Background:Nicotine administration can generate severe oxidative stress and lipid peroxidation.Royal jelly,with its antioxidant properties,acts as a scavenger of reactive oxygen species.This study describes the apithe...Background:Nicotine administration can generate severe oxidative stress and lipid peroxidation.Royal jelly,with its antioxidant properties,acts as a scavenger of reactive oxygen species.This study describes the apitherapy effects of royal jelly on testicular damage following nicotine administration.Methods:Forty-eight male BALB/c mice were divided into 8 groups(n=6):saline,3 different doses of royal jelly(100,150,and 200 mg/kg body weight(BW)per day),nicotine(1.5 mg/kg),and 3 different groups of Nic+Roy(1.5 mg/kg of Nic+100,150,and 200 mg/kg BW per day of royal jelly).Nicotine was administrated intraperitoneally,and royal jelly was prescribed orally for 10 consecutive days.Serum levels of hormones(testosterone,luteinizing hormone,and follicle-stimulating hormone),total antioxidant capacity,nitric oxide(NO)status,malondialdehyde levels,sperm DNA fragmentation,sperm parameters,histopathological changes(H&E staining),immunohistochemistry against apoptotic proteins,and gene expression of Bcl-2,p53,Caspase-3,and Nrf2(real-time PCR)were assessed to evaluate the molecular and histological changes.Results:Hormone levels,sperm parameters,and status of antioxidants were decreased significantly(p<.05)following nicotine administration.Moreover,royal jelly treatment normalized hormonal and antioxidant characteristics,decreased apoptotic gene expression,increased Nfr2 gene expression,and restored histopathological alteration to the physiological status significantly(p<.05).Conclusion:Royal jelly upregulates the antioxidant status,inhibits the mitochondrialdependent apoptosis pathway,and increases the rate of proliferation.This therapeutic agent effectively protected the testis against nicotine-associated damages by antioxidant and anti-apoptotic effects.展开更多
Ginger, turmeric, black seed, artichoke leaves, Azerbaijani thistle honey, and BB (bee bread) have a hepatoprotectiveeffect;therefore, they show effective results separately in case of alcohol-dependent and non-alcoho...Ginger, turmeric, black seed, artichoke leaves, Azerbaijani thistle honey, and BB (bee bread) have a hepatoprotectiveeffect;therefore, they show effective results separately in case of alcohol-dependent and non-alcoholic liver obesity, hepatitis andtoxic liver damage. We studied how it can affect liver enzymes and hepatocytes in this group of patients. We took all these naturalplants and bee products in the optimal dose required by the body and prepared a paste called Herbal, so that everyday people couldeat comfortably as a food supplement, as well as see the therapeutic and prophylactic results. HERBAL paste for liver ingredients:flaxseed, ginger, seed of thistle, powder of yellow ginger, black cumin, and honey. Benefits: Herbal paste prepared based onwell-tested recipes improves the function of the liver and gallbladder. As a hepatoprotector, it affects the recovery of liver cells inliver diseases (hepatitis and cirrhosis), spleen disease, bile ductinfections, gallstones in gallbladders, inflammatory bowel disease,colitis, cholecystitis. It helps to remove toxic substances while taking medicine (antibiotics, chemotherapy, painkillers, etc.). Sideeffects: Individual sensitiveness to the contents of the product. Usage: In acute process 1 teaspoon, during chronic diseases 1dessertspoon twice a day before eating. Results: 48 women and 54 men with the third level of fatty liver dystrophy decreased to thesecond level (fibrosis did not occur). During the treatment of 114 patients who had an HCV (hepatitis C virus), I used HERBALpaste as a protector for the liver. After the analyses, 24 patients, who had liver cirrhosis ALT (alanine aminotransferase) and AST(aspartate aminotransferase) in the blood reduced twice. Another 81 patients from 90 who had virus had disappeared in bloodanalyses and in the exogenous factor of liver and GGT in the blood get normal.展开更多
Throughout history, respiratory tract infections due to viruses, especially influenza viruses, continue to cause serious diseases, up to death, all over the world, as a result of the inability to develop effective tre...Throughout history, respiratory tract infections due to viruses, especially influenza viruses, continue to cause serious diseases, up to death, all over the world, as a result of the inability to develop effective treatment methods or vaccines. Due to changes in the antigenic structures of respiratory viruses, especially RNA viruses, there are difficulties in the production of effective vaccines. The World Health Organization estimates 150,000 hospitalizations and 30,000 to 40,000 deaths due to the flu epidemic in the United States alone, with a total of 25 to 50 million cases each year. Respiratory viruses are a major cause of influenza-like illness symptoms in children and adults, causing significant illness and death each year. Various herbal remedies have been used for the prevention and treatment of viral respiratory diseases in many parts of the world. Among those found to be effective are propolis, licorice root, ginger, black cumin, carob, but there is also scientific evidence for the effectiveness of several complementary treatments for the common cold. For example, oral zinc intake can reduce the severity of the common cold. Regular intake of vitamin C supplements can reduce the duration and severity of viral infections. Various herbs are widely used as medicine to clear viral respiratory infections. Influenza control and treatment mainly depend on chemical or biochemical agents isolated from plants. These agents include various polyphenols, flavonoids, saponins, glucosides, and alkaloids. We added such plants, propolis, and licorice honey to the content of bronxbal paste, which is a combination of supportive therapy, bronchial dilator, immunomodulator, mucolytic, and born antiviral and antibacterial effects during coronavirus and other bacterial-virus-caused pneumonia. We prepared it as a paste and used it in patients who do not have allergies. The plant and bee products in the bronxbal content we have prepared are natural pastes to solve problems that need ongoing rehabilitation, such as coronavirus pneumonia and chronic bronchitis caused by other viruses and bacteria, or Covid-19.展开更多
基金funded by Kermanshah University of Medical Sciences(grant no.96067)。
文摘Background:Nicotine administration can generate severe oxidative stress and lipid peroxidation.Royal jelly,with its antioxidant properties,acts as a scavenger of reactive oxygen species.This study describes the apitherapy effects of royal jelly on testicular damage following nicotine administration.Methods:Forty-eight male BALB/c mice were divided into 8 groups(n=6):saline,3 different doses of royal jelly(100,150,and 200 mg/kg body weight(BW)per day),nicotine(1.5 mg/kg),and 3 different groups of Nic+Roy(1.5 mg/kg of Nic+100,150,and 200 mg/kg BW per day of royal jelly).Nicotine was administrated intraperitoneally,and royal jelly was prescribed orally for 10 consecutive days.Serum levels of hormones(testosterone,luteinizing hormone,and follicle-stimulating hormone),total antioxidant capacity,nitric oxide(NO)status,malondialdehyde levels,sperm DNA fragmentation,sperm parameters,histopathological changes(H&E staining),immunohistochemistry against apoptotic proteins,and gene expression of Bcl-2,p53,Caspase-3,and Nrf2(real-time PCR)were assessed to evaluate the molecular and histological changes.Results:Hormone levels,sperm parameters,and status of antioxidants were decreased significantly(p<.05)following nicotine administration.Moreover,royal jelly treatment normalized hormonal and antioxidant characteristics,decreased apoptotic gene expression,increased Nfr2 gene expression,and restored histopathological alteration to the physiological status significantly(p<.05).Conclusion:Royal jelly upregulates the antioxidant status,inhibits the mitochondrialdependent apoptosis pathway,and increases the rate of proliferation.This therapeutic agent effectively protected the testis against nicotine-associated damages by antioxidant and anti-apoptotic effects.
文摘Ginger, turmeric, black seed, artichoke leaves, Azerbaijani thistle honey, and BB (bee bread) have a hepatoprotectiveeffect;therefore, they show effective results separately in case of alcohol-dependent and non-alcoholic liver obesity, hepatitis andtoxic liver damage. We studied how it can affect liver enzymes and hepatocytes in this group of patients. We took all these naturalplants and bee products in the optimal dose required by the body and prepared a paste called Herbal, so that everyday people couldeat comfortably as a food supplement, as well as see the therapeutic and prophylactic results. HERBAL paste for liver ingredients:flaxseed, ginger, seed of thistle, powder of yellow ginger, black cumin, and honey. Benefits: Herbal paste prepared based onwell-tested recipes improves the function of the liver and gallbladder. As a hepatoprotector, it affects the recovery of liver cells inliver diseases (hepatitis and cirrhosis), spleen disease, bile ductinfections, gallstones in gallbladders, inflammatory bowel disease,colitis, cholecystitis. It helps to remove toxic substances while taking medicine (antibiotics, chemotherapy, painkillers, etc.). Sideeffects: Individual sensitiveness to the contents of the product. Usage: In acute process 1 teaspoon, during chronic diseases 1dessertspoon twice a day before eating. Results: 48 women and 54 men with the third level of fatty liver dystrophy decreased to thesecond level (fibrosis did not occur). During the treatment of 114 patients who had an HCV (hepatitis C virus), I used HERBALpaste as a protector for the liver. After the analyses, 24 patients, who had liver cirrhosis ALT (alanine aminotransferase) and AST(aspartate aminotransferase) in the blood reduced twice. Another 81 patients from 90 who had virus had disappeared in bloodanalyses and in the exogenous factor of liver and GGT in the blood get normal.
文摘Throughout history, respiratory tract infections due to viruses, especially influenza viruses, continue to cause serious diseases, up to death, all over the world, as a result of the inability to develop effective treatment methods or vaccines. Due to changes in the antigenic structures of respiratory viruses, especially RNA viruses, there are difficulties in the production of effective vaccines. The World Health Organization estimates 150,000 hospitalizations and 30,000 to 40,000 deaths due to the flu epidemic in the United States alone, with a total of 25 to 50 million cases each year. Respiratory viruses are a major cause of influenza-like illness symptoms in children and adults, causing significant illness and death each year. Various herbal remedies have been used for the prevention and treatment of viral respiratory diseases in many parts of the world. Among those found to be effective are propolis, licorice root, ginger, black cumin, carob, but there is also scientific evidence for the effectiveness of several complementary treatments for the common cold. For example, oral zinc intake can reduce the severity of the common cold. Regular intake of vitamin C supplements can reduce the duration and severity of viral infections. Various herbs are widely used as medicine to clear viral respiratory infections. Influenza control and treatment mainly depend on chemical or biochemical agents isolated from plants. These agents include various polyphenols, flavonoids, saponins, glucosides, and alkaloids. We added such plants, propolis, and licorice honey to the content of bronxbal paste, which is a combination of supportive therapy, bronchial dilator, immunomodulator, mucolytic, and born antiviral and antibacterial effects during coronavirus and other bacterial-virus-caused pneumonia. We prepared it as a paste and used it in patients who do not have allergies. The plant and bee products in the bronxbal content we have prepared are natural pastes to solve problems that need ongoing rehabilitation, such as coronavirus pneumonia and chronic bronchitis caused by other viruses and bacteria, or Covid-19.
