Segmentation of intracranial aneurysm images acquired using magnetic resonance angiography(MRA)is essential for medical auxiliary treatments,which can effectively prevent subarachnoid hemorrhages.This paper proposes a...Segmentation of intracranial aneurysm images acquired using magnetic resonance angiography(MRA)is essential for medical auxiliary treatments,which can effectively prevent subarachnoid hemorrhages.This paper proposes an image segmentation model based on a dense convolutional attention U-Net,which fuses deep and rich semantic information with shallow-detail information for adaptive and accurate segmentation of MRA-acquired aneurysm images with large size differences.The U-Net model serves as a backbone,combining dense block and convolution block attention module(CBAM).The dense block is composed of a batch normalization layer,an randomly rectified linear unit activation function,and a convolutional layer,for mitigation of vanishing gradients,for multiplexing of aneurysm features,and for improving the network training efficiency.The CBAM is composed of a channel attention module and a spatial attention module,improving the segmentation performance of feature discrimination and enhancing the acquisition of key feature information.Owing to the large variation of aneurysm sizes,multi-scale fusion is performed during up-sampling,for adaptive segmentation of MRA-acquired aneurysm images.The model was tested on the MICCAI 2020 ADAM dataset,and its generalizability was validated on the clinical aneurysm dataset(aneurysm sizes:<3 mm,3–7 mm,and>7 mm)supplied by the Affiliated Hospital of Qingdao University.A good clinical application segmentation performance was demonstrated.展开更多
Objective:The study aimed to discuss the treatment of acute thromboembolic event(TE)during endovascular embolization of intracranial aneurysms.Methods:Between April 2013 and April 2019,158 patients with 167 intracrani...Objective:The study aimed to discuss the treatment of acute thromboembolic event(TE)during endovascular embolization of intracranial aneurysms.Methods:Between April 2013 and April 2019,158 patients with 167 intracranial aneurysms were treated with endovascular embolization in our hospital,in which 9 cases of acute TEs occurred during the embolization procedures.The clinical data,radiological findings and treatments of the 9 patients were reviewed and analyzed.Results:The TEs occurred at the aneurysmal neck in 3 patients,at distal part of the parent artery in 3,in the stent in 2,and at the proximal part of the parent artery in 1.Intra-arterial(IA)infusion of tirofiban were performed in 6 patients,mechanical thromboectomy(MT)with a stent in 2 patients,and combined use of the two methods in 1 patients.According to the modified Thrombolysis In Cerebral Infarction(mTICI)score,7 patients had recanalization of 2b/3a,1 patients had recanalization of 1,and 1 patients had recanalization of 0.At discharge,the mRS score was 0 in 3 patients,1 in 3 patients,and 2,3,4 in 1 patient each.6 months after the endovascular treatment,the mRS score was 0 in 5 patients,1 in 2 patients,and 3 in 1 patient.Conclusions:IA tirofiban and MT are effective remedies for the acute TE during endovascular embolization of intracranial aneurysm,reasonable selection of which may improve the prognosis of patients.展开更多
Segmental arterial mediolysis(SAM) is characterized by intra-abdominal, retroperitoneal bleeding or bowel ischemia, and the etiology is unknown. A 44-year-old man complaining of abdominal pain was admitted to our hosp...Segmental arterial mediolysis(SAM) is characterized by intra-abdominal, retroperitoneal bleeding or bowel ischemia, and the etiology is unknown. A 44-year-old man complaining of abdominal pain was admitted to our hospital. He had been admitted for a left renal infarction three days earlier and had a past medical history of cerebral aneurysm with spontaneous remission. The ruptured site of the splenic arterial aneurysm was clear via a celiac angiography, and we treated it using trans-arterial embolization. Unfortunately, the aneurysm reruptured after two weeks, and we successfully treated it with distal pancreatomy and splenectomy. We recommended a close follow-up and prompt radiological or surgical intervention because SAM can enlarge rapidly and rupture.展开更多
Background:To evaluate the efficacy of stent-assisted coiling(SAC)for the treatment of carotid ophthalmic segment aneurysm segment aneurysms(OSAs)of the internal carotid artery(ICA)through detailed long-term follow-up...Background:To evaluate the efficacy of stent-assisted coiling(SAC)for the treatment of carotid ophthalmic segment aneurysm segment aneurysms(OSAs)of the internal carotid artery(ICA)through detailed long-term follow-up of a large patient cohort.Methods:We retrospectively analyzed 88 consecutive patients with OSAs between January 2009 and January 2020 at our center.Angiographic results were evaluated using the modified Raymond grading system and clinical outcomes were evaluated using the mRS scale.The primary endpoints were major aneurysm recurrence and poor clinical outcomes for at least 18 months of follow-up.The patients were asked to attend clinical follow-up assessments and possibly undergo DSA or MR via telephone.Results:We enrolled 88 patients with 99 OSAs treated with coiling,of whom 76 were treated with SAC.The coiling procedures were successful in all 88 patients.Overall,complications occurred in 8 patients(9.1%).No procedure-related mortality was observed.67(76.1%)experienced immediate aneurysm occlusion at the end of the procedure.Long-term angiographic follow-up(18 months)was available in 45/88 aneurysms(51%)(average 18.7±5.2 months).Four patients continued their follow-up for 5 years after initial aneurysm treatment.After a clinical follow-up time of 28.7 months(range,12-51 months),85 patients(95.5%)achieved favorable clinical outcomes(mRS scores of 0-2).Conclusions:This study indicates that SAC treatment is a safe and effective therapeutic alternative for ruptured and unruptured OSAs.The procedural risks are low with relatively long-term effectiveness.展开更多
With the development of radiography,especially digital subtraction cerebrovascular angiography,which is widely used in clinical practice,interventional embolization of intracranial aneurysms has become more and more p...With the development of radiography,especially digital subtraction cerebrovascular angiography,which is widely used in clinical practice,interventional embolization of intracranial aneurysms has become more and more popular due to its advantages of minimal invasiveness,high efficiency,and rapid postoperative recovery.The choice of patients,often we have to formulate an unconventional and individualized treatment plan based on the specific conditions of each patient’s blood vessel.This case is a segment A1 aneurysm of the right anterior cerebral artery.Due to its special location and wide diameter,in order to reduce the difficulty and risk of the operation during the operation,a bilateral internal carotid artery approach was developed to complete the stent-assisted procedure and special treatment plan for aneurysm embolization.展开更多
Gastric artery aneurysm is a rare and lethal condition,and is caused by inflammatory or degenerative vasculopathies.We describe herein the clinical course of a patient with a ruptured gastric artery aneurysm associate...Gastric artery aneurysm is a rare and lethal condition,and is caused by inflammatory or degenerative vasculopathies.We describe herein the clinical course of a patient with a ruptured gastric artery aneurysm associated with microscopic polyangiitis.Absence of vasculitic changes in the aneurysm resected and negative results of autoantibodies interfered with our diagnostic process.We should have adopted an interventional radiology and initiated steroid therapy promptly to rescue the patient.展开更多
Segmental arterial mediolysis (SAM) is an uncommon non-inflammatory iatrogenic arteriopathy caused by alpha-1 adrenergic agonists or Beta-2 agonists able to release norepinephrine from the peripheral nervous system. C...Segmental arterial mediolysis (SAM) is an uncommon non-inflammatory iatrogenic arteriopathy caused by alpha-1 adrenergic agonists or Beta-2 agonists able to release norepinephrine from the peripheral nervous system. Causative agents include adrenergic agonists used to control blood pressure, B-2 tocolytic agonists, and ractopamine used as a repartitioning agent in animal husbandry. The liberated norepinephrine both injures and stimulates a robust reparative response in the muscular arteries in the abdomen, brain base, and coronary arteries. This response may be augmented by endothelin-1 formed in the arterial adventitia. Three types of arterial lesions develop in the injurious stage: 1) apoptotic induced mediolysis, 2) separation of the outer media from the adventitia and 3) the formation of arterial gaps. The latter enlarge, particularly in elderly patients, to form gap-aneurysms complicated by dissections and dissecting an- eurysms that when ruptured cause the calamitous hemorrhages that clinically announce SAM. The other types of injury remain clinically silent but with repair develop sequelae and can metamorphose into fibromuscular dysplasia. The sequelae are mainly asymptomatic but may cause arterial stenosis and ischemic lesions. The definitive diagnosis of SAM re- quires histological conformation but misinterpreta- tion of smooth muscle vacuolar change has caused di- agnostic errors. Muscular artery cystic necrosis a newly named non-inflammatory muscular artery ar- teriopathy may be confused with SAM both clinically and pathologically. This arteriopathy represents the muscular artery equivalent of cystic media necrosis of the elastic arteries since it exhibits similar morphol- ogic features and can occur concomitantly with this entity. Adrenergic agents to counter hemorrhagic shock in SAM are contraindicated since they may intensify injury and create new lesions. The use of norepinehrine antagonists introduces a new, but as yet untested, treatment option for SAM.展开更多
Segmentation of intracranial aneurysm(IA)from computed tomography angiography(CTA)images is of significant importance for quantitative assessment of IA and further surgical treatment.Manual segmentation of IA is a lab...Segmentation of intracranial aneurysm(IA)from computed tomography angiography(CTA)images is of significant importance for quantitative assessment of IA and further surgical treatment.Manual segmentation of IA is a labor-intensive,time-consuming job and suffers from inter-and intra-observer variabilities.Training deep neural networks usually requires a large amount of labeled data,while annotating data is very time-consuming for the IA segmentation task.This paper presents a novel weight-perceptual self-ensembling model for semi-supervised IA segmentation,which employs unlabeled data by encouraging the predictions of given perturbed input samples to be consistent.Considering that the quality of consistency targets is not comparable to each other,we introduce a novel sample weight perception module to quantify the quality of different consistency targets.Our proposed module can be used to evaluate the contributions of unlabeled samples during training to force the network to focus on those well-predicted samples.We have conducted both horizontal and vertical comparisons on the clinical intracranial aneurysm CTA image dataset.Experimental results show that our proposed method can improve at least 3%Dice coefficient over the fully-supervised baseline,and at least 1.7%over other state-of-the-art semi-supervised methods.展开更多
To the Editor:Currently,most research on the relationships between lipids,immune cells,and intracranial aneurysms(IAs),including unruptured intracranial aneurysms(uIAs)and aneurysmal subarachnoid hemorrhage(aSAH),orig...To the Editor:Currently,most research on the relationships between lipids,immune cells,and intracranial aneurysms(IAs),including unruptured intracranial aneurysms(uIAs)and aneurysmal subarachnoid hemorrhage(aSAH),originates from observational studies.[1]There are inevitable confounding factors in the research design,thus the research conclusions cannot reveal the causal relationship between lipids,immune cells,and IAs.More importantly,it remains unclear whether immune responses mediate the relationship between lipids and IAs.Thus,we performed a Mendelian randomization(MR)analysis,a method that can avoid the interference of confounding factors and determine the correct causal relationships.[2]The purposes of this study are:(1)to determine the causal relationships between gene-mediated serum lipids and IAs;(2)to identify the causal relationships between immune cells and IAs;and(3)to investigate whether immune cells mediate the relationships between lipids and IAs.展开更多
The exact shape of intracranial aneurysms is critical in medical diagnosis and surgical planning.While voxel-based deep learning frameworks have been proposed for this segmentation task,their performance remains limit...The exact shape of intracranial aneurysms is critical in medical diagnosis and surgical planning.While voxel-based deep learning frameworks have been proposed for this segmentation task,their performance remains limited.In this study,we offer a two-step surface-based deep learning pipeline that achieves significantly better results.Our proposed model takes a surface model of an entire set of principal brain arteries containing aneurysms as input and returns aneurysm surfaces as output.A user first generates a surface model by manually specifying multiple thresholds for time-of-flight magnetic resonance angiography images.The system then samples small surface fragments from the entire set of brain arteries and classifies the surface fragments according to whether aneurysms are present using a point-based deep learning network(PointNet++).Finally,the system applies surface segmentation(SO-Net)to surface fragments containing aneurysms.We conduct a direct comparison of the segmentation performance of our proposed surface-based framework and an existing voxel-based method by counting voxels:our framework achieves a much higher Dice similarity(72%)than the prior approach(46%).展开更多
Dear Editor,We extend our academic appreciation to the contributors of this pioneering study,1 which leverages Mendelian Randomization(MR)to investigate the causal relationship between immune cell phenotypes and intra...Dear Editor,We extend our academic appreciation to the contributors of this pioneering study,1 which leverages Mendelian Randomization(MR)to investigate the causal relationship between immune cell phenotypes and intracranial aneurysms(IAs),demonstrating a certain level of innovation.By extracting 731 immunophenotypes from publicly available genetic databases and conducting large-scale analyses,the study comprehensively evaluates the impact of immune cell traits on IAs.Moreover,multivariable MR analysis was employed to adjust for interactions between different immune phenotypes,providing a novel perspective on the interplay between the immune system and IAs.展开更多
Transfer RNA-derived small RNAs,a recently identified class of small noncoding RNAs,play a crucial role in regulating gene expression and are implicated in cerebrovascular diseases.However,the specific biological role...Transfer RNA-derived small RNAs,a recently identified class of small noncoding RNAs,play a crucial role in regulating gene expression and are implicated in cerebrovascular diseases.However,the specific biological roles and mechanisms of transfer RNA-derived small RNAs in intracranial aneurysms(IAs)remain unclear.In this study,we identified that the transfer RNA-Asp-GTC derived fragment(tRF-AspGTC)is highly expressed in the IA tissues of both humans and mice.tRF-AspGTC promotes IA formation by facilitating the phenotypic switching of vascular smooth muscle cells,increasing of matrix metalloproteinase 9 expression,and inducing of oxidative stress and inflammatory responses.Mechanistically,tRF-AspGTC binds to galectin-3,inhibiting tripartite motif 29-mediated ubiquitination and stabilizing galectin-3.This stabilization activates the toll-like receptor 4/MyD88/nuclear factor kappa B pathway,further driving phenotypic switching and inflammation.Clinically,circulating exosomal tRF-AspGTC demonstrates strong diagnostic efficacy for IAs and is identified as an independent risk factor for IA occurrence.These findings highlight the potential of tRF-AspGTC as a promising diagnostic biomarker and therapeutic target for IAs.展开更多
基金This study was funded by the National Natural Science Foundation of China,No.61976126the Shandong Nature Science Foundation of China,No.ZR2019MF003.
文摘Segmentation of intracranial aneurysm images acquired using magnetic resonance angiography(MRA)is essential for medical auxiliary treatments,which can effectively prevent subarachnoid hemorrhages.This paper proposes an image segmentation model based on a dense convolutional attention U-Net,which fuses deep and rich semantic information with shallow-detail information for adaptive and accurate segmentation of MRA-acquired aneurysm images with large size differences.The U-Net model serves as a backbone,combining dense block and convolution block attention module(CBAM).The dense block is composed of a batch normalization layer,an randomly rectified linear unit activation function,and a convolutional layer,for mitigation of vanishing gradients,for multiplexing of aneurysm features,and for improving the network training efficiency.The CBAM is composed of a channel attention module and a spatial attention module,improving the segmentation performance of feature discrimination and enhancing the acquisition of key feature information.Owing to the large variation of aneurysm sizes,multi-scale fusion is performed during up-sampling,for adaptive segmentation of MRA-acquired aneurysm images.The model was tested on the MICCAI 2020 ADAM dataset,and its generalizability was validated on the clinical aneurysm dataset(aneurysm sizes:<3 mm,3–7 mm,and>7 mm)supplied by the Affiliated Hospital of Qingdao University.A good clinical application segmentation performance was demonstrated.
文摘Objective:The study aimed to discuss the treatment of acute thromboembolic event(TE)during endovascular embolization of intracranial aneurysms.Methods:Between April 2013 and April 2019,158 patients with 167 intracranial aneurysms were treated with endovascular embolization in our hospital,in which 9 cases of acute TEs occurred during the embolization procedures.The clinical data,radiological findings and treatments of the 9 patients were reviewed and analyzed.Results:The TEs occurred at the aneurysmal neck in 3 patients,at distal part of the parent artery in 3,in the stent in 2,and at the proximal part of the parent artery in 1.Intra-arterial(IA)infusion of tirofiban were performed in 6 patients,mechanical thromboectomy(MT)with a stent in 2 patients,and combined use of the two methods in 1 patients.According to the modified Thrombolysis In Cerebral Infarction(mTICI)score,7 patients had recanalization of 2b/3a,1 patients had recanalization of 1,and 1 patients had recanalization of 0.At discharge,the mRS score was 0 in 3 patients,1 in 3 patients,and 2,3,4 in 1 patient each.6 months after the endovascular treatment,the mRS score was 0 in 5 patients,1 in 2 patients,and 3 in 1 patient.Conclusions:IA tirofiban and MT are effective remedies for the acute TE during endovascular embolization of intracranial aneurysm,reasonable selection of which may improve the prognosis of patients.
基金Supported by The Department of Surgery,Kishiwada Tokushukai Hospital,Osaka,Japan
文摘Segmental arterial mediolysis(SAM) is characterized by intra-abdominal, retroperitoneal bleeding or bowel ischemia, and the etiology is unknown. A 44-year-old man complaining of abdominal pain was admitted to our hospital. He had been admitted for a left renal infarction three days earlier and had a past medical history of cerebral aneurysm with spontaneous remission. The ruptured site of the splenic arterial aneurysm was clear via a celiac angiography, and we treated it using trans-arterial embolization. Unfortunately, the aneurysm reruptured after two weeks, and we successfully treated it with distal pancreatomy and splenectomy. We recommended a close follow-up and prompt radiological or surgical intervention because SAM can enlarge rapidly and rupture.
基金supported by grants from the National Natural Science Foundation of China,grant no. 81370041, 81771233, 81671655the Outstanding Clinical Discipline Project of Shanghai Pudonggrant no.PWYgy2018-04.
文摘Background:To evaluate the efficacy of stent-assisted coiling(SAC)for the treatment of carotid ophthalmic segment aneurysm segment aneurysms(OSAs)of the internal carotid artery(ICA)through detailed long-term follow-up of a large patient cohort.Methods:We retrospectively analyzed 88 consecutive patients with OSAs between January 2009 and January 2020 at our center.Angiographic results were evaluated using the modified Raymond grading system and clinical outcomes were evaluated using the mRS scale.The primary endpoints were major aneurysm recurrence and poor clinical outcomes for at least 18 months of follow-up.The patients were asked to attend clinical follow-up assessments and possibly undergo DSA or MR via telephone.Results:We enrolled 88 patients with 99 OSAs treated with coiling,of whom 76 were treated with SAC.The coiling procedures were successful in all 88 patients.Overall,complications occurred in 8 patients(9.1%).No procedure-related mortality was observed.67(76.1%)experienced immediate aneurysm occlusion at the end of the procedure.Long-term angiographic follow-up(18 months)was available in 45/88 aneurysms(51%)(average 18.7±5.2 months).Four patients continued their follow-up for 5 years after initial aneurysm treatment.After a clinical follow-up time of 28.7 months(range,12-51 months),85 patients(95.5%)achieved favorable clinical outcomes(mRS scores of 0-2).Conclusions:This study indicates that SAC treatment is a safe and effective therapeutic alternative for ruptured and unruptured OSAs.The procedural risks are low with relatively long-term effectiveness.
文摘With the development of radiography,especially digital subtraction cerebrovascular angiography,which is widely used in clinical practice,interventional embolization of intracranial aneurysms has become more and more popular due to its advantages of minimal invasiveness,high efficiency,and rapid postoperative recovery.The choice of patients,often we have to formulate an unconventional and individualized treatment plan based on the specific conditions of each patient’s blood vessel.This case is a segment A1 aneurysm of the right anterior cerebral artery.Due to its special location and wide diameter,in order to reduce the difficulty and risk of the operation during the operation,a bilateral internal carotid artery approach was developed to complete the stent-assisted procedure and special treatment plan for aneurysm embolization.
文摘Gastric artery aneurysm is a rare and lethal condition,and is caused by inflammatory or degenerative vasculopathies.We describe herein the clinical course of a patient with a ruptured gastric artery aneurysm associated with microscopic polyangiitis.Absence of vasculitic changes in the aneurysm resected and negative results of autoantibodies interfered with our diagnostic process.We should have adopted an interventional radiology and initiated steroid therapy promptly to rescue the patient.
文摘Segmental arterial mediolysis (SAM) is an uncommon non-inflammatory iatrogenic arteriopathy caused by alpha-1 adrenergic agonists or Beta-2 agonists able to release norepinephrine from the peripheral nervous system. Causative agents include adrenergic agonists used to control blood pressure, B-2 tocolytic agonists, and ractopamine used as a repartitioning agent in animal husbandry. The liberated norepinephrine both injures and stimulates a robust reparative response in the muscular arteries in the abdomen, brain base, and coronary arteries. This response may be augmented by endothelin-1 formed in the arterial adventitia. Three types of arterial lesions develop in the injurious stage: 1) apoptotic induced mediolysis, 2) separation of the outer media from the adventitia and 3) the formation of arterial gaps. The latter enlarge, particularly in elderly patients, to form gap-aneurysms complicated by dissections and dissecting an- eurysms that when ruptured cause the calamitous hemorrhages that clinically announce SAM. The other types of injury remain clinically silent but with repair develop sequelae and can metamorphose into fibromuscular dysplasia. The sequelae are mainly asymptomatic but may cause arterial stenosis and ischemic lesions. The definitive diagnosis of SAM re- quires histological conformation but misinterpreta- tion of smooth muscle vacuolar change has caused di- agnostic errors. Muscular artery cystic necrosis a newly named non-inflammatory muscular artery ar- teriopathy may be confused with SAM both clinically and pathologically. This arteriopathy represents the muscular artery equivalent of cystic media necrosis of the elastic arteries since it exhibits similar morphol- ogic features and can occur concomitantly with this entity. Adrenergic agents to counter hemorrhagic shock in SAM are contraindicated since they may intensify injury and create new lesions. The use of norepinehrine antagonists introduces a new, but as yet untested, treatment option for SAM.
基金supported by Shenzhen Fundamental Research Program of China under Grant Nos.JCYJ20200109110420626 and JCYJ20200109110208764the National Natural Science Foundation of China under Grant Nos.U1813204 and 61802385+1 种基金the Natural Science Foundation of Guangdong of China under Grant No.2021A1515012604the Clinical Research Project of Shenzhen Municiple Health Commission under Grant No.SZLY2017011.
文摘Segmentation of intracranial aneurysm(IA)from computed tomography angiography(CTA)images is of significant importance for quantitative assessment of IA and further surgical treatment.Manual segmentation of IA is a labor-intensive,time-consuming job and suffers from inter-and intra-observer variabilities.Training deep neural networks usually requires a large amount of labeled data,while annotating data is very time-consuming for the IA segmentation task.This paper presents a novel weight-perceptual self-ensembling model for semi-supervised IA segmentation,which employs unlabeled data by encouraging the predictions of given perturbed input samples to be consistent.Considering that the quality of consistency targets is not comparable to each other,we introduce a novel sample weight perception module to quantify the quality of different consistency targets.Our proposed module can be used to evaluate the contributions of unlabeled samples during training to force the network to focus on those well-predicted samples.We have conducted both horizontal and vertical comparisons on the clinical intracranial aneurysm CTA image dataset.Experimental results show that our proposed method can improve at least 3%Dice coefficient over the fully-supervised baseline,and at least 1.7%over other state-of-the-art semi-supervised methods.
文摘To the Editor:Currently,most research on the relationships between lipids,immune cells,and intracranial aneurysms(IAs),including unruptured intracranial aneurysms(uIAs)and aneurysmal subarachnoid hemorrhage(aSAH),originates from observational studies.[1]There are inevitable confounding factors in the research design,thus the research conclusions cannot reveal the causal relationship between lipids,immune cells,and IAs.More importantly,it remains unclear whether immune responses mediate the relationship between lipids and IAs.Thus,we performed a Mendelian randomization(MR)analysis,a method that can avoid the interference of confounding factors and determine the correct causal relationships.[2]The purposes of this study are:(1)to determine the causal relationships between gene-mediated serum lipids and IAs;(2)to identify the causal relationships between immune cells and IAs;and(3)to investigate whether immune cells mediate the relationships between lipids and IAs.
基金This research was supported by AMED under Grant No.JP18he1602001.
文摘The exact shape of intracranial aneurysms is critical in medical diagnosis and surgical planning.While voxel-based deep learning frameworks have been proposed for this segmentation task,their performance remains limited.In this study,we offer a two-step surface-based deep learning pipeline that achieves significantly better results.Our proposed model takes a surface model of an entire set of principal brain arteries containing aneurysms as input and returns aneurysm surfaces as output.A user first generates a surface model by manually specifying multiple thresholds for time-of-flight magnetic resonance angiography images.The system then samples small surface fragments from the entire set of brain arteries and classifies the surface fragments according to whether aneurysms are present using a point-based deep learning network(PointNet++).Finally,the system applies surface segmentation(SO-Net)to surface fragments containing aneurysms.We conduct a direct comparison of the segmentation performance of our proposed surface-based framework and an existing voxel-based method by counting voxels:our framework achieves a much higher Dice similarity(72%)than the prior approach(46%).
文摘Dear Editor,We extend our academic appreciation to the contributors of this pioneering study,1 which leverages Mendelian Randomization(MR)to investigate the causal relationship between immune cell phenotypes and intracranial aneurysms(IAs),demonstrating a certain level of innovation.By extracting 731 immunophenotypes from publicly available genetic databases and conducting large-scale analyses,the study comprehensively evaluates the impact of immune cell traits on IAs.Moreover,multivariable MR analysis was employed to adjust for interactions between different immune phenotypes,providing a novel perspective on the interplay between the immune system and IAs.
基金supported by the National Natural Science Foundation of China(Nos.82370425 and 81870914)the Taishan Scholar Program of Shandong Province(No.tsqn202408156).
文摘Transfer RNA-derived small RNAs,a recently identified class of small noncoding RNAs,play a crucial role in regulating gene expression and are implicated in cerebrovascular diseases.However,the specific biological roles and mechanisms of transfer RNA-derived small RNAs in intracranial aneurysms(IAs)remain unclear.In this study,we identified that the transfer RNA-Asp-GTC derived fragment(tRF-AspGTC)is highly expressed in the IA tissues of both humans and mice.tRF-AspGTC promotes IA formation by facilitating the phenotypic switching of vascular smooth muscle cells,increasing of matrix metalloproteinase 9 expression,and inducing of oxidative stress and inflammatory responses.Mechanistically,tRF-AspGTC binds to galectin-3,inhibiting tripartite motif 29-mediated ubiquitination and stabilizing galectin-3.This stabilization activates the toll-like receptor 4/MyD88/nuclear factor kappa B pathway,further driving phenotypic switching and inflammation.Clinically,circulating exosomal tRF-AspGTC demonstrates strong diagnostic efficacy for IAs and is identified as an independent risk factor for IA occurrence.These findings highlight the potential of tRF-AspGTC as a promising diagnostic biomarker and therapeutic target for IAs.
