In this paper, the antacid ability of chitosan/aluminum hydroxide mixture granules was investigated in vitro. It is found that chitosan can not only improve acidneutralizing rate of pharmaceutical aluminum hydroxide, ...In this paper, the antacid ability of chitosan/aluminum hydroxide mixture granules was investigated in vitro. It is found that chitosan can not only improve acidneutralizing rate of pharmaceutical aluminum hydroxide, but also elevate its acidconsuming capacity. But in alkaline, chitosan can depress the reaction of aluminum hydroxide with alkaline.展开更多
Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease（GERD） symptoms. Alginate gel becomes buoyant and CO2-aerated as soon as Gaviscon co...Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease（GERD） symptoms. Alginate gel becomes buoyant and CO2-aerated as soon as Gaviscon comes into contact with gastric contents. This system can be characterized by several indicators, such as strength or coherence, volume, buoyancy, reflux resistance and resilience. In addition, the strength of the raft is influenced by many factors, such as molecular weight and the ratio of D-mannuronic and L-guluronic acid residues（M/G）, which are intrinsic factors in this formulation. Besides, there are several extrinsic factors, such as the presence of specific cations, the amount of carbon dioxide generated and entrapped in the raft. This review focused on how to evaluate the raft, introduced some factors that impact the raft and summarized the degradation of alginate and future advance.展开更多
AIM:To assess the antacid effects of the tonic Chinese herbal prescriptions,Si-Jun-Zi-Tang(SJZT) and Shen-Ling-Bai-Zhu-San(SLBZS).METHODS:Decoctions of the tonic Chinese herbal prescriptions,SJZT and SLBZS,were prepar...AIM:To assess the antacid effects of the tonic Chinese herbal prescriptions,Si-Jun-Zi-Tang(SJZT) and Shen-Ling-Bai-Zhu-San(SLBZS).METHODS:Decoctions of the tonic Chinese herbal prescriptions,SJZT and SLBZS,were prepared according to Chinese original documents.The pH of the prescription decoctions and their neutralizing effects on artif icial gastric acids were determined and compared with water and the active controls,sodium bicarbonate and colloidal aluminum phosphate.A modified model of Vatier's artificial stomach was used to determine the duration of consistent neutralization effect on artificial gastric acids.The neutralization capacity in vitro was determined with the titration method of Fordtran's model.RESULTS:The results showed that both SJZT and SLBZS have antacid effects in vitro.Compared with the water group,SJZT and SLBZS were found to possess signif icant gastric acid neutralizing effects.The duration for consistent neutralization of SLBZS was signif icantly longer than that of water.Also,SLBZS and SJZT exhibited signif icant antacid capacities compared to water.CONCLUSION:SJZT and SLBZS were consistently active in the artificial stomach model and are suggested to have antacid effects similar to the active control drugs.展开更多
文摘In this paper, the antacid ability of chitosan/aluminum hydroxide mixture granules was investigated in vitro. It is found that chitosan can not only improve acidneutralizing rate of pharmaceutical aluminum hydroxide, but also elevate its acidconsuming capacity. But in alkaline, chitosan can depress the reaction of aluminum hydroxide with alkaline.
文摘Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease（GERD） symptoms. Alginate gel becomes buoyant and CO2-aerated as soon as Gaviscon comes into contact with gastric contents. This system can be characterized by several indicators, such as strength or coherence, volume, buoyancy, reflux resistance and resilience. In addition, the strength of the raft is influenced by many factors, such as molecular weight and the ratio of D-mannuronic and L-guluronic acid residues（M/G）, which are intrinsic factors in this formulation. Besides, there are several extrinsic factors, such as the presence of specific cations, the amount of carbon dioxide generated and entrapped in the raft. This review focused on how to evaluate the raft, introduced some factors that impact the raft and summarized the degradation of alginate and future advance.
基金Supported by A Research Grant from Yen Kun Yin Cultural and Educational Foundation, Taipei, Taiwan, China
文摘AIM:To assess the antacid effects of the tonic Chinese herbal prescriptions,Si-Jun-Zi-Tang(SJZT) and Shen-Ling-Bai-Zhu-San(SLBZS).METHODS:Decoctions of the tonic Chinese herbal prescriptions,SJZT and SLBZS,were prepared according to Chinese original documents.The pH of the prescription decoctions and their neutralizing effects on artif icial gastric acids were determined and compared with water and the active controls,sodium bicarbonate and colloidal aluminum phosphate.A modified model of Vatier's artificial stomach was used to determine the duration of consistent neutralization effect on artificial gastric acids.The neutralization capacity in vitro was determined with the titration method of Fordtran's model.RESULTS:The results showed that both SJZT and SLBZS have antacid effects in vitro.Compared with the water group,SJZT and SLBZS were found to possess signif icant gastric acid neutralizing effects.The duration for consistent neutralization of SLBZS was signif icantly longer than that of water.Also,SLBZS and SJZT exhibited signif icant antacid capacities compared to water.CONCLUSION:SJZT and SLBZS were consistently active in the artificial stomach model and are suggested to have antacid effects similar to the active control drugs.
