Whole Slide Imaging (WSI) technology, as a revolutionary digital technology in the field of pathology, is gradually changing the traditional clinical pathological diagnosis model. By converting traditional glass patho...Whole Slide Imaging (WSI) technology, as a revolutionary digital technology in the field of pathology, is gradually changing the traditional clinical pathological diagnosis model. By converting traditional glass pathological sections into complete digital images through high-resolution scanning, it provides a new method for pathological diagnosis. Based on this, this paper studies the application of WSI technology in clinical pathological diagnosis, elaborates on its application value, analyzes the current application status, and proposes corresponding application countermeasures, aiming to provide reference for the standardized and popularized development of this technology in clinical pathological diagnosis.展开更多
Biomass is a resourcewhose organic carbon is formed from atmospheric carbon dioxide.It has numerous characteristics such as low carbon emissions,renewability,and environmental friendliness.The efficient utilization of...Biomass is a resourcewhose organic carbon is formed from atmospheric carbon dioxide.It has numerous characteristics such as low carbon emissions,renewability,and environmental friendliness.The efficient utilization of biomass plays a significant role in promoting the development of clean energy,alleviating environmental pressures,and achieving carbon neutrality goals.Among the numerous processing technologies of biomass,hydrothermal carbonization(HTC)is a promising thermochemical process that can decompose and convert biomass into hydrochar under relatively mild conditions of approximately 180℃–300℃,thereby enabling its efficient resource utilization.In addition,HTC can directly process feedstocks with high moisture content without the need for high-temperature drying,resulting in lower energy consumption.Based on a systematic analysis of the critical articles mainly published in 2011-2025 related to biomass,HTC,and hydrochar applications,in this review,the category of biomass was first classified and the chemical compositions were summarized.Then,the main chemical reaction pathways involved in biomass decomposition and transformation during the HTC process were introduced.Meanwhile,the roles of key process parameters,including reaction temperature,residence time,pH,feedstock type,pressure,mass ratio of biomass to water,and the use of catalysts on HTC,were carefully discussed.Finally,the applications of hydrochar in energy utilization,environmental remediation,soil improvement,adsorbent,microbial fermentation,and phosphorus recovery fields were highlighted.The future directions of the HTC process were also provided,which would respond to climate change by promoting the development of the sustainable carbon materials field.展开更多
Lignin,the most abundant natural aromatic polymer globally,has garnered considerable interest due to its rich and diverse active functional groups and its antioxidant,antimicrobial,and adhesive properties.Recent resea...Lignin,the most abundant natural aromatic polymer globally,has garnered considerable interest due to its rich and diverse active functional groups and its antioxidant,antimicrobial,and adhesive properties.Recent research has significantly improved the performance of lignin-based hydrogels,suggesting their substantial potential in fields such as biomedicine,environmental science,and agriculture.This paper reviews the process of lignin extraction,systematically introduces synthesis strategies for preparing lignin-based hydrogels,and discusses the current state of research on these hydrogels in biomedical and environmental protection fields.It concludes by identifying the existing challenges in lignin hydrogel research and envisioning future prospects and development trends.展开更多
Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/...Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/chemical stability.To enhance the performance of intrinsic g-CN,a supramolecular self-assembly strategy has been proposed to regulate the molecular structure of supramolecular precursors through non-covalent interactions across molecular building blocks,thereby optimizing the electronic structure of g-CN.This review provides a comprehensive overview of the recent progress in supramolecular self-assembly-derived graphitic carbon nitride(SM-CN)from both experimental and theoretical computational research in synthesis strategies,including synthesis methods and influencing factors,providing a theoretical foundation for the design of supramolecular assembly.It also discusses modification strategies,such as internal modification of the conjugated plane,interlayer optimization,and construction of heterointerfaces to improve the electronic structure of SM-CN owing to its unique layered structure.This review further summarizes the applications of SM-CN in environment and energy,including wastewater treatment,sterilization and disinfection/air purification,water splitting,H_(2)O_(2)production,organic synthesis/biomass conversion,CO_(2)reduction,photocatalytic coupling technology.Finally,perspectives and outlooks for the future development of SM-CN aim to inspire further innovation in the design and construction of high-performance SM-CN for broader applications.展开更多
Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i...Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.展开更多
Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance ...Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance and scalability,as current trends require the distribution of computation across network nodes/points.In this paper,we survey a large number of mapping and scheduling techniques designed for NoC architectures.This time,we concentrated on 3D systems.We take a systematic literature review approach to analyze existing methods across static,dynamic,hybrid,and machine-learning-based approaches,alongside preliminary AI-based dynamic models in recent works.We classify them into several main aspects covering power-aware mapping,fault tolerance,load-balancing,and adaptive for dynamic workloads.Also,we assess the efficacy of each method against performance parameters,such as latency,throughput,response time,and error rate.Key challenges,including energy efficiency,real-time adaptability,and reinforcement learning integration,are highlighted as well.To the best of our knowledge,this is one of the recent reviews that identifies both traditional and AI-based algorithms for mapping over a modern NoC,and opens research challenges.Finally,we provide directions for future work toward improved adaptability and scalability via lightweight learned models and hierarchical mapping frameworks.展开更多
[Objectives]To investigate the effects of different planting densities and nitrogen application rates on the yield and quality of the tobacco cultivar Chuxue 80.[Methods]A field experiment was conducted in Hubei Provi...[Objectives]To investigate the effects of different planting densities and nitrogen application rates on the yield and quality of the tobacco cultivar Chuxue 80.[Methods]A field experiment was conducted in Hubei Province,evaluating various combinations of planting density and nitrogen rate for Chuxue 80.[Results]At the maturity stage,the TN1 treatment(5 kg N per 667 m^(2) with a density of 1900 plants per 667 m^(2))demonstrated the most favorable agronomic performance.The TN9 treatment(11 kg N per 667 m^(2) with a density of 1110 plants per 667 m^(2))achieved the highest wrapper tobacco yield and output value.Meanwhile,the TN5 treatment(8 kg N per 667 m^(2) with a density of 1515 plants per 667 m^(2))resulted in the best smoking quality.[Conclusions]The TN9 treatment,with a planting density of 1110 plants per 667 m^(2) and a nitrogen application rate of 11 kg per 667 m^(2),is recommended as the optimal cultivation practice for Chuxue 80 in Hubei Province.展开更多
This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinic...This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.展开更多
Biodegradable metals(BMs)have shown significant potential for applications in the field of orthopedic implants.These materials gradually degrade after implantation,eventually disappear without residue,provide necessar...Biodegradable metals(BMs)have shown significant potential for applications in the field of orthopedic implants.These materials gradually degrade after implantation,eventually disappear without residue,provide necessary mechanical support during degradation,and closely integrate with bone tissues.Fe-based BMs are particularly notable for their good mechanical properties and biocompatibility.However,their slow degradation rate is a limitation.The emergence of Mn-incorporated Fe-based alloys(Fe-Mn alloys)offers the possibilities for addressing issues of slow degradation rate and incompatibility of magnetic resonance imaging(MRI)for Fe alloys.This review summarizes the advantages of Fe-Mn alloys as orthopedic implants,and the cutting-edge advances in degradation,mechanical and magnetic properties,and osteogenic performance.The cytotoxicity issue is addressed for the porous structured Fe-Mn alloys caused by the enrichment of manganese ions,and thus the main challenge and the development are involved for the Fe-Mn alloys to achieve a balance among biocompatibility,structure,and degradation rate.Also the perspectives are proposed for Fe-Mn alloys as orthopedic implants.展开更多
With the deep integration of smart manufacturing and IoT technologies,higher demands are placed on the intelligence and real-time performance of industrial equipment fault detection.For industrial fans,base bolt loose...With the deep integration of smart manufacturing and IoT technologies,higher demands are placed on the intelligence and real-time performance of industrial equipment fault detection.For industrial fans,base bolt loosening faults are difficult to identify through conventional spectrum analysis,and the extreme scarcity of fault data leads to limited training datasets,making traditional deep learning methods inaccurate in fault identification and incapable of detecting loosening severity.This paper employs Bayesian Learning by training on a small fault dataset collected from the actual operation of axial-flow fans in a factory to obtain posterior distribution.This method proposes specific data processing approaches and a configuration of Bayesian Convolutional Neural Network(BCNN).It can effectively improve the model’s generalization ability.Experimental results demonstrate high detection accuracy and alignment with real-world applications,offering practical significance and reference value for industrial fan bolt loosening detection under data-limited conditions.展开更多
Diabetic retinopathy(DR)is a leading cause of vision loss among working-age populations,with early screening significantly reducing the risk of blindness.However,resource-limited regions often face challenges in DR sc...Diabetic retinopathy(DR)is a leading cause of vision loss among working-age populations,with early screening significantly reducing the risk of blindness.However,resource-limited regions often face challenges in DR screening due to a shortage of ophthalmologists.This study reports the implementation and outcomes of the Chinese local standard DB52/T 1726-2023,Regulations for the application of diabetic retinopathy screening artificial intelligence,in Cambodian healthcare institutions.A pilot DR screening program with independent operational capability is established by providing a non-mydriatic fundus camera and deploying a localized diabetic retinopathy artificial intelligence(DR-AI)screening platform at the Cambodia-Kingdom Friendship Hospital in Phnom Penh,along with comprehensive training.From January to August 2025,a total of 565 patients with type 2 diabetes were screened,yielding a DR detection rate of 26.0%(147 cases).Research findings demonstrate that applying mature Chinese DR-AI screening standards and technological solutions through international collaboration in regions with a scarcity of ophthalmic professionals is both feasible and effective.This project serves as a reference for promoting DR-AI in resource-constrained countries and regions,highlighting its significant potential to leverage AI in addressing the global burden of chronic diseases and advancing the modernization of health systems.展开更多
Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao)...Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao),wheat(Xiaomai),and jujube(Dazao),it functions to nourish the heart and calm the mind,harmonize the middle burner and regulate Qi,and alleviate urgency and restlessness.As its clinical application has expanded from traditional emotional disorders to neurological,endocrine,and various psychosomatic diseases,establishing a scientifically precise quality control system and deeply elucidating its pharmacodynamic material basis and mechanism of action have become critical tasks.Modern analytical methods,typified by chromatography,spectroscopy,and their hyphenated techniques,with their high sensitivity,high resolution,and powerful substance characterization capabilities,have become the core driving force for standardizing the quality control and modernizing the clinical application research of this formula.This paper systematically reviews the progress of the aforementioned analytical techniques and chemometrics in interpreting the chemical composition,establishing fingerprint profiles,controlling process quality,and researching the pharmacodynamic material basis of Ganmai Dazao Decoction.Furthermore,it discusses integrated approaches combining analytical techniques with pharmacology and clinical medicine to reveal mechanisms of action and explore therapeutic biomarkers.Finally,it provides an outlook on future directions and challenges,including technological integration and innovation,standardization of whole-process quality control systems,and evidence-based research aimed at internationalization.展开更多
Cancer is the second leading cause of death globally.Its treatment remains a major challenge due to the disease's complexity,heterogeneity,and adaptive nature.Among the array of available treatments,targeted thera...Cancer is the second leading cause of death globally.Its treatment remains a major challenge due to the disease's complexity,heterogeneity,and adaptive nature.Among the array of available treatments,targeted therapy emerges as a paramount approach to address this substantial unmet clinical need,owing to its precise tumor targeting capabilities and potential for mitigating tumor progression risks.Drug conjugates are in high demand for targeted therapy due to their unique ligand specificity and potent cytotoxicity,thereby significantly enhancing therapeutic efficacy and reducing the incidence of adverse effects.Therefore,as a burgeoning field in biomedical research,it is timely to outline the latest advances in drug conjugates-driven cancer treatment.Herein,we aim to present the emerging breakthroughs in this exciting field at the intersection of target ligands,linkers,payloads,and cancer treatments.This review focuses on several drug conjugates-related strategies,including antibody-drug conjugates(ADCs),peptide-drug conjugates(PDCs),small molecule-drug conjugates(SMDCs),aptamer-drug conjugates(ApDCs)and radionuclide-drug conjugates(RDCs).Finally,we discuss the fundamentals behind drug conjugate-based anticancer therapeutics,along with their inherent advantages and associated challenges,as well as recent research advances.展开更多
Smoke generator constitute an important class of pesticide formulations widely used in protected agriculture,forestry,mushroom cultivation,and storage environments.Unlike conventional sprays,smoke generator rely on he...Smoke generator constitute an important class of pesticide formulations widely used in protected agriculture,forestry,mushroom cultivation,and storage environments.Unlike conventional sprays,smoke generator rely on heat-induced phase transitions of active ingredients to produce fine aerosolized particles that disperse through Brownian motion,thereby markedly improving application efficiency.Despite their long history and broad utility,the development of smoke generator has largely stagnated over the past two decades.Here,we provide a comprehensive assessment of their historical evolution,registration landscape,physicochemical mechanisms,and current deployment in agricultural systems.Based on this analysis,we outline key directions for nextgeneration smoke generator technology.First,transitioning from chemical heating to electric heating is essential to enable automation and unmanned pesticide delivery.Second,expanding the air-purification functionality of smoke formulations offers a promising strategy to suppress airborne pest and pathogen populations.Finally,integrating principles of crystal engineering to modulate particle morphology and interfacial affinity may overcome current limitations in deposition efficiency and biological performance.Together,these advances will underpin the development of high-efficiency,intelligent smoke generator and support precision plant protection and sustainable intensification in protected agriculture.展开更多
The rise of portable electronic devices and Internet of Things(IoT)has spurred significant interest in flexible triboelectric nanogenerators(TENGs)as sustainable energy solutions.The electrical performance of TENGs is...The rise of portable electronic devices and Internet of Things(IoT)has spurred significant interest in flexible triboelectric nanogenerators(TENGs)as sustainable energy solutions.The electrical performance of TENGs is profoundly influenced by nanoscale factors,including interface properties and material characteristics,highlighting the critical need for a comprehensive understanding of these parameters to unlock their full potential.This paper summarizes the recent advances in advanced fiber composite TENGs(FC-TENGs),especially electrospun nanofibers,with a focus on key nanoscale properties,covering triboelectric layer interface characteristics,dielectric constant,electron affinity,and crystal phase,all of which are fundamental to optimizing their output performance.Additionally,it explores emerging applications of FC-TENGs in wearable electronics,self-powered sensors,wireless communication systems,human-machine interfaces,and modern healthcare technologies.The review concludes by addressing existing challenges,evaluating future opportunities,and outlining research directions for advancing FC-TENGs.By bridging foundational material science with innovative applications,this review seeks to inspire the development of high-performance,self-powered electrospun composite tribovoltaic nanogenerators,paving the way for a wireless,artificial intelligence(AI)-enabled IoT era.展开更多
Mongolian medicine posits that disruptions to the natural balance of the three roots and seven elements within the human body may lead to ocular disorders,vision impairment,and ultimately myopia.China’s children and ...Mongolian medicine posits that disruptions to the natural balance of the three roots and seven elements within the human body may lead to ocular disorders,vision impairment,and ultimately myopia.China’s children and adolescents not only exhibit high myopia rates but also face increasingly prominent issues of younger onset and severe progression,which critically impact the nation’s future and require urgent attention.Myopia prevention constitutes a systematic project.Traditional Mongolian moxibustion therapy works by applying heat stimulation to specific acupoints to warm meridians,harmonize Qi-blood circulation,regulate elemental balance,thereby enhancing immunity for disease prevention.This holistic approach features non-invasive application with minimal side effects.However,current interventions in myopia management through this method still face challenges including inconsistent operational protocols and insufficiently systematic collaborative research.This paper reviews recent advancements in early intervention using Mongolian moxibustion therapy for myopia,providing insights to optimize myopia prevention strategies.展开更多
With the rapid development of image-generative AI (artificial intelligence) technology, its application in undergraduate Landscape Architecture education has demonstrated significant potential. Based on this, the pres...With the rapid development of image-generative AI (artificial intelligence) technology, its application in undergraduate Landscape Architecture education has demonstrated significant potential. Based on this, the present study explores the implications of integrating image-generative AI into Landscape Architecture courses from three perspectives: stimulating students creative design potential, expanding approaches to form and concept generation, and enhancing the visualization of spatial scenes. Furthermore, it discusses application strategies from three dimensions: AI-assisted conceptual generation, human-machine collaboration for design refinement, and optimization of scheme presentation and evaluation. This paper aims to provide relevant educators with insights and references.展开更多
Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By...Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.展开更多
AIM:To assess the success rate of lacrimal sac hydrostatic pressure application(HPA)maneuver,a conservative office procedure for treatment of congenital nasolacrimal duct obstruction(CNLDO).METHODS:The medical records...AIM:To assess the success rate of lacrimal sac hydrostatic pressure application(HPA)maneuver,a conservative office procedure for treatment of congenital nasolacrimal duct obstruction(CNLDO).METHODS:The medical records of pediatric patients,36mo old or younger,diagnosed with CNLDO between the years 2016-2022,were retrospectively reviewed.In all children,HPA was performed by a pediatric ophthalmologist.Success was defined as the resolution of epiphora and discharge within 48h of the intervention.RESULTS:A total of 281 eyes(194 patients)with CNLDO underwent HPA.Follow-up data were available for 261 eyes(179 patients,50.3%male)and these patients were included in the analysis.The mean follow-up time was 11.6±13mo.Ninety-seven patients(54.2%)had unilateral nasolacrimal duct obstruction,while 82 patients(45.8%)had bilateral CNLDO.The mean age at the time of HPA was 5.8±5.9mo.Complete resolution of symptoms was achieved in 102(39.1%)eyes.Patients 6mo old or younger at the time of HPA had a significantly higher success rate compared to patients older than 6mo(43.7%vs 30.9%,P=0.04).Younger age at the time of pressure application was associated with a higher resolution rate of CNLDO(OR 0.93,P=0.004).Sex assigned at birth,prematurity,laterality of the obstruction and type of symptoms(epiphora,discharge)were not correlated with success.A second HPA was performed in 46 eyes,with resolution of symptoms in 12 eyes(26.1%).CONCLUSION:Hydrostatic pressure applied on the lacrimal sac by an experienced ophthalmologist or an experienced pediatrician may be an effective treatment for CNLDO.We recommend HPA as an initial active conservative approach in all pediatric patients with CNLDO,especially those younger than 6mo.展开更多
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You...Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.展开更多
文摘Whole Slide Imaging (WSI) technology, as a revolutionary digital technology in the field of pathology, is gradually changing the traditional clinical pathological diagnosis model. By converting traditional glass pathological sections into complete digital images through high-resolution scanning, it provides a new method for pathological diagnosis. Based on this, this paper studies the application of WSI technology in clinical pathological diagnosis, elaborates on its application value, analyzes the current application status, and proposes corresponding application countermeasures, aiming to provide reference for the standardized and popularized development of this technology in clinical pathological diagnosis.
基金supported by National Natural Science Foundation of China(22578155,22478147)the Natural Science Foundation of Huaian City(HAB2024051).
文摘Biomass is a resourcewhose organic carbon is formed from atmospheric carbon dioxide.It has numerous characteristics such as low carbon emissions,renewability,and environmental friendliness.The efficient utilization of biomass plays a significant role in promoting the development of clean energy,alleviating environmental pressures,and achieving carbon neutrality goals.Among the numerous processing technologies of biomass,hydrothermal carbonization(HTC)is a promising thermochemical process that can decompose and convert biomass into hydrochar under relatively mild conditions of approximately 180℃–300℃,thereby enabling its efficient resource utilization.In addition,HTC can directly process feedstocks with high moisture content without the need for high-temperature drying,resulting in lower energy consumption.Based on a systematic analysis of the critical articles mainly published in 2011-2025 related to biomass,HTC,and hydrochar applications,in this review,the category of biomass was first classified and the chemical compositions were summarized.Then,the main chemical reaction pathways involved in biomass decomposition and transformation during the HTC process were introduced.Meanwhile,the roles of key process parameters,including reaction temperature,residence time,pH,feedstock type,pressure,mass ratio of biomass to water,and the use of catalysts on HTC,were carefully discussed.Finally,the applications of hydrochar in energy utilization,environmental remediation,soil improvement,adsorbent,microbial fermentation,and phosphorus recovery fields were highlighted.The future directions of the HTC process were also provided,which would respond to climate change by promoting the development of the sustainable carbon materials field.
基金supported by the National Natural Science Foundation of China(21706052,22278114)Natural Science Foundation of Henan Province(242300421575).
文摘Lignin,the most abundant natural aromatic polymer globally,has garnered considerable interest due to its rich and diverse active functional groups and its antioxidant,antimicrobial,and adhesive properties.Recent research has significantly improved the performance of lignin-based hydrogels,suggesting their substantial potential in fields such as biomedicine,environmental science,and agriculture.This paper reviews the process of lignin extraction,systematically introduces synthesis strategies for preparing lignin-based hydrogels,and discusses the current state of research on these hydrogels in biomedical and environmental protection fields.It concludes by identifying the existing challenges in lignin hydrogel research and envisioning future prospects and development trends.
基金supported by the National Natural Science Foundation of China(NSFC No.52271228)the Natural Science Foundation of Shaanxi Province(No.2023-JC-ZD-21)the Doctoral Dissertation Innovation Fund of Xi'an University of Technology(No.101-252072301)。
文摘Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/chemical stability.To enhance the performance of intrinsic g-CN,a supramolecular self-assembly strategy has been proposed to regulate the molecular structure of supramolecular precursors through non-covalent interactions across molecular building blocks,thereby optimizing the electronic structure of g-CN.This review provides a comprehensive overview of the recent progress in supramolecular self-assembly-derived graphitic carbon nitride(SM-CN)from both experimental and theoretical computational research in synthesis strategies,including synthesis methods and influencing factors,providing a theoretical foundation for the design of supramolecular assembly.It also discusses modification strategies,such as internal modification of the conjugated plane,interlayer optimization,and construction of heterointerfaces to improve the electronic structure of SM-CN owing to its unique layered structure.This review further summarizes the applications of SM-CN in environment and energy,including wastewater treatment,sterilization and disinfection/air purification,water splitting,H_(2)O_(2)production,organic synthesis/biomass conversion,CO_(2)reduction,photocatalytic coupling technology.Finally,perspectives and outlooks for the future development of SM-CN aim to inspire further innovation in the design and construction of high-performance SM-CN for broader applications.
基金supported by the National Natural Science Foundation of China(Grant No.32160172)the Key Science-Technology Project of Inner Mongolia(2023KYPT0010)+1 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN03006)the 2023 Inner Mongolia Public Institution High-Level Talent Introduction Scientific Research Support Project.
文摘Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.
文摘Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance and scalability,as current trends require the distribution of computation across network nodes/points.In this paper,we survey a large number of mapping and scheduling techniques designed for NoC architectures.This time,we concentrated on 3D systems.We take a systematic literature review approach to analyze existing methods across static,dynamic,hybrid,and machine-learning-based approaches,alongside preliminary AI-based dynamic models in recent works.We classify them into several main aspects covering power-aware mapping,fault tolerance,load-balancing,and adaptive for dynamic workloads.Also,we assess the efficacy of each method against performance parameters,such as latency,throughput,response time,and error rate.Key challenges,including energy efficiency,real-time adaptability,and reinforcement learning integration,are highlighted as well.To the best of our knowledge,this is one of the recent reviews that identifies both traditional and AI-based algorithms for mapping over a modern NoC,and opens research challenges.Finally,we provide directions for future work toward improved adaptability and scalability via lightweight learned models and hierarchical mapping frameworks.
基金Supported by Science and Technology Project of China Tobacco Zhejiang Industrial Co.,Ltd.(2023330000340093).
文摘[Objectives]To investigate the effects of different planting densities and nitrogen application rates on the yield and quality of the tobacco cultivar Chuxue 80.[Methods]A field experiment was conducted in Hubei Province,evaluating various combinations of planting density and nitrogen rate for Chuxue 80.[Results]At the maturity stage,the TN1 treatment(5 kg N per 667 m^(2) with a density of 1900 plants per 667 m^(2))demonstrated the most favorable agronomic performance.The TN9 treatment(11 kg N per 667 m^(2) with a density of 1110 plants per 667 m^(2))achieved the highest wrapper tobacco yield and output value.Meanwhile,the TN5 treatment(8 kg N per 667 m^(2) with a density of 1515 plants per 667 m^(2))resulted in the best smoking quality.[Conclusions]The TN9 treatment,with a planting density of 1110 plants per 667 m^(2) and a nitrogen application rate of 11 kg per 667 m^(2),is recommended as the optimal cultivation practice for Chuxue 80 in Hubei Province.
基金Supported by National Natural Science Foundation of China(82374346)Double Hundred Outstanding Young and Middle-aged Medical and Health Talents of Wuxi City(BJ2023071)Scientific Research Project of Wuxi Municipal Health Commission(Q202358).
文摘This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.
基金financially supported by the Shandong Province Natural Science Foundation(No.ZR2023ME181)the National Natural Science Foundation of China(No.52305313)the Natural Science Foundation of Hunan Province(Nos.2023JJ40553 and 2023JJ60433)。
文摘Biodegradable metals(BMs)have shown significant potential for applications in the field of orthopedic implants.These materials gradually degrade after implantation,eventually disappear without residue,provide necessary mechanical support during degradation,and closely integrate with bone tissues.Fe-based BMs are particularly notable for their good mechanical properties and biocompatibility.However,their slow degradation rate is a limitation.The emergence of Mn-incorporated Fe-based alloys(Fe-Mn alloys)offers the possibilities for addressing issues of slow degradation rate and incompatibility of magnetic resonance imaging(MRI)for Fe alloys.This review summarizes the advantages of Fe-Mn alloys as orthopedic implants,and the cutting-edge advances in degradation,mechanical and magnetic properties,and osteogenic performance.The cytotoxicity issue is addressed for the porous structured Fe-Mn alloys caused by the enrichment of manganese ions,and thus the main challenge and the development are involved for the Fe-Mn alloys to achieve a balance among biocompatibility,structure,and degradation rate.Also the perspectives are proposed for Fe-Mn alloys as orthopedic implants.
基金funded by the Zhejiang Provincial Key Science and Technology“LingYan”Project Foundation,grant number 2023C01145Zhejiang Gongshang University Higher Education Research Projects,grant number Xgy22028.
文摘With the deep integration of smart manufacturing and IoT technologies,higher demands are placed on the intelligence and real-time performance of industrial equipment fault detection.For industrial fans,base bolt loosening faults are difficult to identify through conventional spectrum analysis,and the extreme scarcity of fault data leads to limited training datasets,making traditional deep learning methods inaccurate in fault identification and incapable of detecting loosening severity.This paper employs Bayesian Learning by training on a small fault dataset collected from the actual operation of axial-flow fans in a factory to obtain posterior distribution.This method proposes specific data processing approaches and a configuration of Bayesian Convolutional Neural Network(BCNN).It can effectively improve the model’s generalization ability.Experimental results demonstrate high detection accuracy and alignment with real-world applications,offering practical significance and reference value for industrial fan bolt loosening detection under data-limited conditions.
基金funded by the Chronic Disease Management Research Project of National Health Commission Capacity Building and Continuing Education Center 2025(GWJJMB202510024146)the Post-Subsidy Project for Standard Development of Guizhou Provincial Market Supervision and Administration Bureau 2025(DB52/T1726-2023)the Guizhou Provincial Health Commission Science and Technology Fund Project(gzwkj2024-076,gzwkj2026-146).
文摘Diabetic retinopathy(DR)is a leading cause of vision loss among working-age populations,with early screening significantly reducing the risk of blindness.However,resource-limited regions often face challenges in DR screening due to a shortage of ophthalmologists.This study reports the implementation and outcomes of the Chinese local standard DB52/T 1726-2023,Regulations for the application of diabetic retinopathy screening artificial intelligence,in Cambodian healthcare institutions.A pilot DR screening program with independent operational capability is established by providing a non-mydriatic fundus camera and deploying a localized diabetic retinopathy artificial intelligence(DR-AI)screening platform at the Cambodia-Kingdom Friendship Hospital in Phnom Penh,along with comprehensive training.From January to August 2025,a total of 565 patients with type 2 diabetes were screened,yielding a DR detection rate of 26.0%(147 cases).Research findings demonstrate that applying mature Chinese DR-AI screening standards and technological solutions through international collaboration in regions with a scarcity of ophthalmic professionals is both feasible and effective.This project serves as a reference for promoting DR-AI in resource-constrained countries and regions,highlighting its significant potential to leverage AI in addressing the global burden of chronic diseases and advancing the modernization of health systems.
文摘Ganmai Dazao Decoction,originating from“Jin Gui Yao Lue”(Synopsis of the Golden Chamber),is a classical prescription for treating visceral agitation.Composed of three medicinal and edible substances-licorice(Gancao),wheat(Xiaomai),and jujube(Dazao),it functions to nourish the heart and calm the mind,harmonize the middle burner and regulate Qi,and alleviate urgency and restlessness.As its clinical application has expanded from traditional emotional disorders to neurological,endocrine,and various psychosomatic diseases,establishing a scientifically precise quality control system and deeply elucidating its pharmacodynamic material basis and mechanism of action have become critical tasks.Modern analytical methods,typified by chromatography,spectroscopy,and their hyphenated techniques,with their high sensitivity,high resolution,and powerful substance characterization capabilities,have become the core driving force for standardizing the quality control and modernizing the clinical application research of this formula.This paper systematically reviews the progress of the aforementioned analytical techniques and chemometrics in interpreting the chemical composition,establishing fingerprint profiles,controlling process quality,and researching the pharmacodynamic material basis of Ganmai Dazao Decoction.Furthermore,it discusses integrated approaches combining analytical techniques with pharmacology and clinical medicine to reveal mechanisms of action and explore therapeutic biomarkers.Finally,it provides an outlook on future directions and challenges,including technological integration and innovation,standardization of whole-process quality control systems,and evidence-based research aimed at internationalization.
基金the Project of China-Japan Joint International Laboratory of Advanced Drug Delivery System Research and Translation of Liaoning Province(No.2024JH2/102100007)the open fund of National Key Laboratory of Advanced DrugFormulations for Overcoming Delivery Barriers(No.2024-KFB-003)+1 种基金the National Natural Science Foundation of China(No.82104109)Scientific Research Project of Liaoning Department of Education(No.LJ212410163045).
文摘Cancer is the second leading cause of death globally.Its treatment remains a major challenge due to the disease's complexity,heterogeneity,and adaptive nature.Among the array of available treatments,targeted therapy emerges as a paramount approach to address this substantial unmet clinical need,owing to its precise tumor targeting capabilities and potential for mitigating tumor progression risks.Drug conjugates are in high demand for targeted therapy due to their unique ligand specificity and potent cytotoxicity,thereby significantly enhancing therapeutic efficacy and reducing the incidence of adverse effects.Therefore,as a burgeoning field in biomedical research,it is timely to outline the latest advances in drug conjugates-driven cancer treatment.Herein,we aim to present the emerging breakthroughs in this exciting field at the intersection of target ligands,linkers,payloads,and cancer treatments.This review focuses on several drug conjugates-related strategies,including antibody-drug conjugates(ADCs),peptide-drug conjugates(PDCs),small molecule-drug conjugates(SMDCs),aptamer-drug conjugates(ApDCs)and radionuclide-drug conjugates(RDCs).Finally,we discuss the fundamentals behind drug conjugate-based anticancer therapeutics,along with their inherent advantages and associated challenges,as well as recent research advances.
基金supported by National Key Research and Development Program of China(2022YFD1700500)Earmarked Fund for Shandong Agriculture Research System(SDARS-05).
文摘Smoke generator constitute an important class of pesticide formulations widely used in protected agriculture,forestry,mushroom cultivation,and storage environments.Unlike conventional sprays,smoke generator rely on heat-induced phase transitions of active ingredients to produce fine aerosolized particles that disperse through Brownian motion,thereby markedly improving application efficiency.Despite their long history and broad utility,the development of smoke generator has largely stagnated over the past two decades.Here,we provide a comprehensive assessment of their historical evolution,registration landscape,physicochemical mechanisms,and current deployment in agricultural systems.Based on this analysis,we outline key directions for nextgeneration smoke generator technology.First,transitioning from chemical heating to electric heating is essential to enable automation and unmanned pesticide delivery.Second,expanding the air-purification functionality of smoke formulations offers a promising strategy to suppress airborne pest and pathogen populations.Finally,integrating principles of crystal engineering to modulate particle morphology and interfacial affinity may overcome current limitations in deposition efficiency and biological performance.Together,these advances will underpin the development of high-efficiency,intelligent smoke generator and support precision plant protection and sustainable intensification in protected agriculture.
基金financially supported by the National Natural Science Foundation of China(52127811,51975120)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX25_0096)。
文摘The rise of portable electronic devices and Internet of Things(IoT)has spurred significant interest in flexible triboelectric nanogenerators(TENGs)as sustainable energy solutions.The electrical performance of TENGs is profoundly influenced by nanoscale factors,including interface properties and material characteristics,highlighting the critical need for a comprehensive understanding of these parameters to unlock their full potential.This paper summarizes the recent advances in advanced fiber composite TENGs(FC-TENGs),especially electrospun nanofibers,with a focus on key nanoscale properties,covering triboelectric layer interface characteristics,dielectric constant,electron affinity,and crystal phase,all of which are fundamental to optimizing their output performance.Additionally,it explores emerging applications of FC-TENGs in wearable electronics,self-powered sensors,wireless communication systems,human-machine interfaces,and modern healthcare technologies.The review concludes by addressing existing challenges,evaluating future opportunities,and outlining research directions for advancing FC-TENGs.By bridging foundational material science with innovative applications,this review seeks to inspire the development of high-performance,self-powered electrospun composite tribovoltaic nanogenerators,paving the way for a wireless,artificial intelligence(AI)-enabled IoT era.
文摘Mongolian medicine posits that disruptions to the natural balance of the three roots and seven elements within the human body may lead to ocular disorders,vision impairment,and ultimately myopia.China’s children and adolescents not only exhibit high myopia rates but also face increasingly prominent issues of younger onset and severe progression,which critically impact the nation’s future and require urgent attention.Myopia prevention constitutes a systematic project.Traditional Mongolian moxibustion therapy works by applying heat stimulation to specific acupoints to warm meridians,harmonize Qi-blood circulation,regulate elemental balance,thereby enhancing immunity for disease prevention.This holistic approach features non-invasive application with minimal side effects.However,current interventions in myopia management through this method still face challenges including inconsistent operational protocols and insufficiently systematic collaborative research.This paper reviews recent advancements in early intervention using Mongolian moxibustion therapy for myopia,providing insights to optimize myopia prevention strategies.
基金Supported by Applied Brand Course of Mianyang Teacher's College(Investigation and Monitoring of Natural Resources).
文摘With the rapid development of image-generative AI (artificial intelligence) technology, its application in undergraduate Landscape Architecture education has demonstrated significant potential. Based on this, the present study explores the implications of integrating image-generative AI into Landscape Architecture courses from three perspectives: stimulating students creative design potential, expanding approaches to form and concept generation, and enhancing the visualization of spatial scenes. Furthermore, it discusses application strategies from three dimensions: AI-assisted conceptual generation, human-machine collaboration for design refinement, and optimization of scheme presentation and evaluation. This paper aims to provide relevant educators with insights and references.
文摘Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.
文摘AIM:To assess the success rate of lacrimal sac hydrostatic pressure application(HPA)maneuver,a conservative office procedure for treatment of congenital nasolacrimal duct obstruction(CNLDO).METHODS:The medical records of pediatric patients,36mo old or younger,diagnosed with CNLDO between the years 2016-2022,were retrospectively reviewed.In all children,HPA was performed by a pediatric ophthalmologist.Success was defined as the resolution of epiphora and discharge within 48h of the intervention.RESULTS:A total of 281 eyes(194 patients)with CNLDO underwent HPA.Follow-up data were available for 261 eyes(179 patients,50.3%male)and these patients were included in the analysis.The mean follow-up time was 11.6±13mo.Ninety-seven patients(54.2%)had unilateral nasolacrimal duct obstruction,while 82 patients(45.8%)had bilateral CNLDO.The mean age at the time of HPA was 5.8±5.9mo.Complete resolution of symptoms was achieved in 102(39.1%)eyes.Patients 6mo old or younger at the time of HPA had a significantly higher success rate compared to patients older than 6mo(43.7%vs 30.9%,P=0.04).Younger age at the time of pressure application was associated with a higher resolution rate of CNLDO(OR 0.93,P=0.004).Sex assigned at birth,prematurity,laterality of the obstruction and type of symptoms(epiphora,discharge)were not correlated with success.A second HPA was performed in 46 eyes,with resolution of symptoms in 12 eyes(26.1%).CONCLUSION:Hydrostatic pressure applied on the lacrimal sac by an experienced ophthalmologist or an experienced pediatrician may be an effective treatment for CNLDO.We recommend HPA as an initial active conservative approach in all pediatric patients with CNLDO,especially those younger than 6mo.
文摘Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.
