Nonscattering optical anapole condition is corresponding to the excitation of radiationless field distributions in open resonators,which offers new degrees of freedom for tailoring light-matter interaction.Conventiona...Nonscattering optical anapole condition is corresponding to the excitation of radiationless field distributions in open resonators,which offers new degrees of freedom for tailoring light-matter interaction.Conventional mechanisms for achieving such a condition relies on sophisticated manipulation of electromagnetic multipolar moments of all orders to guarantee superpositions of suppressed moment strengths at the same wavelength.In contrast,here we report on the excitation of optical radiationless anapole hidden in a resonant state of a Si nanoparticle utilizing a tightly focused radially polarized(RP)beam.The coexistence of magnetic resonant state and anapole condition at the same wavelength further enables the triggering of resonant state by a tightly focused azimuthally polarized(AP)beam whose corresponding electric multipole coefficient could be zero.As a result,high contrast inter-transition between radiationless anapole condition and ideal magnetic resonant scattering can be achieved experimentally in visible spectrum.The proposed mechanism is general which can be realized in different types of nanostructures.Our results showcase that the unique combination of structured light and structured Mie resonances could provide new degrees of freedom for tailoring light-matter interaction,which might shed new light on functional meta-optics.展开更多
AIM： To detect a possible association between the polymorphism of the （-670 A/G） Fas/Apol gene promoter and susceptibility to Crohn＇s disease （CD） and ulcerative colitis （UC） in the Tunisian population. METHOD...AIM： To detect a possible association between the polymorphism of the （-670 A/G） Fas/Apol gene promoter and susceptibility to Crohn＇s disease （CD） and ulcerative colitis （UC） in the Tunisian population. METHODS： The （-670 A/G） Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS： Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of （-670 A/G） Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls （P corrected = 0.004 ＂in CD patients＂ and P corrected = 0.02 ＂in UC patients＂, respectively）. Analysis also showed a statistically significant association between genotype AA of the （-670 A/G） polymorphism and the ileum localization of the lesions （P corrected = 0.048） and between genotype GG and the colon localization （P corrected = 0.009）. The analysis of IBD patients according to clinical behavior revealed no difference. CONCLUSION： Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population.展开更多
Chronic kidney disease （CKD） is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in...Chronic kidney disease （CKD） is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mellitus, hypertension and human immunodeficiency virus （HIV） infection are the major causes of CKD. HIV-associated nephropathy （HIVAN） is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits （including genetic hits） underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era.展开更多
基金financial support from the National Key R&D Program of China (YS2018YFB110012)National Natural Science Foundation of China (NSFC) (Grant Nos. 11674130, 91750110, 61522504 and 61975067)+2 种基金Guangdong Provincial Innovation and Entrepreneurship Project (Grant 2016ZT06D081)Natural Science Foundation of Guangdong Province, China (Grant Nos. 2016A030306016, 2016TQ03X981 and 2016A030308010)Pearl River Nova Program of Guangzhou (No. 201806010040)
文摘Nonscattering optical anapole condition is corresponding to the excitation of radiationless field distributions in open resonators,which offers new degrees of freedom for tailoring light-matter interaction.Conventional mechanisms for achieving such a condition relies on sophisticated manipulation of electromagnetic multipolar moments of all orders to guarantee superpositions of suppressed moment strengths at the same wavelength.In contrast,here we report on the excitation of optical radiationless anapole hidden in a resonant state of a Si nanoparticle utilizing a tightly focused radially polarized(RP)beam.The coexistence of magnetic resonant state and anapole condition at the same wavelength further enables the triggering of resonant state by a tightly focused azimuthally polarized(AP)beam whose corresponding electric multipole coefficient could be zero.As a result,high contrast inter-transition between radiationless anapole condition and ideal magnetic resonant scattering can be achieved experimentally in visible spectrum.The proposed mechanism is general which can be realized in different types of nanostructures.Our results showcase that the unique combination of structured light and structured Mie resonances could provide new degrees of freedom for tailoring light-matter interaction,which might shed new light on functional meta-optics.
基金Supported by Laboratory of Immunology, EPS Charles Nicolle,Tunis, Tunisia
文摘AIM： To detect a possible association between the polymorphism of the （-670 A/G） Fas/Apol gene promoter and susceptibility to Crohn＇s disease （CD） and ulcerative colitis （UC） in the Tunisian population. METHODS： The （-670 A/G） Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS： Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of （-670 A/G） Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls （P corrected = 0.004 ＂in CD patients＂ and P corrected = 0.02 ＂in UC patients＂, respectively）. Analysis also showed a statistically significant association between genotype AA of the （-670 A/G） polymorphism and the ileum localization of the lesions （P corrected = 0.048） and between genotype GG and the colon localization （P corrected = 0.009）. The analysis of IBD patients according to clinical behavior revealed no difference. CONCLUSION： Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population.
基金Supported by NIH Fogarty International Center Grant,No.1D43TW008330-01A1Millennium Promise Award,Noncommunicable Chronic Diseases Leadership Training Program,NHLS Research Trust,Division of Nephrology Research Fund,University of the Witwatersrand,Johannesburg and FRC Individual grant,University of the Witwatersrand,Johannesburg
文摘Chronic kidney disease （CKD） is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mellitus, hypertension and human immunodeficiency virus （HIV） infection are the major causes of CKD. HIV-associated nephropathy （HIVAN） is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits （including genetic hits） underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era.
