It is vital segment to choose the right comparator product during the development and study of generic medicinal product, and this is also definitely specified in the relevant documents from the China Food and Drug Ad...It is vital segment to choose the right comparator product during the development and study of generic medicinal product, and this is also definitely specified in the relevant documents from the China Food and Drug Administration (CFDA)that the comparator product should be innovator product or internationally recognized same medicinal product,which is used in the re-evaluation of generic medicinal product or marketed authorization application of the generic medicinal product.To facilitate the domestic and foreign pharmaceutical enterprises to choose and determine comparator product,four medicinal product evaluation procedures,as well as the corresponding marketed medicinal product list,are detailed elaborated in this paper.At the same time, by taking the Mifepristone Tablet (200mg)as example,the search and determination process of the comparator product for generic medicinal product application in the EU is illustrated with the combination of different marketed medicinal product lists.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, is a home for original research papers of the highest ...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, is a home for original research papers of the highest quality in all areas of mathematics with applications.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, is a home for original research papers of the highest ...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, is a home for original research papers of the highest quality in ,all areas of pure and applied mathematics. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises：展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industria...Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.展开更多
基金National Science and Technology Major Projects for ‘Major New Drugs Innovation and Development’(Grant No.2017ZX09101001,Beijing,China)
文摘It is vital segment to choose the right comparator product during the development and study of generic medicinal product, and this is also definitely specified in the relevant documents from the China Food and Drug Administration (CFDA)that the comparator product should be innovator product or internationally recognized same medicinal product,which is used in the re-evaluation of generic medicinal product or marketed authorization application of the generic medicinal product.To facilitate the domestic and foreign pharmaceutical enterprises to choose and determine comparator product,four medicinal product evaluation procedures,as well as the corresponding marketed medicinal product list,are detailed elaborated in this paper.At the same time, by taking the Mifepristone Tablet (200mg)as example,the search and determination process of the comparator product for generic medicinal product application in the EU is illustrated with the combination of different marketed medicinal product lists.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, is a home for original research papers of the highest quality in all areas of mathematics with applications.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, is a home for original research papers of the highest quality in ,all areas of pure and applied mathematics. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises：
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
文摘Journal overview： Journal of Mathematical Research with Applications （JMRA）, formerly Journal of Mathematical Research and Exposition （JMRE） created in 1981, one of the Transactions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highest quality in all areas of mathematics with applications. The target audience comprises： pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interested in mathematics.
