For large-scale heterogeneous multi-agent systems(MASs)with characteristics of dense-sparse mixed distribution,this paper investigates the practical finite-time deployment problem by establishing a novel crossspecies ...For large-scale heterogeneous multi-agent systems(MASs)with characteristics of dense-sparse mixed distribution,this paper investigates the practical finite-time deployment problem by establishing a novel crossspecies bionic analytical framework based on the partial differential equation-ordinary differential equation(PDE-ODE)approach.Specifically,by designing a specialized network communication protocol and employing the spatial continuum method for densely distributed agents,this paper models the tracking errors of densely distributed agents as a PDE equivalent to a human disease transmission model,and that of sparsely distributed agents as several ODEs equivalent to the predator population models.The coupling relationship between the PDE and ODE models is established through boundary conditions of the PDE,thereby forming a PDE-ODE-based tracking error model for the considered MASs.Furthermore,by integrating adaptive neural control scheme with the aforementioned biological models,a“Flexible Neural Network”endowed with adaptive and self-stabilized capabilities is constructed,which acts upon the considered MASs,enabling their practical finite-time deployment.Finally,effectiveness of the developed approach is illustrated through a numerical example.展开更多
This article investigates the approaching control for fixed-wing Unmanned Aerial Vehi-cle(UAV)aerial recovery in the presence of pre-specified performance requirements,complex air-flows,maneuvering flight of transport...This article investigates the approaching control for fixed-wing Unmanned Aerial Vehi-cle(UAV)aerial recovery in the presence of pre-specified performance requirements,complex air-flows,maneuvering flight of transport aircraft,and different initial deviations.First,a novelcontrol-oriented Six-Degree-Of-Freedom(6-DOF)UAV model considering airflow disturbancesis established for better consistency with the actual UAV system.Then,to achieve satisfactory per-formance in the approaching process,a Flexible Appointed-time Prescribed Performance Control(FAPPC)algorithm,with the features of user-specified time convergence,no overshoot,indepen-dence from the initial value,and singularity-free,is proposed.Specifically,to solve the singularityissue encountered by the existing PPC methods in dealing with sudden disturbances,an adaptiveadjustment signal is introduced in FAPPC to perceive the threat of increasing error and relax thepreset boundaries appropriately.Moreover,minimum learning parameter-based neural networkestimators are developed to approximate unknown lumped disturbances at a low computationalcost.Finally,the stability of the closed system is analyzed via Lyapunov synthesis,and the effective-ness and advantages of the proposed control scheme are demonstrated via simulation andHardware-In-the-Loop(HIL)experimental validation.展开更多
Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially av...Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially available FDA-approved product for patients with relapsed or refractory(R/R)large B-cell lymphoma(LBCL).However,axi-cel has not been approved by the FDA for use in patients with R/R BL.展开更多
OBJECTIVE:To systematically assess the safety and effectiveness of Compound E’jiao Jiang(复方阿胶浆,CEJ)for treating leukopenia.METHODS:Four English and four Chinese databases were searched for randomized controlled ...OBJECTIVE:To systematically assess the safety and effectiveness of Compound E’jiao Jiang(复方阿胶浆,CEJ)for treating leukopenia.METHODS:Four English and four Chinese databases were searched for randomized controlled trials(RCTs)on CEJ for treating leukopenia up to July 1,2024.Two researchers independently screened the studies and extracted necessary data.Methodological quality and risk of bias were assessed using the Cochrane risk-of-bias tool.Articles eligible for Meta-analysis were analyzed using RevMan.RESULTS:A total of 28 RCTs involving 2041 participants were included,with 1034 in the experimental group and 1007 in the control group.The Meta-analysis showed a significant effect of CEJ in treating leukopenia caused by tumor and immune diseases(three RCTs)[risk ratio(RR)=1.17,95%confidence interval(CI)(1.08,1.27),P=0.0002,I^(2)=35%].The combination of CEJ and Western Medicine showed superior results in terms of white blood cell(WBC)counts(fifteen RCTs)[mean difference(MD)=1.12,95%CI(0.83,1.42),P<0.00001,I^(2)=88%],Karnofsky Performance Status(KPS)levels(seven RCTs)[RR=1.39,95%CI(1.25,1.55),P<0.00001,I^(2)=36%],and mitigation of bone marrow toxicity(eleven RCTs)[RR=0.61,95%CI(0.54,0.69),P<0.00001,I^(2)=24%]compared to Western Medicine alone.Adverse events mainly included gastrointestinal and digestive reactions associated with chemotherapy drugs.CONCLUSION:CEJ alone or in combination with Western Medicine for treating leukopenia caused by tumor and immune diseases improved WBC counts,clinical efficacy,and quality of life.It also reduced bone marrow toxicity-induced leukopenia,enhanced the efficacy of chemotherapy while reducing its toxicity,and alleviated symptoms.No significant adverse events were reported in the RCTs,indicating favorable efficacy and safety.The Grading of Recommendations Assessment,Development and Evaluation assessment indicated a low level of evidence for CEJ in improving leukocyte elevation efficacy,KPS levels,and myelosuppressive toxicity.Therefore,large-scale,high-quality,rigorous multicenter double-blind controlled trials are recommended to strengthen the evidence level.展开更多
In this paper,we investigate the semi-global robust output regulation problem of a class of nonlinear networked control systems.By the emulation approach,we propose a class of sampled-data output feedback control laws...In this paper,we investigate the semi-global robust output regulation problem of a class of nonlinear networked control systems.By the emulation approach,we propose a class of sampled-data output feedback control laws to solve this problem.In particular,we first develop a general sampled-data dynamic output feedback control law and characterize the closed-loop system by a hybrid system.Then,we design the internal model based on the sampled error output of the system.Based on the internal model principle,we convert the semi-global robust output regulation problem into a semi-global robust stabilization problem of an augmented hybrid system composed of the internal model and the original system.By proposing the sampled error output feedback control law and by means of Lyapunov analysis,we obtain the maximum allowable transmission interval for sampling and show that semi-global robust stabilization of the augmented hybrid system can be achieved by the proposed sampled-data control law and thus leading to the solution of the semi-global robust output regulation problem.Finally,we apply the proposed control approach to two practical applications to verify the effectiveness of the proposed control approach.展开更多
Safe and just operating spaces(SJOS)are influenced by complex cross-scale interactions and cascading effects spanning global,regional,and local landscape scales.However,existing SJOS research has often focused on sing...Safe and just operating spaces(SJOS)are influenced by complex cross-scale interactions and cascading effects spanning global,regional,and local landscape scales.However,existing SJOS research has often focused on single-scale assessments,overlooking the impacts of multiscale interactions and within-region heterogeneity on urban SJOS.To address this gap,we developed a cross-scale framework for assessing urban SJOS,explicitly incorporating top-down influences from upper-level constraints and bottom-up effects from lower-level heterogeneity.This approach was applied to China's five major metropolises to examine the states and cross-scale dynamics influencing urban SJOS between 1990 and 2020.Our findings reveal that the SJOS of China's metropolises were primarily influenced by factors at national and local landscape scales,with weaker influences from the global and continental scales.A persistent trade-off between social justice and environmental safety was identified across spatiotemporal scales.For instance,Chongqing in southwestern China lagged behind the eastern four metropolises in social performance but exhibited stronger environmental safety due to its extensive natural landscapes,which mitigated the anthropogenic impacts of urban centers.Regional issues,such as the overshoot of PM_(2.5)and ecological footprints(EF),were primarily driven by the bottom-up accumulation of localized pressures,while the overshoot of CO_(2)was attributed to national policy constraints and the universal exceedance of safe thresholds across scales.Addressing urban sustainability requires avoiding adverse cascading effects from other levels by emphasizing landscape heterogeneity within metropolises and fostering coordinated collaboration across scales,particularly at the regional landscape and national levels.展开更多
Decision support systems(DSS)based on physically based numerical models are standard tools used by water services and utilities.However,few DSS based on holistic approaches combining distributed hydrological,hydraulic...Decision support systems(DSS)based on physically based numerical models are standard tools used by water services and utilities.However,few DSS based on holistic approaches combining distributed hydrological,hydraulic,and hydrogeological models are operationally exploited.This holistic approach was adopted for the development of the AquaVar DSS,used for water resource management in the French Mediterranean Var watershed.The year 2019 marked the initial use of the DSS in its operational environment.Over the next 5 years,multiple hydrological events allowed to test the performance of the DSS.The results show that the tool is capable of simulating peak flows associated with two extreme rainfall events(storms Alex and Aline).For a moderate flood,the real-time functionality was able to simulate forecast discharges 26 h before the flood peak,with a maximum local error of 30%.Finally,simulations for the drought period 2022-2023 highlighted the essential need for DSS to evolve in line with changing climatic conditions,which give rise to unprecedented hydrological processes.The lessons learned from these first 5 years of AquaVar use under operational conditions are synthesized,addressing various topics such as DSS modularity,evolution,data positioning,technology,and governance.展开更多
Feature selection(FS)plays a crucial role in medical imaging by reducing dimensionality,improving computational efficiency,and enhancing diagnostic accuracy.Traditional FS techniques,including filter,wrapper,and embed...Feature selection(FS)plays a crucial role in medical imaging by reducing dimensionality,improving computational efficiency,and enhancing diagnostic accuracy.Traditional FS techniques,including filter,wrapper,and embedded methods,have been widely used but often struggle with high-dimensional and heterogeneous medical imaging data.Deep learning-based FS methods,particularly Convolutional Neural Networks(CNNs)and autoencoders,have demonstrated superior performance but lack interpretability.Hybrid approaches that combine classical and deep learning techniques have emerged as a promising solution,offering improved accuracy and explainability.Furthermore,integratingmulti-modal imaging data(e.g.,MagneticResonance Imaging(MRI),ComputedTomography(CT),Positron Emission Tomography(PET),and Ultrasound(US))poses additional challenges in FS,necessitating advanced feature fusion strategies.Multi-modal feature fusion combines information fromdifferent imagingmodalities to improve diagnostic accuracy.Recently,quantum computing has gained attention as a revolutionary approach for FS,providing the potential to handle high-dimensional medical data more efficiently.This systematic literature review comprehensively examines classical,Deep Learning(DL),hybrid,and quantum-based FS techniques inmedical imaging.Key outcomes include a structured taxonomy of FS methods,a critical evaluation of their performance across modalities,and identification of core challenges such as computational burden,interpretability,and ethical considerations.Future research directions—such as explainable AI(XAI),federated learning,and quantum-enhanced FS—are also emphasized to bridge the current gaps.This review provides actionable insights for developing scalable,interpretable,and clinically applicable FS methods in the evolving landscape of medical imaging.展开更多
The prediction of pregnancy-related hazards must be accurate and timely to safeguard mother and fetal health.This study aims to enhance risk prediction in pregnancywith a novel deep learningmodel based on a Long Short...The prediction of pregnancy-related hazards must be accurate and timely to safeguard mother and fetal health.This study aims to enhance risk prediction in pregnancywith a novel deep learningmodel based on a Long Short-Term Memory(LSTM)generator,designed to capture temporal relationships in cardiotocography(CTG)data.This methodology integrates CTG signals with demographic characteristics and utilizes preprocessing techniques such as noise reduction,normalization,and segmentation to create high-quality input for themodel.It uses convolutional layers to extract spatial information,followed by LSTM layers to model sequences for superior predictive performance.The overall results show that themodel is robust,with an accuracy of 91.5%,precision of 89.8%,recall of 90.4%,and F1-score of 90.1%that outperformed the corresponding baselinemodels,CNN(Convolutional Neural Network)and traditional RNN(Recurrent Neural Network),by 2.3%and 6.1%,respectively.Rather,the ability to detect pregnancy-related abnormalities has considerable therapeutic potential,with the possibility for focused treatments and individualized maternal healthcare approaches,the research team concluded.展开更多
Renewable energy sources(RES)have strong uncertainties,which significantly increase the risks of power imbalance and load shedding in composite power systems.It is thus necessary to evaluate the operational reliabilit...Renewable energy sources(RES)have strong uncertainties,which significantly increase the risks of power imbalance and load shedding in composite power systems.It is thus necessary to evaluate the operational reliability for guiding economic dispatch and reducing the risks.Current methods cannot meet the requirement for the operational timeliness of reliability evaluations due to the high computa-tional complexity of the optimal power flow(OPF)calculations of massive contingencies.This paper pro-poses a fully analytical approach to construct fast-to-run analytical functions of reliability indices and avoid reassessments when the load and RES change.The approach consists of uniform design(UD)-based contingency screening and a modified stochastic response surface method(mSRSM).The contin-gency screening method is used to select critical contingencies while considering the uncertainties.The mSRSM is used to construct the analytical functions of the load shedding to the load and RES gener-ation for the selected contingencies.An analytical function of a smooth virtual variable that maps to the load shedding is established in such a way that,when the load and RES vary,the reliability can be assessed within a very short time rather than using laborious OPF calculations.Case studies illustrate the excellent performance of the proposed method for real-time reliability evaluation.展开更多
This paper studies the problem of designing a modelbased decentralized dynamic periodic event-triggering mechanism(DDPETM)for networked control systems(NCSs)subject to packet losses and external disturbances.Firstly,t...This paper studies the problem of designing a modelbased decentralized dynamic periodic event-triggering mechanism(DDPETM)for networked control systems(NCSs)subject to packet losses and external disturbances.Firstly,the entire NCSs,comprising the triggering mechanism,packet losses and output-based controller,are unified into a hybrid dynamical framework.Secondly,by introducing dynamic triggering variables,the DDPETM is designed to conserve network resources while guaranteeing desired performance properties and tolerating the maximum allowable number of successive packet losses.Thirdly,some stability conditions are derived using the Lyapunov approach.Differing from the zero-order-hold(ZOH)case,the model-based control sufficiently exploits the model information at the controller side.Between two updates,the controller predicts the plant state based on the models and received feedback information.With the model-based control,less transmission may be expected than with ZOH.Finally,numerical examples and comparative experiments demonstrate the effectiveness of the proposed method.展开更多
A high-order fully actuated(HOFA)control method is developed for underactuated mechanical systems(UMSs)with model uncertainties and external disturbances.First,a model transformation is made from the original to a pse...A high-order fully actuated(HOFA)control method is developed for underactuated mechanical systems(UMSs)with model uncertainties and external disturbances.First,a model transformation is made from the original to a pseudo strict-feedback form,and an HOFA model is established by using the method of variable elimination.Then,a group of high-order extended state observers(ESOs)are designed to deal with model uncertainties and external disturbances.The HOFA model is further classified and decomposed to achieve output constraints within a finite time range,and a barrier function is designed by combining with a shift function.Additionally,an ESO-based HOFA tracking control strategy for UMS is proposed.Finally,a manipulator model is used to verify the effectiveness of the proposed control strategy.展开更多
A study was conducted to evaluate the soil nutrient status of poplar plantation by Soil Nutrient Systematic Approach (SNSA) in Jianghan Plain, Hubei Province, China. Soil physiochemical properties were analyzed in lab...A study was conducted to evaluate the soil nutrient status of poplar plantation by Soil Nutrient Systematic Approach (SNSA) in Jianghan Plain, Hubei Province, China. Soil physiochemical properties were analyzed in laboratory through collection soil samples of study site. Ten treatments of application different fertilizers were designed such as CK, optimum treatment (N, P, K, Zn), N(P, K, Zn), P(N, K, Zn), K(N, P, Zn), +Mg(N, P, K, Zn, Mg), Zn (N,P,K), +2P(N, 2P, K, Zn), +2K(N, P, 2K, Zn), and 2N+2P+2K(2N, 2P, 2K, Zn) for field experiment to test the effect on tree height, diameter (DBH) growth, and dry weight of poplar. The results showed that there was no significant difference in tree heights between treatments with different fertilizers, diameter growth of poplar trees in treatments of lack of N and Zn was significantly slower than that of trees in optimum treatment, and dry weight of poplar dropped significantly for treatment of CK as well as treatments without application N and Zn. It is concluded that N and Zn were main limiting factor for poplar growth. Results from laboratory analysis and field experiment were uniform per-fectly, which proved that SNSA was reliable in evaluating soil nutrient status of poplar plantation.展开更多
In an actual control system, it is often difficult to find out where the faults are if only based on the outside fault phenomena, acquired frequently from a fault system. So the fault diagnosis by outside fault phenom...In an actual control system, it is often difficult to find out where the faults are if only based on the outside fault phenomena, acquired frequently from a fault system. So the fault diagnosis by outside fault phenomena is considered. Based on the theory of fuzzy recognition and fault diagnosis, this method only depends on experience and statistical data to set up fuzzy query relationship between the outside phenomena (fault characters) and the fault sources (fault patterns). From this relationship the most probable fault sources can be obtained, to attain the goal of quick diagnosis. Based on the above approach, the standard fuzzy relationship matrix is stored in the computer as a system database. And experiment data are given to show the fault diagnosis results. The important parameters can be on line sampled and analyzed, and when faults occur, faults can be found, the alarm is given and the controller output is regulated.展开更多
Stroke is a major cause of death and disability worldwide.It is characterized by a highly interconnected and multiphasic neuropathological cascade of events,in which an intense and protracted inflammatory response pla...Stroke is a major cause of death and disability worldwide.It is characterized by a highly interconnected and multiphasic neuropathological cascade of events,in which an intense and protracted inflammatory response plays a crucial role in worsening brain injury.Neuroinflammation,a key player in the pathophysiology of stroke,has a dual role.In the acute phase of stroke,neuroinflammation exacerbates brain injury,contributing to neuronal damage and blood–brain barrier disruption.This aspect of neuroinflammation is associated with poor neurological outcomes.Conversely,in the recovery phase following stroke,neuroinflammation facilitates brain repair processes,including neurogenesis,angiogenesis,and synaptic plasticity.The transition of neuroinflammation from a harmful to a reparative role is not well understood.Therefore,this review seeks to explore the mechanisms underlying this transition,with the goal of informing the development of therapeutic interventions that are both time-and context-specific.This review aims to elucidate the complex and dual role of neuroinflammation in stroke,highlighting the main actors,biomarkers of the disease,and potential therapeutic approaches.展开更多
The concept of intelligent integrated network management (IINM) is briefly introduced. In order to analyze, design and implement IINM successfully, object oriented approach is testified to be an effective and efficien...The concept of intelligent integrated network management (IINM) is briefly introduced. In order to analyze, design and implement IINM successfully, object oriented approach is testified to be an effective and efficient way. In this paper, object oriented technique is applied to the structural model of IINM system, The Domain object class and the MU object class are used to represent the manager and the managed resources. Especially, NM IA is introduced which is a special object class with intelligent behaviors to manage the resources efficiently.展开更多
The state space representation of the Bezout identity for generalized systems proposed by (Wang and Balas, 1989) is discussed again. A more concise way of description and proof is presented and the physical signific...The state space representation of the Bezout identity for generalized systems proposed by (Wang and Balas, 1989) is discussed again. A more concise way of description and proof is presented and the physical significance of the result in is also analyzed. Thus, our work is of independent interest.展开更多
As Internet becomes largely used in the AEC (architecture, engineering andconstruction) industry, the main focus is in the area of information and project management. In thedynamic engineering consulting, less has bee...As Internet becomes largely used in the AEC (architecture, engineering andconstruction) industry, the main focus is in the area of information and project management. In thedynamic engineering consulting, less has been done so far. This research tries to find thepossibility and potential of the Internet application in design and consulting for the AEC industryby proposing a working model in specific area, steel construction. Several issues have beendiscussed: defining and formatting the typical procedure and character of the steel constructionconsulting, behavior approach based on activities among partners, and the model organization.展开更多
BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidec...BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidectomy vestibular approach and trans-areolar approaches(TAA)are the two most commonly used remote approaches.No previous meta-analysis has compared postoperative infections and swallowing difficulties among the two procedures.AIM To compared the same among patients undergoing lobectomy for unilateral thyroid carcinoma/benign thyroid nodule.METHODS We searched PubMed MEDLINE,Google Scholar,and Cochrane Library from the date of the first published article up to August 2025.The term used were transoral thyroidectomy vestibular approach,trans areolar thyroidectomy,scarless thyroidectomy,remote thyroidectomy,infections,postoperative,inflammation,dysphagia,and swallowing difficulties.We identified 130 studies,of them,30 full texts were screened and only six studies were included in the final meta-analysis.RESULTS Postoperative infections were not different between the two approaches,odd ratio=1.33,95%confidence interval:0.50-3.53,theχ2 was 1.92 and the P-value for overall effect of 0.57.Similarly,transient swallowing difficulty was not different between the two forms of surgery,with odd ratio=0.91,95%confidence interval:0.35-2.40;theχ2 was 1.32,and the P-value for overall effect of 0.85.CONCLUSION No significant statistical differences were evident between trans-oral endoscopic Mirghani H.Infections and swallowing difficulty in scarless thyroidectomy WJCC https://www.wjgnet.com 2 January 6,2026 Volume 14 Issue 1 thyroidectomy vestibular approach and trans-areolar approach regarding postoperative infection and transient swallowing difficulties.Further longer randomized trials are needed.展开更多
The capacity of the central nervous system for structural plasticity and regeneration is commonly believed to show a decreasing progression from“small and simple”brains to the larger,more complex brains of mammals.H...The capacity of the central nervous system for structural plasticity and regeneration is commonly believed to show a decreasing progression from“small and simple”brains to the larger,more complex brains of mammals.However,recent findings revealed that some forms of neural plasticity can show a reverse trend.Although plasticity is a well-preserved,transversal feature across the animal world,a variety of cell populations and mechanisms seem to have evolved to enable structural modifications to take place in widely different brains,likely as adaptations to selective pressures.Increasing evidence now indicates that a trade-off has occurred between regenerative(mostly stem cell–driven)plasticity and developmental(mostly juvenile)remodeling,with the latter primarily aimed not at brain repair but rather at“sculpting”the neural circuits based on experience.In particular,an evolutionary trade-off has occurred between neurogenic processes intended to support the possibility of recruiting new neurons throughout life and the different ways of obtaining new neurons,and between the different brain locations in which plasticity occurs.This review first briefly surveys the different types of plasticity and the complexity of their possible outcomes and then focuses on recent findings showing that the mammalian brain has a stem cell–independent integration of new neurons into pre-existing(mature)neural circuits.This process is still largely unknown but involves neuronal cells that have been blocked in arrested maturation since their embryonic origin(also termed“immature”or“dormant”neurons).These cells can then restart maturation throughout the animal's lifespan to become functional neurons in brain regions,such as the cerebral cortex and amygdala,that are relevant to high-order cognition and emotions.Unlike stem cell–driven postnatal/adult neurogenesis,which significantly decreases from small-brained,short-living species to large-brained ones,immature neurons are particularly abundant in large-brained,long-living mammals,including humans.The immature neural cell populations hosted in these complex brains are an interesting example of an“enlarged road”in the phylogenetic trend of plastic potential decreases commonly observed in the animal world.The topic of dormant neurons that covary with brain size and gyrencephaly represents a prospective turning point in the field of neuroplasticity,with important translational outcomes.These cells can represent a reservoir of undifferentiated neurons,potentially granting plasticity within the high-order circuits subserving the most sophisticated cognitive skills that are important in the growing brains of young,healthy individuals and are frequently affected by debilitating neurodevelopmental and degenerative disorders.展开更多
基金The National Key R&D Program of China(2021ZD0201300)the National Natural Science Foundation of China(624B2058,U1913602 and 61936004)+1 种基金the Innovation Group Project of the National Natural Science Foundation of China(61821003)the 111 Project on Computational Intelligence and Intelligent Control(B18024).
文摘For large-scale heterogeneous multi-agent systems(MASs)with characteristics of dense-sparse mixed distribution,this paper investigates the practical finite-time deployment problem by establishing a novel crossspecies bionic analytical framework based on the partial differential equation-ordinary differential equation(PDE-ODE)approach.Specifically,by designing a specialized network communication protocol and employing the spatial continuum method for densely distributed agents,this paper models the tracking errors of densely distributed agents as a PDE equivalent to a human disease transmission model,and that of sparsely distributed agents as several ODEs equivalent to the predator population models.The coupling relationship between the PDE and ODE models is established through boundary conditions of the PDE,thereby forming a PDE-ODE-based tracking error model for the considered MASs.Furthermore,by integrating adaptive neural control scheme with the aforementioned biological models,a“Flexible Neural Network”endowed with adaptive and self-stabilized capabilities is constructed,which acts upon the considered MASs,enabling their practical finite-time deployment.Finally,effectiveness of the developed approach is illustrated through a numerical example.
基金funded by the National Natural Science Foundation of China(Nos.62173022,61673042)the Academic Excellence Foundation of Beihang University for Ph.D.Studentsthe Outstanding Research Project of Shen Yuan Honors College,Beihang University,China(No.230123104)。
文摘This article investigates the approaching control for fixed-wing Unmanned Aerial Vehi-cle(UAV)aerial recovery in the presence of pre-specified performance requirements,complex air-flows,maneuvering flight of transport aircraft,and different initial deviations.First,a novelcontrol-oriented Six-Degree-Of-Freedom(6-DOF)UAV model considering airflow disturbancesis established for better consistency with the actual UAV system.Then,to achieve satisfactory per-formance in the approaching process,a Flexible Appointed-time Prescribed Performance Control(FAPPC)algorithm,with the features of user-specified time convergence,no overshoot,indepen-dence from the initial value,and singularity-free,is proposed.Specifically,to solve the singularityissue encountered by the existing PPC methods in dealing with sudden disturbances,an adaptiveadjustment signal is introduced in FAPPC to perceive the threat of increasing error and relax thepreset boundaries appropriately.Moreover,minimum learning parameter-based neural networkestimators are developed to approximate unknown lumped disturbances at a low computationalcost.Finally,the stability of the closed system is analyzed via Lyapunov synthesis,and the effective-ness and advantages of the proposed control scheme are demonstrated via simulation andHardware-In-the-Loop(HIL)experimental validation.
基金supported by the Sponsored by Tianjin Health Research Project(Grant No.TJWJ2023ZD003)the Chinese Society of Clinical Oncology Beijing Xisike Clinical Oncology Research Foundation(Grant Nos.Y-NCJH202201-0027 and Y-2022YMJN/MS-0001).
文摘Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially available FDA-approved product for patients with relapsed or refractory(R/R)large B-cell lymphoma(LBCL).However,axi-cel has not been approved by the FDA for use in patients with R/R BL.
基金Supported by The Qihuang Scholars Support Program of the National Administration of Traditional Chinese Medicinet:2021 Qihuang Scholars Support Project(National Chinese Medicine Teaching Letter[2022]6)National Traditional Medicine Administration's Project for Establishing National Famous and Elderly Traditional Medicine Transmission Workshops:Xie Yanming National Famous Traditional Chinese Medicine Expert Transmission Studio(National Chinese Medicine Education Letter[2022]75)。
文摘OBJECTIVE:To systematically assess the safety and effectiveness of Compound E’jiao Jiang(复方阿胶浆,CEJ)for treating leukopenia.METHODS:Four English and four Chinese databases were searched for randomized controlled trials(RCTs)on CEJ for treating leukopenia up to July 1,2024.Two researchers independently screened the studies and extracted necessary data.Methodological quality and risk of bias were assessed using the Cochrane risk-of-bias tool.Articles eligible for Meta-analysis were analyzed using RevMan.RESULTS:A total of 28 RCTs involving 2041 participants were included,with 1034 in the experimental group and 1007 in the control group.The Meta-analysis showed a significant effect of CEJ in treating leukopenia caused by tumor and immune diseases(three RCTs)[risk ratio(RR)=1.17,95%confidence interval(CI)(1.08,1.27),P=0.0002,I^(2)=35%].The combination of CEJ and Western Medicine showed superior results in terms of white blood cell(WBC)counts(fifteen RCTs)[mean difference(MD)=1.12,95%CI(0.83,1.42),P<0.00001,I^(2)=88%],Karnofsky Performance Status(KPS)levels(seven RCTs)[RR=1.39,95%CI(1.25,1.55),P<0.00001,I^(2)=36%],and mitigation of bone marrow toxicity(eleven RCTs)[RR=0.61,95%CI(0.54,0.69),P<0.00001,I^(2)=24%]compared to Western Medicine alone.Adverse events mainly included gastrointestinal and digestive reactions associated with chemotherapy drugs.CONCLUSION:CEJ alone or in combination with Western Medicine for treating leukopenia caused by tumor and immune diseases improved WBC counts,clinical efficacy,and quality of life.It also reduced bone marrow toxicity-induced leukopenia,enhanced the efficacy of chemotherapy while reducing its toxicity,and alleviated symptoms.No significant adverse events were reported in the RCTs,indicating favorable efficacy and safety.The Grading of Recommendations Assessment,Development and Evaluation assessment indicated a low level of evidence for CEJ in improving leukocyte elevation efficacy,KPS levels,and myelosuppressive toxicity.Therefore,large-scale,high-quality,rigorous multicenter double-blind controlled trials are recommended to strengthen the evidence level.
基金supported in part by the National Science and Technology Major Project(2021ZD0112600)the National Natural Science Foundation of China(62373058),Beijing Natural Science Foundation(L233003)+1 种基金the National Science Fund for Distinguished Young Scholars of China(62025301)the Basic Science Center Programs of National Nature Science Foundation of China(62088101).
文摘In this paper,we investigate the semi-global robust output regulation problem of a class of nonlinear networked control systems.By the emulation approach,we propose a class of sampled-data output feedback control laws to solve this problem.In particular,we first develop a general sampled-data dynamic output feedback control law and characterize the closed-loop system by a hybrid system.Then,we design the internal model based on the sampled error output of the system.Based on the internal model principle,we convert the semi-global robust output regulation problem into a semi-global robust stabilization problem of an augmented hybrid system composed of the internal model and the original system.By proposing the sampled error output feedback control law and by means of Lyapunov analysis,we obtain the maximum allowable transmission interval for sampling and show that semi-global robust stabilization of the augmented hybrid system can be achieved by the proposed sampled-data control law and thus leading to the solution of the semi-global robust output regulation problem.Finally,we apply the proposed control approach to two practical applications to verify the effectiveness of the proposed control approach.
基金supported by the National Natural Science Foundation of China(Grant No.42101296)the Natural Science Foundation of Chongqing(Grant No.CSTB2023NSCQ-MSX0041)Chongqing Municipal Training Program of Innovation and Entrepreneurship Project(Grants No.S202410635155 and X202410635116)。
文摘Safe and just operating spaces(SJOS)are influenced by complex cross-scale interactions and cascading effects spanning global,regional,and local landscape scales.However,existing SJOS research has often focused on single-scale assessments,overlooking the impacts of multiscale interactions and within-region heterogeneity on urban SJOS.To address this gap,we developed a cross-scale framework for assessing urban SJOS,explicitly incorporating top-down influences from upper-level constraints and bottom-up effects from lower-level heterogeneity.This approach was applied to China's five major metropolises to examine the states and cross-scale dynamics influencing urban SJOS between 1990 and 2020.Our findings reveal that the SJOS of China's metropolises were primarily influenced by factors at national and local landscape scales,with weaker influences from the global and continental scales.A persistent trade-off between social justice and environmental safety was identified across spatiotemporal scales.For instance,Chongqing in southwestern China lagged behind the eastern four metropolises in social performance but exhibited stronger environmental safety due to its extensive natural landscapes,which mitigated the anthropogenic impacts of urban centers.Regional issues,such as the overshoot of PM_(2.5)and ecological footprints(EF),were primarily driven by the bottom-up accumulation of localized pressures,while the overshoot of CO_(2)was attributed to national policy constraints and the universal exceedance of safe thresholds across scales.Addressing urban sustainability requires avoiding adverse cascading effects from other levels by emphasizing landscape heterogeneity within metropolises and fostering coordinated collaboration across scales,particularly at the regional landscape and national levels.
文摘Decision support systems(DSS)based on physically based numerical models are standard tools used by water services and utilities.However,few DSS based on holistic approaches combining distributed hydrological,hydraulic,and hydrogeological models are operationally exploited.This holistic approach was adopted for the development of the AquaVar DSS,used for water resource management in the French Mediterranean Var watershed.The year 2019 marked the initial use of the DSS in its operational environment.Over the next 5 years,multiple hydrological events allowed to test the performance of the DSS.The results show that the tool is capable of simulating peak flows associated with two extreme rainfall events(storms Alex and Aline).For a moderate flood,the real-time functionality was able to simulate forecast discharges 26 h before the flood peak,with a maximum local error of 30%.Finally,simulations for the drought period 2022-2023 highlighted the essential need for DSS to evolve in line with changing climatic conditions,which give rise to unprecedented hydrological processes.The lessons learned from these first 5 years of AquaVar use under operational conditions are synthesized,addressing various topics such as DSS modularity,evolution,data positioning,technology,and governance.
文摘Feature selection(FS)plays a crucial role in medical imaging by reducing dimensionality,improving computational efficiency,and enhancing diagnostic accuracy.Traditional FS techniques,including filter,wrapper,and embedded methods,have been widely used but often struggle with high-dimensional and heterogeneous medical imaging data.Deep learning-based FS methods,particularly Convolutional Neural Networks(CNNs)and autoencoders,have demonstrated superior performance but lack interpretability.Hybrid approaches that combine classical and deep learning techniques have emerged as a promising solution,offering improved accuracy and explainability.Furthermore,integratingmulti-modal imaging data(e.g.,MagneticResonance Imaging(MRI),ComputedTomography(CT),Positron Emission Tomography(PET),and Ultrasound(US))poses additional challenges in FS,necessitating advanced feature fusion strategies.Multi-modal feature fusion combines information fromdifferent imagingmodalities to improve diagnostic accuracy.Recently,quantum computing has gained attention as a revolutionary approach for FS,providing the potential to handle high-dimensional medical data more efficiently.This systematic literature review comprehensively examines classical,Deep Learning(DL),hybrid,and quantum-based FS techniques inmedical imaging.Key outcomes include a structured taxonomy of FS methods,a critical evaluation of their performance across modalities,and identification of core challenges such as computational burden,interpretability,and ethical considerations.Future research directions—such as explainable AI(XAI),federated learning,and quantum-enhanced FS—are also emphasized to bridge the current gaps.This review provides actionable insights for developing scalable,interpretable,and clinically applicable FS methods in the evolving landscape of medical imaging.
文摘The prediction of pregnancy-related hazards must be accurate and timely to safeguard mother and fetal health.This study aims to enhance risk prediction in pregnancywith a novel deep learningmodel based on a Long Short-Term Memory(LSTM)generator,designed to capture temporal relationships in cardiotocography(CTG)data.This methodology integrates CTG signals with demographic characteristics and utilizes preprocessing techniques such as noise reduction,normalization,and segmentation to create high-quality input for themodel.It uses convolutional layers to extract spatial information,followed by LSTM layers to model sequences for superior predictive performance.The overall results show that themodel is robust,with an accuracy of 91.5%,precision of 89.8%,recall of 90.4%,and F1-score of 90.1%that outperformed the corresponding baselinemodels,CNN(Convolutional Neural Network)and traditional RNN(Recurrent Neural Network),by 2.3%and 6.1%,respectively.Rather,the ability to detect pregnancy-related abnormalities has considerable therapeutic potential,with the possibility for focused treatments and individualized maternal healthcare approaches,the research team concluded.
基金supported by the Joint Research Fund in Smart Grid under cooperative agreement between the National Natural Science Foundation of China(NSFC)and the State Grid Cooperation of China(SGCC,U1966601)the Fundamental Research Funds for the Central Universities of China(2023CDJYXTD-004).
文摘Renewable energy sources(RES)have strong uncertainties,which significantly increase the risks of power imbalance and load shedding in composite power systems.It is thus necessary to evaluate the operational reliability for guiding economic dispatch and reducing the risks.Current methods cannot meet the requirement for the operational timeliness of reliability evaluations due to the high computa-tional complexity of the optimal power flow(OPF)calculations of massive contingencies.This paper pro-poses a fully analytical approach to construct fast-to-run analytical functions of reliability indices and avoid reassessments when the load and RES change.The approach consists of uniform design(UD)-based contingency screening and a modified stochastic response surface method(mSRSM).The contin-gency screening method is used to select critical contingencies while considering the uncertainties.The mSRSM is used to construct the analytical functions of the load shedding to the load and RES gener-ation for the selected contingencies.An analytical function of a smooth virtual variable that maps to the load shedding is established in such a way that,when the load and RES vary,the reliability can be assessed within a very short time rather than using laborious OPF calculations.Case studies illustrate the excellent performance of the proposed method for real-time reliability evaluation.
基金supported by the National Natural Science Foundation of China(U21A20477,61722302,61573069,61903290)the Fundamental Research Funds for the Central Universities(DUT19ZD218).
文摘This paper studies the problem of designing a modelbased decentralized dynamic periodic event-triggering mechanism(DDPETM)for networked control systems(NCSs)subject to packet losses and external disturbances.Firstly,the entire NCSs,comprising the triggering mechanism,packet losses and output-based controller,are unified into a hybrid dynamical framework.Secondly,by introducing dynamic triggering variables,the DDPETM is designed to conserve network resources while guaranteeing desired performance properties and tolerating the maximum allowable number of successive packet losses.Thirdly,some stability conditions are derived using the Lyapunov approach.Differing from the zero-order-hold(ZOH)case,the model-based control sufficiently exploits the model information at the controller side.Between two updates,the controller predicts the plant state based on the models and received feedback information.With the model-based control,less transmission may be expected than with ZOH.Finally,numerical examples and comparative experiments demonstrate the effectiveness of the proposed method.
基金supported in part by the National Natural Science Foundation of China(62373208,62033003,62273105,U191140)Taishan Scholar Program of Shandong Province of China(tsqn202306218)+1 种基金the National Key Research and Development Program of China(2022YFB4703100)the National Natural Science Foundation of Shandong Province(ZR2024YQ032).
文摘A high-order fully actuated(HOFA)control method is developed for underactuated mechanical systems(UMSs)with model uncertainties and external disturbances.First,a model transformation is made from the original to a pseudo strict-feedback form,and an HOFA model is established by using the method of variable elimination.Then,a group of high-order extended state observers(ESOs)are designed to deal with model uncertainties and external disturbances.The HOFA model is further classified and decomposed to achieve output constraints within a finite time range,and a barrier function is designed by combining with a shift function.Additionally,an ESO-based HOFA tracking control strategy for UMS is proposed.Finally,a manipulator model is used to verify the effectiveness of the proposed control strategy.
基金The study was supported by PPI/PPIC China Program (No. HB-19) and Wetland Laboratory Opening Foundation of Hubei Province (No. HNKFJ20021301).
文摘A study was conducted to evaluate the soil nutrient status of poplar plantation by Soil Nutrient Systematic Approach (SNSA) in Jianghan Plain, Hubei Province, China. Soil physiochemical properties were analyzed in laboratory through collection soil samples of study site. Ten treatments of application different fertilizers were designed such as CK, optimum treatment (N, P, K, Zn), N(P, K, Zn), P(N, K, Zn), K(N, P, Zn), +Mg(N, P, K, Zn, Mg), Zn (N,P,K), +2P(N, 2P, K, Zn), +2K(N, P, 2K, Zn), and 2N+2P+2K(2N, 2P, 2K, Zn) for field experiment to test the effect on tree height, diameter (DBH) growth, and dry weight of poplar. The results showed that there was no significant difference in tree heights between treatments with different fertilizers, diameter growth of poplar trees in treatments of lack of N and Zn was significantly slower than that of trees in optimum treatment, and dry weight of poplar dropped significantly for treatment of CK as well as treatments without application N and Zn. It is concluded that N and Zn were main limiting factor for poplar growth. Results from laboratory analysis and field experiment were uniform per-fectly, which proved that SNSA was reliable in evaluating soil nutrient status of poplar plantation.
文摘In an actual control system, it is often difficult to find out where the faults are if only based on the outside fault phenomena, acquired frequently from a fault system. So the fault diagnosis by outside fault phenomena is considered. Based on the theory of fuzzy recognition and fault diagnosis, this method only depends on experience and statistical data to set up fuzzy query relationship between the outside phenomena (fault characters) and the fault sources (fault patterns). From this relationship the most probable fault sources can be obtained, to attain the goal of quick diagnosis. Based on the above approach, the standard fuzzy relationship matrix is stored in the computer as a system database. And experiment data are given to show the fault diagnosis results. The important parameters can be on line sampled and analyzed, and when faults occur, faults can be found, the alarm is given and the controller output is regulated.
基金supported by European Union-NextGeneration EU under the Italian University and Research(MUR)National Innovation Ecosystem grant ECS00000041-VITALITY-CUP E13C22001060006(to MdA)。
文摘Stroke is a major cause of death and disability worldwide.It is characterized by a highly interconnected and multiphasic neuropathological cascade of events,in which an intense and protracted inflammatory response plays a crucial role in worsening brain injury.Neuroinflammation,a key player in the pathophysiology of stroke,has a dual role.In the acute phase of stroke,neuroinflammation exacerbates brain injury,contributing to neuronal damage and blood–brain barrier disruption.This aspect of neuroinflammation is associated with poor neurological outcomes.Conversely,in the recovery phase following stroke,neuroinflammation facilitates brain repair processes,including neurogenesis,angiogenesis,and synaptic plasticity.The transition of neuroinflammation from a harmful to a reparative role is not well understood.Therefore,this review seeks to explore the mechanisms underlying this transition,with the goal of informing the development of therapeutic interventions that are both time-and context-specific.This review aims to elucidate the complex and dual role of neuroinflammation in stroke,highlighting the main actors,biomarkers of the disease,and potential therapeutic approaches.
文摘The concept of intelligent integrated network management (IINM) is briefly introduced. In order to analyze, design and implement IINM successfully, object oriented approach is testified to be an effective and efficient way. In this paper, object oriented technique is applied to the structural model of IINM system, The Domain object class and the MU object class are used to represent the manager and the managed resources. Especially, NM IA is introduced which is a special object class with intelligent behaviors to manage the resources efficiently.
文摘The state space representation of the Bezout identity for generalized systems proposed by (Wang and Balas, 1989) is discussed again. A more concise way of description and proof is presented and the physical significance of the result in is also analyzed. Thus, our work is of independent interest.
文摘As Internet becomes largely used in the AEC (architecture, engineering andconstruction) industry, the main focus is in the area of information and project management. In thedynamic engineering consulting, less has been done so far. This research tries to find thepossibility and potential of the Internet application in design and consulting for the AEC industryby proposing a working model in specific area, steel construction. Several issues have beendiscussed: defining and formatting the typical procedure and character of the steel constructionconsulting, behavior approach based on activities among partners, and the model organization.
文摘BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidectomy vestibular approach and trans-areolar approaches(TAA)are the two most commonly used remote approaches.No previous meta-analysis has compared postoperative infections and swallowing difficulties among the two procedures.AIM To compared the same among patients undergoing lobectomy for unilateral thyroid carcinoma/benign thyroid nodule.METHODS We searched PubMed MEDLINE,Google Scholar,and Cochrane Library from the date of the first published article up to August 2025.The term used were transoral thyroidectomy vestibular approach,trans areolar thyroidectomy,scarless thyroidectomy,remote thyroidectomy,infections,postoperative,inflammation,dysphagia,and swallowing difficulties.We identified 130 studies,of them,30 full texts were screened and only six studies were included in the final meta-analysis.RESULTS Postoperative infections were not different between the two approaches,odd ratio=1.33,95%confidence interval:0.50-3.53,theχ2 was 1.92 and the P-value for overall effect of 0.57.Similarly,transient swallowing difficulty was not different between the two forms of surgery,with odd ratio=0.91,95%confidence interval:0.35-2.40;theχ2 was 1.32,and the P-value for overall effect of 0.85.CONCLUSION No significant statistical differences were evident between trans-oral endoscopic Mirghani H.Infections and swallowing difficulty in scarless thyroidectomy WJCC https://www.wjgnet.com 2 January 6,2026 Volume 14 Issue 1 thyroidectomy vestibular approach and trans-areolar approach regarding postoperative infection and transient swallowing difficulties.Further longer randomized trials are needed.
基金supported by Progetto Trapezio,Compagnia di San Paolo(67935-2021.2174),to LBFondazione CRT(Cassa di Risparmio di Torino,RF=2022.0618),to LBPRIN2022(grant 2022LB4X3N),to LB。
文摘The capacity of the central nervous system for structural plasticity and regeneration is commonly believed to show a decreasing progression from“small and simple”brains to the larger,more complex brains of mammals.However,recent findings revealed that some forms of neural plasticity can show a reverse trend.Although plasticity is a well-preserved,transversal feature across the animal world,a variety of cell populations and mechanisms seem to have evolved to enable structural modifications to take place in widely different brains,likely as adaptations to selective pressures.Increasing evidence now indicates that a trade-off has occurred between regenerative(mostly stem cell–driven)plasticity and developmental(mostly juvenile)remodeling,with the latter primarily aimed not at brain repair but rather at“sculpting”the neural circuits based on experience.In particular,an evolutionary trade-off has occurred between neurogenic processes intended to support the possibility of recruiting new neurons throughout life and the different ways of obtaining new neurons,and between the different brain locations in which plasticity occurs.This review first briefly surveys the different types of plasticity and the complexity of their possible outcomes and then focuses on recent findings showing that the mammalian brain has a stem cell–independent integration of new neurons into pre-existing(mature)neural circuits.This process is still largely unknown but involves neuronal cells that have been blocked in arrested maturation since their embryonic origin(also termed“immature”or“dormant”neurons).These cells can then restart maturation throughout the animal's lifespan to become functional neurons in brain regions,such as the cerebral cortex and amygdala,that are relevant to high-order cognition and emotions.Unlike stem cell–driven postnatal/adult neurogenesis,which significantly decreases from small-brained,short-living species to large-brained ones,immature neurons are particularly abundant in large-brained,long-living mammals,including humans.The immature neural cell populations hosted in these complex brains are an interesting example of an“enlarged road”in the phylogenetic trend of plastic potential decreases commonly observed in the animal world.The topic of dormant neurons that covary with brain size and gyrencephaly represents a prospective turning point in the field of neuroplasticity,with important translational outcomes.These cells can represent a reservoir of undifferentiated neurons,potentially granting plasticity within the high-order circuits subserving the most sophisticated cognitive skills that are important in the growing brains of young,healthy individuals and are frequently affected by debilitating neurodevelopmental and degenerative disorders.
