Common strong noise interferences like metal splashes,smoke,and arc light during welding can seriously pollute the laser stripe images,causing the tracking model to drift and leading to tracking failure.At present,the...Common strong noise interferences like metal splashes,smoke,and arc light during welding can seriously pollute the laser stripe images,causing the tracking model to drift and leading to tracking failure.At present,there are already many mature methods for identifying and extracting feature points of linear laser stripes.When the laser stripe forms a curved shape on the surface of the workpiece,these linear methods will no longer be applicable.To eliminate interference sources,enhance the robustness of the weld tracking model,and effectively extract the feature points of curved laser stripes under strong noise conditions.This paper proposes a Conditional Generative Adversarial Network(CGAN)based anti-interference recognition method for welding images.The generator adopts an improved U-Net++structure,adds a Multi-scale Channel Attention module(MS-CAM),introduces Deep Supervision,and proposes a Multi-output Fusion strategy(MOFS)in the output result to en-hance the image inpainting effect;the discriminator uses PatchGAN.The center of the laser stripe is obtained using the grayscale center of mass method and then combined with polynomial fitting to extract the feature points of the weld seam.The experimental results show that the PSNR of the inpainting image is 26.24 dB,the SSIM is 0.98,and the LPIPS is 0.032.The centerline of the inpainting image and the centerline of the noise-free image laser stripe are fitted with a curve.The error of centerline feature points is no more than 5%,confirming the superiority and feasibility of the method.展开更多
With the advancement of electronic countermeasures,airborne synthetic aperture radar(SAR)systems are facing increasing challenges in maintaining effective performance in hostile environments.In particular,high-power i...With the advancement of electronic countermeasures,airborne synthetic aperture radar(SAR)systems are facing increasing challenges in maintaining effective performance in hostile environments.In particular,high-power interference can severely degrade SAR imaging and signal processing,often rendering target detection impossible.This highlights the urgent need for robust anti-interference solutions in both the signal processing and image processing domains.While current methods address interference across various domains,techniques such as waveform modification and spatial filtering typically increase the system costs and complexity.To overcome these limitations,we propose a novel approach that leverages the multi-domain characteristics of interference to efficiently suppress narrowband interference and repeater modulation interference.Specifically,narrowband interference is mitigated using notch filtering,a signal processing technique that effectively filters out unwanted frequencies,while repeater modulation interference is addressed through strong signal amplitude normalization,which enhances both the signal and image processing quality.These methods were validated through tests on real SAR data,demonstrating significant improvements in the imaging performance and system robustness.Our approach offers valuable insights for advancing anti-interference technologies in SAR systems and provides a cost-effective solution to enhance their resilience in complex electronic warfare environments.展开更多
Cell-selective fluorescent probes have emerged as essential tools for live-cell imaging,enabling the differentiation of specific cell types within complex biological systems.Unlike traditional antibody-based methods t...Cell-selective fluorescent probes have emerged as essential tools for live-cell imaging,enabling the differentiation of specific cell types within complex biological systems.Unlike traditional antibody-based methods that target extracellular proteins,small-molecule probes can access intracellular environments and exploit diverse biochemical features for selective retention or activation.This perspective categorizes the mechanisms of cell selectivity into five principal strategies:Protein-oriented,carbohydrate-oriented,lipid-oriented,gating-oriented,and metabolism-oriented live-cell distinctions.Each class capitalizes on a unique cellular trait ranging from protein expression and membrane composition to transporter activity and metabolic enzyme presence.We discuss representative examples of each mechanism,outline a decision-tree workflow for elucidating a new probe's mode of action,and highlight how understanding these mechanisms is critical for both basic biological research and therapeutic probe design.Looking ahead,the development of such mechanism-informed cell-specific probes holds promise for advancing precision cell targeting in biomedical applications.展开更多
Schizophrenia(SCZ) is a severe mental disorder with an unclear pathogenesis.Increasing evidence suggests that oxidative stress(OS) may contribute to the neuropathological processes underlying SCZ.Biothiols,key endogen...Schizophrenia(SCZ) is a severe mental disorder with an unclear pathogenesis.Increasing evidence suggests that oxidative stress(OS) may contribute to the neuropathological processes underlying SCZ.Biothiols,key endogenous antioxidants,have been proposed as potential biomarkers for the disease.However,due to the presence of the blood-brain barrier(BBB),fluorescent probes are rarely used to image biothiols in the brain of SCZ models.In this study,a series of fluorescent probes for biothiols were developed using dicyanoisophorone derivatives as fluorophores known for their excellent optical properties,and carboxylic esters as recognition units.A parallel synthesis and rapid screening strategy was employed to construct and optimize these probes.By introducing trifluoromethyl and benzothiazole groups into the fluorophore,the emission wavelength was successfully shifted into the near-infrared region.Additionally,various trifluoromethyl-substituted aromatic and nitrogen heterocyclic compounds were incorporated to optimize the carboxylic esters,thereby improving the probes' reactivity and lipophilicity.Systematic evaluation of the physicochemical characteristics,and optical performance led to the identification of DCIBT-11 as the most promising candidate.DCI-BT-11 demonstrated excellent BBB permeability and a good response to biothiols both in vitro and in vivo.Notably,DCI-BT-11 was used for the first time to visualize biothiol flux and assess the therapeutic effects of the antioxidant N-acetylcysteine(NAC) in the brains of SCZ mouse models,offering new insights into the role of OS in the pathogenesis and treatment of SCZ.展开更多
Ferroptosis has exhibited great potential in therapies and intracellular reducing agents of sulfur species(RSSs) in the thiol-dependent redox systems are crucial in ferroptosis.This makes the simultaneous detection of...Ferroptosis has exhibited great potential in therapies and intracellular reducing agents of sulfur species(RSSs) in the thiol-dependent redox systems are crucial in ferroptosis.This makes the simultaneous detection of multiple RSSs significant for evaluating ferroptosis therapy.However,the traditional techniques,including fluorescent(FL) imaging and electrospray ionization-based mass spectrometry(MS) detection,cannot achieve the discrimination of different RSSs.Herein,simultaneous MS detection of multiple RSSs,including cysteine(Cys),homocysteine(Hcy),glutathione(GSH) and hydrogen sulfide(H_(2)S),was obtained upon enhancing ionization efficiency by a fluorescent probe(NBD-O-1).Based on the interaction between NBD-O-1 and RSSs,the complex of RSSs with a fragment of NBD-O-1 can be generated,which can be easily ionized for MS detection in the negative mode.Therefore,the intracellular RSSs can be well detected upon the incubation of He La cells with the probe of NBD-O-1,exhibiting the total RSS levels by the FL imaging and further providing expression of each RSS by enhanced MS detection.Furthermore,the RSSs during ferroptosis in He La cells have been evaluated using the present strategy,demonstrating the potential for ferroptosis examinations.This work has made an unconventional application of a fluorescent probe to enhance the detection of multiple RSSs by MS,providing significant molecular information for addressing the ferroptosis mechanism.展开更多
The detection of amino acid enantiomers holds significant importance in biomedical,chemical,food,and other fields.Traditional chiral recognition methods using fluorescent probes primarily rely on fluorescence intensit...The detection of amino acid enantiomers holds significant importance in biomedical,chemical,food,and other fields.Traditional chiral recognition methods using fluorescent probes primarily rely on fluorescence intensity changes,which can compromise accuracy and repeatability.In this study,we report a novel fluorescent probe(R)-Z1 that achieves effective enantioselective recognition of chiral amino acids in water by altering emission wavelengths(>60 nm).This water-soluble probe(R)-Z1 exhibits cyan or yellow-green luminescence upon interaction with amino acid enantiomers,enabling reliable chiral detection of 14 natural amino acids.It also allows for the determination of enantiomeric excess through monitoring changes in luminescent color.Additionally,a logic operation with two inputs and three outputs was constructed based on these optical properties.Notably,amino acid enantiomers were successfully detected via dual-channel analysis at both the food and cellular levels.This study provides a new dynamic luminescence-based tool for the accurate sensing and detection of amino acid enantiomers.展开更多
To address the challenge of low survival rates and limited data collection efficiency in current virtual probe deployments,which results from anomaly detection mechanisms in location-based service(LBS)applications,thi...To address the challenge of low survival rates and limited data collection efficiency in current virtual probe deployments,which results from anomaly detection mechanisms in location-based service(LBS)applications,this paper proposes a novel virtual probe deployment method based on user behavioral feature analysis.The core idea is to circumvent LBS anomaly detection by mimicking real-user behavior patterns.First,we design an automated data extraction algorithm that recognizes graphical user interface(GUI)elements to collect spatio-temporal behavior data.Then,by analyzing the automatically collected user data,we identify normal users’spatio-temporal patterns and extract their features such as high-activity time windows and spatial clustering characteristics.Subsequently,an antidetection scheduling strategy is developed,integrating spatial clustering optimization,load-balanced allocation,and time window control to generate probe scheduling schemes.Additionally,a self-correction mechanism based on an exponential backoff strategy is implemented to rectify anomalous behaviors andmaintain system stability.Experiments in real-world environments demonstrate that the proposed method significantly outperforms baseline methods in terms of both probe ban rate and task completion rate,while maintaining high time efficiency.This study provides a more reliable and clandestine solution for geosocial data collection and lays the foundation for building more robust virtual probe systems.展开更多
Sulfur dioxide(SO_(2)) and its derivatives have been recognized as harmful environmental pollutants.However,they are often produced during the processing of traditional Chinese medicines,potentially compromising the q...Sulfur dioxide(SO_(2)) and its derivatives have been recognized as harmful environmental pollutants.However,they are often produced during the processing of traditional Chinese medicines,potentially compromising the quality of these medicinal materials and contributing to various health issues.Due to a lack of effective monitoring and imaging tools,the physiological effects of excessive SO_(2) residues in traditional Chinese medicine remain unclear.Therefore,developing a rapid and effective tool for detecting SO_(2) is crucial for understanding its metabolic pathways and effects in vivo.In this study,we developed a near infrared(NIR) and ratiometric fluorescent probe,NIR-RS,which exhibits high sensitivity,selectivity,and rapid response for SO_(2) detection.Notably,NIR-RS accurately quantifies SO_(2) contents in Pinelliae rhizoma(P.rhizoma) samples,with recovery rates from 98.46 % to 102.40 %,and relative standard deviations(RSDs)< 5.0 %.For bioimaging applications,NIR-RS has low cytotoxicity and good mitochondrial-targeting ability,making it suitable for imaging exogenous and endogenous SO_(2) in mitochondria.Additionally,NIR-RS was successfully applied to image SO_(2) content of P.rhizoma samples within cells,revealing that high SO_(2) residue elevated mitochondria adenosine triphosphate(ATP) content,these findings reveal that P.rhizoma with excessive SO_(2) can affect the organism's growth mechanisms through alterations in ATP pathways.In vivo,SO_(2) was found to predominantly accumulate in the liver following gavage with P.rhizoma solution,with accumulation levels increasing in proportion to SO_(2) residue concentration.High SO_(2) concentrations in P.rhizoma can cause pulmonary fibrosis and gastric mucosal damage.This work provides a valuable tool for regulating SO_(2) content in P.rhizoma and may help researcher better understand the metabolism of SO_(2) derivatives and explore their physiological roles in biological systems.展开更多
This paper presents the study and application of the electronic device anti-interference techniques underhigh voltage and/or heavy current electro-magnetic circumstance in power system.[
When signal-to-interference ratio is low, the energy of strong interference leaked from the side lobe of beam pattern will infect the detection of weak target. Therefore, the beam pattern needs to be op...When signal-to-interference ratio is low, the energy of strong interference leaked from the side lobe of beam pattern will infect the detection of weak target. Therefore, the beam pattern needs to be optimized. The existing Dolph-Chebyshev weighting method can get the lowest side lobe level under given main lobe width, but for the other non-uniform circular array and nonlinear array, the low side lobe pattern needs to be designed specially. The second order cone programming optimization （SOCP） algorithm proposed in the paper transforms the optimization of the beam pattern into a standard convex optimization problem. Thus there is a paradigm to follow for any array formation, which not only achieves the purpose of Dolph-Chebyshev weighting, but also solves the problem of the increased side lobe when the signal is at end fire direction The simulation proves that the SOCP algorithm can detect the weak target better than the conventional beam forming.展开更多
An RF transceiver composed of a zero-IF receiver and a direct up-conversion transmitter for cognitive radio applications is presented. The adjustable channel filter array in the receiver is used to suppress adjacent c...An RF transceiver composed of a zero-IF receiver and a direct up-conversion transmitter for cognitive radio applications is presented. The adjustable channel filter array in the receiver is used to suppress adjacent channel interference in televisions signal coexistence environments. The low noise amplifier （LNA） with wide dynamic range and high linearity is employed to enhance the anti-interference competence of the zero-IF receiver. Meanwhile, the high linearity power amplifier （PA） .is used to promote the adjacent channel power ratio （ACPR） characteristic of the direct up-conversion transmitter. The measured error vector magnitude （EVM） results show that the anti-interference competence of the zero-IF receiver is dramatically enhanced by employing a channel filter array. The measured ACPR of the direct up-conversion transmitter is -47. 98 dBc on the channel centered at 714 MHz when the output power is 27 dBm.展开更多
Shallow conductive heterogeneity can lead to static shifts ain the apparent resistivity sounding curve of controlled-source audio-frequency magnetotellurics(CSAMT).The static effect will shift the apparent resistivity...Shallow conductive heterogeneity can lead to static shifts ain the apparent resistivity sounding curve of controlled-source audio-frequency magnetotellurics(CSAMT).The static effect will shift the apparent resistivity curves along with axial log-log coordinates.Such an effect,if not properly processed,can distort the resistivity of rock formation and the depth of interfaces,and even make the geological structures unrecognizable.In this paper,we discuss the reasons and characteristics of the static shift and summarize the previous studies regarding static shift correction.Then,we propose the Guided Image Filtering algorithm to suppress static shifts in CSAMT.In detail,we use the multi-window superposition method to superimpose 1D signals into a 2D matrix image,which is subsequently processed with Guided Image Filtering.In the synthetic model study and field examples,the Guided Image Filtering algorithm has effectively corrected and suppressed static shifts,and finally improved the precision of data interpretation.展开更多
To suppress the interference in the ultra-wideband （AI-UWB） system is a challenging problem. An anti-interference multiband orthogonal frequency-division multiplexing ultra-wideband （AI-UWB） system, based on sprea...To suppress the interference in the ultra-wideband （AI-UWB） system is a challenging problem. An anti-interference multiband orthogonal frequency-division multiplexing ultra-wideband （AI-UWB） system, based on spreading and interleaving is addressed. It will exploit the frequency diversity across the subcarriers and provide the robustness to narrow-band interference, by spreading the coded bit streams within each sub-band and interleaving across all sub-bands. Simulating results show that the spreading and interleaving provide about 5 dB to 10 dB advantages over the conventional multiband orthogonal frequency-division multiplexing ultra-wideband system in signal-to-interference ratio. Spreading and interleaving is an effective cure for enhancing the robustness to narrowband interference.展开更多
Accurate detection of important biomarkers with ultra-low levels in complex biological matrix is one of the frontier scientific issues because of possible signal interference of potential reductive agents and protein ...Accurate detection of important biomarkers with ultra-low levels in complex biological matrix is one of the frontier scientific issues because of possible signal interference of potential reductive agents and protein molecules.Herein,a self-powered anti-interference photoelectrochemical(PEC)immunosensor was explored for sensitive and specific detection of model target of cardiac troponinⅠ(cTnI).Specifically,a novel ternary heterojunction served as the photocathode to offer a remarkable current output and a zwitterionic peptide was introduced to build a robust antifouling biointerface.CuInS(CIS)film with porous network nanostructure was first prepared and then modified in order with ZnInS(ZIS)nanocrystals and Au nanoparticles to fabricate the Au/ZIS/CIS heterojunction photocathode.After capture cTnI antibody(Ab)was immobilized,the zwitterionic peptide KAEAKAEAPPPPC was then anchored to compete the immunosensor.The elaborated PEC immunosensor exhibited high sensitivity for target cTnI antigen(Ag)detection,with good anti-interference against reductive agents and nonspecific proteins.This integration strategy of heterojunction photocathode with zwitterionic peptide provides a new sight to develop advanced PEC immunosensors applying in practical biosamples.展开更多
The ability to predict the anti-interference communications performance of unmanned aerial vehicle(UAV)data links is critical for intelligent route planning of UAVs in real combat scenarios.Previous research in this a...The ability to predict the anti-interference communications performance of unmanned aerial vehicle(UAV)data links is critical for intelligent route planning of UAVs in real combat scenarios.Previous research in this area has encountered several limitations:Classifiers exhibit low training efficiency,their precision is notably reduced when dealing with imbalanced samples,and they cannot be applied to the condition where the UAV’s flight altitude and the antenna bearing vary.This paper proposes the sequential Latin hypercube sampling(SLHS)-support vector machine(SVM)-AdaBoost algorithm,which enhances the training efficiency of the base classifier and circumvents local optima during the search process through SLHS optimization.Additionally,it mitigates the bottleneck of sample imbalance by adjusting the sample weight distribution using the AdaBoost algorithm.Through comparison,the modeling efficiency,prediction accuracy on the test set,and macro-averaged values of precision,recall,and F1-score for SLHS-SVM-AdaBoost are improved by 22.7%,5.7%,36.0%,25.0%,and 34.2%,respectively,compared with Grid-SVM.Additionally,these values are improved by 22.2%,2.1%,11.3%,2.8%,and 7.4%,respectively,compared with particle swarm optimization(PSO)-SVM-AdaBoost.Combining Latin hypercube sampling with the SLHS-SVM-AdaBoost algorithm,the classification prediction model of anti-interference performance of UAV data links,which took factors like three-dimensional position of UAV and antenna bearing into consideration,is established and used to assess the safety of the classical flying path and optimize the flying route.It was found that the risk of loss of communications could not be completely avoided by adjusting the flying altitude based on the classical path,whereas intelligent path planning based on the classification prediction model of anti-interference performance can realize complete avoidance of being interfered meanwhile reducing the route length by at least 2.3%,thus benefiting both safety and operation efficiency.展开更多
The performance of a strapdown inertial navigation system(SINS)largely depends on the accuracy and rapidness of the initial alignment.A novel anti-interference self-alignment algorithm by attitude optimization estimat...The performance of a strapdown inertial navigation system(SINS)largely depends on the accuracy and rapidness of the initial alignment.A novel anti-interference self-alignment algorithm by attitude optimization estimation for SINS on a rocking base is presented in this paper.The algorithm transforms the initial alignment into the initial attitude determination problem by using infinite vector observations to remove the angular motions,the SINS alignment is heuristically established as an optimiza-tion problem of finding the minimum eigenvector.In order to further improve the alignment precision,an adaptive recursive weighted least squares(ARWLS)curve fitting algorithm is used to fit the translational motion interference-contaminated reference vectors according to their time domain characteristics.Simulation studies and experimental results favorably demonstrate its rapidness,accuracy and robustness.展开更多
A zinc sulfate open framework matrix,[Zn(SO_4)(DMSO)](1),was synthesized by solvothermal evaporationusing dimethyl sulfoxide(DMSO)as the solvent.A compositeP@1,which exhibits fluorescence and room tempera-ture phospho...A zinc sulfate open framework matrix,[Zn(SO_4)(DMSO)](1),was synthesized by solvothermal evaporationusing dimethyl sulfoxide(DMSO)as the solvent.A compositeP@1,which exhibits fluorescence and room tempera-ture phosphorescence(RTP)properties,was prepared by doping 2,6-naphthalic acid(P)into matrix1at a low con-centration.P@1emitted a green RTP that was visible to the naked eye and lasted for approximately 2 s.P@1exhib-ited selective phosphorescence enhancement response towards Pb^(2+),with a detection limit of 2.52μmol·L^(-1).Themain detection mechanism is the Pb—O coordination-induced phosphorescence enhancement in the system.Inter-estingly,P@1also functioned as a dual-channel probe for the rapid detection of Fe^(3+)ions through fluorescencequenching with a detection limit of 0.038μmol·L^(-1).The recognition mechanism may be attributed to the competi-tive energy absorption betweenP@1and Fe^(3+)ions.CCDC:2388502,1.展开更多
To address the lack of systematic studies on heavy metal fluorescent probes in typical buffer solutions,this study developed a Fe^(3+)and Cu^(2+)fluorescent probe,DHU‑NP‑4,based on a naphthalimide fluorophore.Comparat...To address the lack of systematic studies on heavy metal fluorescent probes in typical buffer solutions,this study developed a Fe^(3+)and Cu^(2+)fluorescent probe,DHU‑NP‑4,based on a naphthalimide fluorophore.Comparative analysis of the probe's performance in various buffer systems revealed that buffers with high organic content are unsuitable for evaluating such probes.Furthermore,the pH of the solvent system was found to significantly influence the probe's behavior.Under highly acidic conditions(pH≤2),DHU‑NP‑4 exhibited exceptional specificity for Fe^(3+),while in alkaline conditions,it demonstrated high specificity for Cu^(2+).Leveraging these properties,the probe enabled the quantitative detection of Fe^(3+)and Cu^(2+)in solution.展开更多
With the rapid development of internet, users demand for the performance of wireless network is getting higher and higher. Under this background, with the rise of small base stations such as micro-cellular base statio...With the rapid development of internet, users demand for the performance of wireless network is getting higher and higher. Under this background, with the rise of small base stations such as micro-cellular base stations and the appearance of low-power base stations such as micro-cellular base stations and femto-cellular base stations, wireless cellular networks are gradually transformed into emerging heterogeneous wireless networks, and the number of base stations is also greatly increased. Due to the limitation of bandwidth resources, anti-interference and handoff have become common concerns at home and abroad.展开更多
Automatic gauge control(AGC in the article)is the key technology of product thickness accuracy and flatness quality in modern cold rolling mill.Most traditional AGC control algorithms need stable external system condi...Automatic gauge control(AGC in the article)is the key technology of product thickness accuracy and flatness quality in modern cold rolling mill.Most traditional AGC control algorithms need stable external system conditions and hard to stabilize under complex interference that meets coverage requirements.This paper presents a new anti-interference strategy for AGC control of 20-Hi cold reversing mill.The proposed algorithm introduces a united dynamic weights algorithm of feed forward-mass flow to avoid the complex interference problem in AGC control,the relevant control strategy is provided to eliminate the adverse effects.At the same time,the D-value between feed forward-mass flow pre-computation and thickness measurement deviation is dynamic compared,the final gap position regulation is calculated by developing a set of united dynamic weights between feed forward control and mass flow control.Finally,the output of controllers is sent to actuator though a constant rate smoothing.The proposed strategy is compared with conventional AGC control on Experimental platform and project application,the results show that the proposed strategy is more stable than comparison method and majority of system uncertainty produced by mentioned interference is significantly eliminated.展开更多
基金Supported by the"The 14th Five Year Plan"Hubei Provincial ad-vantaged characteristic disciplines(groups)project of Wuhan University of Science and Technology(Grant No.2023B0404)National Natural Science Foundation of China(Grant Nos.52275503 and 72471181)+2 种基金Hubei Provincial Outstanding Youth Fund of China(Grant No.2023AFA092)Hubei Provincial Natural Science Foundation of China(Grant No.2023AFB915)Hubei Provincial Key Research and Development Plan Project of China(Grant No.2023BAB048).
文摘Common strong noise interferences like metal splashes,smoke,and arc light during welding can seriously pollute the laser stripe images,causing the tracking model to drift and leading to tracking failure.At present,there are already many mature methods for identifying and extracting feature points of linear laser stripes.When the laser stripe forms a curved shape on the surface of the workpiece,these linear methods will no longer be applicable.To eliminate interference sources,enhance the robustness of the weld tracking model,and effectively extract the feature points of curved laser stripes under strong noise conditions.This paper proposes a Conditional Generative Adversarial Network(CGAN)based anti-interference recognition method for welding images.The generator adopts an improved U-Net++structure,adds a Multi-scale Channel Attention module(MS-CAM),introduces Deep Supervision,and proposes a Multi-output Fusion strategy(MOFS)in the output result to en-hance the image inpainting effect;the discriminator uses PatchGAN.The center of the laser stripe is obtained using the grayscale center of mass method and then combined with polynomial fitting to extract the feature points of the weld seam.The experimental results show that the PSNR of the inpainting image is 26.24 dB,the SSIM is 0.98,and the LPIPS is 0.032.The centerline of the inpainting image and the centerline of the noise-free image laser stripe are fitted with a curve.The error of centerline feature points is no more than 5%,confirming the superiority and feasibility of the method.
文摘With the advancement of electronic countermeasures,airborne synthetic aperture radar(SAR)systems are facing increasing challenges in maintaining effective performance in hostile environments.In particular,high-power interference can severely degrade SAR imaging and signal processing,often rendering target detection impossible.This highlights the urgent need for robust anti-interference solutions in both the signal processing and image processing domains.While current methods address interference across various domains,techniques such as waveform modification and spatial filtering typically increase the system costs and complexity.To overcome these limitations,we propose a novel approach that leverages the multi-domain characteristics of interference to efficiently suppress narrowband interference and repeater modulation interference.Specifically,narrowband interference is mitigated using notch filtering,a signal processing technique that effectively filters out unwanted frequencies,while repeater modulation interference is addressed through strong signal amplitude normalization,which enhances both the signal and image processing quality.These methods were validated through tests on real SAR data,demonstrating significant improvements in the imaging performance and system robustness.Our approach offers valuable insights for advancing anti-interference technologies in SAR systems and provides a cost-effective solution to enhance their resilience in complex electronic warfare environments.
基金supported by the Starting growth Technological R&D Program(TIPS Program,RS-2024-00468327)funded by the Ministry of SMEs and Startups(MSS,Korea)in 2024 and National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(Nos.2023R1A2C300453411 and RS2024-00411069),Glocal University 30 project(Molecular Imaging Center,POSTECH).
文摘Cell-selective fluorescent probes have emerged as essential tools for live-cell imaging,enabling the differentiation of specific cell types within complex biological systems.Unlike traditional antibody-based methods that target extracellular proteins,small-molecule probes can access intracellular environments and exploit diverse biochemical features for selective retention or activation.This perspective categorizes the mechanisms of cell selectivity into five principal strategies:Protein-oriented,carbohydrate-oriented,lipid-oriented,gating-oriented,and metabolism-oriented live-cell distinctions.Each class capitalizes on a unique cellular trait ranging from protein expression and membrane composition to transporter activity and metabolic enzyme presence.We discuss representative examples of each mechanism,outline a decision-tree workflow for elucidating a new probe's mode of action,and highlight how understanding these mechanisms is critical for both basic biological research and therapeutic probe design.Looking ahead,the development of such mechanism-informed cell-specific probes holds promise for advancing precision cell targeting in biomedical applications.
基金supported by the National Natural Science Foundation of China (Nos.22177025,21807021,22177026)the Science Fund for Creative Research Groups of the Natural Science Foundation of Hebei Province (No.B2021201038)+1 种基金the Foundation of Hebei University (No.050001-513300201004)the Director’s Foundation of the Key Laboratory of Medicinal Chemistry and Molecular Diagnosis,Ministry of Education,Hebei University (No.MCMDZR2024003)。
文摘Schizophrenia(SCZ) is a severe mental disorder with an unclear pathogenesis.Increasing evidence suggests that oxidative stress(OS) may contribute to the neuropathological processes underlying SCZ.Biothiols,key endogenous antioxidants,have been proposed as potential biomarkers for the disease.However,due to the presence of the blood-brain barrier(BBB),fluorescent probes are rarely used to image biothiols in the brain of SCZ models.In this study,a series of fluorescent probes for biothiols were developed using dicyanoisophorone derivatives as fluorophores known for their excellent optical properties,and carboxylic esters as recognition units.A parallel synthesis and rapid screening strategy was employed to construct and optimize these probes.By introducing trifluoromethyl and benzothiazole groups into the fluorophore,the emission wavelength was successfully shifted into the near-infrared region.Additionally,various trifluoromethyl-substituted aromatic and nitrogen heterocyclic compounds were incorporated to optimize the carboxylic esters,thereby improving the probes' reactivity and lipophilicity.Systematic evaluation of the physicochemical characteristics,and optical performance led to the identification of DCIBT-11 as the most promising candidate.DCI-BT-11 demonstrated excellent BBB permeability and a good response to biothiols both in vitro and in vivo.Notably,DCI-BT-11 was used for the first time to visualize biothiol flux and assess the therapeutic effects of the antioxidant N-acetylcysteine(NAC) in the brains of SCZ mouse models,offering new insights into the role of OS in the pathogenesis and treatment of SCZ.
基金supported by the National Key Research and Development Program of China (No.2024YFA1509600)National Natural Science Foundation of China (Nos.22474010 and 22274012)the Fundamental Research Funds for the Central Universities (No.2233300007)。
文摘Ferroptosis has exhibited great potential in therapies and intracellular reducing agents of sulfur species(RSSs) in the thiol-dependent redox systems are crucial in ferroptosis.This makes the simultaneous detection of multiple RSSs significant for evaluating ferroptosis therapy.However,the traditional techniques,including fluorescent(FL) imaging and electrospray ionization-based mass spectrometry(MS) detection,cannot achieve the discrimination of different RSSs.Herein,simultaneous MS detection of multiple RSSs,including cysteine(Cys),homocysteine(Hcy),glutathione(GSH) and hydrogen sulfide(H_(2)S),was obtained upon enhancing ionization efficiency by a fluorescent probe(NBD-O-1).Based on the interaction between NBD-O-1 and RSSs,the complex of RSSs with a fragment of NBD-O-1 can be generated,which can be easily ionized for MS detection in the negative mode.Therefore,the intracellular RSSs can be well detected upon the incubation of He La cells with the probe of NBD-O-1,exhibiting the total RSS levels by the FL imaging and further providing expression of each RSS by enhanced MS detection.Furthermore,the RSSs during ferroptosis in He La cells have been evaluated using the present strategy,demonstrating the potential for ferroptosis examinations.This work has made an unconventional application of a fluorescent probe to enhance the detection of multiple RSSs by MS,providing significant molecular information for addressing the ferroptosis mechanism.
基金the financial support from the National Natural Science Foundation of China(Nos.22377097,22307036,22074114)Natural Science Foundation of Hubei Province of China(Nos.2020CFB623,2021CFB556)Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education(No.LCX202305)。
文摘The detection of amino acid enantiomers holds significant importance in biomedical,chemical,food,and other fields.Traditional chiral recognition methods using fluorescent probes primarily rely on fluorescence intensity changes,which can compromise accuracy and repeatability.In this study,we report a novel fluorescent probe(R)-Z1 that achieves effective enantioselective recognition of chiral amino acids in water by altering emission wavelengths(>60 nm).This water-soluble probe(R)-Z1 exhibits cyan or yellow-green luminescence upon interaction with amino acid enantiomers,enabling reliable chiral detection of 14 natural amino acids.It also allows for the determination of enantiomeric excess through monitoring changes in luminescent color.Additionally,a logic operation with two inputs and three outputs was constructed based on these optical properties.Notably,amino acid enantiomers were successfully detected via dual-channel analysis at both the food and cellular levels.This study provides a new dynamic luminescence-based tool for the accurate sensing and detection of amino acid enantiomers.
基金supported by theNationalNatural Science Foundation of China(No.U23A20305)National Key Research and Development Program of China(No.2022YFB3102900)+1 种基金Innovation Scientists and Technicians Troop Construction Projects of Henan Province,China(No.254000510007)Key Research and Development Project of Henan Province(No.221111321200).
文摘To address the challenge of low survival rates and limited data collection efficiency in current virtual probe deployments,which results from anomaly detection mechanisms in location-based service(LBS)applications,this paper proposes a novel virtual probe deployment method based on user behavioral feature analysis.The core idea is to circumvent LBS anomaly detection by mimicking real-user behavior patterns.First,we design an automated data extraction algorithm that recognizes graphical user interface(GUI)elements to collect spatio-temporal behavior data.Then,by analyzing the automatically collected user data,we identify normal users’spatio-temporal patterns and extract their features such as high-activity time windows and spatial clustering characteristics.Subsequently,an antidetection scheduling strategy is developed,integrating spatial clustering optimization,load-balanced allocation,and time window control to generate probe scheduling schemes.Additionally,a self-correction mechanism based on an exponential backoff strategy is implemented to rectify anomalous behaviors andmaintain system stability.Experiments in real-world environments demonstrate that the proposed method significantly outperforms baseline methods in terms of both probe ban rate and task completion rate,while maintaining high time efficiency.This study provides a more reliable and clandestine solution for geosocial data collection and lays the foundation for building more robust virtual probe systems.
基金supported by the Natural Science Foundation of Hubei Province (Nos.2023AFB376 and 2024AFD287)National Key Research and Development Program (No.2023YFC3503804)the National Natural Science Foundation of China (No.22077044)。
文摘Sulfur dioxide(SO_(2)) and its derivatives have been recognized as harmful environmental pollutants.However,they are often produced during the processing of traditional Chinese medicines,potentially compromising the quality of these medicinal materials and contributing to various health issues.Due to a lack of effective monitoring and imaging tools,the physiological effects of excessive SO_(2) residues in traditional Chinese medicine remain unclear.Therefore,developing a rapid and effective tool for detecting SO_(2) is crucial for understanding its metabolic pathways and effects in vivo.In this study,we developed a near infrared(NIR) and ratiometric fluorescent probe,NIR-RS,which exhibits high sensitivity,selectivity,and rapid response for SO_(2) detection.Notably,NIR-RS accurately quantifies SO_(2) contents in Pinelliae rhizoma(P.rhizoma) samples,with recovery rates from 98.46 % to 102.40 %,and relative standard deviations(RSDs)< 5.0 %.For bioimaging applications,NIR-RS has low cytotoxicity and good mitochondrial-targeting ability,making it suitable for imaging exogenous and endogenous SO_(2) in mitochondria.Additionally,NIR-RS was successfully applied to image SO_(2) content of P.rhizoma samples within cells,revealing that high SO_(2) residue elevated mitochondria adenosine triphosphate(ATP) content,these findings reveal that P.rhizoma with excessive SO_(2) can affect the organism's growth mechanisms through alterations in ATP pathways.In vivo,SO_(2) was found to predominantly accumulate in the liver following gavage with P.rhizoma solution,with accumulation levels increasing in proportion to SO_(2) residue concentration.High SO_(2) concentrations in P.rhizoma can cause pulmonary fibrosis and gastric mucosal damage.This work provides a valuable tool for regulating SO_(2) content in P.rhizoma and may help researcher better understand the metabolism of SO_(2) derivatives and explore their physiological roles in biological systems.
文摘This paper presents the study and application of the electronic device anti-interference techniques underhigh voltage and/or heavy current electro-magnetic circumstance in power system.[
基金Special Item of National Major Scientific Apparatus Development(No.2013YQ140431)
文摘When signal-to-interference ratio is low, the energy of strong interference leaked from the side lobe of beam pattern will infect the detection of weak target. Therefore, the beam pattern needs to be optimized. The existing Dolph-Chebyshev weighting method can get the lowest side lobe level under given main lobe width, but for the other non-uniform circular array and nonlinear array, the low side lobe pattern needs to be designed specially. The second order cone programming optimization （SOCP） algorithm proposed in the paper transforms the optimization of the beam pattern into a standard convex optimization problem. Thus there is a paradigm to follow for any array formation, which not only achieves the purpose of Dolph-Chebyshev weighting, but also solves the problem of the increased side lobe when the signal is at end fire direction The simulation proves that the SOCP algorithm can detect the weak target better than the conventional beam forming.
基金The National Natural Science Foundation of China(No.60621002)the National High Technology Research and Development Program of China(863 Program)(No.2009AA011801)
文摘An RF transceiver composed of a zero-IF receiver and a direct up-conversion transmitter for cognitive radio applications is presented. The adjustable channel filter array in the receiver is used to suppress adjacent channel interference in televisions signal coexistence environments. The low noise amplifier （LNA） with wide dynamic range and high linearity is employed to enhance the anti-interference competence of the zero-IF receiver. Meanwhile, the high linearity power amplifier （PA） .is used to promote the adjacent channel power ratio （ACPR） characteristic of the direct up-conversion transmitter. The measured error vector magnitude （EVM） results show that the anti-interference competence of the zero-IF receiver is dramatically enhanced by employing a channel filter array. The measured ACPR of the direct up-conversion transmitter is -47. 98 dBc on the channel centered at 714 MHz when the output power is 27 dBm.
基金sponsored by the Basic Science Center Project of National Natural Science Foundation of China(72088101)。
文摘Shallow conductive heterogeneity can lead to static shifts ain the apparent resistivity sounding curve of controlled-source audio-frequency magnetotellurics(CSAMT).The static effect will shift the apparent resistivity curves along with axial log-log coordinates.Such an effect,if not properly processed,can distort the resistivity of rock formation and the depth of interfaces,and even make the geological structures unrecognizable.In this paper,we discuss the reasons and characteristics of the static shift and summarize the previous studies regarding static shift correction.Then,we propose the Guided Image Filtering algorithm to suppress static shifts in CSAMT.In detail,we use the multi-window superposition method to superimpose 1D signals into a 2D matrix image,which is subsequently processed with Guided Image Filtering.In the synthetic model study and field examples,the Guided Image Filtering algorithm has effectively corrected and suppressed static shifts,and finally improved the precision of data interpretation.
基金the National "863" High Technology Research Program of China (2005AA123320)Universities Natural Science Research Project of Jiangsu Province (05KJB510101).
文摘To suppress the interference in the ultra-wideband （AI-UWB） system is a challenging problem. An anti-interference multiband orthogonal frequency-division multiplexing ultra-wideband （AI-UWB） system, based on spreading and interleaving is addressed. It will exploit the frequency diversity across the subcarriers and provide the robustness to narrow-band interference, by spreading the coded bit streams within each sub-band and interleaving across all sub-bands. Simulating results show that the spreading and interleaving provide about 5 dB to 10 dB advantages over the conventional multiband orthogonal frequency-division multiplexing ultra-wideband system in signal-to-interference ratio. Spreading and interleaving is an effective cure for enhancing the robustness to narrowband interference.
基金supported by the National Natural Science Foundation of China(Nos.22074073,21275087)the Natural Science Foundation of Shandong Province of China(No.ZR2021YQ11)the Taishan Scholar Program of Shandong Province of China(No.ts20110829)。
文摘Accurate detection of important biomarkers with ultra-low levels in complex biological matrix is one of the frontier scientific issues because of possible signal interference of potential reductive agents and protein molecules.Herein,a self-powered anti-interference photoelectrochemical(PEC)immunosensor was explored for sensitive and specific detection of model target of cardiac troponinⅠ(cTnI).Specifically,a novel ternary heterojunction served as the photocathode to offer a remarkable current output and a zwitterionic peptide was introduced to build a robust antifouling biointerface.CuInS(CIS)film with porous network nanostructure was first prepared and then modified in order with ZnInS(ZIS)nanocrystals and Au nanoparticles to fabricate the Au/ZIS/CIS heterojunction photocathode.After capture cTnI antibody(Ab)was immobilized,the zwitterionic peptide KAEAKAEAPPPPC was then anchored to compete the immunosensor.The elaborated PEC immunosensor exhibited high sensitivity for target cTnI antigen(Ag)detection,with good anti-interference against reductive agents and nonspecific proteins.This integration strategy of heterojunction photocathode with zwitterionic peptide provides a new sight to develop advanced PEC immunosensors applying in practical biosamples.
文摘The ability to predict the anti-interference communications performance of unmanned aerial vehicle(UAV)data links is critical for intelligent route planning of UAVs in real combat scenarios.Previous research in this area has encountered several limitations:Classifiers exhibit low training efficiency,their precision is notably reduced when dealing with imbalanced samples,and they cannot be applied to the condition where the UAV’s flight altitude and the antenna bearing vary.This paper proposes the sequential Latin hypercube sampling(SLHS)-support vector machine(SVM)-AdaBoost algorithm,which enhances the training efficiency of the base classifier and circumvents local optima during the search process through SLHS optimization.Additionally,it mitigates the bottleneck of sample imbalance by adjusting the sample weight distribution using the AdaBoost algorithm.Through comparison,the modeling efficiency,prediction accuracy on the test set,and macro-averaged values of precision,recall,and F1-score for SLHS-SVM-AdaBoost are improved by 22.7%,5.7%,36.0%,25.0%,and 34.2%,respectively,compared with Grid-SVM.Additionally,these values are improved by 22.2%,2.1%,11.3%,2.8%,and 7.4%,respectively,compared with particle swarm optimization(PSO)-SVM-AdaBoost.Combining Latin hypercube sampling with the SLHS-SVM-AdaBoost algorithm,the classification prediction model of anti-interference performance of UAV data links,which took factors like three-dimensional position of UAV and antenna bearing into consideration,is established and used to assess the safety of the classical flying path and optimize the flying route.It was found that the risk of loss of communications could not be completely avoided by adjusting the flying altitude based on the classical path,whereas intelligent path planning based on the classification prediction model of anti-interference performance can realize complete avoidance of being interfered meanwhile reducing the route length by at least 2.3%,thus benefiting both safety and operation efficiency.
基金supported by the National Natural Science Foundation of China(41174162).
文摘The performance of a strapdown inertial navigation system(SINS)largely depends on the accuracy and rapidness of the initial alignment.A novel anti-interference self-alignment algorithm by attitude optimization estimation for SINS on a rocking base is presented in this paper.The algorithm transforms the initial alignment into the initial attitude determination problem by using infinite vector observations to remove the angular motions,the SINS alignment is heuristically established as an optimiza-tion problem of finding the minimum eigenvector.In order to further improve the alignment precision,an adaptive recursive weighted least squares(ARWLS)curve fitting algorithm is used to fit the translational motion interference-contaminated reference vectors according to their time domain characteristics.Simulation studies and experimental results favorably demonstrate its rapidness,accuracy and robustness.
文摘A zinc sulfate open framework matrix,[Zn(SO_4)(DMSO)](1),was synthesized by solvothermal evaporationusing dimethyl sulfoxide(DMSO)as the solvent.A compositeP@1,which exhibits fluorescence and room tempera-ture phosphorescence(RTP)properties,was prepared by doping 2,6-naphthalic acid(P)into matrix1at a low con-centration.P@1emitted a green RTP that was visible to the naked eye and lasted for approximately 2 s.P@1exhib-ited selective phosphorescence enhancement response towards Pb^(2+),with a detection limit of 2.52μmol·L^(-1).Themain detection mechanism is the Pb—O coordination-induced phosphorescence enhancement in the system.Inter-estingly,P@1also functioned as a dual-channel probe for the rapid detection of Fe^(3+)ions through fluorescencequenching with a detection limit of 0.038μmol·L^(-1).The recognition mechanism may be attributed to the competi-tive energy absorption betweenP@1and Fe^(3+)ions.CCDC:2388502,1.
文摘To address the lack of systematic studies on heavy metal fluorescent probes in typical buffer solutions,this study developed a Fe^(3+)and Cu^(2+)fluorescent probe,DHU‑NP‑4,based on a naphthalimide fluorophore.Comparative analysis of the probe's performance in various buffer systems revealed that buffers with high organic content are unsuitable for evaluating such probes.Furthermore,the pH of the solvent system was found to significantly influence the probe's behavior.Under highly acidic conditions(pH≤2),DHU‑NP‑4 exhibited exceptional specificity for Fe^(3+),while in alkaline conditions,it demonstrated high specificity for Cu^(2+).Leveraging these properties,the probe enabled the quantitative detection of Fe^(3+)and Cu^(2+)in solution.
文摘With the rapid development of internet, users demand for the performance of wireless network is getting higher and higher. Under this background, with the rise of small base stations such as micro-cellular base stations and the appearance of low-power base stations such as micro-cellular base stations and femto-cellular base stations, wireless cellular networks are gradually transformed into emerging heterogeneous wireless networks, and the number of base stations is also greatly increased. Due to the limitation of bandwidth resources, anti-interference and handoff have become common concerns at home and abroad.
文摘Automatic gauge control(AGC in the article)is the key technology of product thickness accuracy and flatness quality in modern cold rolling mill.Most traditional AGC control algorithms need stable external system conditions and hard to stabilize under complex interference that meets coverage requirements.This paper presents a new anti-interference strategy for AGC control of 20-Hi cold reversing mill.The proposed algorithm introduces a united dynamic weights algorithm of feed forward-mass flow to avoid the complex interference problem in AGC control,the relevant control strategy is provided to eliminate the adverse effects.At the same time,the D-value between feed forward-mass flow pre-computation and thickness measurement deviation is dynamic compared,the final gap position regulation is calculated by developing a set of united dynamic weights between feed forward control and mass flow control.Finally,the output of controllers is sent to actuator though a constant rate smoothing.The proposed strategy is compared with conventional AGC control on Experimental platform and project application,the results show that the proposed strategy is more stable than comparison method and majority of system uncertainty produced by mentioned interference is significantly eliminated.
