AIM:To identify topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten eyes of 294 patients with KCN were recruited for this study.First,complete ocul...AIM:To identify topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten eyes of 294 patients with KCN were recruited for this study.First,complete ocular examinations were performed for all patients,including visual acuity measurement,refraction,and slit-lamp biomicroscopy.Then,all participants underwent corneal imaging by the Oculus Pentacam HR.RESULTS:The mean age of the participants was 32.40±8.52y(15-60y)and 69.5%of them were male.The mean ACA was 38.47°±5.75°(range:14.40°to 56.50°)in the whole sample,38.24°±6.00°in males,and 38.98°±5.11°in females(P=0.447).The mean ACA was significantly different among different groups of cone morphology,as patients with nipple cones showed the lowest mean ACA.Moreover,there were statistically significant differences in the mean ACA among different groups of cone locations,with patients having central cones exhibiting the lowest mean ACA(P<0.001).Anterior and posterior Q values were significantly,directly correlated with ACA(anterior Q:r=0.122,P=0.014,posterior Q:r=0.192,P<0.001).CONCLUSION:This study provides critical insights into the risk factors for ACA narrowing in KCN patients,which is essential for planning intraocular surgeries.Patients with nipple and central cones exhibited the most significant ACA narrowing.Additionally,more negative Q-values are associated with increased ACA narrowing,highlighting the need for targeted diagnostic and therapeutic strategies.展开更多
AIM:To investigate how angles kappa and alpha affect postoperative visual quality in patients with multifocal intraocular lens(mIOLs)implantation.METHODS:Retrospective cases series.A total of 46 patients(46 eyes)who u...AIM:To investigate how angles kappa and alpha affect postoperative visual quality in patients with multifocal intraocular lens(mIOLs)implantation.METHODS:Retrospective cases series.A total of 46 patients(46 eyes)who underwent phacoemulsification were subsumed.The correlation between Preoperative angles kappa and alpha,wave-front aberrations and objective visual quality of cornea,internal,and total eye after surgery were analyzed using iTrace.RESULTS:The magnitude of angle kappa was negatively correlated with internal and total modulation transfer function(MTF)at 3 mm;the magnitude of angle kappa was positively correlated with astigmatism,trefoil,higher-order aberrations(HOAs)of both internal and total eye at 3 mm.The magnitude of angle alpha was negatively correlated with total MTF and total Strehl ratio at 3 mm.The magnitude of angle alpha was positively correlated with corneal coma at 5 mm,internal astigmatism at both 3 mm and 5 mm,and total spherical aberration(SA)at 3 mm.Multivariate linear regression analysis showed that,among candidate independent variables(kappa,alpha,astigmatism,SA,coma,trefoil,and HOAs),astigmatism is the only independent factor for altering corneal MTF at 3 mm and 5 mm;astigmatism and HOAs emerged as independent factors for altering internal MTF at 3 mm and 5 mm,and total MTF at 3 mm;astigmatism,SA and HOAs emerged as independent factors for altering total MTF at 5 mm.CONCLUSION:With greater preoperative angle kappa or angle alpha,patients who accept mIOL implantation tend to have larger internal astigmatism and HOAs,which resulting in poor visual quality,especially those with small pupil size.展开更多
AIM:To explore the effect of Alpha angle and Kappa angle before multifocal intraocular lenses(MIOLs)implantation on postoperative visual quality of patients.METHODS:Before and 3mo after cataract surgery,Alpha angle an...AIM:To explore the effect of Alpha angle and Kappa angle before multifocal intraocular lenses(MIOLs)implantation on postoperative visual quality of patients.METHODS:Before and 3mo after cataract surgery,Alpha angle and Kappa angle were collected using IOL Master 700,iTrace,and Pentacam for clinical observation.Postoperative visual quality indicators,including high-order aberrations(HOA),modulation transfer function(MTF)and point spread function(PSF),were collected using iTrace.multiple linear regression analysis was used to analyze the correlation of the Kappa angle and the Alpha angle with age,axial length(AL),anterior chamber depth(ACD),keratometry(K),lens thickness(LT)and corneal white to white distance(WTW).Pearson correlation coefficient was used to analyze the correlation between Alpha angle and Kappa angle;Bland Altman analysis was used to evaluate the consistency of pairwise detection results of three instruments.RESULTS:The Alpha angle was modeled as Alpha=2.230+0.003×age-0.036×AL-0.025×K-0.058×WTW and the Kappa angle was modeled as Kappa=0.685+0.003×age-0.013×K-0.061×WTW.The correlation between the total Alpha angle and Kappa angle of the three instruments was weakly positive(r=0.291,P=0.000).Comparing the measurement of Alpha angle and Kappa angle using three instruments,only IOL Master 700 and iTrace showed good consistency in measuring Kappa angle(P=0.4254).After 3mo of surgery,the Alpha angle and Kappa angle significantly decreased(P=0.011,0.018;P=0.008,0.036).△Kappa=1.136-0.021×AL-0.013×K.Kappa angle could positively predict HOA(β=0.18,P=0.000),MTF(β=0.171,P=0.000),PSF(β=0.088,P=0.000),Alpha angle cannot(P>0.05).CONCLUSION:The patients with older age,flatter K and shorter WTW should be alert to the possibility of larger Alpha angle and Kappa angle.Alpha angle should also consider the factor of AL.When selecting patients with MIOLs implantation,there is no need to consider the Alpha angle.Careful consideration should be given to the Kappa angle,and the preoperative standard of<0.5 mm can refer to△Kappa=1.136-0.021×AL-0.013×K and be appropriately relaxed.展开更多
Dear Editor,X-linked retinoschisis(XLRS)is a rare X-linked recessive disorder predominantly afflicting young males.The schisis of the retinal layers is a result of deleterious mutations in the RS1 gene.Insufficient ep...Dear Editor,X-linked retinoschisis(XLRS)is a rare X-linked recessive disorder predominantly afflicting young males.The schisis of the retinal layers is a result of deleterious mutations in the RS1 gene.Insufficient epidemiological data has caused significant variation in reported global prevalence,with estimates fluctuating between 1 in 5000 and 1 in 30000 individuals[1].A large follow-up multicenter study recently published has yielded noteworthy findings concerning the phenotypic spectrum,long-term natural history,and genotype of XLRS.The investigation revealed a significant variability in visual function and disease progression,with particular variants of the RS1 gene displaying diverse phenotypic expressions,suggesting the intricate genetic basis underlying this disorder[2].The range of visual impairments associated with XLRS is extensive,varying from minor to severe.This condition is also characterized by specific retinal abnormalities,including radial streaks emanating from a divided central fovea,schisis affecting the inner layers of the retina in peripheral areas,and a diminished amplitude ratio of b-to a-wave,or even an electronegative electroretinography(ERG)[3].At their initial consultation,the majority of individuals with XLRS exhibit visual acuity(VA)levels between 20/60 and 20/120.However,there is a significant diversity in the condition’s presentation and progression,even among relatives,with VA levels spanning from near-normal to complete loss of sight[4-5].While vision tends to be reasonably consistent over several years for those with XLRS,there is documentation of a more rapid decline in later adulthood,specifically during the fourth and fifth decades,due to central retinal degeneration[5-7].Moreover,those with XLRS face an elevated risk for serious visual issues,such as retinal detachment,vitreous hemorrhages,and neovascular glaucoma[4].Female carriers could be found with slightly abnormal retinal changes without clinical symptoms[5].Even within the same family,the manifestation and progression of the condition can vary greatly,with individuals experiencing anything from nearly normal vision to complete loss of sight[8-9].Earlier investigations have revealed that retinoschisisrelated cystoid degeneration can impact multiple layers of the retina,beginning at the retinal nerve fiber zone and continuing to the nuclear stratum,with considerable fluctuation in the severity of the schisis[10-13].展开更多
Accurate target angle estimation is one of the chal-lenges for wideband radars due to the fact that target occupies multiple range bins,resulting in lower energy or signal to noise ratio in a single range bin.This pap...Accurate target angle estimation is one of the chal-lenges for wideband radars due to the fact that target occupies multiple range bins,resulting in lower energy or signal to noise ratio in a single range bin.This paper proposes a processing technique for enhanced accuracy of target angle estimates for wideband monopulse radars.Firstly,to accumulate the energy of the received echo signals from different scatterers on a target,the phase difference between different scatterers on a target is estimated using the minimum entropy phase estimation method combining with the correlation between adjacent pulses.Then,the monopulse ratio is obtained by using the signals from the accumulated sum and difference channels.The target angle is estimated by weighting the accumulated echo energy for accu-racy enhancement.Experimental results based on both numeri-cal simulation and measured data are presented to validate the effectiveness of the proposed technique.展开更多
Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while...Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while PGM has been demonstrated to regulate starch biosynthesis within chloroplasts,which eventually leads to starch accumulation in amyloplasts.However,the molecular mechanisms of gravity sensing in monocot shoots remain largely unexplored.In this study,we investigated the roles of these genes in rice(Oryza sativa),a model monocot,using CRISPR-Cas9 to generate single,double,and higher-order mutants.The rice genome harbors two orthologs each of SHR and SGR and a single ortholog of PGM.Our results revealed that single mutants of OsPGM,but not OsSHR or OsSGR,showed compromised shoot gravitropism.However,double mutants shr1shr2 and sgr1sgr2 displayed wider tiller angles and reduced gravity sensing,suggesting functional redundancy within each gene pair.Higher-order mutants exhibited progressively severe phenotypes,with quintuple mutants almost unresponsive to gravity stimulation.These findings suggest that these genes act additively through distinct but converging pathways in shoot gravitropism regulation.This study provides novel insights into the molecular mechanisms underlying gravity sensing in monocots and offers valuable knowledge for precision breeding to optimize rice architecture.展开更多
AIM:To evaluate the one-year clinical outcomes of a novel canaloplasty device used in combination with cataract extraction(CE)in patients with mild to severe open angle glaucoma(OAG).METHODS:This study reviewed patien...AIM:To evaluate the one-year clinical outcomes of a novel canaloplasty device used in combination with cataract extraction(CE)in patients with mild to severe open angle glaucoma(OAG).METHODS:This study reviewed patients diagnosed with mild to severe OAG,who underwent canaloplasty with the STREAMLINE®Surgical System combined with CE.The primary outcome was surgical success,defined as achieving≥20%intraocular pressure(IOP)reduction and/or a reduction of≥1 glaucoma medication compared to baseline.Secondary outcomes included mean IOP,average number of glaucoma medications,and best-corrected distance visual acuity(BCDVA).Data was collected preoperatively and at multiple postoperative time points up to one year.RESULTS:A total of 68 eyes of 47 patients were included with mean age was 73.1±7.0y and 60%were females.Surgical success at one year was achieved in 68.8%of eyes,with 67.6%success in mild,80.0%in moderate,and 66.7%in severe OAG cases.IOP was significantly reduced from a baseline of 16.1±0.5 to 14.7±0.4 mm Hg at one year(P=0.0004).The number of medications decreased significantly in all eyes from a baseline of 1.2±0.1 to 0.6±0.1 at one year(P<0.0001).When stratified by glaucoma severity,only the mild group experienced a statistically significant decrease from a baseline of 1.1±0.1 to 0.4±0.1(P<0.0001).BCDVA improved significantly from baseline to one year.No sight-threatening complications were reported.CONCLUSION:Canaloplasty using the STREAMLINE®surgical system combined with CE effectively reduces IOP at one year in mild to severe OAG with minimal complications.IOP lowering efficacy,reduction in IOP lowering medications,and safety in moderate to severe OAG require further study.展开更多
This study experimentally investigates the oscillatory dynamics of wind-driven droplets using high-speed imaging to capture droplet profiles within the symmetry plane and to characterize their natural oscillation freq...This study experimentally investigates the oscillatory dynamics of wind-driven droplets using high-speed imaging to capture droplet profiles within the symmetry plane and to characterize their natural oscillation frequencies.Results reveal that the eigenfrequencies vary spatially due to distinct oscillation modes occurring at different droplet locations.Notably,the fundamental eigenfrequency decreases with reducing droplet volume,while droplet viscosity exerts minimal influence on this frequency.Prior to the onset of motion,the dynamic contact angle consistently remains between the advancing and receding angles.The inertial forces generated by droplet oscillation are found to be significantly greater than the adhesion forces,indicating that classical static models are inadequate for capturing inertial contributions to droplet motion.These findings offer new insights into the role of oscillatory behavior in influencing the dynamics of droplet motion,and contribute to a more detailed understanding of wind-driven droplet transport phenomena.展开更多
This study introduces the lattice spring model(LSM)to investigate the incline angle of a non-uniform three-segment towed array under steady-state conditions.A numerical model was established,and parametric analysis wa...This study introduces the lattice spring model(LSM)to investigate the incline angle of a non-uniform three-segment towed array under steady-state conditions.A numerical model was established,and parametric analysis was conducted to examine the effects of towing speed and cable density on the incline angle.The numerical simulations demonstrate that for a conventional three-segment towed array with heavy vibration-isolation cable and density exceeding that of seawater,the towing speed must exceed 4 kn to maintain the acoustic cable's average incline angle below 10°.To validate the proposed LSM,a 100-meter-long towed array with variable densities was fabricated and tested through lake trials.The experimental results align closely with simulations,confirming LSM as a reliable model for predicting towed array position and posture.The study concludes by analyzing the parallel computing capabilities of LSM and its application in Fluid-Structure Interaction(FSI)problems.The model's precision and parallel computing capabilities make LSM an efficient,reliable tool for analyzing the steady-state behavior of towed systems.展开更多
The ability to localize sound sources rapidly allows human beings to efficiently understand the surrounding environment.Previous studies have suggested that there is an auditory“where”pathway in the cortex for proce...The ability to localize sound sources rapidly allows human beings to efficiently understand the surrounding environment.Previous studies have suggested that there is an auditory“where”pathway in the cortex for processing sound locations.The neural activation in regions along this pathway encodes sound locations by opponent hemifield coding,in which each unilateral region is activated by sounds coming from the contralateral hemifield.However,it is still unclear how these regions interact with each other to form a unified representation of the auditory space.In the present study,we investigated whether functional connectivity in the auditory“where”pathway encoded sound locations during passive listening.Participants underwent functional magnetic resonance imaging while passively listening to sounds from five distinct horizontal locations(−90°,−45°,0°,45°,90°).We were able to decode sound locations from the functional connectivity patterns of the“where”pathway.Furthermore,we found that such neural representation of sound locations was primarily based on the coding of sound lateralization angles to the frontal midline.In addition,whole-brain analysis indicated that functional connectivity between occipital regions and the primary auditory cortex also encoded sound locations by lateralization angles.Overall,our results reveal a lateralization-angle-based representation of sound locations encoded by functional connectivity patterns,which could add on the activation-based opponent hemifield coding to provide a more precise representation of the auditory space.展开更多
AIM:To compare refractive error and angle of deviation in patients with basic esotropia and basic exotropia.METHODS:A retrospective review was conducted on the medical records of patients with basic-type strabismus.De...AIM:To compare refractive error and angle of deviation in patients with basic esotropia and basic exotropia.METHODS:A retrospective review was conducted on the medical records of patients with basic-type strabismus.Demographic data,refractive error,best-corrected distance visual acuity(BCVA),and the horizontal and vertical angle of deviation between basic esotropia and exotropia patients were compared.RESULTS:Among the 7129 patients(mean age 22.98±14.81y)evaluated,44.7%(3185 cases,54.9%male)exhibited basic-type esotropia,while 55.3%(3944 cases,53.9%male)presented with basic-type exotropia.Basic esotropia cases exhibited more hyperopic spherical equivalent measurements in both eyes(right:0.53±3.07 vs left:0.56±2.98 D)than those with basic exotropia(right eye:-0.33±2.84 vs left eye:-0.24±2.68 D,P<0.001 for both eyes).Patients with basic esotropia had significantly greater horizontal deviation angles(near:36.08±18.87 PD and far:35.56±18.75 PD)compared to those with basic exotropia(near:33.75±16.11 PD and far:33.26±15.90 PD,P<0.001).Conversely,patients with basic exotropia had slightly higher vertical deviation angles(near:1.67±5.80 PD and far:1.72±5.89 PD)compared to those with basic esotropia(near:1.12±4.57 PD and far:1.12±4.58 PD,P<0.001).Patients with basic esotropia underwent surgical intervention at younger ages compared to basic exotropia individuals(19.68±15.99 vs 25.66±13.20,P<0.001).CONCLUSION:Basic esotropia patients present more hyperopic refractive errors,better visual acuity,larger horizontal yet smaller vertical ocular misalignments,and tend to undergo strabismus surgery at younger ages relative to basic exotropia cases.展开更多
This paper presents a fixed-time cooperative gui-dance method with impact angle constraints for multiple flight vehicles (MFV) to address the challenges of intercepting large maneuvering targets with difficulty and lo...This paper presents a fixed-time cooperative gui-dance method with impact angle constraints for multiple flight vehicles (MFV) to address the challenges of intercepting large maneuvering targets with difficulty and low precision. A coopera-tive guidance model is proposed, transforming the cooperative interception problem into a consensus problem based on the remaining flight time of the flight vehicles. First, the impact angle constraint is converted into the line of sight (LOS) angle con-straint, and a new fixed-time convergent non-singular terminal sliding surface is introduced, which resolves the singularity issue of the traditional sliding surfaces. With this approach, LOS angle rate and normal overloads can converge in fixed time, ensuring that the upper bound of the system convergence time is not affected by the initial value of the system. Furthermore, the maneuvering movement of the target is considered as a system disturbance, and an extended state observer is employed to estimate and compensate for it in the guidance law. Lastly, by applying consensus theory and distributed communication topology, the remaining flight time of each flight vehicle is syn-chronized to ensure that they intercept the target simulta-neously with different impact angles. Simulation experiments are conducted to validate the effectiveness of the proposed cooper-ative interception and guidance method.展开更多
Ceramic cores fabricated by stereolithography exhibit great potential in casting turbine blades.Previous research on ceramic core molding was primarily conducted using vertical printing techniques,which not only resul...Ceramic cores fabricated by stereolithography exhibit great potential in casting turbine blades.Previous research on ceramic core molding was primarily conducted using vertical printing techniques,which not only resulted in lengthy molding durations but also compromised the mechanical strength.In this work,silica(SiO--_2)ceramic cores,with fine complex geometric shapes,were fabricated using 65vol.%ceramic slurry by digital light processing(DLP)with different printing angles.Printing angles significantly impact the surface accuracy,shrinkage,printing efficiency of green bodies,as well as the microstructure and mechanical properties of sintered ceramic core samples.As the printing angle in the green body increases,the bonding area decreases,surface roughness on the XY plane worsens,shrinkage in the Z direction becomes more pronounced,and the printing efficiency declines.Similarly,an increase in the printing angle in the sintered body leads to a reduction in bending strength.At a printing angle of 30°,the printing time is reduced to half of that at 90°,which improves the molding efficiency.Meanwhile,the obtained bulk density of 1.71 g·cm~(-3),open porosity of 24%,and fiexural strength of 10.6±1 MPa can meet the requirements of sintered ceramic cores.Therefore,designing and optimizing the printing angles can achieve the balance between shrinkage,printing efficiency,and fiexural strength.展开更多
Flag leaf angle(FLANG)is one of the key traits in wheat breeding due to its impact on plant architecture,light interception,and yield potential.An image-based method of measuring FLANG in wheat would reduce the labor ...Flag leaf angle(FLANG)is one of the key traits in wheat breeding due to its impact on plant architecture,light interception,and yield potential.An image-based method of measuring FLANG in wheat would reduce the labor and error of manual measurement of this trait.We describe a method for acquiring in-field FLANG images and a lightweight deep learning model named LeafPoseNet that incorporates a spatial attention mechanism for FLANG estimation.In a test dataset with wheat varieties exhibiting diverse FLANG,LeafPoseNet achieved high accuracy in predicting the FLANG,with a mean absolute error(MAE)of 1.75°,a root mean square error(RMSE)of 2.17°,and a coefficient of determination(R2)of 0.998,significantly outperforming established models such as YOLO12x-pose,YOLO11x-pose,HigherHRNet,Lightweight-OpenPose,and LitePose.We performed phenotyping and genome-wide association study to identify the genomic regions associated with FLANG in a panel of 221 diverse bread wheat genotypes,and identified 10 quantitative trait loci.Among them,qFLANG2B.2 was found to harbor a potential causal gene,TraesCS2B01G313700,which may regulate FLANG formation by modulating brassinosteroid levels.This method provides a low-cost,high-accuracy solution for in-field phenotyping of wheat FLANG,facilitating both wheat FLANG genetic studies and ideal plant type breeding.展开更多
BACKGROUND Colorectal cancer(CRC)represents a major global public health issue,ranking as the third most common cancer worldwide.Given the substantial prevalence of CRC,there is a critical need to identify precise pro...BACKGROUND Colorectal cancer(CRC)represents a major global public health issue,ranking as the third most common cancer worldwide.Given the substantial prevalence of CRC,there is a critical need to identify precise prognostic and predictive biomar-ker tools for better treatment outcomes.Phase angle(PA)has been proposed as a prognostic marker in various non-malignant and malignant clinical conditions.AIM To investigate the relationship between PA and survival outcomes in the first-line treatment of metastatic CRC(mCRC).METHODS In this prospective observational study,we obtained data on patients who started first-line systemic chemotherapy from the beginning of 2020 until the end of 2022.The PA,assessed by the bioelectrical impedance analysis scale,was evaluated as a possible prognostic factor for treatment outcomes,which were measured as pro-gression-free survival(PFS)and objective response rate(ORR).RESULTS Using the cut-point value for PA set at 4.60°,144 patients were divided into two cohorts.The high PA group of patients exhibited a significantly longer median PFS than the low PA group,14.8 vs 10.5 months,respectively.No difference in ORR was observed.However,patients with PA≥4.60°had a higher disease control rate.CONCLUSION PA represents a novel and objective pre-chemotherapy prognostic factor to identify mCRC patients who are at increased risk of a worse survival outcome.展开更多
AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorde...AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorders.METHODS:In this cross-sectional study,aqueous humor samples of 22 eyes of POAG patients(POAG group),24 eyes of cataract patients without metabolic disorders(cataract group),and 24 eyes of cataract patients with metabolic disorders(cataract+metabolic disorders group)were assessed for 15 adipokines by Luminex bead-based multiplex array.The correlation between aqueous humor adipokines and clinical indicators of POAG was analyzed and compared across the groups.RESULTS:The analysis revealed that the levels of adiponectin,leptin,adipsin,retinol-binding protein 4(RBP4),angiopoietin-2,angiopoietin-like protein 4(ANGPTL4),chemokine(C-C motif)ligand 2(CCL2),interleukin-8(IL-8),and interleukin-18(IL-18)in the aqueous humor of the POAG group were significantly higher than those in the cataract group.Additionally,the level of angiopoietin-2 in the POAG group was higher than in the cataract+metabolic disorders group.However,no significant correlation was found between the levels of adipokines in the POAG group and intraocular pressure(IOP),severity of POAG,or the use of glaucoma medications.CONCLUSION:This study demonstrates significant differences in aqueous humor adipokine levels between POAG and cataract patients.The findings suggest that the levels of aqueous humor adipokines may reflect the inflammatory states in POAG and systemic metabolic abnormalities.展开更多
AIM:To explore whether plasma proteins serve as potential therapeutic targets for primary open angle glaucoma(POAG)based on a Mendelian randomization(MR)study.METHODS:Large-scale protein quantitative trait loci(pQTLs)...AIM:To explore whether plasma proteins serve as potential therapeutic targets for primary open angle glaucoma(POAG)based on a Mendelian randomization(MR)study.METHODS:Large-scale protein quantitative trait loci(pQTLs)data from the Icelandic deCODE database and two large POAG Genome-Wide Association Study(GWAS)summary datasets were used in this study.Causal associations between plasma proteins and POAG were identified using summary-data-based MR(SMR)analysis and the heterogeneity in dependent instruments(HEIDI)test.Colocalization analysis was then conducted to assess the genetic associations between these two factors.Phenotype-wide MR analysis was performed to validate protein targets as potential drug targets and to evaluate potential side effects.Finally,protein-protein interactions(PPI)were studied,and the Drug-Gene Interaction Database(DGIDb)was used to identify associations between drugs and the identified proteins.RESULTS:Four proteins(SVEP1,TMEM190,ROBO1,and ENPP5)were identified as potential drug targets in this study.Phenome-wide MR analysis showed that SVEP1,ROBO1,and ENPP5 were not associated with adverse effects,while TMEM190 was linked to nerve root and plexus disorders,as well as subarachnoid hemorrhage.Ticagrelor was suggested as a potential new drug for the treatment of glaucoma by regulating SVEP1.CONCLUSION:Four plasma proteins—SVEP1,TMEM190,ROBO1,and ENPP5—are identified as potential therapeutic targets for POAG through an MR approach.Phenome-wide MR analysis reveals that SVEP1,ROBO1,and ENPP5 are not associated with adverse effects,while TMEM190 is linked to nerve root and plexus disorders,as well as subarachnoid hemorrhage.Ticagrelor is proposed as a potential therapeutic drug for glaucoma by regulating SVEP1.These findings highlight the potential of plasma proteins as drug targets for POAG and provide valuable insights for further research.展开更多
Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements u...Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements using a protractor.Terrestrial laser scanning(TLS),however,provides new opportunities to measure branch angles more efficiently.Despite this potential,studies validating branch angle measurements from TLS have been limited.Here,our aim is to evaluate both manual and automatic branch angle measurements of European beech from TLS data using traditional field-measurements with a protractor as a reference.We evaluated the accuracy of branch angle measurements based on four automated algorithms(aRchiQSM,TreeQSM,Laplacian,SemanticLaplacian)from TLS data.Additionally,we assessed different ways of manual branch angle measurements in the field.Our study was based on a dataset comprising 124 branch angles measured from six European beech in a European deciduous forest.Our results show that manual branch angle measurements from TLS data are in high agreement with the reference(root-mean-squared error,RMSE:[3.57°-4.18°],concordance correlation coefficient,CCC:[0.950.97])across different branch length positions.Automated algorithms also are in high agreement with the reference although RMSE is approximately twice as large compared to manual branch angle measurements from TLS(RMSE:[9.29°-10.55°],CCC:[0.830.86])with manual leaf points removal.When applying the automatic wood-leaf separation algorithm,the performance of the four methods declined significantly,with only approximately 20 branch angles successfully identified.Moreover,it is important to note that there is no influence of the measurement position(branch surface versus center)for branch angle measurements.However,for curved branches,the selection of branch measurement length significantly impacts the branch angle measurement.This study provides a comprehensive understanding of branch angle measurements in forests.We show that automated measurement methods based on TLS data of branch angles are a valuable tool to quantify branch angles at larger scales.展开更多
Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametr...Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametric bank angle profiles in Mars atmospheric entry missions.The methodology includes a universal approach to handling path constraints and a reliable solution method based on the Particle Swarm Optimization(PSO)algorithm.For illustrative purposes,a mission with the objective of maximizing terminal altitude is considered.The original entry optimization problem is converted into optimizing three coefficients for the bank angle profiles with terminal constraints by formulating a parametric Mars entry bank angle profile and constraint handling methods.The parameter optimization problem is addressed using the PSO algorithm,with reliability enhanced by increasing the PSO swarm size.To improve computational efficiency,an enhanced Deep Operator Network(Deep ONet)is used as a dynamics solver to predict terminal states under various bank angle profiles rapidly.Numerical simulations demonstrate that the proposed methodology ensures reliable convergence with a sufficiently large PSO swarm while maintaining high computational efficiency facilitated by the neural-network-based dynamics solver.Compared to the existing methodologies,this methodology offers a streamlined process,the reduced sensitivity to initial guesses,and the improved computational efficiency.展开更多
基金Supported by Iranian University of Medical Sciences(code:IR.IUMS.REC.1401.371).
文摘AIM:To identify topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten eyes of 294 patients with KCN were recruited for this study.First,complete ocular examinations were performed for all patients,including visual acuity measurement,refraction,and slit-lamp biomicroscopy.Then,all participants underwent corneal imaging by the Oculus Pentacam HR.RESULTS:The mean age of the participants was 32.40±8.52y(15-60y)and 69.5%of them were male.The mean ACA was 38.47°±5.75°(range:14.40°to 56.50°)in the whole sample,38.24°±6.00°in males,and 38.98°±5.11°in females(P=0.447).The mean ACA was significantly different among different groups of cone morphology,as patients with nipple cones showed the lowest mean ACA.Moreover,there were statistically significant differences in the mean ACA among different groups of cone locations,with patients having central cones exhibiting the lowest mean ACA(P<0.001).Anterior and posterior Q values were significantly,directly correlated with ACA(anterior Q:r=0.122,P=0.014,posterior Q:r=0.192,P<0.001).CONCLUSION:This study provides critical insights into the risk factors for ACA narrowing in KCN patients,which is essential for planning intraocular surgeries.Patients with nipple and central cones exhibited the most significant ACA narrowing.Additionally,more negative Q-values are associated with increased ACA narrowing,highlighting the need for targeted diagnostic and therapeutic strategies.
文摘AIM:To investigate how angles kappa and alpha affect postoperative visual quality in patients with multifocal intraocular lens(mIOLs)implantation.METHODS:Retrospective cases series.A total of 46 patients(46 eyes)who underwent phacoemulsification were subsumed.The correlation between Preoperative angles kappa and alpha,wave-front aberrations and objective visual quality of cornea,internal,and total eye after surgery were analyzed using iTrace.RESULTS:The magnitude of angle kappa was negatively correlated with internal and total modulation transfer function(MTF)at 3 mm;the magnitude of angle kappa was positively correlated with astigmatism,trefoil,higher-order aberrations(HOAs)of both internal and total eye at 3 mm.The magnitude of angle alpha was negatively correlated with total MTF and total Strehl ratio at 3 mm.The magnitude of angle alpha was positively correlated with corneal coma at 5 mm,internal astigmatism at both 3 mm and 5 mm,and total spherical aberration(SA)at 3 mm.Multivariate linear regression analysis showed that,among candidate independent variables(kappa,alpha,astigmatism,SA,coma,trefoil,and HOAs),astigmatism is the only independent factor for altering corneal MTF at 3 mm and 5 mm;astigmatism and HOAs emerged as independent factors for altering internal MTF at 3 mm and 5 mm,and total MTF at 3 mm;astigmatism,SA and HOAs emerged as independent factors for altering total MTF at 5 mm.CONCLUSION:With greater preoperative angle kappa or angle alpha,patients who accept mIOL implantation tend to have larger internal astigmatism and HOAs,which resulting in poor visual quality,especially those with small pupil size.
基金Supported by National Natural Science Foundation of China(No.81902751).
文摘AIM:To explore the effect of Alpha angle and Kappa angle before multifocal intraocular lenses(MIOLs)implantation on postoperative visual quality of patients.METHODS:Before and 3mo after cataract surgery,Alpha angle and Kappa angle were collected using IOL Master 700,iTrace,and Pentacam for clinical observation.Postoperative visual quality indicators,including high-order aberrations(HOA),modulation transfer function(MTF)and point spread function(PSF),were collected using iTrace.multiple linear regression analysis was used to analyze the correlation of the Kappa angle and the Alpha angle with age,axial length(AL),anterior chamber depth(ACD),keratometry(K),lens thickness(LT)and corneal white to white distance(WTW).Pearson correlation coefficient was used to analyze the correlation between Alpha angle and Kappa angle;Bland Altman analysis was used to evaluate the consistency of pairwise detection results of three instruments.RESULTS:The Alpha angle was modeled as Alpha=2.230+0.003×age-0.036×AL-0.025×K-0.058×WTW and the Kappa angle was modeled as Kappa=0.685+0.003×age-0.013×K-0.061×WTW.The correlation between the total Alpha angle and Kappa angle of the three instruments was weakly positive(r=0.291,P=0.000).Comparing the measurement of Alpha angle and Kappa angle using three instruments,only IOL Master 700 and iTrace showed good consistency in measuring Kappa angle(P=0.4254).After 3mo of surgery,the Alpha angle and Kappa angle significantly decreased(P=0.011,0.018;P=0.008,0.036).△Kappa=1.136-0.021×AL-0.013×K.Kappa angle could positively predict HOA(β=0.18,P=0.000),MTF(β=0.171,P=0.000),PSF(β=0.088,P=0.000),Alpha angle cannot(P>0.05).CONCLUSION:The patients with older age,flatter K and shorter WTW should be alert to the possibility of larger Alpha angle and Kappa angle.Alpha angle should also consider the factor of AL.When selecting patients with MIOLs implantation,there is no need to consider the Alpha angle.Careful consideration should be given to the Kappa angle,and the preoperative standard of<0.5 mm can refer to△Kappa=1.136-0.021×AL-0.013×K and be appropriately relaxed.
基金Supported by Capital’s Funds for Health Improvement and Research(No.2024-2-4087)Central Guidance for Local Scientific and Technological Development Funding Projects(No.2022ZY0026).
文摘Dear Editor,X-linked retinoschisis(XLRS)is a rare X-linked recessive disorder predominantly afflicting young males.The schisis of the retinal layers is a result of deleterious mutations in the RS1 gene.Insufficient epidemiological data has caused significant variation in reported global prevalence,with estimates fluctuating between 1 in 5000 and 1 in 30000 individuals[1].A large follow-up multicenter study recently published has yielded noteworthy findings concerning the phenotypic spectrum,long-term natural history,and genotype of XLRS.The investigation revealed a significant variability in visual function and disease progression,with particular variants of the RS1 gene displaying diverse phenotypic expressions,suggesting the intricate genetic basis underlying this disorder[2].The range of visual impairments associated with XLRS is extensive,varying from minor to severe.This condition is also characterized by specific retinal abnormalities,including radial streaks emanating from a divided central fovea,schisis affecting the inner layers of the retina in peripheral areas,and a diminished amplitude ratio of b-to a-wave,or even an electronegative electroretinography(ERG)[3].At their initial consultation,the majority of individuals with XLRS exhibit visual acuity(VA)levels between 20/60 and 20/120.However,there is a significant diversity in the condition’s presentation and progression,even among relatives,with VA levels spanning from near-normal to complete loss of sight[4-5].While vision tends to be reasonably consistent over several years for those with XLRS,there is documentation of a more rapid decline in later adulthood,specifically during the fourth and fifth decades,due to central retinal degeneration[5-7].Moreover,those with XLRS face an elevated risk for serious visual issues,such as retinal detachment,vitreous hemorrhages,and neovascular glaucoma[4].Female carriers could be found with slightly abnormal retinal changes without clinical symptoms[5].Even within the same family,the manifestation and progression of the condition can vary greatly,with individuals experiencing anything from nearly normal vision to complete loss of sight[8-9].Earlier investigations have revealed that retinoschisisrelated cystoid degeneration can impact multiple layers of the retina,beginning at the retinal nerve fiber zone and continuing to the nuclear stratum,with considerable fluctuation in the severity of the schisis[10-13].
文摘Accurate target angle estimation is one of the chal-lenges for wideband radars due to the fact that target occupies multiple range bins,resulting in lower energy or signal to noise ratio in a single range bin.This paper proposes a processing technique for enhanced accuracy of target angle estimates for wideband monopulse radars.Firstly,to accumulate the energy of the received echo signals from different scatterers on a target,the phase difference between different scatterers on a target is estimated using the minimum entropy phase estimation method combining with the correlation between adjacent pulses.Then,the monopulse ratio is obtained by using the signals from the accumulated sum and difference channels.The target angle is estimated by weighting the accumulated echo energy for accu-racy enhancement.Experimental results based on both numeri-cal simulation and measured data are presented to validate the effectiveness of the proposed technique.
基金supported by grants from the Biological Breeding-National Science and Technology Major Project(2024ZD04077)the National Natural Science Foundation of China(31801323)+1 种基金the Innovation Program of the Chinese Academy of Agricultural Sciencesthe Science and Technology Innovation Project of the Shandong Academy of Agricultural Sciences(CXGC2023F14)。
文摘Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while PGM has been demonstrated to regulate starch biosynthesis within chloroplasts,which eventually leads to starch accumulation in amyloplasts.However,the molecular mechanisms of gravity sensing in monocot shoots remain largely unexplored.In this study,we investigated the roles of these genes in rice(Oryza sativa),a model monocot,using CRISPR-Cas9 to generate single,double,and higher-order mutants.The rice genome harbors two orthologs each of SHR and SGR and a single ortholog of PGM.Our results revealed that single mutants of OsPGM,but not OsSHR or OsSGR,showed compromised shoot gravitropism.However,double mutants shr1shr2 and sgr1sgr2 displayed wider tiller angles and reduced gravity sensing,suggesting functional redundancy within each gene pair.Higher-order mutants exhibited progressively severe phenotypes,with quintuple mutants almost unresponsive to gravity stimulation.These findings suggest that these genes act additively through distinct but converging pathways in shoot gravitropism regulation.This study provides novel insights into the molecular mechanisms underlying gravity sensing in monocots and offers valuable knowledge for precision breeding to optimize rice architecture.
文摘AIM:To evaluate the one-year clinical outcomes of a novel canaloplasty device used in combination with cataract extraction(CE)in patients with mild to severe open angle glaucoma(OAG).METHODS:This study reviewed patients diagnosed with mild to severe OAG,who underwent canaloplasty with the STREAMLINE®Surgical System combined with CE.The primary outcome was surgical success,defined as achieving≥20%intraocular pressure(IOP)reduction and/or a reduction of≥1 glaucoma medication compared to baseline.Secondary outcomes included mean IOP,average number of glaucoma medications,and best-corrected distance visual acuity(BCDVA).Data was collected preoperatively and at multiple postoperative time points up to one year.RESULTS:A total of 68 eyes of 47 patients were included with mean age was 73.1±7.0y and 60%were females.Surgical success at one year was achieved in 68.8%of eyes,with 67.6%success in mild,80.0%in moderate,and 66.7%in severe OAG cases.IOP was significantly reduced from a baseline of 16.1±0.5 to 14.7±0.4 mm Hg at one year(P=0.0004).The number of medications decreased significantly in all eyes from a baseline of 1.2±0.1 to 0.6±0.1 at one year(P<0.0001).When stratified by glaucoma severity,only the mild group experienced a statistically significant decrease from a baseline of 1.1±0.1 to 0.4±0.1(P<0.0001).BCDVA improved significantly from baseline to one year.No sight-threatening complications were reported.CONCLUSION:Canaloplasty using the STREAMLINE®surgical system combined with CE effectively reduces IOP at one year in mild to severe OAG with minimal complications.IOP lowering efficacy,reduction in IOP lowering medications,and safety in moderate to severe OAG require further study.
基金supported by the National Natural Science Foundation ofChina(GrantNo.12402291)the Beijing Natural Science Foundation(No.3244043)the Research Start-up Funds of Hangzhou International Innovation Institute of Beihang University(Grant Nos.2024KQ008,2024KQ062).
文摘This study experimentally investigates the oscillatory dynamics of wind-driven droplets using high-speed imaging to capture droplet profiles within the symmetry plane and to characterize their natural oscillation frequencies.Results reveal that the eigenfrequencies vary spatially due to distinct oscillation modes occurring at different droplet locations.Notably,the fundamental eigenfrequency decreases with reducing droplet volume,while droplet viscosity exerts minimal influence on this frequency.Prior to the onset of motion,the dynamic contact angle consistently remains between the advancing and receding angles.The inertial forces generated by droplet oscillation are found to be significantly greater than the adhesion forces,indicating that classical static models are inadequate for capturing inertial contributions to droplet motion.These findings offer new insights into the role of oscillatory behavior in influencing the dynamics of droplet motion,and contribute to a more detailed understanding of wind-driven droplet transport phenomena.
基金supported by the Key Research Project of Zhejiang Lab(Grant No.K2022MEOAC01)。
文摘This study introduces the lattice spring model(LSM)to investigate the incline angle of a non-uniform three-segment towed array under steady-state conditions.A numerical model was established,and parametric analysis was conducted to examine the effects of towing speed and cable density on the incline angle.The numerical simulations demonstrate that for a conventional three-segment towed array with heavy vibration-isolation cable and density exceeding that of seawater,the towing speed must exceed 4 kn to maintain the acoustic cable's average incline angle below 10°.To validate the proposed LSM,a 100-meter-long towed array with variable densities was fabricated and tested through lake trials.The experimental results align closely with simulations,confirming LSM as a reliable model for predicting towed array position and posture.The study concludes by analyzing the parallel computing capabilities of LSM and its application in Fluid-Structure Interaction(FSI)problems.The model's precision and parallel computing capabilities make LSM an efficient,reliable tool for analyzing the steady-state behavior of towed systems.
基金supported by the National Key Research and Development Program of China(2023YFF1203502)the National Natural Science Foundation of China(62171300,62301343,and 62394314)+1 种基金the Project of Cultivation for Young Top-Notch Talents of Beijing Municipal Institutions(BPHR202203109)the Capital Medical University Research and Development Fund(PYZ22027).
文摘The ability to localize sound sources rapidly allows human beings to efficiently understand the surrounding environment.Previous studies have suggested that there is an auditory“where”pathway in the cortex for processing sound locations.The neural activation in regions along this pathway encodes sound locations by opponent hemifield coding,in which each unilateral region is activated by sounds coming from the contralateral hemifield.However,it is still unclear how these regions interact with each other to form a unified representation of the auditory space.In the present study,we investigated whether functional connectivity in the auditory“where”pathway encoded sound locations during passive listening.Participants underwent functional magnetic resonance imaging while passively listening to sounds from five distinct horizontal locations(−90°,−45°,0°,45°,90°).We were able to decode sound locations from the functional connectivity patterns of the“where”pathway.Furthermore,we found that such neural representation of sound locations was primarily based on the coding of sound lateralization angles to the frontal midline.In addition,whole-brain analysis indicated that functional connectivity between occipital regions and the primary auditory cortex also encoded sound locations by lateralization angles.Overall,our results reveal a lateralization-angle-based representation of sound locations encoded by functional connectivity patterns,which could add on the activation-based opponent hemifield coding to provide a more precise representation of the auditory space.
文摘AIM:To compare refractive error and angle of deviation in patients with basic esotropia and basic exotropia.METHODS:A retrospective review was conducted on the medical records of patients with basic-type strabismus.Demographic data,refractive error,best-corrected distance visual acuity(BCVA),and the horizontal and vertical angle of deviation between basic esotropia and exotropia patients were compared.RESULTS:Among the 7129 patients(mean age 22.98±14.81y)evaluated,44.7%(3185 cases,54.9%male)exhibited basic-type esotropia,while 55.3%(3944 cases,53.9%male)presented with basic-type exotropia.Basic esotropia cases exhibited more hyperopic spherical equivalent measurements in both eyes(right:0.53±3.07 vs left:0.56±2.98 D)than those with basic exotropia(right eye:-0.33±2.84 vs left eye:-0.24±2.68 D,P<0.001 for both eyes).Patients with basic esotropia had significantly greater horizontal deviation angles(near:36.08±18.87 PD and far:35.56±18.75 PD)compared to those with basic exotropia(near:33.75±16.11 PD and far:33.26±15.90 PD,P<0.001).Conversely,patients with basic exotropia had slightly higher vertical deviation angles(near:1.67±5.80 PD and far:1.72±5.89 PD)compared to those with basic esotropia(near:1.12±4.57 PD and far:1.12±4.58 PD,P<0.001).Patients with basic esotropia underwent surgical intervention at younger ages compared to basic exotropia individuals(19.68±15.99 vs 25.66±13.20,P<0.001).CONCLUSION:Basic esotropia patients present more hyperopic refractive errors,better visual acuity,larger horizontal yet smaller vertical ocular misalignments,and tend to undergo strabismus surgery at younger ages relative to basic exotropia cases.
基金supported by the National Natural Science Foundation of China(61903099)the Natural Science Foundation of Heilongjiang Province(LH2020F025)+2 种基金the Project of Science and Technology Research Program of Chongqing Education Commission of China(KJZD-K20200470)the Postdoctoral Science Foundation of China(2021M690812)the Postdoctoral Science Fund of Heilongjiang Province(LBH-Z21048).
文摘This paper presents a fixed-time cooperative gui-dance method with impact angle constraints for multiple flight vehicles (MFV) to address the challenges of intercepting large maneuvering targets with difficulty and low precision. A coopera-tive guidance model is proposed, transforming the cooperative interception problem into a consensus problem based on the remaining flight time of the flight vehicles. First, the impact angle constraint is converted into the line of sight (LOS) angle con-straint, and a new fixed-time convergent non-singular terminal sliding surface is introduced, which resolves the singularity issue of the traditional sliding surfaces. With this approach, LOS angle rate and normal overloads can converge in fixed time, ensuring that the upper bound of the system convergence time is not affected by the initial value of the system. Furthermore, the maneuvering movement of the target is considered as a system disturbance, and an extended state observer is employed to estimate and compensate for it in the guidance law. Lastly, by applying consensus theory and distributed communication topology, the remaining flight time of each flight vehicle is syn-chronized to ensure that they intercept the target simulta-neously with different impact angles. Simulation experiments are conducted to validate the effectiveness of the proposed cooper-ative interception and guidance method.
基金the Youth Innovation Promotion Association of Chinese Academy of Science(No.2021160)the National Natural Science Foundation of China(No.51802319)the Technology and Engineering Center for Space(No.CSU-QZKT-2019-04)。
文摘Ceramic cores fabricated by stereolithography exhibit great potential in casting turbine blades.Previous research on ceramic core molding was primarily conducted using vertical printing techniques,which not only resulted in lengthy molding durations but also compromised the mechanical strength.In this work,silica(SiO--_2)ceramic cores,with fine complex geometric shapes,were fabricated using 65vol.%ceramic slurry by digital light processing(DLP)with different printing angles.Printing angles significantly impact the surface accuracy,shrinkage,printing efficiency of green bodies,as well as the microstructure and mechanical properties of sintered ceramic core samples.As the printing angle in the green body increases,the bonding area decreases,surface roughness on the XY plane worsens,shrinkage in the Z direction becomes more pronounced,and the printing efficiency declines.Similarly,an increase in the printing angle in the sintered body leads to a reduction in bending strength.At a printing angle of 30°,the printing time is reduced to half of that at 90°,which improves the molding efficiency.Meanwhile,the obtained bulk density of 1.71 g·cm~(-3),open porosity of 24%,and fiexural strength of 10.6±1 MPa can meet the requirements of sintered ceramic cores.Therefore,designing and optimizing the printing angles can achieve the balance between shrinkage,printing efficiency,and fiexural strength.
基金supported by the Biological Breeding-National Science and Technology Major Project(2023ZD04076)the National Key Research and Development Program of China(2023YFF1000100)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA0450000).
文摘Flag leaf angle(FLANG)is one of the key traits in wheat breeding due to its impact on plant architecture,light interception,and yield potential.An image-based method of measuring FLANG in wheat would reduce the labor and error of manual measurement of this trait.We describe a method for acquiring in-field FLANG images and a lightweight deep learning model named LeafPoseNet that incorporates a spatial attention mechanism for FLANG estimation.In a test dataset with wheat varieties exhibiting diverse FLANG,LeafPoseNet achieved high accuracy in predicting the FLANG,with a mean absolute error(MAE)of 1.75°,a root mean square error(RMSE)of 2.17°,and a coefficient of determination(R2)of 0.998,significantly outperforming established models such as YOLO12x-pose,YOLO11x-pose,HigherHRNet,Lightweight-OpenPose,and LitePose.We performed phenotyping and genome-wide association study to identify the genomic regions associated with FLANG in a panel of 221 diverse bread wheat genotypes,and identified 10 quantitative trait loci.Among them,qFLANG2B.2 was found to harbor a potential causal gene,TraesCS2B01G313700,which may regulate FLANG formation by modulating brassinosteroid levels.This method provides a low-cost,high-accuracy solution for in-field phenotyping of wheat FLANG,facilitating both wheat FLANG genetic studies and ideal plant type breeding.
文摘BACKGROUND Colorectal cancer(CRC)represents a major global public health issue,ranking as the third most common cancer worldwide.Given the substantial prevalence of CRC,there is a critical need to identify precise prognostic and predictive biomar-ker tools for better treatment outcomes.Phase angle(PA)has been proposed as a prognostic marker in various non-malignant and malignant clinical conditions.AIM To investigate the relationship between PA and survival outcomes in the first-line treatment of metastatic CRC(mCRC).METHODS In this prospective observational study,we obtained data on patients who started first-line systemic chemotherapy from the beginning of 2020 until the end of 2022.The PA,assessed by the bioelectrical impedance analysis scale,was evaluated as a possible prognostic factor for treatment outcomes,which were measured as pro-gression-free survival(PFS)and objective response rate(ORR).RESULTS Using the cut-point value for PA set at 4.60°,144 patients were divided into two cohorts.The high PA group of patients exhibited a significantly longer median PFS than the low PA group,14.8 vs 10.5 months,respectively.No difference in ORR was observed.However,patients with PA≥4.60°had a higher disease control rate.CONCLUSION PA represents a novel and objective pre-chemotherapy prognostic factor to identify mCRC patients who are at increased risk of a worse survival outcome.
基金Supported by National Key R&D Program of China(No.2023YFC2506100)the Changping Key Research Project of the Beijing Natural Science Foundation Program(No.L234016).
文摘AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorders.METHODS:In this cross-sectional study,aqueous humor samples of 22 eyes of POAG patients(POAG group),24 eyes of cataract patients without metabolic disorders(cataract group),and 24 eyes of cataract patients with metabolic disorders(cataract+metabolic disorders group)were assessed for 15 adipokines by Luminex bead-based multiplex array.The correlation between aqueous humor adipokines and clinical indicators of POAG was analyzed and compared across the groups.RESULTS:The analysis revealed that the levels of adiponectin,leptin,adipsin,retinol-binding protein 4(RBP4),angiopoietin-2,angiopoietin-like protein 4(ANGPTL4),chemokine(C-C motif)ligand 2(CCL2),interleukin-8(IL-8),and interleukin-18(IL-18)in the aqueous humor of the POAG group were significantly higher than those in the cataract group.Additionally,the level of angiopoietin-2 in the POAG group was higher than in the cataract+metabolic disorders group.However,no significant correlation was found between the levels of adipokines in the POAG group and intraocular pressure(IOP),severity of POAG,or the use of glaucoma medications.CONCLUSION:This study demonstrates significant differences in aqueous humor adipokine levels between POAG and cataract patients.The findings suggest that the levels of aqueous humor adipokines may reflect the inflammatory states in POAG and systemic metabolic abnormalities.
基金Supported by the National Natural Science Foundation of China(No.81770920)Open Project of State Key Laboratory of Ophthalmology(No.303060202400383).
文摘AIM:To explore whether plasma proteins serve as potential therapeutic targets for primary open angle glaucoma(POAG)based on a Mendelian randomization(MR)study.METHODS:Large-scale protein quantitative trait loci(pQTLs)data from the Icelandic deCODE database and two large POAG Genome-Wide Association Study(GWAS)summary datasets were used in this study.Causal associations between plasma proteins and POAG were identified using summary-data-based MR(SMR)analysis and the heterogeneity in dependent instruments(HEIDI)test.Colocalization analysis was then conducted to assess the genetic associations between these two factors.Phenotype-wide MR analysis was performed to validate protein targets as potential drug targets and to evaluate potential side effects.Finally,protein-protein interactions(PPI)were studied,and the Drug-Gene Interaction Database(DGIDb)was used to identify associations between drugs and the identified proteins.RESULTS:Four proteins(SVEP1,TMEM190,ROBO1,and ENPP5)were identified as potential drug targets in this study.Phenome-wide MR analysis showed that SVEP1,ROBO1,and ENPP5 were not associated with adverse effects,while TMEM190 was linked to nerve root and plexus disorders,as well as subarachnoid hemorrhage.Ticagrelor was suggested as a potential new drug for the treatment of glaucoma by regulating SVEP1.CONCLUSION:Four plasma proteins—SVEP1,TMEM190,ROBO1,and ENPP5—are identified as potential therapeutic targets for POAG through an MR approach.Phenome-wide MR analysis reveals that SVEP1,ROBO1,and ENPP5 are not associated with adverse effects,while TMEM190 is linked to nerve root and plexus disorders,as well as subarachnoid hemorrhage.Ticagrelor is proposed as a potential therapeutic drug for glaucoma by regulating SVEP1.These findings highlight the potential of plasma proteins as drug targets for POAG and provide valuable insights for further research.
基金supported by the Chinese Scholarship Council under Grant 202106910006.
文摘Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements using a protractor.Terrestrial laser scanning(TLS),however,provides new opportunities to measure branch angles more efficiently.Despite this potential,studies validating branch angle measurements from TLS have been limited.Here,our aim is to evaluate both manual and automatic branch angle measurements of European beech from TLS data using traditional field-measurements with a protractor as a reference.We evaluated the accuracy of branch angle measurements based on four automated algorithms(aRchiQSM,TreeQSM,Laplacian,SemanticLaplacian)from TLS data.Additionally,we assessed different ways of manual branch angle measurements in the field.Our study was based on a dataset comprising 124 branch angles measured from six European beech in a European deciduous forest.Our results show that manual branch angle measurements from TLS data are in high agreement with the reference(root-mean-squared error,RMSE:[3.57°-4.18°],concordance correlation coefficient,CCC:[0.950.97])across different branch length positions.Automated algorithms also are in high agreement with the reference although RMSE is approximately twice as large compared to manual branch angle measurements from TLS(RMSE:[9.29°-10.55°],CCC:[0.830.86])with manual leaf points removal.When applying the automatic wood-leaf separation algorithm,the performance of the four methods declined significantly,with only approximately 20 branch angles successfully identified.Moreover,it is important to note that there is no influence of the measurement position(branch surface versus center)for branch angle measurements.However,for curved branches,the selection of branch measurement length significantly impacts the branch angle measurement.This study provides a comprehensive understanding of branch angle measurements in forests.We show that automated measurement methods based on TLS data of branch angles are a valuable tool to quantify branch angles at larger scales.
基金supported in part by the National Defense Basic Scientific Research Program of China(No.JCKY2021603B030)the Shenzhen Fundamental Research Program,China(No.JCYJ20220818102601004)the Science Center Program of National Natural Science Foundation of China(No.62188101)。
文摘Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametric bank angle profiles in Mars atmospheric entry missions.The methodology includes a universal approach to handling path constraints and a reliable solution method based on the Particle Swarm Optimization(PSO)algorithm.For illustrative purposes,a mission with the objective of maximizing terminal altitude is considered.The original entry optimization problem is converted into optimizing three coefficients for the bank angle profiles with terminal constraints by formulating a parametric Mars entry bank angle profile and constraint handling methods.The parameter optimization problem is addressed using the PSO algorithm,with reliability enhanced by increasing the PSO swarm size.To improve computational efficiency,an enhanced Deep Operator Network(Deep ONet)is used as a dynamics solver to predict terminal states under various bank angle profiles rapidly.Numerical simulations demonstrate that the proposed methodology ensures reliable convergence with a sufficiently large PSO swarm while maintaining high computational efficiency facilitated by the neural-network-based dynamics solver.Compared to the existing methodologies,this methodology offers a streamlined process,the reduced sensitivity to initial guesses,and the improved computational efficiency.
