In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of d...In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of death from coronavirus disease 2019(COVID-19).In 2024,Kavli Prize recognizes the pioneering work of integrating engineered nanocarriers with biological functions for biomedical applications.The development of nanomedicine has changed the ways we approach the fundamental understand-ing,diagnosis,treatment,and prevention of diseases.These suc-cessful cases brought great excitement to the field of nanomedicine;however,many challenges still remain.In particular,it is critical to optimize nanocarriers to improve delivery effi-ciency and selectivity as well as reduce toxic side effects.展开更多
Liquid lens offers a novel approach to achieving large depth of field,wide viewing angle,high speed,and high-quality imaging in zoom optical systems.However,the aperture and reliability limit the lens’s performance i...Liquid lens offers a novel approach to achieving large depth of field,wide viewing angle,high speed,and high-quality imaging in zoom optical systems.However,the aperture and reliability limit the lens’s performance in various optical applications.The liquid material is crucial for the reliability of the large-aperture liquid lens.To solve the dielectric failure problem associated with the large aperture,we first reveal the mechanism of dielectric failure based on the transport properties of electrolyte solutions and the impact of electrochemical reaction rates from physical chemistry so as to propose a theoretical method to suppress dielectric failure fundamentally.Based on this theory,we develop a series of non-aqueous organic solutions to suppress high-voltage dielectric failure.Next,we identify the optimal formulation for comprehensive optical performance and fabricate a centimeter-level large-aperture electrowetting liquid lens.This lens features an optical power variation range of−11.98m^(−1) to 12.93m^(−1),with clear and high-quality imaging function,which can enlarge the field of view and depth adjustment range of holographic reconstructions while maintaining excellent edge clarity of the reconstructed images.The proposed centimeter-level large-aperture non-aqueous electrowetting liquid lens effectively suppresses dielectric failure under high voltage,demonstrates excellent optical performance,and holds exciting potential for applications in 3D display,precision measurement,biomedical observation,and more.展开更多
文摘In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of death from coronavirus disease 2019(COVID-19).In 2024,Kavli Prize recognizes the pioneering work of integrating engineered nanocarriers with biological functions for biomedical applications.The development of nanomedicine has changed the ways we approach the fundamental understand-ing,diagnosis,treatment,and prevention of diseases.These suc-cessful cases brought great excitement to the field of nanomedicine;however,many challenges still remain.In particular,it is critical to optimize nanocarriers to improve delivery effi-ciency and selectivity as well as reduce toxic side effects.
基金supported by the National Natural Science Foundation of China under Grant No.U23A20368,62175006,and 62275009.
文摘Liquid lens offers a novel approach to achieving large depth of field,wide viewing angle,high speed,and high-quality imaging in zoom optical systems.However,the aperture and reliability limit the lens’s performance in various optical applications.The liquid material is crucial for the reliability of the large-aperture liquid lens.To solve the dielectric failure problem associated with the large aperture,we first reveal the mechanism of dielectric failure based on the transport properties of electrolyte solutions and the impact of electrochemical reaction rates from physical chemistry so as to propose a theoretical method to suppress dielectric failure fundamentally.Based on this theory,we develop a series of non-aqueous organic solutions to suppress high-voltage dielectric failure.Next,we identify the optimal formulation for comprehensive optical performance and fabricate a centimeter-level large-aperture electrowetting liquid lens.This lens features an optical power variation range of−11.98m^(−1) to 12.93m^(−1),with clear and high-quality imaging function,which can enlarge the field of view and depth adjustment range of holographic reconstructions while maintaining excellent edge clarity of the reconstructed images.The proposed centimeter-level large-aperture non-aqueous electrowetting liquid lens effectively suppresses dielectric failure under high voltage,demonstrates excellent optical performance,and holds exciting potential for applications in 3D display,precision measurement,biomedical observation,and more.
