AIM:To investigate how angles kappa and alpha affect postoperative visual quality in patients with multifocal intraocular lens(mIOLs)implantation.METHODS:Retrospective cases series.A total of 46 patients(46 eyes)who u...AIM:To investigate how angles kappa and alpha affect postoperative visual quality in patients with multifocal intraocular lens(mIOLs)implantation.METHODS:Retrospective cases series.A total of 46 patients(46 eyes)who underwent phacoemulsification were subsumed.The correlation between Preoperative angles kappa and alpha,wave-front aberrations and objective visual quality of cornea,internal,and total eye after surgery were analyzed using iTrace.RESULTS:The magnitude of angle kappa was negatively correlated with internal and total modulation transfer function(MTF)at 3 mm;the magnitude of angle kappa was positively correlated with astigmatism,trefoil,higher-order aberrations(HOAs)of both internal and total eye at 3 mm.The magnitude of angle alpha was negatively correlated with total MTF and total Strehl ratio at 3 mm.The magnitude of angle alpha was positively correlated with corneal coma at 5 mm,internal astigmatism at both 3 mm and 5 mm,and total spherical aberration(SA)at 3 mm.Multivariate linear regression analysis showed that,among candidate independent variables(kappa,alpha,astigmatism,SA,coma,trefoil,and HOAs),astigmatism is the only independent factor for altering corneal MTF at 3 mm and 5 mm;astigmatism and HOAs emerged as independent factors for altering internal MTF at 3 mm and 5 mm,and total MTF at 3 mm;astigmatism,SA and HOAs emerged as independent factors for altering total MTF at 5 mm.CONCLUSION:With greater preoperative angle kappa or angle alpha,patients who accept mIOL implantation tend to have larger internal astigmatism and HOAs,which resulting in poor visual quality,especially those with small pupil size.展开更多
AIM:To explore the effect of Alpha angle and Kappa angle before multifocal intraocular lenses(MIOLs)implantation on postoperative visual quality of patients.METHODS:Before and 3mo after cataract surgery,Alpha angle an...AIM:To explore the effect of Alpha angle and Kappa angle before multifocal intraocular lenses(MIOLs)implantation on postoperative visual quality of patients.METHODS:Before and 3mo after cataract surgery,Alpha angle and Kappa angle were collected using IOL Master 700,iTrace,and Pentacam for clinical observation.Postoperative visual quality indicators,including high-order aberrations(HOA),modulation transfer function(MTF)and point spread function(PSF),were collected using iTrace.multiple linear regression analysis was used to analyze the correlation of the Kappa angle and the Alpha angle with age,axial length(AL),anterior chamber depth(ACD),keratometry(K),lens thickness(LT)and corneal white to white distance(WTW).Pearson correlation coefficient was used to analyze the correlation between Alpha angle and Kappa angle;Bland Altman analysis was used to evaluate the consistency of pairwise detection results of three instruments.RESULTS:The Alpha angle was modeled as Alpha=2.230+0.003×age-0.036×AL-0.025×K-0.058×WTW and the Kappa angle was modeled as Kappa=0.685+0.003×age-0.013×K-0.061×WTW.The correlation between the total Alpha angle and Kappa angle of the three instruments was weakly positive(r=0.291,P=0.000).Comparing the measurement of Alpha angle and Kappa angle using three instruments,only IOL Master 700 and iTrace showed good consistency in measuring Kappa angle(P=0.4254).After 3mo of surgery,the Alpha angle and Kappa angle significantly decreased(P=0.011,0.018;P=0.008,0.036).△Kappa=1.136-0.021×AL-0.013×K.Kappa angle could positively predict HOA(β=0.18,P=0.000),MTF(β=0.171,P=0.000),PSF(β=0.088,P=0.000),Alpha angle cannot(P>0.05).CONCLUSION:The patients with older age,flatter K and shorter WTW should be alert to the possibility of larger Alpha angle and Kappa angle.Alpha angle should also consider the factor of AL.When selecting patients with MIOLs implantation,there is no need to consider the Alpha angle.Careful consideration should be given to the Kappa angle,and the preoperative standard of<0.5 mm can refer to△Kappa=1.136-0.021×AL-0.013×K and be appropriately relaxed.展开更多
AIM:To describe the alterations of the vitreous pathology and anterior chamber(AC)angle structures following transscleral cyclophotocoagulation(TSCP)and better understand the mechanism of post-laser intraocular pressu...AIM:To describe the alterations of the vitreous pathology and anterior chamber(AC)angle structures following transscleral cyclophotocoagulation(TSCP)and better understand the mechanism of post-laser intraocular pressure(IOP)reduction in angle-closure glaucoma(ACG).METHODS:Porcine eyes ex vivo and rabbit eyes in vivo were used.In porcine eyes,permeability rates of the anterior vitreous cortex(AVC)and anterior hyaloid membrane(AHM)were assessed using Schirmer’s strips.Permeability rates in the circumlental space were compared with or without TSCP bursts.Fluorescein diffusion times from the vitreous to the AC were compared between eyes with and without TSCP.In rabbit eyes,changes in IOP and AC angle structures under ultrasound biomicroscopy(UBM)were evaluated at intervals of 30min,7d,and 14d after TSCP.Vitreous pathology was examined using scanning electron microscopy(SEM)immediately and 14d after TSCP.RESULTS:In porcine eyes(n=20),the median(range)permeability rates were 10.3(range 9.8–10.8)mm/min for the AVC and 4.3(range 3.9–4.9)mm/min for the AHM(P=0.009).Permeability rates in the circumlental space were 4.2(range 3.8–4.9)mm/min in areas without TSCP,6.2(range 5.7–6.8)mm/min in areas with non-burst TSCP,and 11.3(range 10.9–11.8)mm/min in areas with burst TSCP(P=0.002).The median(range)fluorescein diffusion time was 5(range 3–8)min in eyes undergoing TSCP,whereas it was 40min(range 35–68)in eyes without TSCP(P<0.001).In rabbit eyes(n=20),SEM showed immediate localized damage to the AHM,AVC,and posterior lens zonules in areas subjected to TSCP bursts,and obvious lens zonule loss with cellular infiltration and possible vitreous liquefaction by post-op day 14.Persistent widening of AC angles was noted at postoperative days 7 and 14,although a significant reduction in IOP was only observed at postoperative day 7.CONCLUSION:TSCP-induced damage on the zonules,AHM,and AVC potentially enhances fluid outflow from the vitreous,leading to a widened AC angle and vitreous liquefaction in rabbits.These observations offer insights into mechanisms of TSCP in lowering IOP and pathogenic roles of vitreous in ACG.展开更多
AIM:To identify topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten eyes of 294 patients with KCN were recruited for this study.First,complete ocul...AIM:To identify topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten eyes of 294 patients with KCN were recruited for this study.First,complete ocular examinations were performed for all patients,including visual acuity measurement,refraction,and slit-lamp biomicroscopy.Then,all participants underwent corneal imaging by the Oculus Pentacam HR.RESULTS:The mean age of the participants was 32.40±8.52y(15-60y)and 69.5%of them were male.The mean ACA was 38.47°±5.75°(range:14.40°to 56.50°)in the whole sample,38.24°±6.00°in males,and 38.98°±5.11°in females(P=0.447).The mean ACA was significantly different among different groups of cone morphology,as patients with nipple cones showed the lowest mean ACA.Moreover,there were statistically significant differences in the mean ACA among different groups of cone locations,with patients having central cones exhibiting the lowest mean ACA(P<0.001).Anterior and posterior Q values were significantly,directly correlated with ACA(anterior Q:r=0.122,P=0.014,posterior Q:r=0.192,P<0.001).CONCLUSION:This study provides critical insights into the risk factors for ACA narrowing in KCN patients,which is essential for planning intraocular surgeries.Patients with nipple and central cones exhibited the most significant ACA narrowing.Additionally,more negative Q-values are associated with increased ACA narrowing,highlighting the need for targeted diagnostic and therapeutic strategies.展开更多
Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements u...Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements using a protractor.Terrestrial laser scanning(TLS),however,provides new opportunities to measure branch angles more efficiently.Despite this potential,studies validating branch angle measurements from TLS have been limited.Here,our aim is to evaluate both manual and automatic branch angle measurements of European beech from TLS data using traditional field-measurements with a protractor as a reference.We evaluated the accuracy of branch angle measurements based on four automated algorithms(aRchiQSM,TreeQSM,Laplacian,SemanticLaplacian)from TLS data.Additionally,we assessed different ways of manual branch angle measurements in the field.Our study was based on a dataset comprising 124 branch angles measured from six European beech in a European deciduous forest.Our results show that manual branch angle measurements from TLS data are in high agreement with the reference(root-mean-squared error,RMSE:[3.57°-4.18°],concordance correlation coefficient,CCC:[0.950.97])across different branch length positions.Automated algorithms also are in high agreement with the reference although RMSE is approximately twice as large compared to manual branch angle measurements from TLS(RMSE:[9.29°-10.55°],CCC:[0.830.86])with manual leaf points removal.When applying the automatic wood-leaf separation algorithm,the performance of the four methods declined significantly,with only approximately 20 branch angles successfully identified.Moreover,it is important to note that there is no influence of the measurement position(branch surface versus center)for branch angle measurements.However,for curved branches,the selection of branch measurement length significantly impacts the branch angle measurement.This study provides a comprehensive understanding of branch angle measurements in forests.We show that automated measurement methods based on TLS data of branch angles are a valuable tool to quantify branch angles at larger scales.展开更多
Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while...Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while PGM has been demonstrated to regulate starch biosynthesis within chloroplasts,which eventually leads to starch accumulation in amyloplasts.However,the molecular mechanisms of gravity sensing in monocot shoots remain largely unexplored.In this study,we investigated the roles of these genes in rice(Oryza sativa),a model monocot,using CRISPR-Cas9 to generate single,double,and higher-order mutants.The rice genome harbors two orthologs each of SHR and SGR and a single ortholog of PGM.Our results revealed that single mutants of OsPGM,but not OsSHR or OsSGR,showed compromised shoot gravitropism.However,double mutants shr1shr2 and sgr1sgr2 displayed wider tiller angles and reduced gravity sensing,suggesting functional redundancy within each gene pair.Higher-order mutants exhibited progressively severe phenotypes,with quintuple mutants almost unresponsive to gravity stimulation.These findings suggest that these genes act additively through distinct but converging pathways in shoot gravitropism regulation.This study provides novel insights into the molecular mechanisms underlying gravity sensing in monocots and offers valuable knowledge for precision breeding to optimize rice architecture.展开更多
The spatial relationship between structural planes and principal stresses significantly affects the mechanical properties of deep hard rock.This paper examines the effect of the loading angle under true triaxial compr...The spatial relationship between structural planes and principal stresses significantly affects the mechanical properties of deep hard rock.This paper examines the effect of the loading angle under true triaxial compression.While previous studies focused on the angleβbetween the maximum principal stress and the structural plane,the role of angleω,between the intermediate principal stress and the structural plane,is often overlooked.Utilizing artificially prefabricated granite specimens with a single non-penetrating structural plane,we set the loading angleβto range from 0°to 90°across seven groups,and assignedωvalues of 0°and 90°in two separate groups.The results show that the peak strength is negatively correlated withβup to 45°,beyond which it tends to stabilize.The angleωexerts a strengthening effect on the peak strength.Deformation mainly occurs post-peak,with the strain values ε_(1) and ε_(3) reaching levels 2−3 times higher than those in intact rock.The structural plane significantly influences failure mode whenω=0°,while failure localizes near the σ_(3) surface of the specimens whenω=90°.The findings enhance data on structural plane rocks under triaxial compression and inform theoretical research,excavation,and support design of rock structures.展开更多
This paper presents a fixed-time cooperative gui-dance method with impact angle constraints for multiple flight vehicles (MFV) to address the challenges of intercepting large maneuvering targets with difficulty and lo...This paper presents a fixed-time cooperative gui-dance method with impact angle constraints for multiple flight vehicles (MFV) to address the challenges of intercepting large maneuvering targets with difficulty and low precision. A coopera-tive guidance model is proposed, transforming the cooperative interception problem into a consensus problem based on the remaining flight time of the flight vehicles. First, the impact angle constraint is converted into the line of sight (LOS) angle con-straint, and a new fixed-time convergent non-singular terminal sliding surface is introduced, which resolves the singularity issue of the traditional sliding surfaces. With this approach, LOS angle rate and normal overloads can converge in fixed time, ensuring that the upper bound of the system convergence time is not affected by the initial value of the system. Furthermore, the maneuvering movement of the target is considered as a system disturbance, and an extended state observer is employed to estimate and compensate for it in the guidance law. Lastly, by applying consensus theory and distributed communication topology, the remaining flight time of each flight vehicle is syn-chronized to ensure that they intercept the target simulta-neously with different impact angles. Simulation experiments are conducted to validate the effectiveness of the proposed cooper-ative interception and guidance method.展开更多
Ceramic cores fabricated by stereolithography exhibit great potential in casting turbine blades.Previous research on ceramic core molding was primarily conducted using vertical printing techniques,which not only resul...Ceramic cores fabricated by stereolithography exhibit great potential in casting turbine blades.Previous research on ceramic core molding was primarily conducted using vertical printing techniques,which not only resulted in lengthy molding durations but also compromised the mechanical strength.In this work,silica(SiO--_2)ceramic cores,with fine complex geometric shapes,were fabricated using 65vol.%ceramic slurry by digital light processing(DLP)with different printing angles.Printing angles significantly impact the surface accuracy,shrinkage,printing efficiency of green bodies,as well as the microstructure and mechanical properties of sintered ceramic core samples.As the printing angle in the green body increases,the bonding area decreases,surface roughness on the XY plane worsens,shrinkage in the Z direction becomes more pronounced,and the printing efficiency declines.Similarly,an increase in the printing angle in the sintered body leads to a reduction in bending strength.At a printing angle of 30°,the printing time is reduced to half of that at 90°,which improves the molding efficiency.Meanwhile,the obtained bulk density of 1.71 g·cm~(-3),open porosity of 24%,and fiexural strength of 10.6±1 MPa can meet the requirements of sintered ceramic cores.Therefore,designing and optimizing the printing angles can achieve the balance between shrinkage,printing efficiency,and fiexural strength.展开更多
The integration of renewable energy sources(RESs)with inverter interfaces has fundamentally reshaped power system dynamics,challenging traditional stability analysis frameworks designed for synchronous generator-domin...The integration of renewable energy sources(RESs)with inverter interfaces has fundamentally reshaped power system dynamics,challenging traditional stability analysis frameworks designed for synchronous generator-dominated grids.Conventional classifica-tions,which decouple voltage,frequency,and rotor angle stability,fail to address the emerging strong voltage‒angle coupling effects caused by RES dynamics.This coupling introduces complex oscillation modes and undermines system robustness,neces-sitating novel stability assessment tools.Recent studies focus on eigenvalue distributions and damping redistribution but lack quantitative criteria and interpretative clarity for coupled stability.This work proposes a transient energy-based framework to resolve these gaps.By decomposing transient energy into subsystem-dissipated components and coupling-induced energy exchange,the method establishes stability criteria compatible with a broad variety of inverter-interfaced devices while offering an intuitive energy-based interpretation for engineers.The coupling strength is also quantified by defining the relative coupling strength index,which is directly related to the transient energy interpretation of the coupled stability.Angle‒voltage coupling may induce instability by injecting transient energy into the system,even if the individual phase angle and voltage dynamics themselves are stable.The main contributions include a systematic stability evaluation framework and an energy decomposition approach that bridges theoretical analysis with practical applicability,addressing the urgent need for tools for managing modern power system evolving stability challenges.展开更多
BACKGROUND Colorectal cancer(CRC)represents a major global public health issue,ranking as the third most common cancer worldwide.Given the substantial prevalence of CRC,there is a critical need to identify precise pro...BACKGROUND Colorectal cancer(CRC)represents a major global public health issue,ranking as the third most common cancer worldwide.Given the substantial prevalence of CRC,there is a critical need to identify precise prognostic and predictive biomar-ker tools for better treatment outcomes.Phase angle(PA)has been proposed as a prognostic marker in various non-malignant and malignant clinical conditions.AIM To investigate the relationship between PA and survival outcomes in the first-line treatment of metastatic CRC(mCRC).METHODS In this prospective observational study,we obtained data on patients who started first-line systemic chemotherapy from the beginning of 2020 until the end of 2022.The PA,assessed by the bioelectrical impedance analysis scale,was evaluated as a possible prognostic factor for treatment outcomes,which were measured as pro-gression-free survival(PFS)and objective response rate(ORR).RESULTS Using the cut-point value for PA set at 4.60°,144 patients were divided into two cohorts.The high PA group of patients exhibited a significantly longer median PFS than the low PA group,14.8 vs 10.5 months,respectively.No difference in ORR was observed.However,patients with PA≥4.60°had a higher disease control rate.CONCLUSION PA represents a novel and objective pre-chemotherapy prognostic factor to identify mCRC patients who are at increased risk of a worse survival outcome.展开更多
The marine propeller typically functions within thefilowfiield generated by a water vehicle.Investigations into the geometric parameters of the propeller are commonly conducted under open‑water conditions as simultane...The marine propeller typically functions within thefilowfiield generated by a water vehicle.Investigations into the geometric parameters of the propeller are commonly conducted under open‑water conditions as simultaneously simulating both vehicle and propeller holds several computational challenges.While during operation,this propellant device must face several forces like gravity,hydrodynamic load,and centrifugal force,which cause different problems like cavitation and structural failure,etc.Since these issues affect performance,it necessitates comprehensive analysis.In this study,hydrodynamic analysis is performed by using commercial software STAR CCM+.In hydrodynamic analysis,the effect of the rake angles–5°,5°,10°and 15°on hydrodynamic coeffiicients and effiiciency of the DTMB 4119 in the open water is analyzed using Computational Fluid Dynamics(CFD)and the control volume approach.The Shear Stress Transport(SST)k‑ωturbulence model is used in Computational Fluid Dynamics(CFD)simulation.Hydrodynamic analysis reveals that the rake angles 5°and 10°cause the open water effiiciency of David Taylor Model Basin(DTMB)4119 to improve by 0.4 to 1.32%with exception of the rake angles–5°and 15°,which possess different effects on effiiciency.The angle–5°causes a decrease in propeller effiiciency under heavy loading situations(low advance coeffiicient)apart from a minorfiluctuation at light loading conditions(high advance coeffiicient),while the angle 15°produces a drop in effiiciency by higher advance ratios but little variation at lower advance ratios.展开更多
Flag leaf angle(FLANG)is one of the key traits in wheat breeding due to its impact on plant architecture,light interception,and yield potential.An image-based method of measuring FLANG in wheat would reduce the labor ...Flag leaf angle(FLANG)is one of the key traits in wheat breeding due to its impact on plant architecture,light interception,and yield potential.An image-based method of measuring FLANG in wheat would reduce the labor and error of manual measurement of this trait.We describe a method for acquiring in-field FLANG images and a lightweight deep learning model named LeafPoseNet that incorporates a spatial attention mechanism for FLANG estimation.In a test dataset with wheat varieties exhibiting diverse FLANG,LeafPoseNet achieved high accuracy in predicting the FLANG,with a mean absolute error(MAE)of 1.75°,a root mean square error(RMSE)of 2.17°,and a coefficient of determination(R2)of 0.998,significantly outperforming established models such as YOLO12x-pose,YOLO11x-pose,HigherHRNet,Lightweight-OpenPose,and LitePose.We performed phenotyping and genome-wide association study to identify the genomic regions associated with FLANG in a panel of 221 diverse bread wheat genotypes,and identified 10 quantitative trait loci.Among them,qFLANG2B.2 was found to harbor a potential causal gene,TraesCS2B01G313700,which may regulate FLANG formation by modulating brassinosteroid levels.This method provides a low-cost,high-accuracy solution for in-field phenotyping of wheat FLANG,facilitating both wheat FLANG genetic studies and ideal plant type breeding.展开更多
AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorde...AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorders.METHODS:In this cross-sectional study,aqueous humor samples of 22 eyes of POAG patients(POAG group),24 eyes of cataract patients without metabolic disorders(cataract group),and 24 eyes of cataract patients with metabolic disorders(cataract+metabolic disorders group)were assessed for 15 adipokines by Luminex bead-based multiplex array.The correlation between aqueous humor adipokines and clinical indicators of POAG was analyzed and compared across the groups.RESULTS:The analysis revealed that the levels of adiponectin,leptin,adipsin,retinol-binding protein 4(RBP4),angiopoietin-2,angiopoietin-like protein 4(ANGPTL4),chemokine(C-C motif)ligand 2(CCL2),interleukin-8(IL-8),and interleukin-18(IL-18)in the aqueous humor of the POAG group were significantly higher than those in the cataract group.Additionally,the level of angiopoietin-2 in the POAG group was higher than in the cataract+metabolic disorders group.However,no significant correlation was found between the levels of adipokines in the POAG group and intraocular pressure(IOP),severity of POAG,or the use of glaucoma medications.CONCLUSION:This study demonstrates significant differences in aqueous humor adipokine levels between POAG and cataract patients.The findings suggest that the levels of aqueous humor adipokines may reflect the inflammatory states in POAG and systemic metabolic abnormalities.展开更多
Stall flutter poses great challenges to flight safety.To alleviate this problem,a steady blowing control considering the perturbation and wake-induced vibration at a large angle of attack is developed in this paper,wh...Stall flutter poses great challenges to flight safety.To alleviate this problem,a steady blowing control considering the perturbation and wake-induced vibration at a large angle of attack is developed in this paper,where two blowings are configured on upper and lower tail surfaces to suppress the stall flutter.The stall flutter with one-degree-of-freedom is first evaluated by numerical simulation.The equation of motion for stall flutter is solved by the Newmark-β method.Then,the stall flutter responses for five blowing speeds,i.e.,0,4,12,20,and 28 m/s under the airspeed range of 3–9 m/s,are studied in detail.The stall flutter suppression mechanism can be summarized as follows:a large blowing speed can inject energy into the boundary layer and enhance the high-pressure zone,which delays the flow separation on the suction surface.In this way,the formation of the leading-edge separation vortex is suppressed.Thus,the dynamic stall vortex is weakened and accelerates shedding.In addition,the driving moment is reduced,which leads to a decrement in the stall flutter amplitude.When the blowing speed is 28 m/s(stall flutter amplitude=0.1357 rad),compared with uncontrolled case(stall flutter amplitude=0.6002 rad),the amplitude can decrease by 77.39%,which demonstrates the effectiveness of the proposed steady blowing based active control strategy.展开更多
Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametr...Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametric bank angle profiles in Mars atmospheric entry missions.The methodology includes a universal approach to handling path constraints and a reliable solution method based on the Particle Swarm Optimization(PSO)algorithm.For illustrative purposes,a mission with the objective of maximizing terminal altitude is considered.The original entry optimization problem is converted into optimizing three coefficients for the bank angle profiles with terminal constraints by formulating a parametric Mars entry bank angle profile and constraint handling methods.The parameter optimization problem is addressed using the PSO algorithm,with reliability enhanced by increasing the PSO swarm size.To improve computational efficiency,an enhanced Deep Operator Network(Deep ONet)is used as a dynamics solver to predict terminal states under various bank angle profiles rapidly.Numerical simulations demonstrate that the proposed methodology ensures reliable convergence with a sufficiently large PSO swarm while maintaining high computational efficiency facilitated by the neural-network-based dynamics solver.Compared to the existing methodologies,this methodology offers a streamlined process,the reduced sensitivity to initial guesses,and the improved computational efficiency.展开更多
AIM:To measure abducens nerve palsy patients’visual angle using real time video-based gaze tracking system.METHODS:This research was a cross-sectional study.The subjects were taken by convenience sampling technique i...AIM:To measure abducens nerve palsy patients’visual angle using real time video-based gaze tracking system.METHODS:This research was a cross-sectional study.The subjects were taken by convenience sampling technique in the Neuro-ophthalmology department at Sardjito General Hospital Yogyakarta,Indonesia,and had met the inclusion and exclusion criteria.The visual angle measurements were performed using an eye tracker with a computer webcam(GENICULA system/Gaze Tracking Artificial Intelligence for Ocular Motor Palsy).The analytical method used was the Mann-Whitney test to compare the visual angle between the abducens nerve palsy group and the healthy eye group.The Wilcoxon test was used to see the significance of differences in visual angle improvement in abducens nerve palsy patients.RESULTS:A total of 39 subjects participated,with a mean age of 46.54±15.67y;17 were male and 22 were female.The visual angle was 20.88±3.76 in the abducens nerve palsy group(n=39 eyes)and 23.10±2.91 in the normal group(n=39 eyes,P=0.011).The visual angle improvement of abducens nerve palsy before and after cured was statistically significant(P=0.039).CONCLUSION:The real time video-based gaze tracking system is easy to use,efficient,and accurate.A slight decrease in visual angle measurement can be detected using this GENICULA system and therefore it is important for diagnosis slight deviation in abducens nerve palsy.展开更多
With the rapid development of deep resource extraction and underground space construction,the design of anchored support systems for jointed rock masses in complex stress environments faces significant challenges.This...With the rapid development of deep resource extraction and underground space construction,the design of anchored support systems for jointed rock masses in complex stress environments faces significant challenges.This study investigates the influence of prefabricated crack dip angles on the mechanical properties of anchored rock masses in deep soft rock roadways.By constructing similarity models of NPR(Negative Poisson’s Ratio)and PR(Positive Poisson’s Ratio)anchored solids,biaxial compression experiments under varying crack dip angles were conducted.Strain gauges,3D Digital Image Correlation(3D DIC),and acoustic emission monitoring were employed to systematically analyze the strength characteristics,deformation-damage evolution,and energy dissipation mechanisms of the two types of anchor systems.The results show that:(1)The stress-strain curves of anchored solids with prefabricated cracks exhibit a distinct bimodal characteristic.Compared to PR anchors,NPR anchors show 20%and 23%improvements in peak strength and elastic modulus,respectively,with residual strength enhanced by up to 34%.(2)Owing to high pre-tightening force and large deformation capacity,NPR anchors maintain superior integrity under increasing crack dip angles,demonstrating more uniform free-surface displacement and localized shear-tensile composite crack patterns.(3)Acoustic emission analysis reveals that NPR anchors exhibit higher cumulative energy absorption(300%improvement over PR anchors)and lack low-rate energy development phases,indicating enhanced ductility and impact resistance at high crack dip angles.(4)Crack dip angle critically governs failure mechanisms by modulating the connectivity between shear cracks and prefabricated fissures:bimodal effects dominate at low angles,while vertical tensile crack propagation replaces bimodal behavior at high angles.The study proposes prioritizing NPR anchor cables in deep engineering applications and optimizing support parameters based on crack dip angles to mitigate stress concentration and ensure the long-term stability of surrounding rock.展开更多
Unsteady aerodynamic characteristics at high angles of attack are of great importance to the design and development of advanced fighter aircraft, which are characterized by post-stall maneuverability with multiple Deg...Unsteady aerodynamic characteristics at high angles of attack are of great importance to the design and development of advanced fighter aircraft, which are characterized by post-stall maneuverability with multiple Degrees-of-Freedom(multi-DOF) and complex flow field structure.In this paper, a special kind of cable-driven parallel mechanism is firstly utilized as a new suspension method to conduct unsteady dynamic wind tunnel tests at high angles of attack, thereby providing experimental aerodynamic data. These tests include a wide range of multi-DOF coupled oscillatory motions with various amplitudes and frequencies. Then, for aerodynamic modeling and analysis, a novel data-driven Feature-Level Attention Recurrent neural network(FLAR) is proposed. This model incorporates a specially designed feature-level attention module that focuses on the state variables affecting the aerodynamic coefficients, thereby enhancing the physical interpretability of the aerodynamic model. Subsequently, spin maneuver simulations, using a mathematical model as the baseline, are conducted to validate the effectiveness of the FLAR. Finally, the results on wind tunnel data reveal that the FLAR accurately predicts aerodynamic coefficients, and observations through the visualization of attention scores identify the key state variables that affect the aerodynamic coefficients. It is concluded that the proposed FLAR enhances the interpretability of the aerodynamic model while achieving good prediction accuracy and generalization capability for multi-DOF coupling motion at high angles of attack.展开更多
文摘AIM:To investigate how angles kappa and alpha affect postoperative visual quality in patients with multifocal intraocular lens(mIOLs)implantation.METHODS:Retrospective cases series.A total of 46 patients(46 eyes)who underwent phacoemulsification were subsumed.The correlation between Preoperative angles kappa and alpha,wave-front aberrations and objective visual quality of cornea,internal,and total eye after surgery were analyzed using iTrace.RESULTS:The magnitude of angle kappa was negatively correlated with internal and total modulation transfer function(MTF)at 3 mm;the magnitude of angle kappa was positively correlated with astigmatism,trefoil,higher-order aberrations(HOAs)of both internal and total eye at 3 mm.The magnitude of angle alpha was negatively correlated with total MTF and total Strehl ratio at 3 mm.The magnitude of angle alpha was positively correlated with corneal coma at 5 mm,internal astigmatism at both 3 mm and 5 mm,and total spherical aberration(SA)at 3 mm.Multivariate linear regression analysis showed that,among candidate independent variables(kappa,alpha,astigmatism,SA,coma,trefoil,and HOAs),astigmatism is the only independent factor for altering corneal MTF at 3 mm and 5 mm;astigmatism and HOAs emerged as independent factors for altering internal MTF at 3 mm and 5 mm,and total MTF at 3 mm;astigmatism,SA and HOAs emerged as independent factors for altering total MTF at 5 mm.CONCLUSION:With greater preoperative angle kappa or angle alpha,patients who accept mIOL implantation tend to have larger internal astigmatism and HOAs,which resulting in poor visual quality,especially those with small pupil size.
基金Supported by National Natural Science Foundation of China(No.81902751).
文摘AIM:To explore the effect of Alpha angle and Kappa angle before multifocal intraocular lenses(MIOLs)implantation on postoperative visual quality of patients.METHODS:Before and 3mo after cataract surgery,Alpha angle and Kappa angle were collected using IOL Master 700,iTrace,and Pentacam for clinical observation.Postoperative visual quality indicators,including high-order aberrations(HOA),modulation transfer function(MTF)and point spread function(PSF),were collected using iTrace.multiple linear regression analysis was used to analyze the correlation of the Kappa angle and the Alpha angle with age,axial length(AL),anterior chamber depth(ACD),keratometry(K),lens thickness(LT)and corneal white to white distance(WTW).Pearson correlation coefficient was used to analyze the correlation between Alpha angle and Kappa angle;Bland Altman analysis was used to evaluate the consistency of pairwise detection results of three instruments.RESULTS:The Alpha angle was modeled as Alpha=2.230+0.003×age-0.036×AL-0.025×K-0.058×WTW and the Kappa angle was modeled as Kappa=0.685+0.003×age-0.013×K-0.061×WTW.The correlation between the total Alpha angle and Kappa angle of the three instruments was weakly positive(r=0.291,P=0.000).Comparing the measurement of Alpha angle and Kappa angle using three instruments,only IOL Master 700 and iTrace showed good consistency in measuring Kappa angle(P=0.4254).After 3mo of surgery,the Alpha angle and Kappa angle significantly decreased(P=0.011,0.018;P=0.008,0.036).△Kappa=1.136-0.021×AL-0.013×K.Kappa angle could positively predict HOA(β=0.18,P=0.000),MTF(β=0.171,P=0.000),PSF(β=0.088,P=0.000),Alpha angle cannot(P>0.05).CONCLUSION:The patients with older age,flatter K and shorter WTW should be alert to the possibility of larger Alpha angle and Kappa angle.Alpha angle should also consider the factor of AL.When selecting patients with MIOLs implantation,there is no need to consider the Alpha angle.Careful consideration should be given to the Kappa angle,and the preoperative standard of<0.5 mm can refer to△Kappa=1.136-0.021×AL-0.013×K and be appropriately relaxed.
基金Supported by National Natural Science Foundation of China(No.82201171,No.82171050,No.82471072).
文摘AIM:To describe the alterations of the vitreous pathology and anterior chamber(AC)angle structures following transscleral cyclophotocoagulation(TSCP)and better understand the mechanism of post-laser intraocular pressure(IOP)reduction in angle-closure glaucoma(ACG).METHODS:Porcine eyes ex vivo and rabbit eyes in vivo were used.In porcine eyes,permeability rates of the anterior vitreous cortex(AVC)and anterior hyaloid membrane(AHM)were assessed using Schirmer’s strips.Permeability rates in the circumlental space were compared with or without TSCP bursts.Fluorescein diffusion times from the vitreous to the AC were compared between eyes with and without TSCP.In rabbit eyes,changes in IOP and AC angle structures under ultrasound biomicroscopy(UBM)were evaluated at intervals of 30min,7d,and 14d after TSCP.Vitreous pathology was examined using scanning electron microscopy(SEM)immediately and 14d after TSCP.RESULTS:In porcine eyes(n=20),the median(range)permeability rates were 10.3(range 9.8–10.8)mm/min for the AVC and 4.3(range 3.9–4.9)mm/min for the AHM(P=0.009).Permeability rates in the circumlental space were 4.2(range 3.8–4.9)mm/min in areas without TSCP,6.2(range 5.7–6.8)mm/min in areas with non-burst TSCP,and 11.3(range 10.9–11.8)mm/min in areas with burst TSCP(P=0.002).The median(range)fluorescein diffusion time was 5(range 3–8)min in eyes undergoing TSCP,whereas it was 40min(range 35–68)in eyes without TSCP(P<0.001).In rabbit eyes(n=20),SEM showed immediate localized damage to the AHM,AVC,and posterior lens zonules in areas subjected to TSCP bursts,and obvious lens zonule loss with cellular infiltration and possible vitreous liquefaction by post-op day 14.Persistent widening of AC angles was noted at postoperative days 7 and 14,although a significant reduction in IOP was only observed at postoperative day 7.CONCLUSION:TSCP-induced damage on the zonules,AHM,and AVC potentially enhances fluid outflow from the vitreous,leading to a widened AC angle and vitreous liquefaction in rabbits.These observations offer insights into mechanisms of TSCP in lowering IOP and pathogenic roles of vitreous in ACG.
基金Supported by Iranian University of Medical Sciences(code:IR.IUMS.REC.1401.371).
文摘AIM:To identify topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten eyes of 294 patients with KCN were recruited for this study.First,complete ocular examinations were performed for all patients,including visual acuity measurement,refraction,and slit-lamp biomicroscopy.Then,all participants underwent corneal imaging by the Oculus Pentacam HR.RESULTS:The mean age of the participants was 32.40±8.52y(15-60y)and 69.5%of them were male.The mean ACA was 38.47°±5.75°(range:14.40°to 56.50°)in the whole sample,38.24°±6.00°in males,and 38.98°±5.11°in females(P=0.447).The mean ACA was significantly different among different groups of cone morphology,as patients with nipple cones showed the lowest mean ACA.Moreover,there were statistically significant differences in the mean ACA among different groups of cone locations,with patients having central cones exhibiting the lowest mean ACA(P<0.001).Anterior and posterior Q values were significantly,directly correlated with ACA(anterior Q:r=0.122,P=0.014,posterior Q:r=0.192,P<0.001).CONCLUSION:This study provides critical insights into the risk factors for ACA narrowing in KCN patients,which is essential for planning intraocular surgeries.Patients with nipple and central cones exhibited the most significant ACA narrowing.Additionally,more negative Q-values are associated with increased ACA narrowing,highlighting the need for targeted diagnostic and therapeutic strategies.
基金supported by the Chinese Scholarship Council under Grant 202106910006.
文摘Branch angles are an important plant morphological trait affecting light interception within forest canopies.However,studies on branch angles have been limited due to the time-consuming nature of manual measurements using a protractor.Terrestrial laser scanning(TLS),however,provides new opportunities to measure branch angles more efficiently.Despite this potential,studies validating branch angle measurements from TLS have been limited.Here,our aim is to evaluate both manual and automatic branch angle measurements of European beech from TLS data using traditional field-measurements with a protractor as a reference.We evaluated the accuracy of branch angle measurements based on four automated algorithms(aRchiQSM,TreeQSM,Laplacian,SemanticLaplacian)from TLS data.Additionally,we assessed different ways of manual branch angle measurements in the field.Our study was based on a dataset comprising 124 branch angles measured from six European beech in a European deciduous forest.Our results show that manual branch angle measurements from TLS data are in high agreement with the reference(root-mean-squared error,RMSE:[3.57°-4.18°],concordance correlation coefficient,CCC:[0.950.97])across different branch length positions.Automated algorithms also are in high agreement with the reference although RMSE is approximately twice as large compared to manual branch angle measurements from TLS(RMSE:[9.29°-10.55°],CCC:[0.830.86])with manual leaf points removal.When applying the automatic wood-leaf separation algorithm,the performance of the four methods declined significantly,with only approximately 20 branch angles successfully identified.Moreover,it is important to note that there is no influence of the measurement position(branch surface versus center)for branch angle measurements.However,for curved branches,the selection of branch measurement length significantly impacts the branch angle measurement.This study provides a comprehensive understanding of branch angle measurements in forests.We show that automated measurement methods based on TLS data of branch angles are a valuable tool to quantify branch angles at larger scales.
基金supported by grants from the Biological Breeding-National Science and Technology Major Project(2024ZD04077)the National Natural Science Foundation of China(31801323)+1 种基金the Innovation Program of the Chinese Academy of Agricultural Sciencesthe Science and Technology Innovation Project of the Shandong Academy of Agricultural Sciences(CXGC2023F14)。
文摘Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while PGM has been demonstrated to regulate starch biosynthesis within chloroplasts,which eventually leads to starch accumulation in amyloplasts.However,the molecular mechanisms of gravity sensing in monocot shoots remain largely unexplored.In this study,we investigated the roles of these genes in rice(Oryza sativa),a model monocot,using CRISPR-Cas9 to generate single,double,and higher-order mutants.The rice genome harbors two orthologs each of SHR and SGR and a single ortholog of PGM.Our results revealed that single mutants of OsPGM,but not OsSHR or OsSGR,showed compromised shoot gravitropism.However,double mutants shr1shr2 and sgr1sgr2 displayed wider tiller angles and reduced gravity sensing,suggesting functional redundancy within each gene pair.Higher-order mutants exhibited progressively severe phenotypes,with quintuple mutants almost unresponsive to gravity stimulation.These findings suggest that these genes act additively through distinct but converging pathways in shoot gravitropism regulation.This study provides novel insights into the molecular mechanisms underlying gravity sensing in monocots and offers valuable knowledge for precision breeding to optimize rice architecture.
基金Projects(51979268,52279117,52309146)supported by the National Natural Science Foundation of ChinaProject(SKLGME-JBGS2401)supported by the Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering,China。
文摘The spatial relationship between structural planes and principal stresses significantly affects the mechanical properties of deep hard rock.This paper examines the effect of the loading angle under true triaxial compression.While previous studies focused on the angleβbetween the maximum principal stress and the structural plane,the role of angleω,between the intermediate principal stress and the structural plane,is often overlooked.Utilizing artificially prefabricated granite specimens with a single non-penetrating structural plane,we set the loading angleβto range from 0°to 90°across seven groups,and assignedωvalues of 0°and 90°in two separate groups.The results show that the peak strength is negatively correlated withβup to 45°,beyond which it tends to stabilize.The angleωexerts a strengthening effect on the peak strength.Deformation mainly occurs post-peak,with the strain values ε_(1) and ε_(3) reaching levels 2−3 times higher than those in intact rock.The structural plane significantly influences failure mode whenω=0°,while failure localizes near the σ_(3) surface of the specimens whenω=90°.The findings enhance data on structural plane rocks under triaxial compression and inform theoretical research,excavation,and support design of rock structures.
基金supported by the National Natural Science Foundation of China(61903099)the Natural Science Foundation of Heilongjiang Province(LH2020F025)+2 种基金the Project of Science and Technology Research Program of Chongqing Education Commission of China(KJZD-K20200470)the Postdoctoral Science Foundation of China(2021M690812)the Postdoctoral Science Fund of Heilongjiang Province(LBH-Z21048).
文摘This paper presents a fixed-time cooperative gui-dance method with impact angle constraints for multiple flight vehicles (MFV) to address the challenges of intercepting large maneuvering targets with difficulty and low precision. A coopera-tive guidance model is proposed, transforming the cooperative interception problem into a consensus problem based on the remaining flight time of the flight vehicles. First, the impact angle constraint is converted into the line of sight (LOS) angle con-straint, and a new fixed-time convergent non-singular terminal sliding surface is introduced, which resolves the singularity issue of the traditional sliding surfaces. With this approach, LOS angle rate and normal overloads can converge in fixed time, ensuring that the upper bound of the system convergence time is not affected by the initial value of the system. Furthermore, the maneuvering movement of the target is considered as a system disturbance, and an extended state observer is employed to estimate and compensate for it in the guidance law. Lastly, by applying consensus theory and distributed communication topology, the remaining flight time of each flight vehicle is syn-chronized to ensure that they intercept the target simulta-neously with different impact angles. Simulation experiments are conducted to validate the effectiveness of the proposed cooper-ative interception and guidance method.
基金the Youth Innovation Promotion Association of Chinese Academy of Science(No.2021160)the National Natural Science Foundation of China(No.51802319)the Technology and Engineering Center for Space(No.CSU-QZKT-2019-04)。
文摘Ceramic cores fabricated by stereolithography exhibit great potential in casting turbine blades.Previous research on ceramic core molding was primarily conducted using vertical printing techniques,which not only resulted in lengthy molding durations but also compromised the mechanical strength.In this work,silica(SiO--_2)ceramic cores,with fine complex geometric shapes,were fabricated using 65vol.%ceramic slurry by digital light processing(DLP)with different printing angles.Printing angles significantly impact the surface accuracy,shrinkage,printing efficiency of green bodies,as well as the microstructure and mechanical properties of sintered ceramic core samples.As the printing angle in the green body increases,the bonding area decreases,surface roughness on the XY plane worsens,shrinkage in the Z direction becomes more pronounced,and the printing efficiency declines.Similarly,an increase in the printing angle in the sintered body leads to a reduction in bending strength.At a printing angle of 30°,the printing time is reduced to half of that at 90°,which improves the molding efficiency.Meanwhile,the obtained bulk density of 1.71 g·cm~(-3),open porosity of 24%,and fiexural strength of 10.6±1 MPa can meet the requirements of sintered ceramic cores.Therefore,designing and optimizing the printing angles can achieve the balance between shrinkage,printing efficiency,and fiexural strength.
基金supported by the Science and Technology Project of China Southern Power Grid Co.,Ltd under Grant 036000KC23090004(GDKJXM20231026).
文摘The integration of renewable energy sources(RESs)with inverter interfaces has fundamentally reshaped power system dynamics,challenging traditional stability analysis frameworks designed for synchronous generator-dominated grids.Conventional classifica-tions,which decouple voltage,frequency,and rotor angle stability,fail to address the emerging strong voltage‒angle coupling effects caused by RES dynamics.This coupling introduces complex oscillation modes and undermines system robustness,neces-sitating novel stability assessment tools.Recent studies focus on eigenvalue distributions and damping redistribution but lack quantitative criteria and interpretative clarity for coupled stability.This work proposes a transient energy-based framework to resolve these gaps.By decomposing transient energy into subsystem-dissipated components and coupling-induced energy exchange,the method establishes stability criteria compatible with a broad variety of inverter-interfaced devices while offering an intuitive energy-based interpretation for engineers.The coupling strength is also quantified by defining the relative coupling strength index,which is directly related to the transient energy interpretation of the coupled stability.Angle‒voltage coupling may induce instability by injecting transient energy into the system,even if the individual phase angle and voltage dynamics themselves are stable.The main contributions include a systematic stability evaluation framework and an energy decomposition approach that bridges theoretical analysis with practical applicability,addressing the urgent need for tools for managing modern power system evolving stability challenges.
文摘BACKGROUND Colorectal cancer(CRC)represents a major global public health issue,ranking as the third most common cancer worldwide.Given the substantial prevalence of CRC,there is a critical need to identify precise prognostic and predictive biomar-ker tools for better treatment outcomes.Phase angle(PA)has been proposed as a prognostic marker in various non-malignant and malignant clinical conditions.AIM To investigate the relationship between PA and survival outcomes in the first-line treatment of metastatic CRC(mCRC).METHODS In this prospective observational study,we obtained data on patients who started first-line systemic chemotherapy from the beginning of 2020 until the end of 2022.The PA,assessed by the bioelectrical impedance analysis scale,was evaluated as a possible prognostic factor for treatment outcomes,which were measured as pro-gression-free survival(PFS)and objective response rate(ORR).RESULTS Using the cut-point value for PA set at 4.60°,144 patients were divided into two cohorts.The high PA group of patients exhibited a significantly longer median PFS than the low PA group,14.8 vs 10.5 months,respectively.No difference in ORR was observed.However,patients with PA≥4.60°had a higher disease control rate.CONCLUSION PA represents a novel and objective pre-chemotherapy prognostic factor to identify mCRC patients who are at increased risk of a worse survival outcome.
文摘The marine propeller typically functions within thefilowfiield generated by a water vehicle.Investigations into the geometric parameters of the propeller are commonly conducted under open‑water conditions as simultaneously simulating both vehicle and propeller holds several computational challenges.While during operation,this propellant device must face several forces like gravity,hydrodynamic load,and centrifugal force,which cause different problems like cavitation and structural failure,etc.Since these issues affect performance,it necessitates comprehensive analysis.In this study,hydrodynamic analysis is performed by using commercial software STAR CCM+.In hydrodynamic analysis,the effect of the rake angles–5°,5°,10°and 15°on hydrodynamic coeffiicients and effiiciency of the DTMB 4119 in the open water is analyzed using Computational Fluid Dynamics(CFD)and the control volume approach.The Shear Stress Transport(SST)k‑ωturbulence model is used in Computational Fluid Dynamics(CFD)simulation.Hydrodynamic analysis reveals that the rake angles 5°and 10°cause the open water effiiciency of David Taylor Model Basin(DTMB)4119 to improve by 0.4 to 1.32%with exception of the rake angles–5°and 15°,which possess different effects on effiiciency.The angle–5°causes a decrease in propeller effiiciency under heavy loading situations(low advance coeffiicient)apart from a minorfiluctuation at light loading conditions(high advance coeffiicient),while the angle 15°produces a drop in effiiciency by higher advance ratios but little variation at lower advance ratios.
基金supported by the Biological Breeding-National Science and Technology Major Project(2023ZD04076)the National Key Research and Development Program of China(2023YFF1000100)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA0450000).
文摘Flag leaf angle(FLANG)is one of the key traits in wheat breeding due to its impact on plant architecture,light interception,and yield potential.An image-based method of measuring FLANG in wheat would reduce the labor and error of manual measurement of this trait.We describe a method for acquiring in-field FLANG images and a lightweight deep learning model named LeafPoseNet that incorporates a spatial attention mechanism for FLANG estimation.In a test dataset with wheat varieties exhibiting diverse FLANG,LeafPoseNet achieved high accuracy in predicting the FLANG,with a mean absolute error(MAE)of 1.75°,a root mean square error(RMSE)of 2.17°,and a coefficient of determination(R2)of 0.998,significantly outperforming established models such as YOLO12x-pose,YOLO11x-pose,HigherHRNet,Lightweight-OpenPose,and LitePose.We performed phenotyping and genome-wide association study to identify the genomic regions associated with FLANG in a panel of 221 diverse bread wheat genotypes,and identified 10 quantitative trait loci.Among them,qFLANG2B.2 was found to harbor a potential causal gene,TraesCS2B01G313700,which may regulate FLANG formation by modulating brassinosteroid levels.This method provides a low-cost,high-accuracy solution for in-field phenotyping of wheat FLANG,facilitating both wheat FLANG genetic studies and ideal plant type breeding.
基金Supported by National Key R&D Program of China(No.2023YFC2506100)the Changping Key Research Project of the Beijing Natural Science Foundation Program(No.L234016).
文摘AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorders.METHODS:In this cross-sectional study,aqueous humor samples of 22 eyes of POAG patients(POAG group),24 eyes of cataract patients without metabolic disorders(cataract group),and 24 eyes of cataract patients with metabolic disorders(cataract+metabolic disorders group)were assessed for 15 adipokines by Luminex bead-based multiplex array.The correlation between aqueous humor adipokines and clinical indicators of POAG was analyzed and compared across the groups.RESULTS:The analysis revealed that the levels of adiponectin,leptin,adipsin,retinol-binding protein 4(RBP4),angiopoietin-2,angiopoietin-like protein 4(ANGPTL4),chemokine(C-C motif)ligand 2(CCL2),interleukin-8(IL-8),and interleukin-18(IL-18)in the aqueous humor of the POAG group were significantly higher than those in the cataract group.Additionally,the level of angiopoietin-2 in the POAG group was higher than in the cataract+metabolic disorders group.However,no significant correlation was found between the levels of adipokines in the POAG group and intraocular pressure(IOP),severity of POAG,or the use of glaucoma medications.CONCLUSION:This study demonstrates significant differences in aqueous humor adipokine levels between POAG and cataract patients.The findings suggest that the levels of aqueous humor adipokines may reflect the inflammatory states in POAG and systemic metabolic abnormalities.
基金co-supported by the National Natural Science Foundation of China(Nos.52472394,52425211,52201327,52272360)。
文摘Stall flutter poses great challenges to flight safety.To alleviate this problem,a steady blowing control considering the perturbation and wake-induced vibration at a large angle of attack is developed in this paper,where two blowings are configured on upper and lower tail surfaces to suppress the stall flutter.The stall flutter with one-degree-of-freedom is first evaluated by numerical simulation.The equation of motion for stall flutter is solved by the Newmark-β method.Then,the stall flutter responses for five blowing speeds,i.e.,0,4,12,20,and 28 m/s under the airspeed range of 3–9 m/s,are studied in detail.The stall flutter suppression mechanism can be summarized as follows:a large blowing speed can inject energy into the boundary layer and enhance the high-pressure zone,which delays the flow separation on the suction surface.In this way,the formation of the leading-edge separation vortex is suppressed.Thus,the dynamic stall vortex is weakened and accelerates shedding.In addition,the driving moment is reduced,which leads to a decrement in the stall flutter amplitude.When the blowing speed is 28 m/s(stall flutter amplitude=0.1357 rad),compared with uncontrolled case(stall flutter amplitude=0.6002 rad),the amplitude can decrease by 77.39%,which demonstrates the effectiveness of the proposed steady blowing based active control strategy.
基金supported in part by the National Defense Basic Scientific Research Program of China(No.JCKY2021603B030)the Shenzhen Fundamental Research Program,China(No.JCYJ20220818102601004)the Science Center Program of National Natural Science Foundation of China(No.62188101)。
文摘Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametric bank angle profiles in Mars atmospheric entry missions.The methodology includes a universal approach to handling path constraints and a reliable solution method based on the Particle Swarm Optimization(PSO)algorithm.For illustrative purposes,a mission with the objective of maximizing terminal altitude is considered.The original entry optimization problem is converted into optimizing three coefficients for the bank angle profiles with terminal constraints by formulating a parametric Mars entry bank angle profile and constraint handling methods.The parameter optimization problem is addressed using the PSO algorithm,with reliability enhanced by increasing the PSO swarm size.To improve computational efficiency,an enhanced Deep Operator Network(Deep ONet)is used as a dynamics solver to predict terminal states under various bank angle profiles rapidly.Numerical simulations demonstrate that the proposed methodology ensures reliable convergence with a sufficiently large PSO swarm while maintaining high computational efficiency facilitated by the neural-network-based dynamics solver.Compared to the existing methodologies,this methodology offers a streamlined process,the reduced sensitivity to initial guesses,and the improved computational efficiency.
文摘AIM:To measure abducens nerve palsy patients’visual angle using real time video-based gaze tracking system.METHODS:This research was a cross-sectional study.The subjects were taken by convenience sampling technique in the Neuro-ophthalmology department at Sardjito General Hospital Yogyakarta,Indonesia,and had met the inclusion and exclusion criteria.The visual angle measurements were performed using an eye tracker with a computer webcam(GENICULA system/Gaze Tracking Artificial Intelligence for Ocular Motor Palsy).The analytical method used was the Mann-Whitney test to compare the visual angle between the abducens nerve palsy group and the healthy eye group.The Wilcoxon test was used to see the significance of differences in visual angle improvement in abducens nerve palsy patients.RESULTS:A total of 39 subjects participated,with a mean age of 46.54±15.67y;17 were male and 22 were female.The visual angle was 20.88±3.76 in the abducens nerve palsy group(n=39 eyes)and 23.10±2.91 in the normal group(n=39 eyes,P=0.011).The visual angle improvement of abducens nerve palsy before and after cured was statistically significant(P=0.039).CONCLUSION:The real time video-based gaze tracking system is easy to use,efficient,and accurate.A slight decrease in visual angle measurement can be detected using this GENICULA system and therefore it is important for diagnosis slight deviation in abducens nerve palsy.
基金supported by the National Natural Science Foundation of China(Grant Nos.52174096 and 52304110).
文摘With the rapid development of deep resource extraction and underground space construction,the design of anchored support systems for jointed rock masses in complex stress environments faces significant challenges.This study investigates the influence of prefabricated crack dip angles on the mechanical properties of anchored rock masses in deep soft rock roadways.By constructing similarity models of NPR(Negative Poisson’s Ratio)and PR(Positive Poisson’s Ratio)anchored solids,biaxial compression experiments under varying crack dip angles were conducted.Strain gauges,3D Digital Image Correlation(3D DIC),and acoustic emission monitoring were employed to systematically analyze the strength characteristics,deformation-damage evolution,and energy dissipation mechanisms of the two types of anchor systems.The results show that:(1)The stress-strain curves of anchored solids with prefabricated cracks exhibit a distinct bimodal characteristic.Compared to PR anchors,NPR anchors show 20%and 23%improvements in peak strength and elastic modulus,respectively,with residual strength enhanced by up to 34%.(2)Owing to high pre-tightening force and large deformation capacity,NPR anchors maintain superior integrity under increasing crack dip angles,demonstrating more uniform free-surface displacement and localized shear-tensile composite crack patterns.(3)Acoustic emission analysis reveals that NPR anchors exhibit higher cumulative energy absorption(300%improvement over PR anchors)and lack low-rate energy development phases,indicating enhanced ductility and impact resistance at high crack dip angles.(4)Crack dip angle critically governs failure mechanisms by modulating the connectivity between shear cracks and prefabricated fissures:bimodal effects dominate at low angles,while vertical tensile crack propagation replaces bimodal behavior at high angles.The study proposes prioritizing NPR anchor cables in deep engineering applications and optimizing support parameters based on crack dip angles to mitigate stress concentration and ensure the long-term stability of surrounding rock.
基金supported by the National Natural Science Foundation of China(Nos.12172315,12072304,11702232)the Fujian Provincial Natural Science Foundation,China(No.2021J01050)the Aeronautical Science Foundation of China(No.20220013068002).
文摘Unsteady aerodynamic characteristics at high angles of attack are of great importance to the design and development of advanced fighter aircraft, which are characterized by post-stall maneuverability with multiple Degrees-of-Freedom(multi-DOF) and complex flow field structure.In this paper, a special kind of cable-driven parallel mechanism is firstly utilized as a new suspension method to conduct unsteady dynamic wind tunnel tests at high angles of attack, thereby providing experimental aerodynamic data. These tests include a wide range of multi-DOF coupled oscillatory motions with various amplitudes and frequencies. Then, for aerodynamic modeling and analysis, a novel data-driven Feature-Level Attention Recurrent neural network(FLAR) is proposed. This model incorporates a specially designed feature-level attention module that focuses on the state variables affecting the aerodynamic coefficients, thereby enhancing the physical interpretability of the aerodynamic model. Subsequently, spin maneuver simulations, using a mathematical model as the baseline, are conducted to validate the effectiveness of the FLAR. Finally, the results on wind tunnel data reveal that the FLAR accurately predicts aerodynamic coefficients, and observations through the visualization of attention scores identify the key state variables that affect the aerodynamic coefficients. It is concluded that the proposed FLAR enhances the interpretability of the aerodynamic model while achieving good prediction accuracy and generalization capability for multi-DOF coupling motion at high angles of attack.
