Dear Editor,Genome editing tools are leading a revolution in plant breeding.In particular,prime editors(PEs)can install all types of base changes and small insertions/deletions at precise positions in plant genomes(An...Dear Editor,Genome editing tools are leading a revolution in plant breeding.In particular,prime editors(PEs)can install all types of base changes and small insertions/deletions at precise positions in plant genomes(Anzalone et al.,2019).PEs are by far the most powerful approach for improving traits conferred by gain-of-function point mutations.Early versions of PEs suffered from low editing efficiency,but the latest PEs can perform edits at a much higher efficiency thanks to the extensive efforts of re-searchers from around the world.Most modifications to improve PE efficiency have focused on the optimization of PE protein components and structure.展开更多
基金supported by grants from the National Key Research and Development Program of China(2023YFD1202905)the National Natural Science Foundation of China(32272629).
文摘Dear Editor,Genome editing tools are leading a revolution in plant breeding.In particular,prime editors(PEs)can install all types of base changes and small insertions/deletions at precise positions in plant genomes(Anzalone et al.,2019).PEs are by far the most powerful approach for improving traits conferred by gain-of-function point mutations.Early versions of PEs suffered from low editing efficiency,but the latest PEs can perform edits at a much higher efficiency thanks to the extensive efforts of re-searchers from around the world.Most modifications to improve PE efficiency have focused on the optimization of PE protein components and structure.
