This paper focuses on the original animated short film Glimmer,conducting an in-depth exploration of its artistic expression characteristics and the application boundaries of AIGC(Artificial Intelligence Generated Con...This paper focuses on the original animated short film Glimmer,conducting an in-depth exploration of its artistic expression characteristics and the application boundaries of AIGC(Artificial Intelligence Generated Content)technology.Presented in a sketch style,the film creates unique visual effects and emotional atmospheres through techniques such as lines and light-dark contrast,demonstrating the distinctive charm of the sketch style in animation creation.Meanwhile,the paper reflects on the application of AIGC technology in animation creation,pointing out its optimization potential in aspects such as character expressions,scene design,storyboard scripts,and creative sound effects.The study emphasizes that although AIGC technology brings opportunities,issues related to originality and dependence on the technology(by creators)also need attention.This paper aims to provide theoretical references and practical guidance for animation education and creation,promote the integrated development of animation art and technology,and drive innovation and progress in the field of animation creation.展开更多
Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design...Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design(CAD)system that presents a new method for DED classification called(IAOO-PSO),which is a powerful Feature Selection technique(FS)that integrates with Opposition-Based Learning(OBL)and Particle Swarm Optimization(PSO).We improve the speed of convergence with the PSO algorithmand the exploration with the IAOO algorithm.The IAOO is demonstrated to possess superior global optimization capabilities,as validated on the IEEE Congress on Evolutionary Computation 2022(CEC’22)benchmark suite and compared with seven Metaheuristic(MH)algorithms.Additionally,an IAOO-PSO model based on Support Vector Machines(SVMs)classifier is proposed for FS and classification,where the IAOO-PSO is used to identify the most relevant features.This model was applied to the DED dataset comprising 20,000 cases and 26 features,achieving a high classification accuracy of 99.8%,which significantly outperforms other optimization algorithms.The experimental results demonstrate the reliability,success,and efficiency of the IAOO-PSO technique for both FS and classification in the detection of DED.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this com...Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this complex problem.One such model,the Oncopig,has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation.However,the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.Methods:Herein,we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and re-placed in the tissue.The study consisted of 3 animals in 3 cohorts(total of 9 animals)that were evaluated at 14,21,and 28 days.CT imaging,immunohistochemistry,multiplex immunofluorescence,and comprehensive blood analyses were used to quantify composition of the hepatic masses that developed following AdCre inoculation.Results:The tumors were hypovascular on CT and predominantly composed of CD45+cells with a strong lymphohistiocytic component,with no carcinomas identified.Ki-67 staining showed proliferation of CD45+immune cells but no neoplastic component.To provide further insight,the results are evaluated in the context of tumor growth kinetics.Conclusion:While progress has been made in generating targetable lesions,achieving a robust large animal model of liver cancer that faithfully recapitulates the human disease remains a challenging goal.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.展开更多
Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecul...Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.展开更多
The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention a...The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies.展开更多
Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in ...Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors.展开更多
Taking Ne Zha as an example,this paper analyzes the strengths and weaknesses of Chinese animated films at the presentstage.Under the condition of both opportunities and challenges,some measures to develop Chinese anim...Taking Ne Zha as an example,this paper analyzes the strengths and weaknesses of Chinese animated films at the presentstage.Under the condition of both opportunities and challenges,some measures to develop Chinese animated films are proposed.展开更多
Rapid technical advances in the field of computeropened new avenues in animal behavior research.animation （CA） and virtual reality （VR） haveAnimated stimuli are powerful tools as theyoffer standardization, repeata...Rapid technical advances in the field of computeropened new avenues in animal behavior research.animation （CA） and virtual reality （VR） haveAnimated stimuli are powerful tools as theyoffer standardization, repeatability, and complete control over the stimulus presented, thereby＂reducing＂ and ＂replacing＂ the animals used, and ＂refining＂ the experimental design in line withthe 3Rs. However, appropriate use of these technologies raises conceptual and technical questions.In this review, we offer guidelines for common technical and conceptual considerations related tothe use of animated stimuli in animal behavior research. Following the steps required to create ananimated stimulus, we discuss （I） the creation, （11） the presentation, and （111） the validation of CAsand VRs. Although our review is geared toward computer-graphically designed stimuli, consider-ations on presentation and validation also apply to video playbacks. CA and VR allow both new be-havioral questions to be addressed and existing questions to be addressed in new ways, thus weexpect a rich future for these methods in both ultimate and proximate studies of animal behavior.展开更多
Objective: Mood Assessment via Animated Characters (MAAC) is a novel, computer-based instrument to improve assessment and communication about feelings in young children with internalizing distress. Well-validated asse...Objective: Mood Assessment via Animated Characters (MAAC) is a novel, computer-based instrument to improve assessment and communication about feelings in young children with internalizing distress. Well-validated assessment instruments are lacking for those under age eight years. Method: Children ages 4 - 10 years with primary diagnosis of anxiety disorder (n = 74;33 boys, 41 girls) or no diagnosis (n = 83;40 boys, 43 girls) completed MAAC for 16 feelings. Those 8 - 10 years also completed standardized measures of internalizing symptoms. Results: MAAC’s emotions clustered into positive, negative, fearful, and calm/neutral factors. Clinical children rated themselves less positive (difference score -3.18;p = 0.002) and less calm/neutral (difference score -2.06;p = 0.04), and explored fewer emotions spontaneously (difference score = -2.37;p = 0.02) than nonanxious controls. Older children’s responses correlated with scores on several standardized measures. Conclusions: MAAC appears to be highly engaging, with clinical utility in the assessment of young anxious children. Applications in other populations are considered for future study.展开更多
This invited review is based upon a recent oral paper I presented at the Virtual Reality Symposiumof the 34th International Ethological Conference （2015, Cairns, Australia）, and as such it describesstudies conducted...This invited review is based upon a recent oral paper I presented at the Virtual Reality Symposiumof the 34th International Ethological Conference （2015, Cairns, Australia）, and as such it describesstudies conducted mainly in my own laboratory. It reviews how we utilized visual stimuli for induc-ing behavioral responses in the zebrafish with a focus on shoaling, group forming behavior. Thezebrafish is gaining increasing popularity in neuroscience. With this interest, its behavior is alsomore frequently studied. One of the many advantages of the zebrafish over traditional laboratoryrodents is that this species is diurnal, and it relies heavily upon its visual system. Thus, similarly toour own species, zebrafish respond to visual stimuli in a robust and easily quantifiable manner. Forthe past decade, we have been exploring how to use such visual stimuli, and have developed nu-merous paradigms with which we can induce and quantify a variety of behavioral responses,including shoaling. This review summarizes some of these studies, and discusses questions includ-ing whether one should use live fish as stimulus, whether and how one could present animated（moving images） of fish, and how one could optimize a range of stimulus presentation parametersto elicit the most robust responses in zebrafish. Although the zebrafish is a relative newcomer inethology and behavioral neuroscience, and although many of our findings only represent the firststeps in this research, our results suggest that the behavioral analysis of the zebrafish will have animportant place in biomedical research.展开更多
Based on the software support of SIMAN/CINEMA, this paper presents anintegrated approach to flexible modelling and simulation with animation. Themethodology provides a structured way of integrating mathematical and lo...Based on the software support of SIMAN/CINEMA, this paper presents anintegrated approach to flexible modelling and simulation with animation. Themethodology provides a structured way of integrating mathematical and logicalmodel, statistical experimentation, and statistical analysis with computeranimation. Within this methodology, an animated simulation study is separatedinto six different activities: simulation objectives identification, system modeldevelopment, simulation experiment specification, animation layoutconstruction, real-time simulation and animation run, and output dataanalysis. These six activities are objectives driven, relatively independent, andintegrate through software organization and simulation files. The key ideasbehind this methodology are objectives orientation, modelling flexibility,simulation and animation integration, and application tailorability. Though themethodology is closely related to SIMAN/CINEMA, it can be extended to othersoftware environments.展开更多
Cartoons serve as significant sources of entertainment for children and adolescents.However,numerous animated videos contain unsuitable content,such as violence,eroticism,abuse,and vehicular accidents.Current content ...Cartoons serve as significant sources of entertainment for children and adolescents.However,numerous animated videos contain unsuitable content,such as violence,eroticism,abuse,and vehicular accidents.Current content detection methods rely on manual inspection,which is resource-intensive,time-consuming,and not always reliable.Therefore,more efficient detection methods are necessary to safeguard young viewers.This paper addresses this significant problem by proposing a novel deep learning-based system,AnimeNet,designed to detect varying degrees of violent and erotic content in videos.AnimeNet utilizes a novel Convolutional Neural Network(CNN)model to extract image features effectively,classifying violent and erotic scenes in videos and images.The novelty of the work lies in the introduction of a novel channel-spatial attention module,enhancing the feature extraction performance of the CNN model,an advancement over previous efforts in the literature.To validate the approach,I compared AnimeNet with state-of-the-art classification methods,including ResNet,RegNet,ConvNext,ViT,and MobileNet.These were used to identify violent and erotic scenes within specific video frames.The results showed that AnimeNet outperformed these models,proving it to be well-suited for real-time applications in videos or images.This work presents a significant leap forward in automatic content detection in animation,offering a high-accuracy solution that is less resource-intensive and more reliable than current methods.The proposed approach enables it possible to better protect young audiences from exposure to unsuitable content,underlining its importance and potential for broad social impact.展开更多
China’s domestic animation industry is deeply rooted in its rich traditional cultural heritage.While continuously exploring and showcasing the unique charm of such cultural heritage through storytelling,imagery estab...China’s domestic animation industry is deeply rooted in its rich traditional cultural heritage.While continuously exploring and showcasing the unique charm of such cultural heritage through storytelling,imagery establishment,and spirit creation,Chinese animation also seamlessly integrates modern aesthetic characteristics and cultural values into its development within the context of the new era.By adopting a contemporary perspective,it innovatively expresses the essence of traditional culture while striving to shape and present a reliable,admirable and respectable image of China.Chinese animation aims to create credible contemporary animation images by drawing inspiration from traditional Chinese cultural archetypes.It also seeks to revitalize admirable traditional cultural imagery using vibrant and prevailing ACGN visuals,while shaping credible characters with richer cultural connotations and crafting stories with more enchanting plots to convey the spiritual essence of the Chinese nation.By establishing reliable,admirable and respectable animation images,the Chinese animation industry strives to enhance its capability to“tell China’s stories well and make the voice of China heard,”to better promote the image of China in the new era from a global perspective.展开更多
Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experienci...Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.展开更多
As a visual art, film has already been one of the main forms to exhibit culture in modem society. This paper tries to explore American animated films, one of the most successful and tipical styles of American films, f...As a visual art, film has already been one of the main forms to exhibit culture in modem society. This paper tries to explore American animated films, one of the most successful and tipical styles of American films, from the view of post-colonialism so as to receal American animated films make every effort to set up the image of the Other and to propagate American culture and value. It is American cultural hegemony.展开更多
文摘This paper focuses on the original animated short film Glimmer,conducting an in-depth exploration of its artistic expression characteristics and the application boundaries of AIGC(Artificial Intelligence Generated Content)technology.Presented in a sketch style,the film creates unique visual effects and emotional atmospheres through techniques such as lines and light-dark contrast,demonstrating the distinctive charm of the sketch style in animation creation.Meanwhile,the paper reflects on the application of AIGC technology in animation creation,pointing out its optimization potential in aspects such as character expressions,scene design,storyboard scripts,and creative sound effects.The study emphasizes that although AIGC technology brings opportunities,issues related to originality and dependence on the technology(by creators)also need attention.This paper aims to provide theoretical references and practical guidance for animation education and creation,promote the integrated development of animation art and technology,and drive innovation and progress in the field of animation creation.
文摘Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design(CAD)system that presents a new method for DED classification called(IAOO-PSO),which is a powerful Feature Selection technique(FS)that integrates with Opposition-Based Learning(OBL)and Particle Swarm Optimization(PSO).We improve the speed of convergence with the PSO algorithmand the exploration with the IAOO algorithm.The IAOO is demonstrated to possess superior global optimization capabilities,as validated on the IEEE Congress on Evolutionary Computation 2022(CEC’22)benchmark suite and compared with seven Metaheuristic(MH)algorithms.Additionally,an IAOO-PSO model based on Support Vector Machines(SVMs)classifier is proposed for FS and classification,where the IAOO-PSO is used to identify the most relevant features.This model was applied to the DED dataset comprising 20,000 cases and 26 features,achieving a high classification accuracy of 99.8%,which significantly outperforms other optimization algorithms.The experimental results demonstrate the reliability,success,and efficiency of the IAOO-PSO technique for both FS and classification in the detection of DED.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
基金Institutional Research Grant,MD Anderson Cancer CenterUPWARDS Training Program(Undergraduate Students Working Towards Research in Science),Grant/Award Number:1R25CA240137-01A1the CPRIT Research Training Award CPRIT Training Program,Grant/Award Number:RP210028。
文摘Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this complex problem.One such model,the Oncopig,has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation.However,the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.Methods:Herein,we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and re-placed in the tissue.The study consisted of 3 animals in 3 cohorts(total of 9 animals)that were evaluated at 14,21,and 28 days.CT imaging,immunohistochemistry,multiplex immunofluorescence,and comprehensive blood analyses were used to quantify composition of the hepatic masses that developed following AdCre inoculation.Results:The tumors were hypovascular on CT and predominantly composed of CD45+cells with a strong lymphohistiocytic component,with no carcinomas identified.Ki-67 staining showed proliferation of CD45+immune cells but no neoplastic component.To provide further insight,the results are evaluated in the context of tumor growth kinetics.Conclusion:While progress has been made in generating targetable lesions,achieving a robust large animal model of liver cancer that faithfully recapitulates the human disease remains a challenging goal.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.
基金Ministry of Research,Innovation and Digitization,CCCDI-UEFISCDI,Grant/Award Number:PN-IV-P7-7.1-PED-2024-1578,within PNCDI Ⅳ.
文摘Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.
基金National Natural Science Foundation of China,Grant/Award Number:82000102 and 82270112。
文摘The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies.
文摘Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors.
文摘Taking Ne Zha as an example,this paper analyzes the strengths and weaknesses of Chinese animated films at the presentstage.Under the condition of both opportunities and challenges,some measures to develop Chinese animated films are proposed.
文摘Rapid technical advances in the field of computeropened new avenues in animal behavior research.animation （CA） and virtual reality （VR） haveAnimated stimuli are powerful tools as theyoffer standardization, repeatability, and complete control over the stimulus presented, thereby＂reducing＂ and ＂replacing＂ the animals used, and ＂refining＂ the experimental design in line withthe 3Rs. However, appropriate use of these technologies raises conceptual and technical questions.In this review, we offer guidelines for common technical and conceptual considerations related tothe use of animated stimuli in animal behavior research. Following the steps required to create ananimated stimulus, we discuss （I） the creation, （11） the presentation, and （111） the validation of CAsand VRs. Although our review is geared toward computer-graphically designed stimuli, consider-ations on presentation and validation also apply to video playbacks. CA and VR allow both new be-havioral questions to be addressed and existing questions to be addressed in new ways, thus weexpect a rich future for these methods in both ultimate and proximate studies of animal behavior.
文摘Objective: Mood Assessment via Animated Characters (MAAC) is a novel, computer-based instrument to improve assessment and communication about feelings in young children with internalizing distress. Well-validated assessment instruments are lacking for those under age eight years. Method: Children ages 4 - 10 years with primary diagnosis of anxiety disorder (n = 74;33 boys, 41 girls) or no diagnosis (n = 83;40 boys, 43 girls) completed MAAC for 16 feelings. Those 8 - 10 years also completed standardized measures of internalizing symptoms. Results: MAAC’s emotions clustered into positive, negative, fearful, and calm/neutral factors. Clinical children rated themselves less positive (difference score -3.18;p = 0.002) and less calm/neutral (difference score -2.06;p = 0.04), and explored fewer emotions spontaneously (difference score = -2.37;p = 0.02) than nonanxious controls. Older children’s responses correlated with scores on several standardized measures. Conclusions: MAAC appears to be highly engaging, with clinical utility in the assessment of young anxious children. Applications in other populations are considered for future study.
文摘This invited review is based upon a recent oral paper I presented at the Virtual Reality Symposiumof the 34th International Ethological Conference （2015, Cairns, Australia）, and as such it describesstudies conducted mainly in my own laboratory. It reviews how we utilized visual stimuli for induc-ing behavioral responses in the zebrafish with a focus on shoaling, group forming behavior. Thezebrafish is gaining increasing popularity in neuroscience. With this interest, its behavior is alsomore frequently studied. One of the many advantages of the zebrafish over traditional laboratoryrodents is that this species is diurnal, and it relies heavily upon its visual system. Thus, similarly toour own species, zebrafish respond to visual stimuli in a robust and easily quantifiable manner. Forthe past decade, we have been exploring how to use such visual stimuli, and have developed nu-merous paradigms with which we can induce and quantify a variety of behavioral responses,including shoaling. This review summarizes some of these studies, and discusses questions includ-ing whether one should use live fish as stimulus, whether and how one could present animated（moving images） of fish, and how one could optimize a range of stimulus presentation parametersto elicit the most robust responses in zebrafish. Although the zebrafish is a relative newcomer inethology and behavioral neuroscience, and although many of our findings only represent the firststeps in this research, our results suggest that the behavioral analysis of the zebrafish will have animportant place in biomedical research.
文摘Based on the software support of SIMAN/CINEMA, this paper presents anintegrated approach to flexible modelling and simulation with animation. Themethodology provides a structured way of integrating mathematical and logicalmodel, statistical experimentation, and statistical analysis with computeranimation. Within this methodology, an animated simulation study is separatedinto six different activities: simulation objectives identification, system modeldevelopment, simulation experiment specification, animation layoutconstruction, real-time simulation and animation run, and output dataanalysis. These six activities are objectives driven, relatively independent, andintegrate through software organization and simulation files. The key ideasbehind this methodology are objectives orientation, modelling flexibility,simulation and animation integration, and application tailorability. Though themethodology is closely related to SIMAN/CINEMA, it can be extended to othersoftware environments.
文摘Cartoons serve as significant sources of entertainment for children and adolescents.However,numerous animated videos contain unsuitable content,such as violence,eroticism,abuse,and vehicular accidents.Current content detection methods rely on manual inspection,which is resource-intensive,time-consuming,and not always reliable.Therefore,more efficient detection methods are necessary to safeguard young viewers.This paper addresses this significant problem by proposing a novel deep learning-based system,AnimeNet,designed to detect varying degrees of violent and erotic content in videos.AnimeNet utilizes a novel Convolutional Neural Network(CNN)model to extract image features effectively,classifying violent and erotic scenes in videos and images.The novelty of the work lies in the introduction of a novel channel-spatial attention module,enhancing the feature extraction performance of the CNN model,an advancement over previous efforts in the literature.To validate the approach,I compared AnimeNet with state-of-the-art classification methods,including ResNet,RegNet,ConvNext,ViT,and MobileNet.These were used to identify violent and erotic scenes within specific video frames.The results showed that AnimeNet outperformed these models,proving it to be well-suited for real-time applications in videos or images.This work presents a significant leap forward in automatic content detection in animation,offering a high-accuracy solution that is less resource-intensive and more reliable than current methods.The proposed approach enables it possible to better protect young audiences from exposure to unsuitable content,underlining its importance and potential for broad social impact.
基金funded by “Multi-dimensional Reconstruction and Symbol Hybridity:Research on Innovative Expression of Traditional Culture in Domestic Animated Films”(WHCY2023B28)a project funded by the Cultural Industry Development Research Center of Sichuan Provincial Key Research Base of Philosophy and Social Sciences+1 种基金funded by “An Intertextual Analysis of Li Bing’s Story from a Cross-media Perspective”(RX2300002875)a research project funded by the Li Bing Research Center at the Sichuan Provincial Key Research Base of Philosophy and Social Sciences
文摘China’s domestic animation industry is deeply rooted in its rich traditional cultural heritage.While continuously exploring and showcasing the unique charm of such cultural heritage through storytelling,imagery establishment,and spirit creation,Chinese animation also seamlessly integrates modern aesthetic characteristics and cultural values into its development within the context of the new era.By adopting a contemporary perspective,it innovatively expresses the essence of traditional culture while striving to shape and present a reliable,admirable and respectable image of China.Chinese animation aims to create credible contemporary animation images by drawing inspiration from traditional Chinese cultural archetypes.It also seeks to revitalize admirable traditional cultural imagery using vibrant and prevailing ACGN visuals,while shaping credible characters with richer cultural connotations and crafting stories with more enchanting plots to convey the spiritual essence of the Chinese nation.By establishing reliable,admirable and respectable animation images,the Chinese animation industry strives to enhance its capability to“tell China’s stories well and make the voice of China heard,”to better promote the image of China in the new era from a global perspective.
基金supported by the Brain&Behavior Research Foundation(30233).
文摘Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.
文摘As a visual art, film has already been one of the main forms to exhibit culture in modem society. This paper tries to explore American animated films, one of the most successful and tipical styles of American films, from the view of post-colonialism so as to receal American animated films make every effort to set up the image of the Other and to propagate American culture and value. It is American cultural hegemony.
