARID1A 胃腺癌 组织学分化 淋巴结转移 免疫组化
暂未订购
Projection of extreme climate change in the Asian arid region and the Tibetan Plateau in the early and middle 21st century based on NEX-GDDP-CMIP6 被引量:1
20
作者 Yankun Sun Rui Zhu Tao Wang 《Atmospheric and Oceanic Science Letters》 2025年第3期53-58,共6页
In the context of global warming,it is anticipated that both the intensity and the frequency of future global extreme high precipitation(EHP)and extreme high temperature(EHT)events will increase.To evaluate the future... In the context of global warming,it is anticipated that both the intensity and the frequency of future global extreme high precipitation(EHP)and extreme high temperature(EHT)events will increase.To evaluate the future extreme climate changes in the Asian arid region and Tibetan Plateau,this study applied the NASA Earth Exchange Global Daily Downscaled Projections(NEX-GDDP-CMIP6)to assess the changes in EHP(Rx5d and R95pTOT)and EHT(TX90p and TXx)under different emission scenarios in the 21st century.Findings suggest that both the frequency and the intensity of the extreme indices will increase,exhibiting accelerated growth under higher emission scenarios,particularly under the SSP5-8.5 emission scenario.It is suggested that the growth of EHT and EHP in the early subperiod of the 21st century(2026-2045)will be relatively moderate,with small differences between different emission scenarios.However,by the middle subperiod of the 21st century(2041-2060),the differences between different emission scenarios will become larger than the 2035s and the growth will become more intense.In western central Asia,TX90p,TXx,Rx5d,and R95pTOT increase by 9.7%-14.2%(13.3%-24.7%),1.3℃-1.7℃(1.6℃-2.7℃),6.5%-8.9%(8.2%-8.8%),and 18.1%-27.0%(25.6%-30.0%)by the early(middle)subperiod;in eastern central Asia,TX90p,TXx,Rx5d,and R95pTOT increase 8.1%-12.0%(11.3%-21.1%),1.4℃-1.8℃(1.9℃-2.9℃),7.4%-9.7%(10.4%-13.8%),and 20.2%-29.3%(32.0%-40.8%)by the early(middle)subperiod;and over the Tibetan Plateau,TX90p,TXx,Rx5d,and R95pTOT increase 12.5%-17.4%(17.0%-31.0%),1.2℃-1.5℃(1.6℃-2.5℃),7.2%-10.0%(9.9%-15.0%),and 26.6%-33.1%(36.1%-55.3%)by the early(middle)subperiod. 展开更多
关键词 Extreme high precipitation Extreme high temperature Asian arid region Tibetan plateau NEX-GDDP-CMIP6
在线阅读 下载PDF
上一页 1 2 36 下一页 到第
使用帮助 返回顶部