The 15th China International Animation Copyright Fair concluded successfully at the ACTIF Center in Shipai Town,Dongguan City,also known as the'"Capital of Art Toys in China.n Over 600 Chinese and foreign ent...The 15th China International Animation Copyright Fair concluded successfully at the ACTIF Center in Shipai Town,Dongguan City,also known as the'"Capital of Art Toys in China.n Over 600 Chinese and foreign enterprises and institutions participated in the event,which featured over 2,000 film and animation IPs from more than 40 countries and regions.展开更多
With the development of educational digitalization,how to effectively apply digital animation technology to traditional classroom teaching has become an urgent problem to be solved.This study explores the application ...With the development of educational digitalization,how to effectively apply digital animation technology to traditional classroom teaching has become an urgent problem to be solved.This study explores the application of Manim in the course of Mathematical Methods for Physics.Taking the visualization of Fourier series,complex numbers,and other content as examples,it improves students’understanding of complex and abstract mathematical physics concepts through dynamic and visual teaching methods.The teaching effect shows that Manim helps to enhance students’learning experience,improve teaching efficiency and effectiveness,and has a positive impact on students’active learning ability.The research in this paper can provide references and inspiration for the educational digitalization of higher education.展开更多
目的采用数据挖掘方法总结肺纤维化动物模型的特点及建立药效指标评价体系。方法通过中国知网(CNKI)、万方数据库(Wangfang)、维普中文科技期刊全文数据库(VIP)、PubMed、Web of Science、Embase数据库检索与肺纤维化动物药效研究相关...目的采用数据挖掘方法总结肺纤维化动物模型的特点及建立药效指标评价体系。方法通过中国知网(CNKI)、万方数据库(Wangfang)、维普中文科技期刊全文数据库(VIP)、PubMed、Web of Science、Embase数据库检索与肺纤维化动物药效研究相关的文献,归纳整理、分析肺纤维化动物模型的造模方法、干预药物等,并统计检测指标类型、方法等,构建肺纤维化动物药效指标体系。结果共纳入1174篇文献,动物造模常见的诱导因素有肿瘤药物、环境/职业暴露颗粒、物理因素等,以C57 BL/6小鼠、SD大鼠为主要研究对象,其中博来霉素以无创性气管滴注诱导肺纤维化动物模型最常见。肺纤维化动物药效研究中常见的干预药物有化学药、抑制剂/激动剂、天然药物、中药复方等。肺纤维化动物药效研究中检测指标包括一般情况、肺功能、肺组织病理、细胞外基质、上皮间质转化、细胞因子、氧化应激等七类,其中一般情况以体质量、肺系数、生存分析检测为主;肺功能指标主要包括用力肺活量、动态肺顺应性、潮气量等;常见的肺组织病理染色方法有HE染色、Masson染色及天狼猩红染色等;细胞外基质检测指标以Ⅰ型胶原蛋白、羟脯氨酸、纤维连接蛋白等为主;上皮间质转化指标有α-平滑肌肌动蛋白、E-钙黏蛋白、波形蛋白等;细胞因子检测指标主要有转化生长因子β1、肿瘤坏死因子α、白细胞介素6等;氧化应激检测指标主要包括丙二醛、超氧化物歧化酶、谷胱甘肽等。根据检测指标频次≥200次作为肺纤维化动物药效研究检测的强推荐指标,将一般情况(体质量、肺系数)、肺病理(HE染色、Masson染色等)、细胞外基质(羟脯氨酸、Ⅰ型胶原蛋白、Ⅲ型胶原蛋白、纤维连接蛋白)、上皮间质化(α-平滑肌肌动蛋白)、细胞因子(肿瘤坏死因子α、白细胞介素6/1β、转化生长因子β1)作为肺纤维化动物药效研究检测的强推荐指标。结论本研究为肺纤维化动物模型构建及药效指标评价体系的建立提供了更多参考。展开更多
文摘The 15th China International Animation Copyright Fair concluded successfully at the ACTIF Center in Shipai Town,Dongguan City,also known as the'"Capital of Art Toys in China.n Over 600 Chinese and foreign enterprises and institutions participated in the event,which featured over 2,000 film and animation IPs from more than 40 countries and regions.
基金supported by the Teaching Reform Research Project of Shaanxi University of Science&Technology(23Y083)the Project of National University Association for Mathematical Methods in Physics(JZW-23-SL-02)+3 种基金the Graduate Course Construction Project of Shaanxi University of Science&Technology(KC2024Y03)the 2024 National Higher Education University Physics Reform Research Project(2024PR064)the Teaching Reform Research Project of the International Office of Shaanxi University of Science&Technology(YB202410)Graduate Education and Teaching Reform Research Project of Shaanxi University of Science&Technology(JG2025Y18).
文摘With the development of educational digitalization,how to effectively apply digital animation technology to traditional classroom teaching has become an urgent problem to be solved.This study explores the application of Manim in the course of Mathematical Methods for Physics.Taking the visualization of Fourier series,complex numbers,and other content as examples,it improves students’understanding of complex and abstract mathematical physics concepts through dynamic and visual teaching methods.The teaching effect shows that Manim helps to enhance students’learning experience,improve teaching efficiency and effectiveness,and has a positive impact on students’active learning ability.The research in this paper can provide references and inspiration for the educational digitalization of higher education.
文摘目的采用数据挖掘方法总结肺纤维化动物模型的特点及建立药效指标评价体系。方法通过中国知网(CNKI)、万方数据库(Wangfang)、维普中文科技期刊全文数据库(VIP)、PubMed、Web of Science、Embase数据库检索与肺纤维化动物药效研究相关的文献,归纳整理、分析肺纤维化动物模型的造模方法、干预药物等,并统计检测指标类型、方法等,构建肺纤维化动物药效指标体系。结果共纳入1174篇文献,动物造模常见的诱导因素有肿瘤药物、环境/职业暴露颗粒、物理因素等,以C57 BL/6小鼠、SD大鼠为主要研究对象,其中博来霉素以无创性气管滴注诱导肺纤维化动物模型最常见。肺纤维化动物药效研究中常见的干预药物有化学药、抑制剂/激动剂、天然药物、中药复方等。肺纤维化动物药效研究中检测指标包括一般情况、肺功能、肺组织病理、细胞外基质、上皮间质转化、细胞因子、氧化应激等七类,其中一般情况以体质量、肺系数、生存分析检测为主;肺功能指标主要包括用力肺活量、动态肺顺应性、潮气量等;常见的肺组织病理染色方法有HE染色、Masson染色及天狼猩红染色等;细胞外基质检测指标以Ⅰ型胶原蛋白、羟脯氨酸、纤维连接蛋白等为主;上皮间质转化指标有α-平滑肌肌动蛋白、E-钙黏蛋白、波形蛋白等;细胞因子检测指标主要有转化生长因子β1、肿瘤坏死因子α、白细胞介素6等;氧化应激检测指标主要包括丙二醛、超氧化物歧化酶、谷胱甘肽等。根据检测指标频次≥200次作为肺纤维化动物药效研究检测的强推荐指标,将一般情况(体质量、肺系数)、肺病理(HE染色、Masson染色等)、细胞外基质(羟脯氨酸、Ⅰ型胶原蛋白、Ⅲ型胶原蛋白、纤维连接蛋白)、上皮间质化(α-平滑肌肌动蛋白)、细胞因子(肿瘤坏死因子α、白细胞介素6/1β、转化生长因子β1)作为肺纤维化动物药效研究检测的强推荐指标。结论本研究为肺纤维化动物模型构建及药效指标评价体系的建立提供了更多参考。
