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Application-aware routing with QoS support in SDN networks 被引量:1
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作者 张泽鑫 Li Jun Wu Haibo 《High Technology Letters》 EI CAS 2016年第4期404-411,共8页
Software defined networking( SDN) offers programmable interface to effectively control their networks by decoupling control and data plane. The network operators utilize a centralized controller to deploy advanced net... Software defined networking( SDN) offers programmable interface to effectively control their networks by decoupling control and data plane. The network operators utilize a centralized controller to deploy advanced network management strategies. An architecture for application-aware routing which can support dynamic quality of service( Qo S) in SDN networks is proposed. The applicationaware routing as a multi-constrained optimal path( MCOP) problem is proposed,where applications are treated as Qo S flow and best-effort flows. With the SDN controller applications,it is able to dynamically lead routing decisions based on application characteristics and requirements,leading to a better overall user experience and higher utilization of network resources. The simulation results show that the improvement of application-aware routing framework on discovering appropriate routes,which can provide Qo S guarantees for a specific application in SDN networks. 展开更多
关键词 application aware software defined networking(SDN) networks quality of service(Qo S) multiple constraints path selection
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Curvularin derivatives from hydrothermal vent sediment fungus Penicillium sp.HL-50 guided by molecular networking and their antiinflammatory activity 被引量:1
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作者 Chunxue Yu Zixuan Xia +6 位作者 Zhipeng Xu Xiyang Tang Wenjuan Ding Jihua Wei Danmei Tian Bin Wu Jinshan Tang 《Chinese Journal of Natural Medicines》 2025年第1期119-128,共10页
Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid ... Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,^(13)C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC_(50)values ranging from 0.44 to 4.40μmol·L^(-1).Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(i NOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes,downregulating the expression of inflammation-related proteins,and inhibiting the release of inflammatory cytokines,indicating its potential application in the treatment of inflammatory diseases. 展开更多
关键词 Penicillium sp.HL-50 Curvularin derivatives Molecular networking Anti-inflammatory activity
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Call for Papers─Feature Topic Vol.23,No.1,2026 Space-Terrestrial Integrated 6G Network:Architecture,Networking,and Transmission Technologies
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《China Communications》 2025年第6期F0003-F0003,共1页
With the large-scale deployment of satellite constellations such as Starlink and the rapid advancement of technologies including artificial intelligence (AI) and non-terrestrial networks (NTNs), the integration of hig... With the large-scale deployment of satellite constellations such as Starlink and the rapid advancement of technologies including artificial intelligence (AI) and non-terrestrial networks (NTNs), the integration of high, medium, and low Earth orbit satellite networks with terrestrial networks has become a critical direction for future communication technologies. The objective is to develop a space-terrestrial integrated 6G network that ensures ubiquitous connectivity and seamless services, facilitating intelligent interconnection and collaborative symbiosis among humans, machines, and objects. This integration has become a central focus of global technological innovation. 展开更多
关键词 communication technologiesthe space terrestrial integrated G network g network satellite constellations terrestrial networks artificial intelligence ai intelligent int satellite networks
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Cross-Domain Time Synchronization in Software-Defined Time-Sensitive Networking
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作者 Zhang Xiaodong Shou Guochu +2 位作者 Li Hongxing Liu Yaqiong Hu Yihong 《China Communications》 2025年第9期289-306,共18页
The rise of time-sensitive applications with broad geographical scope drives the development of time-sensitive networking(TSN)from intra-domain to inter-domain to ensure overall end-to-end connectivity requirements in... The rise of time-sensitive applications with broad geographical scope drives the development of time-sensitive networking(TSN)from intra-domain to inter-domain to ensure overall end-to-end connectivity requirements in heterogeneous deployments.When multiple TSN networks interconnect over non-TSN networks,all devices in the network need to be syn-chronized by sharing a uniform time reference.How-ever,most non-TSN networks are best-effort.Path delay asymmetry and random noise accumulation can introduce unpredictable time errors during end-to-end time synchronization.These factors can degrade syn-chronization performance.Therefore,cross-domain time synchronization becomes a challenging issue for multiple TSN networks interconnected by non-TSN networks.This paper presents a cross-domain time synchronization scheme that follows the software-defined TSN(SD-TSN)paradigm.It utilizes a com-bined control plane constructed by a coordinate con-troller and a domain controller for centralized control and management of cross-domain time synchroniza-tion.The general operation flow of the cross-domain time synchronization process is designed.The mecha-nism of cross-domain time synchronization is revealed by introducing a synchronization model and an error compensation method.A TSN cross-domain proto-type testbed is constructed for verification.Results show that the scheme can achieve end-to-end high-precision time synchronization with accuracy and sta-bility. 展开更多
关键词 cross-domain time synchronization de-terministic communications error compensation software-defined networking(SDN) time-sensitive networking(TSN)
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A High Destruction-Resistant Resilient Networking Platform for Air-to-Ground Cooperative Communications
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作者 Dong Ping Ren Jiaxin +3 位作者 Guo Jiannan Zhang Yuzhen Liu Qianwen Amr Tolba 《China Communications》 2025年第4期27-41,共15页
With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.Howev... With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.However,battlefield uncertainties,such as equipment failures and enemy attacks,can impact these collaborative operations'stability and communication efficiency.To this end,we design a highly destruction-resistant air-ground cooperative resilient networking platform that aims to enhance the robustness of network communications by integrating ground vehicle information for UAV network deployment.It then incorporates the concept of virtual guiding force,enabling the UAV swarm to adaptively configure its network layout based on ground vehicle information,thereby improving network destruction resistance.Simulation results demonstrate that the UAV swarm involved in the proposed platform exhibits balanced flight energy consumption and excellent performance in network destruction resistance. 展开更多
关键词 air-to-ground coordination network destruction resistance SpringBoot UAV
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A Hierarchical-Based Sequential Caching Scheme in Named Data Networking
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作者 Zhang Junmin Jin Jihuan +3 位作者 Hou Rui Dong Mianxiong Kaoru Ota Zeng Deze 《China Communications》 2025年第5期48-60,共13页
Named data networking(NDNs)is an idealized deployment of information-centric networking(ICN)that has attracted attention from scientists and scholars worldwide.A distributed in-network caching scheme can efficiently r... Named data networking(NDNs)is an idealized deployment of information-centric networking(ICN)that has attracted attention from scientists and scholars worldwide.A distributed in-network caching scheme can efficiently realize load balancing.However,such a ubiquitous caching approach may cause problems including duplicate caching and low data diversity,thus reducing the caching efficiency of NDN routers.To mitigate these caching problems and improve the NDN caching efficiency,in this paper,a hierarchical-based sequential caching(HSC)scheme is proposed.In this scheme,the NDN routers in the data transmission path are divided into various levels and data with different request frequencies are cached in distinct router levels.The aim is to cache data with high request frequencies in the router that is closest to the content requester to increase the response probability of the nearby data,improve the data caching efficiency of named data networks,shorten the response time,and reduce cache redundancy.Simulation results show that this scheme can effectively improve the cache hit rate(CHR)and reduce the average request delay(ARD)and average route hop(ARH). 展开更多
关键词 hierarchical router named data networking sequential caching
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Deep Learning-Based Natural Language Processing Model and Optical Character Recognition for Detection of Online Grooming on Social Networking Services
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作者 Sangmin Kim Byeongcheon Lee +2 位作者 Muazzam Maqsood Jihoon Moon Seungmin Rho 《Computer Modeling in Engineering & Sciences》 2025年第5期2079-2108,共30页
The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children a... The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children and adolescents who are increasingly exposed to online grooming crimes.Early and accurate identification of grooming conversations is crucial in preventing long-term harm to victims.However,research on grooming detection in South Korea remains limited,as existing models trained primarily on English text and fail to reflect the unique linguistic features of SNS conversations,leading to inaccurate classifications.To address these issues,this study proposes a novel framework that integrates optical character recognition(OCR)technology with KcELECTRA,a deep learning-based natural language processing(NLP)model that shows excellent performance in processing the colloquial Korean language.In the proposed framework,the KcELECTRA model is fine-tuned by an extensive dataset,including Korean social media conversations,Korean ethical verification data from AI-Hub,and Korean hate speech data from Hug-gingFace,to enable more accurate classification of text extracted from social media conversation images.Experimental results show that the proposed framework achieves an accuracy of 0.953,outperforming existing transformer-based models.Furthermore,OCR technology shows high accuracy in extracting text from images,demonstrating that the proposed framework is effective for online grooming detection.The proposed framework is expected to contribute to the more accurate detection of grooming text and the prevention of grooming-related crimes. 展开更多
关键词 Online grooming KcELECTRA natural language processing optical character recognition social networking service text classification
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Multi-Band Integrated Networking for Efficient Spectrum Utilization in 6G
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作者 Wang Ailing Kong Lei +4 位作者 Liu Jianjun Xia Liang Wang Xiaoqian Wang Qixing Liu Guangyi 《China Communications》 2025年第4期42-54,共13页
The sixth-generation(6G)networks will consist of multiple bands such as low-frequency,midfrequency,millimeter wave,terahertz and other bands to meet various business requirements and networking scenarios.The dynamic c... The sixth-generation(6G)networks will consist of multiple bands such as low-frequency,midfrequency,millimeter wave,terahertz and other bands to meet various business requirements and networking scenarios.The dynamic complementarity of multiple bands are crucial for enhancing the spectrum efficiency,reducing network energy consumption,and ensuring a consistent user experience.This paper investigates the present researches and challenges associated with deployment of multi-band integrated networks in existing infrastructures.Then,an evolutionary path for integrated networking is proposed with the consideration of maturity of emerging technologies and practical network deployment.The proposed design principles for 6G multi-band integrated networking aim to achieve on-demand networking objectives,while the architecture supports full spectrum access and collaboration between high and low frequencies.In addition,the potential key air interface technologies and intelligent technologies for integrated networking are comprehensively discussed.It will be a crucial basis for the subsequent standards promotion of 6G multi-band integrated networking technology. 展开更多
关键词 full spectrum access high and low frequency collaboration multi-band integrated networking 6G spectrum efficiency
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Key technologies for networking in satellite-terrestrial integrated network
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作者 Haijun ZHANG Sichen LU Xiaoqi ZHANG 《Chinese Journal of Aeronautics》 2025年第9期267-270,共4页
1.Introduction As a key development of the next-generation spatial information infrastructure,1the Satellite-Terrestrial Integrated Network(STIN)has become a strategic priority actively pursued by major spacefaring na... 1.Introduction As a key development of the next-generation spatial information infrastructure,1the Satellite-Terrestrial Integrated Network(STIN)has become a strategic priority actively pursued by major spacefaring nations and regions,including the United States,Europe,China,and Russia.Specifically,Space X’s Starlink project has deployed over 6750 satellites,2while One Web has completed its initial phase of satellite constellation deployment with more than 600 satellites. 展开更多
关键词 satellite terrestrial integrated network satellite constellation starlink project next generation spatial information infrastructure Starlink OneWeb STIN
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Cytotoxic anthrone–cyclopentenone heterodimers from the fungus Penicillium sp.guided by molecular networking
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作者 Ruiyun Huo Jiayu Dong +2 位作者 Gaoran Liu Ying Shi Ling Liu 《Chinese Journal of Natural Medicines》 2025年第10期1259-1267,共9页
(±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified co... (±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified compounds(5–7),were isolated from the crude extract of the mangrove-derived fungus Penicillium sp.,guided by heteronuclear single quantum correlation(HSQC)-based small molecule accurate recognition technology(SMART 2.0)and liquid chromatography-tandem mass spectrometry(LC-MS/MS)-based molecular networking.The structural elucidation of new compounds was accomplished through comprehensive spectroscopic analysis,and their absolute configurations were determined using DP4+^(13)C nuclear magnetic resonance(NMR)calculations and electronic circular dichroism(ECD)calculations.Compounds 1a/1b–4a/4b demonstrated moderate cytotoxicity against three human cancer cell lines HeLa,HCT116 and MCF-7 with half maximal inhibitory concentration(IC50)values ranging from 15.95±1.64 to 28.56±2.59μmol·L–1. 展开更多
关键词 Mangrove-derived fungi Molecular networking HSQC-based SMART Structure elucidation DP4+13C NMR calculation Cytotoxic activity
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Conditional Generative Adversarial Network-Based Travel Route Recommendation
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作者 Sunbin Shin Luong Vuong Nguyen +3 位作者 Grzegorz J.Nalepa Paulo Novais Xuan Hau Pham Jason J.Jung 《Computers, Materials & Continua》 2026年第1期1178-1217,共40页
Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of... Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of user preferences.To address this,we propose a Conditional Generative Adversarial Network(CGAN)that generates diverse and highly relevant itineraries.Our approach begins by constructing a conditional vector that encapsulates a user’s profile.This vector uniquely fuses embeddings from a Heterogeneous Information Network(HIN)to model complex user-place-route relationships,a Recurrent Neural Network(RNN)to capture sequential path dynamics,and Neural Collaborative Filtering(NCF)to incorporate collaborative signals from the wider user base.This comprehensive condition,further enhanced with features representing user interaction confidence and uncertainty,steers a CGAN stabilized by spectral normalization to generate high-fidelity latent route representations,effectively mitigating the data sparsity problem.Recommendations are then formulated using an Anchor-and-Expand algorithm,which selects relevant starting Points of Interest(POI)based on user history,then expands routes through latent similarity matching and geographic coherence optimization,culminating in Traveling Salesman Problem(TSP)-based route optimization for practical travel distances.Experiments on a real-world check-in dataset validate our model’s unique generative capability,achieving F1 scores ranging from 0.163 to 0.305,and near-zero pairs−F1 scores between 0.002 and 0.022.These results confirm the model’s success in generating novel travel routes by recommending new locations and sequences rather than replicating users’past itineraries.This work provides a robust solution for personalized travel planning,capable of generating novel and compelling routes for both new and existing users by learning from collective travel intelligence. 展开更多
关键词 Travel route recommendation conditional generative adversarial network heterogeneous information network anchor-and-expand algorithm
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Artificial Intelligence (AI)-Enabled Unmanned Aerial Vehicle (UAV) Systems for Optimizing User Connectivity in Sixth-Generation (6G) Ubiquitous Networks
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作者 Zeeshan Ali Haider Inam Ullah +2 位作者 Ahmad Abu Shareha Rashid Nasimov Sufyan Ali Memon 《Computers, Materials & Continua》 2026年第1期534-549,共16页
The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-gener... The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment. 展开更多
关键词 6G networks UAV-based communication cooperative reinforcement learning network optimization user connectivity energy efficiency
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Detecting and Mitigating Distributed Denial of Service Attacks in Software-Defined Networking
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作者 Abdullah M.Alnajim Faisal Mohammed Alotaibi Sheroz Khan 《Computers, Materials & Continua》 2025年第6期4515-4535,共21页
Distributed denial of service(DDoS)attacks are common network attacks that primarily target Internet of Things(IoT)devices.They are critical for emerging wireless services,especially for applications with limited late... Distributed denial of service(DDoS)attacks are common network attacks that primarily target Internet of Things(IoT)devices.They are critical for emerging wireless services,especially for applications with limited latency.DDoS attacks pose significant risks to entrepreneurial businesses,preventing legitimate customers from accessing their websites.These attacks require intelligent analytics before processing service requests.Distributed denial of service(DDoS)attacks exploit vulnerabilities in IoT devices by launchingmulti-point distributed attacks.These attacks generate massive traffic that overwhelms the victim’s network,disrupting normal operations.The consequences of distributed denial of service(DDoS)attacks are typically more severe in software-defined networks(SDNs)than in traditional networks.The centralised architecture of these networks can exacerbate existing vulnerabilities,as these weaknesses may not be effectively addressed in this model.The preliminary objective for detecting and mitigating distributed denial of service(DDoS)attacks in software-defined networks(SDN)is to monitor traffic patterns and identify anomalies that indicate distributed denial of service(DDoS)attacks.It implements measures to counter the effects ofDDoS attacks,and ensure network reliability and availability by leveraging the flexibility and programmability of SDN to adaptively respond to threats.The authors present a mechanism that leverages the OpenFlow and sFlow protocols to counter the threats posed by DDoS attacks.The results indicate that the proposed model effectively mitigates the negative effects of DDoS attacks in an SDN environment. 展开更多
关键词 Software-defined networking(SDN) distributed denial of service(DDoS)attack sampling Flow(sFlow) OpenFlow OpenDaylight controller
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Artificial Neural Network Model for Thermal Conductivity Estimation of Metal Oxide Water-Based Nanofluids
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作者 Nikhil S.Mane Sheetal Kumar Dewangan +3 位作者 Sayantan Mukherjee Pradnyavati Mane Deepak Kumar Singh Ravindra Singh Saluja 《Computers, Materials & Continua》 2026年第1期316-331,共16页
The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a n... The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a necessary step before their practical application.As these investigations are time and resource-consuming undertakings,an effective prediction model can significantly improve the efficiency of research operations.In this work,an Artificial Neural Network(ANN)model is developed to predict the thermal conductivity of metal oxide water-based nanofluid.For this,a comprehensive set of 691 data points was collected from the literature.This dataset is split into training(70%),validation(15%),and testing(15%)and used to train the ANN model.The developed model is a backpropagation artificial neural network with a 4–12–1 architecture.The performance of the developed model shows high accuracy with R values above 0.90 and rapid convergence.It shows that the developed ANN model accurately predicts the thermal conductivity of nanofluids. 展开更多
关键词 Artificial neural networks nanofluids thermal conductivity PREDICTION
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Recurrent MAPPO for Joint UAV Trajectory and Traffic Offloading in Space-Air-Ground Integrated Networks
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作者 Zheyuan Jia Fenglin Jin +1 位作者 Jun Xie Yuan He 《Computers, Materials & Continua》 2026年第1期447-461,共15页
This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential g... This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential growth of mobile devices and data traffic has substantially increased network congestion,particularly in urban areas and regions with limited terrestrial infrastructure.Our approach jointly optimizes unmanned aerial vehicle(UAV)trajectories and satellite-assisted offloading strategies to simultaneously maximize data throughput,minimize energy consumption,and maintain equitable resource distribution.The proposed RMAPPO framework incorporates recurrent neural networks(RNNs)to model temporal dependencies in UAV mobility patterns and utilizes a decentralized multi-agent reinforcement learning architecture to reduce communication overhead while improving system robustness.The proposed RMAPPO algorithm was evaluated through simulation experiments,with the results indicating that it significantly enhances the cumulative traffic offloading rate of nodes and reduces the energy consumption of UAVs. 展开更多
关键词 Space-air-ground integrated networks UAV traffic offloading reinforcement learning
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Investigating the potential mechanisms of Wenqing Yin against atopic dermatitis based on network pharmacology,experimental pharmacology,and molecular docking
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作者 Yi Wang Zhen Liu +3 位作者 Si-Man Li Lin Lin Wei Dai Meng-Yue Ren 《Traditional Medicine Research》 2026年第2期1-11,共11页
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o... Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses. 展开更多
关键词 Wenqing Yin atopic dermatitis mouse model UPLC-Orbitrap-MS/MS network pharmacology
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Graph Attention Networks for Skin Lesion Classification with CNN-Driven Node Features
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作者 Ghadah Naif Alwakid Samabia Tehsin +3 位作者 Mamoona Humayun Asad Farooq Ibrahim Alrashdi Amjad Alsirhani 《Computers, Materials & Continua》 2026年第1期1964-1984,共21页
Skin diseases affect millions worldwide.Early detection is key to preventing disfigurement,lifelong disability,or death.Dermoscopic images acquired in primary-care settings show high intra-class visual similarity and ... Skin diseases affect millions worldwide.Early detection is key to preventing disfigurement,lifelong disability,or death.Dermoscopic images acquired in primary-care settings show high intra-class visual similarity and severe class imbalance,and occasional imaging artifacts can create ambiguity for state-of-the-art convolutional neural networks(CNNs).We frame skin lesion recognition as graph-based reasoning and,to ensure fair evaluation and avoid data leakage,adopt a strict lesion-level partitioning strategy.Each image is first over-segmented using SLIC(Simple Linear Iterative Clustering)to produce perceptually homogeneous superpixels.These superpixels form the nodes of a region-adjacency graph whose edges encode spatial continuity.Node attributes are 1280-dimensional embeddings extracted with a lightweight yet expressive EfficientNet-B0 backbone,providing strong representational power at modest computational cost.The resulting graphs are processed by a five-layer Graph Attention Network(GAT)that learns to weight inter-node relationships dynamically and aggregates multi-hop context before classifying lesions into seven classes with a log-softmax output.Extensive experiments on the DermaMNIST benchmark show the proposed pipeline achieves 88.35%accuracy and 98.04%AUC,outperforming contemporary CNNs,AutoML approaches,and alternative graph neural networks.An ablation study indicates EfficientNet-B0 produces superior node descriptors compared with ResNet-18 and DenseNet,and that roughly five GAT layers strike a good balance between being too shallow and over-deep while avoiding oversmoothing.The method requires no data augmentation or external metadata,making it a drop-in upgrade for clinical computer-aided diagnosis systems. 展开更多
关键词 Graph neural network image classification DermaMNIST dataset graph representation
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A Dual-Attention CNN-BiLSTM Model for Network Intrusion Detection
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作者 Zheng Zhang Jie Hao +2 位作者 Liquan Chen Tianhao Hou Yanan Liu 《Computers, Materials & Continua》 2026年第1期1119-1140,共22页
With the increasing severity of network security threats,Network Intrusion Detection(NID)has become a key technology to ensure network security.To address the problem of low detection rate of traditional intrusion det... With the increasing severity of network security threats,Network Intrusion Detection(NID)has become a key technology to ensure network security.To address the problem of low detection rate of traditional intrusion detection models,this paper proposes a Dual-Attention model for NID,which combines Convolutional Neural Network(CNN)and Bidirectional Long Short-Term Memory(BiLSTM)to design two modules:the FocusConV and the TempoNet module.The FocusConV module,which automatically adjusts and weights CNN extracted local features,focuses on local features that are more important for intrusion detection.The TempoNet module focuses on global information,identifies more important features in time steps or sequences,and filters and weights the information globally to further improve the accuracy and robustness of NID.Meanwhile,in order to solve the class imbalance problem in the dataset,the EQL v2 method is used to compute the class weights of each class and to use them in the loss computation,which optimizes the performance of the model on the class imbalance problem.Extensive experiments were conducted on the NSL-KDD,UNSW-NB15,and CIC-DDos2019 datasets,achieving average accuracy rates of 99.66%,87.47%,and 99.39%,respectively,demonstrating excellent detection accuracy and robustness.The model also improves the detection performance of minority classes in the datasets.On the UNSW-NB15 dataset,the detection rates for Analysis,Exploits,and Shellcode attacks increased by 7%,7%,and 10%,respectively,demonstrating the Dual-Attention CNN-BiLSTM model’s excellent performance in NID. 展开更多
关键词 network intrusion detection class imbalance problem deep learning
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P4LoF: Scheduling Loop-Free Multi-Flow Updates in Programmable Networks
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作者 Jiqiang Xia Qi Zhan +2 位作者 Le Tian Yuxiang Hu Jianhua Peng 《Computers, Materials & Continua》 2026年第1期1236-1254,共19页
The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.H... The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency. 展开更多
关键词 network management update consistency programmable data plane P4
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FMCSNet: Mobile Devices-Oriented Lightweight Multi-Scale Object Detection via Fast Multi-Scale Channel Shuffling Network Model
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作者 Lijuan Huang Xianyi Liu +1 位作者 Jinping Liu Pengfei Xu 《Computers, Materials & Continua》 2026年第1期1292-1311,共20页
The ubiquity of mobile devices has driven advancements in mobile object detection.However,challenges in multi-scale object detection in open,complex environments persist due to limited computational resources.Traditio... The ubiquity of mobile devices has driven advancements in mobile object detection.However,challenges in multi-scale object detection in open,complex environments persist due to limited computational resources.Traditional approaches like network compression,quantization,and lightweight design often sacrifice accuracy or feature representation robustness.This article introduces the Fast Multi-scale Channel Shuffling Network(FMCSNet),a novel lightweight detection model optimized for mobile devices.FMCSNet integrates a fully convolutional Multilayer Perceptron(MLP)module,offering global perception without significantly increasing parameters,effectively bridging the gap between CNNs and Vision Transformers.FMCSNet achieves a delicate balance between computation and accuracy mainly by two key modules:the ShiftMLP module,including a shift operation and an MLP module,and a Partial group Convolutional(PGConv)module,reducing computation while enhancing information exchange between channels.With a computational complexity of 1.4G FLOPs and 1.3M parameters,FMCSNet outperforms CNN-based and DWConv-based ShuffleNetv2 by 1%and 4.5%mAP on the Pascal VOC 2007 dataset,respectively.Additionally,FMCSNet achieves a mAP of 30.0(0.5:0.95 IoU threshold)with only 2.5G FLOPs and 2.0M parameters.It achieves 32 FPS on low-performance i5-series CPUs,meeting real-time detection requirements.The versatility of the PGConv module’s adaptability across scenarios further highlights FMCSNet as a promising solution for real-time mobile object detection. 展开更多
关键词 Object detection lightweight network partial group convolution multilayer perceptron
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