Objective To investigate the effect of computer aided 3D simulation technique for treating complicated foot and ankle fractures precisely.Methods From November 2007 to August 2009,255 patients with complicated foot an...Objective To investigate the effect of computer aided 3D simulation technique for treating complicated foot and ankle fractures precisely.Methods From November 2007 to August 2009,255 patients with complicated foot and ankle fractures展开更多
According to the regulations of the People＇s Republic of China national standard as the basis, on the part of chemical industry product quality inspection and analysis of the implementation of computer management has...According to the regulations of the People＇s Republic of China national standard as the basis, on the part of chemical industry product quality inspection and analysis of the implementation of computer management has developed a set of software applications, the software in chemical products quality inspection and analysis of the means of management is an innovation. The software functions, can automatically process data, judge the product grade, quality analysis, objective and fair, convenient, fast, accurate, stable, practical, and easy to popularize.展开更多
Computer network technology has a very important role in electronic information engineering.The application of this technology not only enriches the traditional information engineering functions,but also effectively g...Computer network technology has a very important role in electronic information engineering.The application of this technology not only enriches the traditional information engineering functions,but also effectively guarantees the efficiency and quality.At present,due to the wide variety of external information that Chinese citizens are exposed to,in addition to the variegated and mixed content,it is easy for information to be leaked or stolen.In order to avoid similar situations,it is necessary for people to pay more attention to network system security,so as to ensure that the quality of life of citizens can be guaranteed.In view of that,this paper discusses and analyzes the application of computer network technology in electronic information engineering.展开更多
With the rapid development of modern information technology, e-commerce has been a huge driving force, and rapid development. Electronic commerce is usually carried out by computer technology and network communication...With the rapid development of modern information technology, e-commerce has been a huge driving force, and rapid development. Electronic commerce is usually carried out by computer technology and network communication technology in business activity, in the network environment, buyers can not meet for various business activities, a business model to achieve online shopping, online payment, consumers and other business. With the continuous development of computer technology, computer network technology is applied more and more widely in e-commerce, e-commerce is developing rapidly, so to constantly improve in computer application in electronic commerce, improve the security of electronic commerce, provide a powerful technical guarantee for the development of electronic commerce. In this paper, the application of computer technology in electronic commerce is analyzed.展开更多
Under the background of the continuous combination of science and technology and modern production, the national macro requirements for enterprise construction have been adjusted and changed more obviously than in the...Under the background of the continuous combination of science and technology and modern production, the national macro requirements for enterprise construction have been adjusted and changed more obviously than in the past. It is not simply based on quantitative production, but more emphasis on the upgrading and progress of technology. This change also provides new ideas and ways for enterprise innovation. As an important basis for leading the development trend of the times, chemical enterprises should also receive more attention and attention in this case, especially in terms of chemical design, we should especially emphasize the significance of the application of computer software technology.展开更多
In recent years, with the increase of the speed of social development, the network level of its computer has also been continuously improved, in its computer network application and popularization stage, has achieved ...In recent years, with the increase of the speed of social development, the network level of its computer has also been continuously improved, in its computer network application and popularization stage, has achieved good results. But there are also more and more problems, such as data theft and system damage, which need to be analyzed and applied in security technologies to maintain network security.展开更多
With the rapid development of computer technology in China, computer technology has been integrated into every corner of peoples lives which leads to many hidden security risks in the big data environment. The open In...With the rapid development of computer technology in China, computer technology has been integrated into every corner of peoples lives which leads to many hidden security risks in the big data environment. The open Internet environment in the big data environment leads some people to attempt to gain benefits on the Internet by improper means. For example, some lawless elements attract peoples attention by making vulgar video pictures, pornographic and violent online games or vulgar advertisements, and steal the personal information and privacy of netizens in order to obtain illegitimate interests. These security risks pose a serious threat to the information security of network users. Based on the big data environment, this paper discusses some network information security existing in this era environment and analyzes how to make rational use of computer technology to effectively protect peoples information security, hoping to provide some help for the development and progress of computer technology and the purification of network environment in China.展开更多
The prerequisite for doctors to diagnose and treat patients is to be able to accurately determine the patient's physical condition, which requires the help of some medical image data to help doctors to judge. At p...The prerequisite for doctors to diagnose and treat patients is to be able to accurately determine the patient's physical condition, which requires the help of some medical image data to help doctors to judge. At present, many hospitals in China are equipped with more advanced and complete imaging equipment. The normal operation of these equipment is closely related to computer image processing technology. This technology is a new technology based on computer technology and biomedical technology. Its key role is to provide convenient conditions for doctors to carry out treatment scientifically and efficiently, and improve the comprehensive service level of the hospital. This paper analyzes and studies the progress and application of computer image processing technology in medical imaging.展开更多
With the rapid development of the social process, information technology has been widely used in People's Daily life, which also brings great convenience to people's life and work, and various industries have ...With the rapid development of the social process, information technology has been widely used in People's Daily life, which also brings great convenience to people's life and work, and various industries have gradually accelerated the pace of information construction. In this paper, engineering project management as the research object, from multiple perspectives, based on computer application technology in the application of engineering project management research and analysis, for reference.展开更多
At the present stage, with the continuous improvement of Chinas economic level, the realization of science and technology development has laid a foundation, and the development level of science and technology continue...At the present stage, with the continuous improvement of Chinas economic level, the realization of science and technology development has laid a foundation, and the development level of science and technology continues to improve, but also comprehensively promote the rapid development and improvement of many industries in China. At present, with the continuous improvement of the development level of informatization in China, computers can be used on a larger scale in commercial office projects, whether in the peoples daily life. Computer technology hairpin for computer electronic information rapid development and improvement, need to meet and penetration in the social development area, need to solve the problem of information management, in the specific construction industry, with the engineering construction industry and development mode constantly improve, and related construction units has very advanced construction technology development, will directly lead to the management difficulty, but there are great problems and deficiencies. This paper is mainly for the computer electronic information engineering management and use, put forward the corresponding measures.展开更多
With the continuous development of current science and technology and information technology, people have begun to pay attention to using these technologies to improve their quality of life and work efficiency in thei...With the continuous development of current science and technology and information technology, people have begun to pay attention to using these technologies to improve their quality of life and work efficiency in their daily life and work. Currently, computer technology is widely used in all walks of life. Radio and television engineering also attaches great importance to carrying out work through computer technology. At present, the actual situation of applying computer technology to radio and television engineering should continue to promote exploration and development. The following will focus on the current application of computer technology to radio and television. The advantages and practical applications in engineering are discussed, and finally an example of the application of computer technology to radio and television engineering is given.展开更多
Computer network technology plays a core role in electronic information engineering, and has a positive significance in information transmission, data sharing, security protection and other aspects. The integration of...Computer network technology plays a core role in electronic information engineering, and has a positive significance in information transmission, data sharing, security protection and other aspects. The integration of the two plays an important role in promoting the development of electronic information engineering. With the development of computer network technology, it will inevitably be more deeply and widely applied in electronic information engineering, and the two will achieve a deeper integration. The transmission and sharing of network information are completed through electronic information engineering. Computer network technology promotes the development of electronic information engineering. When computer network technology is combined with electronic information engineering, it can fundamentally improve the development level of electronic information engineering. In the development of social economy and science and technology, electronic information engineering will usher in a broader space for development, which is also a demand for computer network technology.展开更多
Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BC...Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility.展开更多
This paper discusses the related contents of the integration application of information technology and computer software engineering.First,it briefly expounds the concepts and integration background of information tec...This paper discusses the related contents of the integration application of information technology and computer software engineering.First,it briefly expounds the concepts and integration background of information technology and computer software engineering.Then,it deeply analyzes the application status and significance of the integration application of information technology and computer software engineering in different fields.Finally,it briefly describes the specific application paths of the integration of information technology and computer software engineering,hoping to provide some valuable references for promoting the in-depth integration and development of information technology and computer software engineering.展开更多
α-Trifluoromethyl ketones are a class of useful compounds with versatile applications.Their synthetic application via the transformation of the C—F bonds is of particular interest by allowing the synthesis of organi...α-Trifluoromethyl ketones are a class of useful compounds with versatile applications.Their synthetic application via the transformation of the C—F bonds is of particular interest by allowing the synthesis of organic compounds with diverse structures.Herein,the advances in the research areas ofα-trifluoromethyl ketone synthesis and their defluorination reactions are reviewed.Discussion on the mechanisms of the typical reactions has also been provided,in hope of affording some guides to the chemistry ofα-trifluoromethyl ketones in the synthetic methods toward themselves and their derivatives.展开更多
In this paper, a modified temperature-phase transformation-stress/strain field coupled 3D non-linear mathematical model was used in the computer simulation on heat treatment processes of workpieces including catch jaw...In this paper, a modified temperature-phase transformation-stress/strain field coupled 3D non-linear mathematical model was used in the computer simulation on heat treatment processes of workpieces including catch jaw, anchor ring, cold roller, large-scale bearing roller, nitriding crank shaft, etc. The simulation on complicated technologies such as pre-cooled quenching, double media quenching, self-tempering, difference temperature heating, nitriding distortion was carried out. The optimum design of heat treatment technology has been realized. The successful application of computer simulation on heat treatment have also been demonstrated.展开更多
Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vi...Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vironment and intensify carbon emissions.However,the use of microbially induced calcium carbonate pre-cipitation(MICP)to obtain bio-cement is a novel technique with the potential to induce soil stability,providing a low-carbon,environment-friendly,and sustainable integrated solution for some geotechnical engineering pro-blems in the environment.This paper presents a comprehensive review of the latest progress in soil improvement based on the MICP strategy.It systematically summarizes and overviews the mineralization mechanism,influ-encing factors,improved methods,engineering characteristics,and current field application status of the MICP.Additionally,it also explores the limitations and correspondingly proposes prospective applications via the MICP approach for soil improvement.This review indicates that the utilization of different environmental calcium-based wastes in MICP and combination of materials and MICP are conducive to meeting engineering and market demand.Furthermore,we recommend and encourage global collaborative study and practice with a view to commercializing MICP technique in the future.The current review purports to provide insights for engineers and interdisciplinary researchers,and guidance for future engineering applications.展开更多
BACKGROUND Although gastroscopy is a commonly used diagnostic and therapeutic technique,postoperative gastrointestinal dysfunction is prone to occur.Traditional Chinese medicine theory suggests that postoperative gast...BACKGROUND Although gastroscopy is a commonly used diagnostic and therapeutic technique,postoperative gastrointestinal dysfunction is prone to occur.Traditional Chinese medicine theory suggests that postoperative gastrointestinal disorders are related to spleen and stomach weakness.This study hypothesizes that the combination of acupoint application at the Ziwu Liuzhu acupoint and percutaneous acupoint electrical stimulation can promote postoperative gastrointestinal function recovery and alleviate stress reactions.AIM To investigate the effects of acupoint application of Ziwu Liuzhu combined with percutaneous acupoint electrical stimulation on postoperative gastrointestinal function recovery and stress response in patients undergoing gastrointestinal endoscopy surgery.METHODS A total of 120 patients who underwent gastroscopy surgery were selected and treated between October 2024 and January 2025.This study used a stratified block randomization method,and then allocated groups using computer-generated random number sequences(SAS 9.4 software).The groups were divided into two groups:A control group of 60 patients who received routine postoperative intervention measures,and an observation group of 60 patients who received acupuncture point application combined with transcutaneous acupoint electrical CONCLUSION The combination of percutaneous acupoint electrical stimulation in gastroscopy patients has been demonstrated to be both highly safe and effective.The benefits of this approach include the promotion of postoperative gastrointestinal function,the reduction of stress response,the attainment of optimal results,and the enhancement of patient satisfaction.展开更多
Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promi...Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for therapeutic interventions.Exos derived from mesenchymal stem cells(MSCs)have significant immunomodulatory properties.They effectively regulate immune responses by modulating both innate and adaptive immunity.These Exos can inhibit excessive inflammatory responses and promote tissue repair.Moreover,they participate in antigen presentation,which is essential for activating immune responses.The cargo of these Exos,including ligands,proteins,and microRNAs,can suppress T cell activity or enhance the population of immunosuppressive cells to dampen the immune response.By inhibiting lymphocyte proliferation,acting on macrophages,and increasing the population of regulatory T cells,these Exos contribute to maintaining immune and metabolic homeostasis.Furthermore,they can activate immune-related signaling pathways or serve as vehicles to deliver microRNAs and other bioactive substances to target tumor cells,which holds potential for immunotherapy applications.Given the immense therapeutic potential of MSC-derived Exos,this review comprehensively explores their mechanisms of immune regulation and therapeutic applications in areas such as infection control,tumor suppression,and autoimmune disease management.This article aims to provide valuable insights into the mechanisms behind the actions of MSC-derived Exos,offering theoretical references for their future clinical utilization as cell-free drug preparations.展开更多
文摘Objective To investigate the effect of computer aided 3D simulation technique for treating complicated foot and ankle fractures precisely.Methods From November 2007 to August 2009,255 patients with complicated foot and ankle fractures
文摘According to the regulations of the People＇s Republic of China national standard as the basis, on the part of chemical industry product quality inspection and analysis of the implementation of computer management has developed a set of software applications, the software in chemical products quality inspection and analysis of the means of management is an innovation. The software functions, can automatically process data, judge the product grade, quality analysis, objective and fair, convenient, fast, accurate, stable, practical, and easy to popularize.
文摘Computer network technology has a very important role in electronic information engineering.The application of this technology not only enriches the traditional information engineering functions,but also effectively guarantees the efficiency and quality.At present,due to the wide variety of external information that Chinese citizens are exposed to,in addition to the variegated and mixed content,it is easy for information to be leaked or stolen.In order to avoid similar situations,it is necessary for people to pay more attention to network system security,so as to ensure that the quality of life of citizens can be guaranteed.In view of that,this paper discusses and analyzes the application of computer network technology in electronic information engineering.
文摘With the rapid development of modern information technology, e-commerce has been a huge driving force, and rapid development. Electronic commerce is usually carried out by computer technology and network communication technology in business activity, in the network environment, buyers can not meet for various business activities, a business model to achieve online shopping, online payment, consumers and other business. With the continuous development of computer technology, computer network technology is applied more and more widely in e-commerce, e-commerce is developing rapidly, so to constantly improve in computer application in electronic commerce, improve the security of electronic commerce, provide a powerful technical guarantee for the development of electronic commerce. In this paper, the application of computer technology in electronic commerce is analyzed.
文摘Under the background of the continuous combination of science and technology and modern production, the national macro requirements for enterprise construction have been adjusted and changed more obviously than in the past. It is not simply based on quantitative production, but more emphasis on the upgrading and progress of technology. This change also provides new ideas and ways for enterprise innovation. As an important basis for leading the development trend of the times, chemical enterprises should also receive more attention and attention in this case, especially in terms of chemical design, we should especially emphasize the significance of the application of computer software technology.
文摘In recent years, with the increase of the speed of social development, the network level of its computer has also been continuously improved, in its computer network application and popularization stage, has achieved good results. But there are also more and more problems, such as data theft and system damage, which need to be analyzed and applied in security technologies to maintain network security.
文摘With the rapid development of computer technology in China, computer technology has been integrated into every corner of peoples lives which leads to many hidden security risks in the big data environment. The open Internet environment in the big data environment leads some people to attempt to gain benefits on the Internet by improper means. For example, some lawless elements attract peoples attention by making vulgar video pictures, pornographic and violent online games or vulgar advertisements, and steal the personal information and privacy of netizens in order to obtain illegitimate interests. These security risks pose a serious threat to the information security of network users. Based on the big data environment, this paper discusses some network information security existing in this era environment and analyzes how to make rational use of computer technology to effectively protect peoples information security, hoping to provide some help for the development and progress of computer technology and the purification of network environment in China.
文摘The prerequisite for doctors to diagnose and treat patients is to be able to accurately determine the patient's physical condition, which requires the help of some medical image data to help doctors to judge. At present, many hospitals in China are equipped with more advanced and complete imaging equipment. The normal operation of these equipment is closely related to computer image processing technology. This technology is a new technology based on computer technology and biomedical technology. Its key role is to provide convenient conditions for doctors to carry out treatment scientifically and efficiently, and improve the comprehensive service level of the hospital. This paper analyzes and studies the progress and application of computer image processing technology in medical imaging.
文摘With the rapid development of the social process, information technology has been widely used in People's Daily life, which also brings great convenience to people's life and work, and various industries have gradually accelerated the pace of information construction. In this paper, engineering project management as the research object, from multiple perspectives, based on computer application technology in the application of engineering project management research and analysis, for reference.
文摘At the present stage, with the continuous improvement of Chinas economic level, the realization of science and technology development has laid a foundation, and the development level of science and technology continues to improve, but also comprehensively promote the rapid development and improvement of many industries in China. At present, with the continuous improvement of the development level of informatization in China, computers can be used on a larger scale in commercial office projects, whether in the peoples daily life. Computer technology hairpin for computer electronic information rapid development and improvement, need to meet and penetration in the social development area, need to solve the problem of information management, in the specific construction industry, with the engineering construction industry and development mode constantly improve, and related construction units has very advanced construction technology development, will directly lead to the management difficulty, but there are great problems and deficiencies. This paper is mainly for the computer electronic information engineering management and use, put forward the corresponding measures.
文摘With the continuous development of current science and technology and information technology, people have begun to pay attention to using these technologies to improve their quality of life and work efficiency in their daily life and work. Currently, computer technology is widely used in all walks of life. Radio and television engineering also attaches great importance to carrying out work through computer technology. At present, the actual situation of applying computer technology to radio and television engineering should continue to promote exploration and development. The following will focus on the current application of computer technology to radio and television. The advantages and practical applications in engineering are discussed, and finally an example of the application of computer technology to radio and television engineering is given.
文摘Computer network technology plays a core role in electronic information engineering, and has a positive significance in information transmission, data sharing, security protection and other aspects. The integration of the two plays an important role in promoting the development of electronic information engineering. With the development of computer network technology, it will inevitably be more deeply and widely applied in electronic information engineering, and the two will achieve a deeper integration. The transmission and sharing of network information are completed through electronic information engineering. Computer network technology promotes the development of electronic information engineering. When computer network technology is combined with electronic information engineering, it can fundamentally improve the development level of electronic information engineering. In the development of social economy and science and technology, electronic information engineering will usher in a broader space for development, which is also a demand for computer network technology.
基金supported by the National Key R&D Program of China(2021YFF1200602)the National Science Fund for Excellent Overseas Scholars(0401260011)+3 种基金the National Defense Science and Technology Innovation Fund of Chinese Academy of Sciences(c02022088)the Tianjin Science and Technology Program(20JCZDJC00810)the National Natural Science Foundation of China(82202798)the Shanghai Sailing Program(22YF1404200).
文摘Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility.
文摘This paper discusses the related contents of the integration application of information technology and computer software engineering.First,it briefly expounds the concepts and integration background of information technology and computer software engineering.Then,it deeply analyzes the application status and significance of the integration application of information technology and computer software engineering in different fields.Finally,it briefly describes the specific application paths of the integration of information technology and computer software engineering,hoping to provide some valuable references for promoting the in-depth integration and development of information technology and computer software engineering.
文摘α-Trifluoromethyl ketones are a class of useful compounds with versatile applications.Their synthetic application via the transformation of the C—F bonds is of particular interest by allowing the synthesis of organic compounds with diverse structures.Herein,the advances in the research areas ofα-trifluoromethyl ketone synthesis and their defluorination reactions are reviewed.Discussion on the mechanisms of the typical reactions has also been provided,in hope of affording some guides to the chemistry ofα-trifluoromethyl ketones in the synthetic methods toward themselves and their derivatives.
文摘In this paper, a modified temperature-phase transformation-stress/strain field coupled 3D non-linear mathematical model was used in the computer simulation on heat treatment processes of workpieces including catch jaw, anchor ring, cold roller, large-scale bearing roller, nitriding crank shaft, etc. The simulation on complicated technologies such as pre-cooled quenching, double media quenching, self-tempering, difference temperature heating, nitriding distortion was carried out. The optimum design of heat treatment technology has been realized. The successful application of computer simulation on heat treatment have also been demonstrated.
基金funded by the National Natural Science Foundation of China(No.41962016)the Natural Science Foundation of NingXia(Nos.2023AAC02023,2023A1218,and 2021AAC02006).
文摘Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vironment and intensify carbon emissions.However,the use of microbially induced calcium carbonate pre-cipitation(MICP)to obtain bio-cement is a novel technique with the potential to induce soil stability,providing a low-carbon,environment-friendly,and sustainable integrated solution for some geotechnical engineering pro-blems in the environment.This paper presents a comprehensive review of the latest progress in soil improvement based on the MICP strategy.It systematically summarizes and overviews the mineralization mechanism,influ-encing factors,improved methods,engineering characteristics,and current field application status of the MICP.Additionally,it also explores the limitations and correspondingly proposes prospective applications via the MICP approach for soil improvement.This review indicates that the utilization of different environmental calcium-based wastes in MICP and combination of materials and MICP are conducive to meeting engineering and market demand.Furthermore,we recommend and encourage global collaborative study and practice with a view to commercializing MICP technique in the future.The current review purports to provide insights for engineers and interdisciplinary researchers,and guidance for future engineering applications.
基金Supported by Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project,No.2023ZL230。
文摘BACKGROUND Although gastroscopy is a commonly used diagnostic and therapeutic technique,postoperative gastrointestinal dysfunction is prone to occur.Traditional Chinese medicine theory suggests that postoperative gastrointestinal disorders are related to spleen and stomach weakness.This study hypothesizes that the combination of acupoint application at the Ziwu Liuzhu acupoint and percutaneous acupoint electrical stimulation can promote postoperative gastrointestinal function recovery and alleviate stress reactions.AIM To investigate the effects of acupoint application of Ziwu Liuzhu combined with percutaneous acupoint electrical stimulation on postoperative gastrointestinal function recovery and stress response in patients undergoing gastrointestinal endoscopy surgery.METHODS A total of 120 patients who underwent gastroscopy surgery were selected and treated between October 2024 and January 2025.This study used a stratified block randomization method,and then allocated groups using computer-generated random number sequences(SAS 9.4 software).The groups were divided into two groups:A control group of 60 patients who received routine postoperative intervention measures,and an observation group of 60 patients who received acupuncture point application combined with transcutaneous acupoint electrical CONCLUSION The combination of percutaneous acupoint electrical stimulation in gastroscopy patients has been demonstrated to be both highly safe and effective.The benefits of this approach include the promotion of postoperative gastrointestinal function,the reduction of stress response,the attainment of optimal results,and the enhancement of patient satisfaction.
基金Supported by the National Natural Science Foundation of China,No.82072537the General Project of Hunan Natural Science Foundation,No.2022JJ30412 and No.2021JJ30464.
文摘Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for therapeutic interventions.Exos derived from mesenchymal stem cells(MSCs)have significant immunomodulatory properties.They effectively regulate immune responses by modulating both innate and adaptive immunity.These Exos can inhibit excessive inflammatory responses and promote tissue repair.Moreover,they participate in antigen presentation,which is essential for activating immune responses.The cargo of these Exos,including ligands,proteins,and microRNAs,can suppress T cell activity or enhance the population of immunosuppressive cells to dampen the immune response.By inhibiting lymphocyte proliferation,acting on macrophages,and increasing the population of regulatory T cells,these Exos contribute to maintaining immune and metabolic homeostasis.Furthermore,they can activate immune-related signaling pathways or serve as vehicles to deliver microRNAs and other bioactive substances to target tumor cells,which holds potential for immunotherapy applications.Given the immense therapeutic potential of MSC-derived Exos,this review comprehensively explores their mechanisms of immune regulation and therapeutic applications in areas such as infection control,tumor suppression,and autoimmune disease management.This article aims to provide valuable insights into the mechanisms behind the actions of MSC-derived Exos,offering theoretical references for their future clinical utilization as cell-free drug preparations.
