The development of advanced antibacterial materials to combat multidrug-resistant pathogens remains a significant challenge in the healthcare sector.Herein,we report the design and synthesis of a novel pillar[5]arene-...The development of advanced antibacterial materials to combat multidrug-resistant pathogens remains a significant challenge in the healthcare sector.Herein,we report the design and synthesis of a novel pillar[5]arene-based platinum metallacycle(P5Pt)specifically engineered to combat multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus(MRSA).The obtained metallacycle serves as a host molecule that can bind with an ethylene glycollinked bis-biotin diester linker,resulting in a water-soluble supramolecular nanosystem(P5Pt-Bio).Both P5Pt and P5Pt-Bio demonstrate remarkable efficacy against drug-resistant bacteria,particularly MRSA,with minimum inhibitory concentrations of 3.1μM for P5Pt-Bio.Mechanistic investigations,including scanning electron microscopy and protein leakage assays,reveal significant disruption of bacterial membranes,ultimately leading to bacterial cell death.Notably,P5Pt-Bio displays excellent biocompatibility with human keratinocyte cells.These findings underscore the potential of pillar[5]arene-based supramolecular nanosystems as versatile platforms for antibacterial applications.展开更多
Herein,we report the fabrication of a hierarchically cavity-porous bilayer and a hierarchically cavity-porous monolayer two-dimensional(2D)pillararene-based hydrogen-bonded organic framework,based on hydrogen bonds be...Herein,we report the fabrication of a hierarchically cavity-porous bilayer and a hierarchically cavity-porous monolayer two-dimensional(2D)pillararene-based hydrogen-bonded organic framework,based on hydrogen bonds between the carboxyl groups of functionalized pillar[6]arene and between the carboxylate anions of functionalized pillar[6]arene and the amidine groups of tetraphenylethylene derivatives.These frameworks exhibit excellent structural crystallinity and stability,as characterized by single crystal X-ray diffraction,powder X-ray diffraction,high-resolution transmission electron microscopy,thermogravimetry,and gas adsorption studies.Atomic force microscopy confirms that the ultrathin thickness of the monolayer and bilayer pillararene-based hydrogen-bonded organic frameworks can be realized on the micrometre scale.Electrochemical impedance and cyclic voltammetry(CV)measurements confirm that these frameworks possess fast lithium ion diffusion channels,efficient polysulfide-capture ability,and accelerated sulfur redox kinetics in Li–S batteries.This work presents a novel and straightforward strategy and platform for designing 2D framework materials,porous materials,and Li–S battery materials with specific monolayer and bilayer configurations.展开更多
基金supported by the National Natural Science Foundation of China(22271154,M-0411)the Science Fund for Distinguished Young Scholars of Jiangsu Province(BK20240078)+1 种基金the Innovation Support Program of Jiangsu Province(BZ2023055)the China Postdoctoral Science Foundation(2024M754126)。
文摘The development of advanced antibacterial materials to combat multidrug-resistant pathogens remains a significant challenge in the healthcare sector.Herein,we report the design and synthesis of a novel pillar[5]arene-based platinum metallacycle(P5Pt)specifically engineered to combat multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus(MRSA).The obtained metallacycle serves as a host molecule that can bind with an ethylene glycollinked bis-biotin diester linker,resulting in a water-soluble supramolecular nanosystem(P5Pt-Bio).Both P5Pt and P5Pt-Bio demonstrate remarkable efficacy against drug-resistant bacteria,particularly MRSA,with minimum inhibitory concentrations of 3.1μM for P5Pt-Bio.Mechanistic investigations,including scanning electron microscopy and protein leakage assays,reveal significant disruption of bacterial membranes,ultimately leading to bacterial cell death.Notably,P5Pt-Bio displays excellent biocompatibility with human keratinocyte cells.These findings underscore the potential of pillar[5]arene-based supramolecular nanosystems as versatile platforms for antibacterial applications.
基金the National Natural Science Foundation of China(No.22201268)Joint Funds of Provincial Science and Technology Research and Development Program of Henan(Advantageous Discipline Cultivation,No.242301420058)projects for financial support.J.T.thank the National Key Research and Development Program of China(No.2024YFA1510600)+3 种基金the National Natural Science Foundation of China(No.22271306)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0610000)the Shanghai Rising-Star Program(No.22QA1411200)the National Key Research and Development Program of China(No.2022YFA1206200).
文摘Herein,we report the fabrication of a hierarchically cavity-porous bilayer and a hierarchically cavity-porous monolayer two-dimensional(2D)pillararene-based hydrogen-bonded organic framework,based on hydrogen bonds between the carboxyl groups of functionalized pillar[6]arene and between the carboxylate anions of functionalized pillar[6]arene and the amidine groups of tetraphenylethylene derivatives.These frameworks exhibit excellent structural crystallinity and stability,as characterized by single crystal X-ray diffraction,powder X-ray diffraction,high-resolution transmission electron microscopy,thermogravimetry,and gas adsorption studies.Atomic force microscopy confirms that the ultrathin thickness of the monolayer and bilayer pillararene-based hydrogen-bonded organic frameworks can be realized on the micrometre scale.Electrochemical impedance and cyclic voltammetry(CV)measurements confirm that these frameworks possess fast lithium ion diffusion channels,efficient polysulfide-capture ability,and accelerated sulfur redox kinetics in Li–S batteries.This work presents a novel and straightforward strategy and platform for designing 2D framework materials,porous materials,and Li–S battery materials with specific monolayer and bilayer configurations.
