Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊...Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。展开更多
The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three ...The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.展开更多
Artificial intelligence(AI)is revolutionizing traditional drug discovery and development models by seamlessly integrating data,computational power,and algorithms.This synergy enhances the efficiency,accuracy,and succe...Artificial intelligence(AI)is revolutionizing traditional drug discovery and development models by seamlessly integrating data,computational power,and algorithms.This synergy enhances the efficiency,accuracy,and success rates of drug research,shortens development timelines,and reduces costs.Coupled with machine learning(ML)and deep learning(DL),AI has demonstrated significant advancements across various domains,including drug characterization,target discovery and validation,small molecule drug design,and the acceleration of clinical trials.Through molecular generation techniques,AI facilitates the creation of novel drug molecules,predicting their properties and activities,while virtual screening(VS)optimizes drug candidates.Additionally,AI enhances clinical trial efficiency by predicting outcomes,designing trials,and enabling drug repositioning.However,AI's application in drug development faces challenges,including the need for robust data-sharing mechanisms and the establishment of more comprehensive intellectual property protections for algorithms.AI-driven pharmaceutical companies must also integrate biological sciences and algorithms effectively,ensuring the successful fusion of wet and dry laboratory experiments.Despite these challenges,the potential of AI in drug development remains undeniable.As AI technology evolves and these barriers are addressed,AI-driven therapeutics are poised for a broader and more impactful future in the pharmaceutical industry.展开更多
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊...Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。展开更多
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊...Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。展开更多
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊...Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd. cn/browse/al/al2019/。展开更多
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊...Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。展开更多
BACKGROUND Newborns with low-birth-weight may lag behind those with normal-birth-weight in terms of growth,development,and nutritional status,which increases mothers’concerns about the child’s future health and lead...BACKGROUND Newborns with low-birth-weight may lag behind those with normal-birth-weight in terms of growth,development,and nutritional status,which increases mothers’concerns about the child’s future health and leads to anxiety and depression.Providing nutritional support to newborns with low-birth-weight to facilitate optimal growth and development may help alleviate maternal anxiety and depre-ssion.RESULTS No significant difference in baseline data was observed between the two groups(P>0.05).Milk intake and TBIL levels in Group S were significantly better than those in Group L at 1,2,3,and 4 weeks after nutritional support(P<0.05).No significant differences in vomiting,abdominal distension,constipation,diarrhea,and residual adverse reactions were observed between the two groups during nutritional support(P>0.05).Group S had a significantly reduce of fewer complications(i.e.,neonatal necrotizing enterocolitis and infection)than did Group L during nutritional support(P<0.05).Before nutritional support,no significant differences in developmental indicators(weight,length,and head circumference)were noted between the two groups(P>0.05).However,after nutritional support,the weight,length,and head circumference of both groups were higher than those before intervention,with Group S having significantly higher values than did Group L(P<0.05).Mothers of children who received nutritional support had decreased SAS and SDS scores,with Group S mothers having significantly lower scores than did Group L mothers(P<0.05).CONCLUSION Enteral nutrition support had significant effects on newborns weighing<2 kg within 24 hours of birth.In particular,it promoted the maturation of gastrointestinal function,enhanced nutrient absorption,promoted optimal short-term growth and development,and alleviated the mother’s anxiety and depression.展开更多
BACKGROUND First-time mothers may encounter various problems during postpartum,which can result in negative emotions that can affect infant care.In today’s Internet era,continuous nursing services can be provided to ...BACKGROUND First-time mothers may encounter various problems during postpartum,which can result in negative emotions that can affect infant care.In today’s Internet era,continuous nursing services can be provided to mothers and their babies after delivery through Internet-based platforms.This approach can help reduce negative emotions of primiparas and promote better health for both mothers and babies.AIM To explore the effect of Internet Plus-based postpartum healthcare services on postpartum depression of primiparas and neonatal growth and development and thus provide a scientific basis for strengthening postpartum healthcare measures and better protect maternal and child health.METHODS The study retrospectively collected data of primiparas and their newborns who underwent prenatal examination and successfully delivered at the Ninth People’s Hospital of Suzhou City.The observation group included 30 primiparas and their newborns who received Internet Plus-based postpartum healthcare services between July and December 2024.According to the principle of matching(1:1)control study,the control group included 30 primiparas and their newborns who received routine postpartum healthcare services between January and June 2024.The maternal role adaptation questionnaire scores,breastfeeding rates,Edinburgh postnatal depression scale(EPDS)scores,and newborn growth and development(height,head circumference,and weight)were compared between the two groups at the time of discharge after delivery and 6-week postpartum follow-up.RESULTS Upon hospital discharge,the two groups did not demonstrate significant differences in maternal role adaptation scores,breastfeeding rates,EPDS scores,as well as newborn height,head circumference,and weight at birth(P>0.05).At the 6-week postpartum follow-up,the maternal role adaptation score and breastfeeding rate were higher in the observation group than in the control group(P<0.05).In addition,one case of postpartum depression was reported in the observation group and eight in the control group.Moreover,the control group exhibited a significant increase in EPDS scores compared with scores at hospital discharge(P<0.05),whereas the observation group showed only a marginal,nonsignificant increase in EPDS scores(P>0.05).The EPDS score of the observation group was significantly lower than that of the control group(P<0.05),indicating a lower risk of postpartum depression in the observation group.The length,head circumference,and weight of the newborns 6 weeks after birth were increased compared with those at birth,and the growth rate was higher in the observation group than in the control group(P<0.05),indicating better growth and development in the observation group.CONCLUSION Internet Plus-based postpartum healthcare services improve maternal role adaptation,increase breastfeeding rates,mitigate postpartum depression risk,and promote neonatal growth and development in primiparas.展开更多
A morphology-based growth stage system should describe the growth and development of a crop and thereby help farmers and agronomists in formulating reasonable managementmeasures conducive to the development of marketa...A morphology-based growth stage system should describe the growth and development of a crop and thereby help farmers and agronomists in formulating reasonable managementmeasures conducive to the development of marketable products.However,existing growth stage systems for soybean are either based on plant growth or covered particular phases of flower or pod development,making it difficult to use for tracking the entire growth period of individual flowers and pods.Therefore,the first flower and pod,located at the base of the primary raceme in the eighth trifoliate node of the main stem,were chosen to illustrate growth dynamics during the full reproductive period.The size and fresh weight of the primary raceme in the eighth trifoliate leaf axil,the first flower and pod,the pistils in the first flower,and seeds in the first pod were examined,and the growth of these organs was depicted.Integrating the morphological characteristics and growth features of flowers and pods,as well as existing growth stage systems,the growth and development were delineated in 13 stages.In detail,we classified the flower phase based on the relative positions of floral components,inspired by the ratio of bract to flower used for staging,refined the lag phase proposed previously,retained the use of pod length to define the early pod phase,and innovatively described the late pod phase by the seed appearance.The developmental events in each stage of flower and pod were distinctive and closely connected to the corresponding morphology.Taken together,a more detailed growth stage system for describing individual flowers and pods in soybean was established.This system will serve as a valuable research tool for describing the development,gene expression,and cellular metabolism associated with the formation of flowers,pods,and seeds.展开更多
This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OEC...This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OECD).Using panel data from 2000 to 2021,the study employs several econometric techniques,including fixed effects,feasible generalized least squares,two-stage least squares,and the generalized method of moments.Our primary findings reveal that unemployment has a significant negative impact on CO_(2)emissions,thereby supporting the validity of the EPC hypothesis within OECD countries.This suggests a trade-off between unemployment and reductions in CO_(2)emissions.Similarly,the results validate the EKC hypothesis,with further analysis indicating that the EKC exhibits an N-shaped curve-an important contribution to the literature on environmental dynamics in advanced economies.Additionally,the results show that both trade openness and renewable energy usage have significantly improved environmental quality in OECD economies.Finally,extensive causality testing identifies both one-way and two-way causal relationships among the key variables examined.These findings have important policy implications for the management of environmental quality and macroeconomic variables in the OECD context.展开更多
Purpose–As an important part of the management of railway passenger transport,the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency a...Purpose–As an important part of the management of railway passenger transport,the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency and service quality of railway passenger transport enterprises.This paper aims to comprehensively and deeply discuss the evolution and development process of China’s railway passenger transport clearing method,analyze its characteristics and influences in each stage,identify the main factors affecting its evolution and development and then put forward thoughts on improving the future development of the clearing method.Design/methodology/approach–Through a detailed review of the railway passenger transport clearing methods from the planned economy period to the reform and opening up period and into the new century,the basis,mode,subject and object of clearing in different development stages are systematically compared.Findings–It comprehensively reveals the evolution of the clearing method,sorted out the characteristics and changes of the clearing method at each stage and the adaptability to the development of railway passenger transport at that time.The characteristics of the development of clearing measures for railway passenger transport in different stages and their far-reaching influence on railway passenger transport business are deeply analyzed.Originality/value–This paper summarized the factors influencing the development of China’s railway passenger transportation clearing approach evolution,including the simplified rules of clearing,enhanced the market adaptability,establishing and perfecting the incentive mechanism,strengthening the construction of informatization,etc.This paper puts forward the ways to improve the railway passenger transportation clearing future development thinking.展开更多
[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the ...[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the research subject to examine the effects of three different configuration modes:three rows with one film,four rows with one film,and six rows with one film,on the growth and development of cotton,as well as on yield and the amount of residual film in the field.[Results]In comparison to the configuration modes of four rows with one film and six rows with one film,the development process in the row spacing configuration mode of three rows with one film was accelerated by 1-4 d.This configuration mode exhibited variability in several agronomic traits,particularly in plant height,the number of fruiting branches per plant,and the number of leaves per plant,with the observed trend indicating T3>T2>T1.Conversely,the height of the first fruiting branch node displayed an inverse trend.In terms of yield composition,no significant differences were observed in boll weight and yield among various configuration modes.However,T3 exhibited the highest boll weight at 5.68 g and a yield of 462.67 kg/667 m 2.Additionally,significant differences were noted in harvesting density and the number of bolls per plant.T3 demonstrated the lowest harvesting density at 1.11×104 plants/666.7 m 2,the highest number of bolls per plant at 8.63,and the highest boll opening rate at 97.48%.Furthermore,T3 also resulted in the least amount of agricultural film residue during the current season.[Conclusions]Among the three planting configuration modes examined,the low-density planting configuration mode consisting of three rows and one film demonstrated a significant advantage at the individual plant level.This approach yielded results comparable to those of the high density planting configuration mode while also reducing costs.Furthermore,low density planting positively influenced the cotton boll opening rate,leading to a decreased amount of residual film and promoting ecological health within the agricultural land.展开更多
Multiple sets of marine shale sequences occur in western Hubei Province and its adjacent areas within the Middle-Upper Yangtze region,offering substantial resource potential.However,their shale gas preservation condit...Multiple sets of marine shale sequences occur in western Hubei Province and its adjacent areas within the Middle-Upper Yangtze region,offering substantial resource potential.However,their shale gas preservation conditions differ significantly due to the heterogeneous porosity and fracture system resulting from multistage tectonic reworking.This necessitates developing region-specific evaluation systems and exploitation techniques.Drawing on previous application cases and guided by the research paradigm of geology-engineering integration,this study presents key technologies potentially applicable to shales in western Hubei Province,spanning from reservoir and sweet spot evaluation to fractu ring scheme design and fracturing perfo rmance monitoring.Several insights are gained accordingly.In terms of pore evaluation,the pore heterogeneity caused by compaction and rebound can be quantified using ideal shape coefficients and fractal dimensions,both of which are influenced by structural deformations,thereby guiding reservoir classification.For seismic data interpretation,pre-stack elastic inversion and azimuthal anisotropy inversion can be employed as core techniques,overcoming the limitation of individual post-stack attributes in typically detecting only major faults.Furthermore,the inversion boundaries are constrained using log-seismic joint quality control and geomechanical simulation,contributing to enhanced reliability of sweet spot evaluation and efficient exploration in areas with complex structures.For fracturing scheme design,scientifically formulated well shut-in strategies,tailored to regional geological characteristics,are essential to activate the fracture-matrix imbibition effect.Parameters with vastly different scales used in the design,such as meter-scale fracture halflength and millidarcy-scale fracture conductivity,can be co-optimized using artificial intelligence(AI)algorithms such as the genetic algorithm(GA)and the simultaneous perturbation stochastic approximation(SPSA)algorithm.Dynamic monitoring of fracturing performance can be achieved using trace chemical tracer technology,thereby reducing target ambiguity caused by structural complexity.Research on shale gas in the structurally complex areas of western Hubei faces multiple challenges,spanning from basic geological understanding to development engineering.These challenges create an urgent need for deep interdisciplinary collaboration.Therefore,this study highlights research into geology-engineering integration,aiming to enhance the efficiency of shale gas exploration and development in western Hubei.展开更多
The Yangtze River Economic Belt is the birthplace of the world s rice farming culture,and is the origin of common rice(Oryza sativa L.),wild rice(Oryza Rufipogon Griff.),medicinal rice(Oryza officinalis Wall.ex G.Watt...The Yangtze River Economic Belt is the birthplace of the world s rice farming culture,and is the origin of common rice(Oryza sativa L.),wild rice(Oryza Rufipogon Griff.),medicinal rice(Oryza officinalis Wall.ex G.Watt),and wart-grain rice(Oryza granate Nees et Arn.ex Hook.f.).Rice culture is the main theme of agricultural culture in this economic belt and an outstanding representative of excellent traditional Chinese culture.This study provides an overview of the history of rice cultivation in the belt from the prehistory,post-history and modern progress.It studies the agricultural cultural heritage resources of the whole rice industry chain from the biological genetic resources,world cultural heritage,key cultural relics protection units,national archaeological site parks,movable cultural relics,important agricultural cultural heritage,intangible cultural heritage,China time-honored brands,historical names,traditional markers,tribute culture,archival and documentary heritage.It also analyzes the six main problems in the inheritance and development of rice farming culture,and proposes 8 strategies,including promoting the inheritance and innovative development of excellent traditional Chinese culture through the inheritance of rice farming culture,promoting the Exploration of the Origins of Chinese Civilization Project through rice farming culture,and creating the Yangtze River National Cultural Park with rice farming culture as the main theme.展开更多
Related to ABI3 and VP1(RAV)transcription factors belong to the AP2 and B3 superfamily.RAVs genes have been reported to be involved in plant growth and development regulation.This study screened three RAV genes from M...Related to ABI3 and VP1(RAV)transcription factors belong to the AP2 and B3 superfamily.RAVs genes have been reported to be involved in plant growth and development regulation.This study screened three RAV genes from Medicago truncatula and named one of them MtRAV1.The MtRAV1 overexpressing plants exhibits traits such as plant dwarfing,delayed flowering,reduced leaf and floral organs,increased branching,and reduced pods and seeds.Gene expression analysis results showed that overexpression of Mt RAV1 inhibited the expression of Flowering Locus T(MtFTa1),Suppressor of Overexpression of CO1(MtSOC1),GA3-oxidase1(MtGA3OX1),DWARF14(MtD14)and Carotenoid Cleavage Dioxygenase7(MtCCD7).To further investigate the regulation pathway involved by MtRAV1,RNA-sequencing(RNA-seq)and DNA affinity purification sequencing(DAP-seq)analysis were conducted.RNA-seq results indicated that MtRAV1 might affect plant growth and development by regulating some genes in photosynthesis,circadian rhythm and plant hormone signaling pathways,especially the auxin signaling pathway.Conjoint analysis of DAP-seq and RNA-seq revealed that Mt RAV1 might inhibit the expression of Ferredoxin(Mt Fd-l3),Light-harvesting Chlorophyll a/b Binding Protein 1(Mt Lhcb-l2)and Small Auxin Up-regulated RNA(Mt SAUR-l),which related to photosystem II and auxin signaling pathway.Summarily,MtRAV1 was preliminarily proven to be a key growth inhibitory factor in M.truncatula.展开更多
This paper highlights the critical role of medical device design and development documents within the quality system,including their compliance with regulatory standards,their function as a traceable record,their supp...This paper highlights the critical role of medical device design and development documents within the quality system,including their compliance with regulatory standards,their function as a traceable record,their support for all stages,and their use in risk and change management.It also covers document template creation,review record association,information management,adverse event traceability,and the reconciliation of differences in international declarations.展开更多
Formation, development and degeneration of Tamarix taklamakanensis M.T. Liu community may be affected by wind-sand disturbance. On the basis of field survey and experiments that took eight years from 1994, it was foun...Formation, development and degeneration of Tamarix taklamakanensis M.T. Liu community may be affected by wind-sand disturbance. On the basis of field survey and experiments that took eight years from 1994, it was found that the plant community was formed in wet and low-lying land, developed in sand burying land, and died out in the land with strong wind erosion and severe sand burying. In the initial stage of the community formation, the low-lying land that was formed by wind erosion provided a suitable habitat for seed germination and plant rooting, but salt stress from ground water reduced seedling survival rate. In the developing stage of the community, sand burying stimulated vigorous growth of the shrubs. In the degenerative stage of the community, the wind erosion and sand burying resulted in dying out of the shrubs. It is therefore concluded that wind-sand disturbance has a positive role in the formation and development of the community, and is in a close association with the process of the community degeneration. Taking the habitat of T taklamakanensis into account, it may be appropriate to note that, under the conditions of frequent disturbance and severe stress, desert pioneer species are adaptable and able to survive. This might be a supplement to the CSR strategy.展开更多
In order to improve the meat production performance of local sheep varieties in Gansu Province, Dorset was introduced to crossbreed with the local sheep varieties, including Tan sheep, Small Tail Han sheep and Mongoli...In order to improve the meat production performance of local sheep varieties in Gansu Province, Dorset was introduced to crossbreed with the local sheep varieties, including Tan sheep, Small Tail Han sheep and Mongolia sheep. The offspring of different crossbreeding combinations were sampled randomly at different growth stages, and their growth and development traits were measured so as to screen out the best crossbreeding mode. The results showed that under the same crossbreeding mode, the growth rate of F3 was higher than that of F2, and of F2 was higher than that of F1. Among the F3 population, the growth rates of Dorset ×Han and Dorset × Mongolia hybrids were higher. Compared with those of Dorset ×Tan F3 hybrids, the body weights of male and female Dorset × Han and Dorset ×Mongolia F3 hybrids were increased by 5.59%, 4.40%, 5.93% and 3.76%, respectively. Among the F2 population, the growth rates of Dorset × Han and Dorset ×Mongolia hybrids were also higher. The body weights of male and female Dorset ×Han and Dorset × Mongolia F2 hybrids were higher than those of Dorset × Tan ×Han F2 hybrids by 5.99%, 3.67%, 9.80% and 5.00%, respectively. In the F1 population, the growth rates of Dorset × Han and Dorset × Mongolia hybrids were higher.Compared with those of Tan × Han F1 hybrids, the body weights of male and female Dorset × Han and Dorset × Mongolia F1 hybrids were increased by 11.32%,5.22%, 7.60% and 7.20%, respectively. Therefore, in the feeding area of Small Tai Han sheep, Mongolia sheep and Tan sheep, Dorset was the best sire for producing hybrid lambs. The economic benefit of crossbred offspring was obvious.展开更多
The growth and development of Jingjiang Taro [Colocasia esculenta（L.） Schott] were observed, laying foundation for highly-yielding cultivation technology system of Xiangsha taro. The results indicate that germinatio...The growth and development of Jingjiang Taro [Colocasia esculenta（L.） Schott] were observed, laying foundation for highly-yielding cultivation technology system of Xiangsha taro. The results indicate that germination of the second taro happened from 46 d after sprouting （7-8 leaves）; the first taro began to expand, from 125 d after sprouting （12 leaves） when the the second taro was been formed; the third taro began to form from 141 to 150 d after sprouting （15-16 leaves）. The fresh weight of the second and third taros quickly increased from the time of 15 leaves to harvest. Early September is a transformation term of Xiangsha taro from vegetative body dominant to corm growth dominant.展开更多
文摘Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。
基金supported by the National Medical Products Administration Commissioned Research Project (No.20211440216)the National Administration of Traditional Chinese Medicine Science and Technology Project (No.GZY-KJS-2024-03)+3 种基金the State Key Laboratory of Drug Regulatory Science Project (No.2023SKLDRS0104)the Basic Research Program Natural Science Fund-Frontier Leading Technology Basic Research Special Project of Jiangsu Province (No.BK20232014)the Programs Foundation for Leading Talents in National Administration of Traditional Chinese Medicine of China“Qihuang scholars”Projectthe Tianjin Administration for Market Regulation Science and Technology Key Projects (No.2022-W35)。
文摘The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.
基金supported by the National Natural Science Foundation of China(Grant No.:82304564)the Liaoning Province Education Department Scientific Research Funding Project(Grant No.:LJKZ0777).
文摘Artificial intelligence(AI)is revolutionizing traditional drug discovery and development models by seamlessly integrating data,computational power,and algorithms.This synergy enhances the efficiency,accuracy,and success rates of drug research,shortens development timelines,and reduces costs.Coupled with machine learning(ML)and deep learning(DL),AI has demonstrated significant advancements across various domains,including drug characterization,target discovery and validation,small molecule drug design,and the acceleration of clinical trials.Through molecular generation techniques,AI facilitates the creation of novel drug molecules,predicting their properties and activities,while virtual screening(VS)optimizes drug candidates.Additionally,AI enhances clinical trial efficiency by predicting outcomes,designing trials,and enabling drug repositioning.However,AI's application in drug development faces challenges,including the need for robust data-sharing mechanisms and the establishment of more comprehensive intellectual property protections for algorithms.AI-driven pharmaceutical companies must also integrate biological sciences and algorithms effectively,ensuring the successful fusion of wet and dry laboratory experiments.Despite these challenges,the potential of AI in drug development remains undeniable.As AI technology evolves and these barriers are addressed,AI-driven therapeutics are poised for a broader and more impactful future in the pharmaceutical industry.
文摘Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。
文摘Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。
文摘Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd. cn/browse/al/al2019/。
文摘Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。
文摘BACKGROUND Newborns with low-birth-weight may lag behind those with normal-birth-weight in terms of growth,development,and nutritional status,which increases mothers’concerns about the child’s future health and leads to anxiety and depression.Providing nutritional support to newborns with low-birth-weight to facilitate optimal growth and development may help alleviate maternal anxiety and depre-ssion.RESULTS No significant difference in baseline data was observed between the two groups(P>0.05).Milk intake and TBIL levels in Group S were significantly better than those in Group L at 1,2,3,and 4 weeks after nutritional support(P<0.05).No significant differences in vomiting,abdominal distension,constipation,diarrhea,and residual adverse reactions were observed between the two groups during nutritional support(P>0.05).Group S had a significantly reduce of fewer complications(i.e.,neonatal necrotizing enterocolitis and infection)than did Group L during nutritional support(P<0.05).Before nutritional support,no significant differences in developmental indicators(weight,length,and head circumference)were noted between the two groups(P>0.05).However,after nutritional support,the weight,length,and head circumference of both groups were higher than those before intervention,with Group S having significantly higher values than did Group L(P<0.05).Mothers of children who received nutritional support had decreased SAS and SDS scores,with Group S mothers having significantly lower scores than did Group L mothers(P<0.05).CONCLUSION Enteral nutrition support had significant effects on newborns weighing<2 kg within 24 hours of birth.In particular,it promoted the maturation of gastrointestinal function,enhanced nutrient absorption,promoted optimal short-term growth and development,and alleviated the mother’s anxiety and depression.
基金Supported by 2024 Academy Level Research Start up Fund,No.YK202434.
文摘BACKGROUND First-time mothers may encounter various problems during postpartum,which can result in negative emotions that can affect infant care.In today’s Internet era,continuous nursing services can be provided to mothers and their babies after delivery through Internet-based platforms.This approach can help reduce negative emotions of primiparas and promote better health for both mothers and babies.AIM To explore the effect of Internet Plus-based postpartum healthcare services on postpartum depression of primiparas and neonatal growth and development and thus provide a scientific basis for strengthening postpartum healthcare measures and better protect maternal and child health.METHODS The study retrospectively collected data of primiparas and their newborns who underwent prenatal examination and successfully delivered at the Ninth People’s Hospital of Suzhou City.The observation group included 30 primiparas and their newborns who received Internet Plus-based postpartum healthcare services between July and December 2024.According to the principle of matching(1:1)control study,the control group included 30 primiparas and their newborns who received routine postpartum healthcare services between January and June 2024.The maternal role adaptation questionnaire scores,breastfeeding rates,Edinburgh postnatal depression scale(EPDS)scores,and newborn growth and development(height,head circumference,and weight)were compared between the two groups at the time of discharge after delivery and 6-week postpartum follow-up.RESULTS Upon hospital discharge,the two groups did not demonstrate significant differences in maternal role adaptation scores,breastfeeding rates,EPDS scores,as well as newborn height,head circumference,and weight at birth(P>0.05).At the 6-week postpartum follow-up,the maternal role adaptation score and breastfeeding rate were higher in the observation group than in the control group(P<0.05).In addition,one case of postpartum depression was reported in the observation group and eight in the control group.Moreover,the control group exhibited a significant increase in EPDS scores compared with scores at hospital discharge(P<0.05),whereas the observation group showed only a marginal,nonsignificant increase in EPDS scores(P>0.05).The EPDS score of the observation group was significantly lower than that of the control group(P<0.05),indicating a lower risk of postpartum depression in the observation group.The length,head circumference,and weight of the newborns 6 weeks after birth were increased compared with those at birth,and the growth rate was higher in the observation group than in the control group(P<0.05),indicating better growth and development in the observation group.CONCLUSION Internet Plus-based postpartum healthcare services improve maternal role adaptation,increase breastfeeding rates,mitigate postpartum depression risk,and promote neonatal growth and development in primiparas.
基金supported by the National Key Research and Development Program of China(2023YFD2301500).
文摘A morphology-based growth stage system should describe the growth and development of a crop and thereby help farmers and agronomists in formulating reasonable managementmeasures conducive to the development of marketable products.However,existing growth stage systems for soybean are either based on plant growth or covered particular phases of flower or pod development,making it difficult to use for tracking the entire growth period of individual flowers and pods.Therefore,the first flower and pod,located at the base of the primary raceme in the eighth trifoliate node of the main stem,were chosen to illustrate growth dynamics during the full reproductive period.The size and fresh weight of the primary raceme in the eighth trifoliate leaf axil,the first flower and pod,the pistils in the first flower,and seeds in the first pod were examined,and the growth of these organs was depicted.Integrating the morphological characteristics and growth features of flowers and pods,as well as existing growth stage systems,the growth and development were delineated in 13 stages.In detail,we classified the flower phase based on the relative positions of floral components,inspired by the ratio of bract to flower used for staging,refined the lag phase proposed previously,retained the use of pod length to define the early pod phase,and innovatively described the late pod phase by the seed appearance.The developmental events in each stage of flower and pod were distinctive and closely connected to the corresponding morphology.Taken together,a more detailed growth stage system for describing individual flowers and pods in soybean was established.This system will serve as a valuable research tool for describing the development,gene expression,and cellular metabolism associated with the formation of flowers,pods,and seeds.
文摘This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OECD).Using panel data from 2000 to 2021,the study employs several econometric techniques,including fixed effects,feasible generalized least squares,two-stage least squares,and the generalized method of moments.Our primary findings reveal that unemployment has a significant negative impact on CO_(2)emissions,thereby supporting the validity of the EPC hypothesis within OECD countries.This suggests a trade-off between unemployment and reductions in CO_(2)emissions.Similarly,the results validate the EKC hypothesis,with further analysis indicating that the EKC exhibits an N-shaped curve-an important contribution to the literature on environmental dynamics in advanced economies.Additionally,the results show that both trade openness and renewable energy usage have significantly improved environmental quality in OECD economies.Finally,extensive causality testing identifies both one-way and two-way causal relationships among the key variables examined.These findings have important policy implications for the management of environmental quality and macroeconomic variables in the OECD context.
基金supported by the Research and Development Plan Project of China State Railway Group Co.,Ltd.(Project No.P2023X029).
文摘Purpose–As an important part of the management of railway passenger transport,the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency and service quality of railway passenger transport enterprises.This paper aims to comprehensively and deeply discuss the evolution and development process of China’s railway passenger transport clearing method,analyze its characteristics and influences in each stage,identify the main factors affecting its evolution and development and then put forward thoughts on improving the future development of the clearing method.Design/methodology/approach–Through a detailed review of the railway passenger transport clearing methods from the planned economy period to the reform and opening up period and into the new century,the basis,mode,subject and object of clearing in different development stages are systematically compared.Findings–It comprehensively reveals the evolution of the clearing method,sorted out the characteristics and changes of the clearing method at each stage and the adaptability to the development of railway passenger transport at that time.The characteristics of the development of clearing measures for railway passenger transport in different stages and their far-reaching influence on railway passenger transport business are deeply analyzed.Originality/value–This paper summarized the factors influencing the development of China’s railway passenger transportation clearing approach evolution,including the simplified rules of clearing,enhanced the market adaptability,establishing and perfecting the incentive mechanism,strengthening the construction of informatization,etc.This paper puts forward the ways to improve the railway passenger transportation clearing future development thinking.
基金Supported by China Agriculture(Cotton)Research System(CARS-15-46)Intellectual Aid Xinjiang Innovation and Expansion Talent Program of Xinjiang Uygur Autonomous Region(2024500207).
文摘[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the research subject to examine the effects of three different configuration modes:three rows with one film,four rows with one film,and six rows with one film,on the growth and development of cotton,as well as on yield and the amount of residual film in the field.[Results]In comparison to the configuration modes of four rows with one film and six rows with one film,the development process in the row spacing configuration mode of three rows with one film was accelerated by 1-4 d.This configuration mode exhibited variability in several agronomic traits,particularly in plant height,the number of fruiting branches per plant,and the number of leaves per plant,with the observed trend indicating T3>T2>T1.Conversely,the height of the first fruiting branch node displayed an inverse trend.In terms of yield composition,no significant differences were observed in boll weight and yield among various configuration modes.However,T3 exhibited the highest boll weight at 5.68 g and a yield of 462.67 kg/667 m 2.Additionally,significant differences were noted in harvesting density and the number of bolls per plant.T3 demonstrated the lowest harvesting density at 1.11×104 plants/666.7 m 2,the highest number of bolls per plant at 8.63,and the highest boll opening rate at 97.48%.Furthermore,T3 also resulted in the least amount of agricultural film residue during the current season.[Conclusions]Among the three planting configuration modes examined,the low-density planting configuration mode consisting of three rows and one film demonstrated a significant advantage at the individual plant level.This approach yielded results comparable to those of the high density planting configuration mode while also reducing costs.Furthermore,low density planting positively influenced the cotton boll opening rate,leading to a decreased amount of residual film and promoting ecological health within the agricultural land.
基金supported by the Excellence Research Group Program of the Hubei Provincial Natural Science Foundation(originally termed Basic Science Center Program)(JCKXXM202500016)the Key Program of the National Natural Science Foundation of China(42230812)the National Natural Science Foundation of China(42073068)。
文摘Multiple sets of marine shale sequences occur in western Hubei Province and its adjacent areas within the Middle-Upper Yangtze region,offering substantial resource potential.However,their shale gas preservation conditions differ significantly due to the heterogeneous porosity and fracture system resulting from multistage tectonic reworking.This necessitates developing region-specific evaluation systems and exploitation techniques.Drawing on previous application cases and guided by the research paradigm of geology-engineering integration,this study presents key technologies potentially applicable to shales in western Hubei Province,spanning from reservoir and sweet spot evaluation to fractu ring scheme design and fracturing perfo rmance monitoring.Several insights are gained accordingly.In terms of pore evaluation,the pore heterogeneity caused by compaction and rebound can be quantified using ideal shape coefficients and fractal dimensions,both of which are influenced by structural deformations,thereby guiding reservoir classification.For seismic data interpretation,pre-stack elastic inversion and azimuthal anisotropy inversion can be employed as core techniques,overcoming the limitation of individual post-stack attributes in typically detecting only major faults.Furthermore,the inversion boundaries are constrained using log-seismic joint quality control and geomechanical simulation,contributing to enhanced reliability of sweet spot evaluation and efficient exploration in areas with complex structures.For fracturing scheme design,scientifically formulated well shut-in strategies,tailored to regional geological characteristics,are essential to activate the fracture-matrix imbibition effect.Parameters with vastly different scales used in the design,such as meter-scale fracture halflength and millidarcy-scale fracture conductivity,can be co-optimized using artificial intelligence(AI)algorithms such as the genetic algorithm(GA)and the simultaneous perturbation stochastic approximation(SPSA)algorithm.Dynamic monitoring of fracturing performance can be achieved using trace chemical tracer technology,thereby reducing target ambiguity caused by structural complexity.Research on shale gas in the structurally complex areas of western Hubei faces multiple challenges,spanning from basic geological understanding to development engineering.These challenges create an urgent need for deep interdisciplinary collaboration.Therefore,this study highlights research into geology-engineering integration,aiming to enhance the efficiency of shale gas exploration and development in western Hubei.
基金Supported by Social Science Foundation of Hubei Province(HBSKJJ20243227)Doctoral Initiation Project of Hubei University of Science and Technology(BK201819).
文摘The Yangtze River Economic Belt is the birthplace of the world s rice farming culture,and is the origin of common rice(Oryza sativa L.),wild rice(Oryza Rufipogon Griff.),medicinal rice(Oryza officinalis Wall.ex G.Watt),and wart-grain rice(Oryza granate Nees et Arn.ex Hook.f.).Rice culture is the main theme of agricultural culture in this economic belt and an outstanding representative of excellent traditional Chinese culture.This study provides an overview of the history of rice cultivation in the belt from the prehistory,post-history and modern progress.It studies the agricultural cultural heritage resources of the whole rice industry chain from the biological genetic resources,world cultural heritage,key cultural relics protection units,national archaeological site parks,movable cultural relics,important agricultural cultural heritage,intangible cultural heritage,China time-honored brands,historical names,traditional markers,tribute culture,archival and documentary heritage.It also analyzes the six main problems in the inheritance and development of rice farming culture,and proposes 8 strategies,including promoting the inheritance and innovative development of excellent traditional Chinese culture through the inheritance of rice farming culture,promoting the Exploration of the Origins of Chinese Civilization Project through rice farming culture,and creating the Yangtze River National Cultural Park with rice farming culture as the main theme.
基金supported by the Key Projects in Science and Technology of Inner Mongolia,China(2021ZD0031)the China Agriculture Research System of MOF and MARA(CARS-34)+1 种基金the Performance Incentive and Guidance Special Project of Scientific Research Institution,Chongqing Science and Technology Committee,China(cstc2022jxjl80019)the Natural Science Foundation of Chongqing,China(CSTB2022NSCQ-BHX0744)。
文摘Related to ABI3 and VP1(RAV)transcription factors belong to the AP2 and B3 superfamily.RAVs genes have been reported to be involved in plant growth and development regulation.This study screened three RAV genes from Medicago truncatula and named one of them MtRAV1.The MtRAV1 overexpressing plants exhibits traits such as plant dwarfing,delayed flowering,reduced leaf and floral organs,increased branching,and reduced pods and seeds.Gene expression analysis results showed that overexpression of Mt RAV1 inhibited the expression of Flowering Locus T(MtFTa1),Suppressor of Overexpression of CO1(MtSOC1),GA3-oxidase1(MtGA3OX1),DWARF14(MtD14)and Carotenoid Cleavage Dioxygenase7(MtCCD7).To further investigate the regulation pathway involved by MtRAV1,RNA-sequencing(RNA-seq)and DNA affinity purification sequencing(DAP-seq)analysis were conducted.RNA-seq results indicated that MtRAV1 might affect plant growth and development by regulating some genes in photosynthesis,circadian rhythm and plant hormone signaling pathways,especially the auxin signaling pathway.Conjoint analysis of DAP-seq and RNA-seq revealed that Mt RAV1 might inhibit the expression of Ferredoxin(Mt Fd-l3),Light-harvesting Chlorophyll a/b Binding Protein 1(Mt Lhcb-l2)and Small Auxin Up-regulated RNA(Mt SAUR-l),which related to photosystem II and auxin signaling pathway.Summarily,MtRAV1 was preliminarily proven to be a key growth inhibitory factor in M.truncatula.
文摘This paper highlights the critical role of medical device design and development documents within the quality system,including their compliance with regulatory standards,their function as a traceable record,their support for all stages,and their use in risk and change management.It also covers document template creation,review record association,information management,adverse event traceability,and the reconciliation of differences in international declarations.
文摘Formation, development and degeneration of Tamarix taklamakanensis M.T. Liu community may be affected by wind-sand disturbance. On the basis of field survey and experiments that took eight years from 1994, it was found that the plant community was formed in wet and low-lying land, developed in sand burying land, and died out in the land with strong wind erosion and severe sand burying. In the initial stage of the community formation, the low-lying land that was formed by wind erosion provided a suitable habitat for seed germination and plant rooting, but salt stress from ground water reduced seedling survival rate. In the developing stage of the community, sand burying stimulated vigorous growth of the shrubs. In the degenerative stage of the community, the wind erosion and sand burying resulted in dying out of the shrubs. It is therefore concluded that wind-sand disturbance has a positive role in the formation and development of the community, and is in a close association with the process of the community degeneration. Taking the habitat of T taklamakanensis into account, it may be appropriate to note that, under the conditions of frequent disturbance and severe stress, desert pioneer species are adaptable and able to survive. This might be a supplement to the CSR strategy.
文摘In order to improve the meat production performance of local sheep varieties in Gansu Province, Dorset was introduced to crossbreed with the local sheep varieties, including Tan sheep, Small Tail Han sheep and Mongolia sheep. The offspring of different crossbreeding combinations were sampled randomly at different growth stages, and their growth and development traits were measured so as to screen out the best crossbreeding mode. The results showed that under the same crossbreeding mode, the growth rate of F3 was higher than that of F2, and of F2 was higher than that of F1. Among the F3 population, the growth rates of Dorset ×Han and Dorset × Mongolia hybrids were higher. Compared with those of Dorset ×Tan F3 hybrids, the body weights of male and female Dorset × Han and Dorset ×Mongolia F3 hybrids were increased by 5.59%, 4.40%, 5.93% and 3.76%, respectively. Among the F2 population, the growth rates of Dorset × Han and Dorset ×Mongolia hybrids were also higher. The body weights of male and female Dorset ×Han and Dorset × Mongolia F2 hybrids were higher than those of Dorset × Tan ×Han F2 hybrids by 5.99%, 3.67%, 9.80% and 5.00%, respectively. In the F1 population, the growth rates of Dorset × Han and Dorset × Mongolia hybrids were higher.Compared with those of Tan × Han F1 hybrids, the body weights of male and female Dorset × Han and Dorset × Mongolia F1 hybrids were increased by 11.32%,5.22%, 7.60% and 7.20%, respectively. Therefore, in the feeding area of Small Tai Han sheep, Mongolia sheep and Tan sheep, Dorset was the best sire for producing hybrid lambs. The economic benefit of crossbred offspring was obvious.
基金Supported by Jiangsu Self-innovation Fund for Agricultural Science and Technology[CX(12)2008]~~
文摘The growth and development of Jingjiang Taro [Colocasia esculenta（L.） Schott] were observed, laying foundation for highly-yielding cultivation technology system of Xiangsha taro. The results indicate that germination of the second taro happened from 46 d after sprouting （7-8 leaves）; the first taro began to expand, from 125 d after sprouting （12 leaves） when the the second taro was been formed; the third taro began to form from 141 to 150 d after sprouting （15-16 leaves）. The fresh weight of the second and third taros quickly increased from the time of 15 leaves to harvest. Early September is a transformation term of Xiangsha taro from vegetative body dominant to corm growth dominant.
