Accurately simulating water flow movement in vadose zone is crucial for effective water resources assessment.Richards'equation,which describes the movement of water flow in the vadose zone,is highly nonlinear and ...Accurately simulating water flow movement in vadose zone is crucial for effective water resources assessment.Richards'equation,which describes the movement of water flow in the vadose zone,is highly nonlinear and challenging to solve.Existing numerical methods often face issues such as numerical dispersion,oscillation,and mass non-conservation when spatial and temporal discretization conditions are not appropriately configured.To address these problems and achieve accurate and stable numerical solutions,a finite analytic method based on water content-based Richards'equation(FAM-W)is proposed.The performance of the FAM-W is compared with analytical solutions,Finite Difference Method(FDM),and Finite Analytic Method based on the pressure Head-based Richards'equation(FAM-H).Compared to analytical solution and other numerical methods(FDM and FAM-H),FAM-W demonstrates superior accuracy and efficiency in controlling mass balance errors,regardless of spatial step sizes.This study introduces a novel approach for modelling water flow in the vadose zone,offering significant benefits for water resources management.展开更多
The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies ...The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies using vari‑ous analytical methods have identified peculiar trends in various illnesses,with Firmicutes being the most prevalent phylum,followed by Bacteroidetes,Proteobacteria,and Actinobacteria.However,more Firmicutes and fewer Bac‑teroidetes have been observed in cats infected with Feline coronavirus.Alterations in the composition of these gut microbiota can be solved by microbiota modification through dietary fiber,probiotics,and fecal microbiota transplan‑tation.Therefore,it is critical to understand the composition of the gut microbiota,the changes in and roles of the gut environment,and the importance of these concepts for overall health while considering the exchange of microbes between humans and domestic animals.This review provides comprehensive information on feline gut microbiota composition,modulation,and analytic methods used for characterizing the gut microbiota.展开更多
Compared to the conventional permanent magnet synchronous machine(PMSM),the main characteristic of permanent magnet torque machine(PMTM)with high torque is that armature current is high,which has a great influence on ...Compared to the conventional permanent magnet synchronous machine(PMSM),the main characteristic of permanent magnet torque machine(PMTM)with high torque is that armature current is high,which has a great influence on magnetic circuit saturation,so this paper proposes a novel analytical method(AM)considering this problem.The key of this new AM is to consider armature reaction flux and armature leakage flux,which are closely related to output torque.Firstly,the expressions,including magnetomotive force(MMF)generated by permanent magnets(PMs)and armature windings are derived,and meanwhile slotting effect is considered by planning flux path.In addition,the expression of leakage flux density generated by armature windings are calculated,and flux density equivalence coefficient of tooth is calculated to be 2/3,which is used to solve the problem of uneven saturation of each tooth.Then,based on main flux factor and leakage flux factor proposed,an improved iteration process is proposed,and by this new process,the flux density of each yoke and tooth can be obtained,which is beneficial to obtain more accurate air-gap flux density and flux linkage.Finally,a prototype of 60-pole 54-slot is fabricated,and the performances of the electric machine,such as back electromotive force(EMF)and output torque,are calculated by this new AM and finite element method(FEM).The results of FEM and experimental test show that this new AM is good enough to calculate the performance of PMTM.展开更多
The chiral nature of biological systems enables their stereoselective interaction with chiral compounds. It has been well documented that the enantiomers ofa chiral drug may show differences in drug disposition especi...The chiral nature of biological systems enables their stereoselective interaction with chiral compounds. It has been well documented that the enantiomers ofa chiral drug may show differences in drug disposition especially in metabolic behavior. As a result, it is of vital importance to separate the enantiomers of a chiral drug in metabolic studies. This paper discusses enantioselective methods （include high-performance liquid chromatography, gas chromatography, capillary electrophoresis and high-performance liquid chromatography-mass spectrometry） that applied in chiral drug metabolism, using most recent examples where possible.展开更多
In the present work, the different sample collection, pretreatment and analytical methods for polycyclic aromatic hydrocarbons （PAHs） in airborne particulates is systematacially reviewed, and the applications of the...In the present work, the different sample collection, pretreatment and analytical methods for polycyclic aromatic hydrocarbons （PAHs） in airborne particulates is systematacially reviewed, and the applications of these pretreatment and analytical methods for PAHs are compared in detail. Some comments on the future expectation are also presented.展开更多
Nanoliposomes are considered to be the most successful nanoparticle drug delivery system, but their fate in vivo has not been fully understood due to lack of reliable bioanalytical methods, which seriously limits the ...Nanoliposomes are considered to be the most successful nanoparticle drug delivery system, but their fate in vivo has not been fully understood due to lack of reliable bioanalytical methods, which seriously limits the development of liposomal drugs. Hence, an overview of currently used bioanalytical methods is imperative to lay the groundwork for the need of developing a bioanalytical method for liposome measurements in vivo. Currently, major analytical methods for nanoliposomes measurement in vivo include fluorescence labeling, radiolabeling, magnetic resonance imaging（MRI）, mass spectrometry and computed tomography. In this review, these bioanalytical methods are summarized, and the advantages and disadvantages of each are discussed. We provide insights into the applicability and limitations of these analytical methods in the application of nanoliposomes measurement in vivo, and highlight the recent development of instrumental analysis techniques. The review is devoted to providing a comprehensive overview of the investigation of nanoliposomes design and associated fate in vivo, promoting the development of bioanalytical techniques for nanoliposomes measurement, and understanding the pharmacokinetic behavior, effectiveness and potential toxicity of nanoliposomes in vivo.展开更多
Assessment of acid sulfate soil risk is an important step for acid sulfate soil management and its reliability depends very much on the suitability and accuracy of various analytical methods for estimating sulfide-der...Assessment of acid sulfate soil risk is an important step for acid sulfate soil management and its reliability depends very much on the suitability and accuracy of various analytical methods for estimating sulfide-derived potential acidity, actual acidity and acid-neutralizing capacity in acid sulfate soils. This paper critically reviews various analytical methods that are currently used for determination of the above parameters, as well as their implications for environmental risk assessment of acid sulfate soi1s.展开更多
Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of ...Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies. Ever since it was introduced as an effective antifungal agent, many methods have been developed and validated for its assay in pharmaceuticals and biological materials. This article reviews the various methods reported during the last 25 years.展开更多
Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma （PPAR-gamma）. I...Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma （PPAR-gamma）. It was the tenth-best-selling drug in the U.S. in 2008. This article examines published analytical methods reported so far in the literature for the determination of pioglitazone in biological samples and pharmaceutical formulations. They include various techniques like electrochemical methods, spectrophotometry, capillary electrophoresis, high-performance liquid chromatography, liquid chromatography-electrospray ionization-tandem mass spectrometry and high-performance thin layer chromatography.展开更多
The purpose of this study was to investigate the effect of bolt profile on load transfer mechanism of fully grouted bolts in jointed rocks using analytical and numerical methods. Based on the analytical method with de...The purpose of this study was to investigate the effect of bolt profile on load transfer mechanism of fully grouted bolts in jointed rocks using analytical and numerical methods. Based on the analytical method with development of methods, a new model is presented. To validate the analytical model, five different profiles modeled by ANSYS software. The profile of rock bolts T3 and T4with load transfer capacity,respectively 180 and 195 kN in the jointed rocks was selected as the optimum profiles. Finally, the selected profiles were examined in Tabas Coal Mine. FLAC analysis indicates that patterns 6+7 with2 NO flexi bolt 4 m better than other patterns within the faulted zone.展开更多
A versatile analytical method(VAM) for calculating the harmonic components of the magnetomotive force(MMF) generated by diverse armature windings in AC machines has been proposed, and the versatility of this method ha...A versatile analytical method(VAM) for calculating the harmonic components of the magnetomotive force(MMF) generated by diverse armature windings in AC machines has been proposed, and the versatility of this method has been established in early literature. However, its practical applications and significance in advancing the analysis of AC machines need further elaboration. This paper aims to complement VAM by augmenting its theory, offering additional insights into its conclusions, as well as demonstrating its utility in assessing armature windings and its application of calculating torque for permanent magnet synchronous machines(PMSM). This work contributes to advancing the analysis of AC machines and underscores the potential for improved design and performance optimization.展开更多
This study proposed the newly-designed Pelagic and demersal trawls for the fishing vessels operating in Cameroonian waters in pelagic and demersal fishing grounds. The engineering performances of both trawls were inve...This study proposed the newly-designed Pelagic and demersal trawls for the fishing vessels operating in Cameroonian waters in pelagic and demersal fishing grounds. The engineering performances of both trawls were investigated using physical modelling method and analytical method based on the predicted equations. In a flume tank, a series of physical model tests based on Tauti’s law were performed to investigate the hydrodynamic and geometrical performances of both trawls and to assess the applicability of the analytical methods based on predicted equations. The results showed that in model scale, the working towing speed and door spread for the pelagic trawl were 3.5 knots and 1.85 m, respectively, and for the bottom trawl net they were 4.0 knots and 1.8 m. At that speed and door spread, the drag force, net opening height, and wing-end spread of the pelagic model trawl were 36.73 N, 0.89 m, and 0.86 m, respectively, and the swept area was 0.76 m<sup>2</sup>. Bottom trawl speed and door spread were 30.43 N, 0.38 m, and 0.45 m, respectively, and the swept area was 0.25 m<sup>2</sup>. The maximum difference between the experimental and analytical results of hydrodynamic performances was less than 56.22% and 41.45%, respectively, for pelagic and bottom trawls, the results of the geometrical performances obtained using predicted equations were close to the experimental results in the flume tank with a maximum relative error less than 12.85%. The newly developed pelagic and bottom trawls had advanced engineering performance for high catch efficiency and selectivity and could be used in commercial fishing operations in Cameroonian waters.展开更多
In recent times, the overall interest over Supercritical Fluid Chromatography (SFC) is truly growing within various domains but especially for pharmaceutical analysis. However, in the best of our knowledge modern SFC ...In recent times, the overall interest over Supercritical Fluid Chromatography (SFC) is truly growing within various domains but especially for pharmaceutical analysis. However, in the best of our knowledge modern SFC is not yet applied for drug quality control in the daily routine framework. Among the numerous reported SFC methods, none of them could be found to fully satisfy to all steps of the analytical method lifecycle. Thereby, the present contribution aims to provide an overview of the current and past achievements related to SFC techniques, with a targeted attention to this lifecycle and its successive steps. The included discussions were therefore structured accordingly and emphasizing the analytical method lifecycle in accord with the International Conference on Harmonisation (ICH). Recent and important scientific outputs in the field of analytical SFC, as well as instrumental evolution, qualification strategies, method development methodologies and discussions on the topic of method validation are reviewed.展开更多
The layout forms of several breakwater structures can be generalized as asymmetrical arrangements in actual engineering.However,the problem of wave diffraction around asymmetrically arranged breakwaters has not been a...The layout forms of several breakwater structures can be generalized as asymmetrical arrangements in actual engineering.However,the problem of wave diffraction around asymmetrically arranged breakwaters has not been adequately investigated.In this study,we propose an analytical method of wave diffraction for regular waves passing through asymmetrically arranged breakwaters,and we use the Nyström method to obtain the analytical solution numerically.We compared the results of this method with those of previous analytical solutions and with numerical results to demonstrate the validity of our approach.We also provided diffraction coefficient diagrams of breakwaters with different layout forms.Moreover,we described the analytical expression for the problem of diffraction through long-wave incident breakwaters and presented an analysis of the relationship between the diffraction coefficients and the widths of breakwater gates.The analytical method presented in this study contributes to the limited literature on the theory of wave diffraction through asymmetrically arranged breakwaters.展开更多
An anisotropic diffusion filter can be used to model a flow-dependent background error covariance matrix,which can be achieved by solving the advection-diffusion equation.Because of the directionality of the advection...An anisotropic diffusion filter can be used to model a flow-dependent background error covariance matrix,which can be achieved by solving the advection-diffusion equation.Because of the directionality of the advection term,the discrete method needs to be chosen very carefully.The finite analytic method is an alternative scheme to solve the advection-diffusion equation.As a combination of analytical and numerical methods,it not only has high calculation accuracy but also holds the characteristic of the auto upwind.To demonstrate its ability,the one-dimensional steady and unsteady advection-diffusion equation numerical examples are respectively solved by the finite analytic method.The more widely used upwind difference method is used as a control approach.The result indicates that the finite analytic method has higher accuracy than the upwind difference method.For the two-dimensional case,the finite analytic method still has a better performance.In the three-dimensional variational assimilation experiment,the finite analytic method can effectively improve analysis field accuracy,and its effect is significantly better than the upwind difference and the central difference method.Moreover,it is still a more effective solution method in the strong flow region where the advective-diffusion filter performs most prominently.展开更多
On the basis of the concept of finite element methods, the rigorous analytical solutions of structural response in terms of the design variables are researched in this paper. The spatial trusses are taken as an exampl...On the basis of the concept of finite element methods, the rigorous analytical solutions of structural response in terms of the design variables are researched in this paper. The spatial trusses are taken as an example for the solution of the analytical expressions of the explicit displacements which are proved mathematically; then some conclusions are reached that are useful to structural sensitivity analysis and optimization. In the third part of the paper, a generalized geometric programming method is sugviped for the optimal model with the explicit displacement. Finally, the analytical solutions of the displacements of three trusses are given as examples.展开更多
Over the past decade,the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry,nuclear magnetic resonance,and multivariate statistics.Currently,metabolomic...Over the past decade,the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry,nuclear magnetic resonance,and multivariate statistics.Currently,metabolomics garners widespread application across diverse fields including drug research and development,early disease detection,toxicology,food and nutrition science,biology,prescription,and chinmedomics,among others.Metabolomics serves as an effective characterization technique,offering insights into physiological process alterations in vivo.These changes may result from various exogenous factors like environmental conditions,stress,medications,as well as endogenous elements including genetic and protein-based influences.The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods,poised to further broaden the scope of this domain.Today,metabolomics has evolved into a valuable and widely accepted instrument in the life sciences.However,comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant.This review aims to fill that gap,providing an overview of current trends and recent advancements in metabolomics.Particular emphasis is placed on sample preparation,sophisticated analytical techniques,and their applications in life science research.展开更多
Green analytical chemistry(GAC)focuses on mitigating the adverse effects of analytical activities on human safety,human health,and environment.In addition to the 12 principles of GAC,proper GAC tools should be develop...Green analytical chemistry(GAC)focuses on mitigating the adverse effects of analytical activities on human safety,human health,and environment.In addition to the 12 principles of GAC,proper GAC tools should be developed and employed to assess the greenness of different analytical assays.The 15 widely used GAC metrics,i.e.,national environmental methods index(NEMI),advanced NEMI,assessment of green profile(AGP),chloroform-oriented toxicity estimation scale(ChlorTox Scale),Analytical Eco-Scale,Green Certificate Modified Eco-Scale,analytical method greenness score(AMGS),green analytical procedure index(GAPI),ComplexGAPI,red-green-blue(RGB)additive color model,RGB 12 algorithm,analytical greenness calculator(AGREE),AGREE preparation(AGREEprep),HEXAGON,and blue applicability grade index(BAGI),are selected as the typical tools.This article comprehensively presents and elucidates the principles,characteristics,merits,and demerits of 15 widely used GAC tools.This review is helpful for researchers to use the current GAC metrics to assess the environmental sustainability of analytical assays.展开更多
Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely ...Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely used“generic”(absolute intensity)cut-point approach has limited generalisability to population-level free-living data.Further,current methods generally fail to account for differences in people's physical capacity.展开更多
This special issue focuses on simulation optimization(SO),which combines stochastic simulation with optimization techniques to address complex decisionmaking problems under uncertainty.SO has gained increasing importa...This special issue focuses on simulation optimization(SO),which combines stochastic simulation with optimization techniques to address complex decisionmaking problems under uncertainty.SO has gained increasing importance in areas such as transportation,supply chain and manufacturing,providing solutions where traditional analytical methods may fail.Recent advances in computing,data analytics,and artificial intelligence have significantly enhanced the efficiency and capability of SO methods,enabling the development of innovative techniques.This special issue aims to highlight recent theoretical and practical advancements in SO,showcasing its potential to solve real-world problems and inspiring further research and application in this dynamic field.展开更多
基金supported by the National Natural Science Foundation of China(No.42372287 and No.U24A20178)the Fundamental Research Funds for the Central Universities CHD(No.2024SHEEAR002)+3 种基金the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shaanxi Province(No.2020024)the China Postdoctoral Science Foundation(GZC20232955,2024M753472,and 2024MD763937)the Science-Technology Foundation for Young Scientists of Gansu Province,China(No.24JRRA097)the Study of biodiversity survey and limiting factor analysis of Yinkentala(2023ZL01).
文摘Accurately simulating water flow movement in vadose zone is crucial for effective water resources assessment.Richards'equation,which describes the movement of water flow in the vadose zone,is highly nonlinear and challenging to solve.Existing numerical methods often face issues such as numerical dispersion,oscillation,and mass non-conservation when spatial and temporal discretization conditions are not appropriately configured.To address these problems and achieve accurate and stable numerical solutions,a finite analytic method based on water content-based Richards'equation(FAM-W)is proposed.The performance of the FAM-W is compared with analytical solutions,Finite Difference Method(FDM),and Finite Analytic Method based on the pressure Head-based Richards'equation(FAM-H).Compared to analytical solution and other numerical methods(FDM and FAM-H),FAM-W demonstrates superior accuracy and efficiency in controlling mass balance errors,regardless of spatial step sizes.This study introduces a novel approach for modelling water flow in the vadose zone,offering significant benefits for water resources management.
基金funded this manuscript for the Central Universities(Grant Nos.2662023DKPY004 and 2662021DKQD005).
文摘The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies using vari‑ous analytical methods have identified peculiar trends in various illnesses,with Firmicutes being the most prevalent phylum,followed by Bacteroidetes,Proteobacteria,and Actinobacteria.However,more Firmicutes and fewer Bac‑teroidetes have been observed in cats infected with Feline coronavirus.Alterations in the composition of these gut microbiota can be solved by microbiota modification through dietary fiber,probiotics,and fecal microbiota transplan‑tation.Therefore,it is critical to understand the composition of the gut microbiota,the changes in and roles of the gut environment,and the importance of these concepts for overall health while considering the exchange of microbes between humans and domestic animals.This review provides comprehensive information on feline gut microbiota composition,modulation,and analytic methods used for characterizing the gut microbiota.
基金supported in part by the National Natural Science Foundation of China under Grant 52125701.
文摘Compared to the conventional permanent magnet synchronous machine(PMSM),the main characteristic of permanent magnet torque machine(PMTM)with high torque is that armature current is high,which has a great influence on magnetic circuit saturation,so this paper proposes a novel analytical method(AM)considering this problem.The key of this new AM is to consider armature reaction flux and armature leakage flux,which are closely related to output torque.Firstly,the expressions,including magnetomotive force(MMF)generated by permanent magnets(PMs)and armature windings are derived,and meanwhile slotting effect is considered by planning flux path.In addition,the expression of leakage flux density generated by armature windings are calculated,and flux density equivalence coefficient of tooth is calculated to be 2/3,which is used to solve the problem of uneven saturation of each tooth.Then,based on main flux factor and leakage flux factor proposed,an improved iteration process is proposed,and by this new process,the flux density of each yoke and tooth can be obtained,which is beneficial to obtain more accurate air-gap flux density and flux linkage.Finally,a prototype of 60-pole 54-slot is fabricated,and the performances of the electric machine,such as back electromotive force(EMF)and output torque,are calculated by this new AM and finite element method(FEM).The results of FEM and experimental test show that this new AM is good enough to calculate the performance of PMTM.
基金National Natural Science Foundation of China(Grant No.30225047 and 30701038)
文摘The chiral nature of biological systems enables their stereoselective interaction with chiral compounds. It has been well documented that the enantiomers ofa chiral drug may show differences in drug disposition especially in metabolic behavior. As a result, it is of vital importance to separate the enantiomers of a chiral drug in metabolic studies. This paper discusses enantioselective methods （include high-performance liquid chromatography, gas chromatography, capillary electrophoresis and high-performance liquid chromatography-mass spectrometry） that applied in chiral drug metabolism, using most recent examples where possible.
基金Project supported by the National Natural Science Foundation of China (No. 20437020 20575073) NSFC-JSPS Joint Research Project (No. 20511140134) the Major Research Program of Chinese Academy of Sciences (KZCX3-SW-432)
文摘In the present work, the different sample collection, pretreatment and analytical methods for polycyclic aromatic hydrocarbons （PAHs） in airborne particulates is systematacially reviewed, and the applications of these pretreatment and analytical methods for PAHs are compared in detail. Some comments on the future expectation are also presented.
基金supported by the National Natural Science Foundation of China (Grant No. 81430087, 81673396, 81603182)
文摘Nanoliposomes are considered to be the most successful nanoparticle drug delivery system, but their fate in vivo has not been fully understood due to lack of reliable bioanalytical methods, which seriously limits the development of liposomal drugs. Hence, an overview of currently used bioanalytical methods is imperative to lay the groundwork for the need of developing a bioanalytical method for liposome measurements in vivo. Currently, major analytical methods for nanoliposomes measurement in vivo include fluorescence labeling, radiolabeling, magnetic resonance imaging（MRI）, mass spectrometry and computed tomography. In this review, these bioanalytical methods are summarized, and the advantages and disadvantages of each are discussed. We provide insights into the applicability and limitations of these analytical methods in the application of nanoliposomes measurement in vivo, and highlight the recent development of instrumental analysis techniques. The review is devoted to providing a comprehensive overview of the investigation of nanoliposomes design and associated fate in vivo, promoting the development of bioanalytical techniques for nanoliposomes measurement, and understanding the pharmacokinetic behavior, effectiveness and potential toxicity of nanoliposomes in vivo.
文摘Assessment of acid sulfate soil risk is an important step for acid sulfate soil management and its reliability depends very much on the suitability and accuracy of various analytical methods for estimating sulfide-derived potential acidity, actual acidity and acid-neutralizing capacity in acid sulfate soils. This paper critically reviews various analytical methods that are currently used for determination of the above parameters, as well as their implications for environmental risk assessment of acid sulfate soi1s.
文摘Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies. Ever since it was introduced as an effective antifungal agent, many methods have been developed and validated for its assay in pharmaceuticals and biological materials. This article reviews the various methods reported during the last 25 years.
文摘Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma （PPAR-gamma）. It was the tenth-best-selling drug in the U.S. in 2008. This article examines published analytical methods reported so far in the literature for the determination of pioglitazone in biological samples and pharmaceutical formulations. They include various techniques like electrochemical methods, spectrophotometry, capillary electrophoresis, high-performance liquid chromatography, liquid chromatography-electrospray ionization-tandem mass spectrometry and high-performance thin layer chromatography.
文摘The purpose of this study was to investigate the effect of bolt profile on load transfer mechanism of fully grouted bolts in jointed rocks using analytical and numerical methods. Based on the analytical method with development of methods, a new model is presented. To validate the analytical model, five different profiles modeled by ANSYS software. The profile of rock bolts T3 and T4with load transfer capacity,respectively 180 and 195 kN in the jointed rocks was selected as the optimum profiles. Finally, the selected profiles were examined in Tabas Coal Mine. FLAC analysis indicates that patterns 6+7 with2 NO flexi bolt 4 m better than other patterns within the faulted zone.
基金supported by the Natural Science Foundation of China under Grant U22A20214 and Grant 51837010。
文摘A versatile analytical method(VAM) for calculating the harmonic components of the magnetomotive force(MMF) generated by diverse armature windings in AC machines has been proposed, and the versatility of this method has been established in early literature. However, its practical applications and significance in advancing the analysis of AC machines need further elaboration. This paper aims to complement VAM by augmenting its theory, offering additional insights into its conclusions, as well as demonstrating its utility in assessing armature windings and its application of calculating torque for permanent magnet synchronous machines(PMSM). This work contributes to advancing the analysis of AC machines and underscores the potential for improved design and performance optimization.
文摘This study proposed the newly-designed Pelagic and demersal trawls for the fishing vessels operating in Cameroonian waters in pelagic and demersal fishing grounds. The engineering performances of both trawls were investigated using physical modelling method and analytical method based on the predicted equations. In a flume tank, a series of physical model tests based on Tauti’s law were performed to investigate the hydrodynamic and geometrical performances of both trawls and to assess the applicability of the analytical methods based on predicted equations. The results showed that in model scale, the working towing speed and door spread for the pelagic trawl were 3.5 knots and 1.85 m, respectively, and for the bottom trawl net they were 4.0 knots and 1.8 m. At that speed and door spread, the drag force, net opening height, and wing-end spread of the pelagic model trawl were 36.73 N, 0.89 m, and 0.86 m, respectively, and the swept area was 0.76 m<sup>2</sup>. Bottom trawl speed and door spread were 30.43 N, 0.38 m, and 0.45 m, respectively, and the swept area was 0.25 m<sup>2</sup>. The maximum difference between the experimental and analytical results of hydrodynamic performances was less than 56.22% and 41.45%, respectively, for pelagic and bottom trawls, the results of the geometrical performances obtained using predicted equations were close to the experimental results in the flume tank with a maximum relative error less than 12.85%. The newly developed pelagic and bottom trawls had advanced engineering performance for high catch efficiency and selectivity and could be used in commercial fishing operations in Cameroonian waters.
文摘In recent times, the overall interest over Supercritical Fluid Chromatography (SFC) is truly growing within various domains but especially for pharmaceutical analysis. However, in the best of our knowledge modern SFC is not yet applied for drug quality control in the daily routine framework. Among the numerous reported SFC methods, none of them could be found to fully satisfy to all steps of the analytical method lifecycle. Thereby, the present contribution aims to provide an overview of the current and past achievements related to SFC techniques, with a targeted attention to this lifecycle and its successive steps. The included discussions were therefore structured accordingly and emphasizing the analytical method lifecycle in accord with the International Conference on Harmonisation (ICH). Recent and important scientific outputs in the field of analytical SFC, as well as instrumental evolution, qualification strategies, method development methodologies and discussions on the topic of method validation are reviewed.
基金supported by the National Natural Science Foundation of China(Grant No.51679132)the Science and Technology Commission of Shanghai Municipality(Grant No.21ZR1427000)Shanghai Frontiers Science Center of“Full Penetration”Far-Reaching Offshore Ocean Energy and Power.
文摘The layout forms of several breakwater structures can be generalized as asymmetrical arrangements in actual engineering.However,the problem of wave diffraction around asymmetrically arranged breakwaters has not been adequately investigated.In this study,we propose an analytical method of wave diffraction for regular waves passing through asymmetrically arranged breakwaters,and we use the Nyström method to obtain the analytical solution numerically.We compared the results of this method with those of previous analytical solutions and with numerical results to demonstrate the validity of our approach.We also provided diffraction coefficient diagrams of breakwaters with different layout forms.Moreover,we described the analytical expression for the problem of diffraction through long-wave incident breakwaters and presented an analysis of the relationship between the diffraction coefficients and the widths of breakwater gates.The analytical method presented in this study contributes to the limited literature on the theory of wave diffraction through asymmetrically arranged breakwaters.
基金The National Key Research and Development Program of China under contract Nos 2022YFC3104804,2021YFC3101501,and 2017YFC1404103the National Programme on Global Change and Air-Sea Interaction of China under contract No.GASI-IPOVAI-04the National Natural Science Foundation of China under contract Nos 41876014,41606039,and 11801402.
文摘An anisotropic diffusion filter can be used to model a flow-dependent background error covariance matrix,which can be achieved by solving the advection-diffusion equation.Because of the directionality of the advection term,the discrete method needs to be chosen very carefully.The finite analytic method is an alternative scheme to solve the advection-diffusion equation.As a combination of analytical and numerical methods,it not only has high calculation accuracy but also holds the characteristic of the auto upwind.To demonstrate its ability,the one-dimensional steady and unsteady advection-diffusion equation numerical examples are respectively solved by the finite analytic method.The more widely used upwind difference method is used as a control approach.The result indicates that the finite analytic method has higher accuracy than the upwind difference method.For the two-dimensional case,the finite analytic method still has a better performance.In the three-dimensional variational assimilation experiment,the finite analytic method can effectively improve analysis field accuracy,and its effect is significantly better than the upwind difference and the central difference method.Moreover,it is still a more effective solution method in the strong flow region where the advective-diffusion filter performs most prominently.
文摘On the basis of the concept of finite element methods, the rigorous analytical solutions of structural response in terms of the design variables are researched in this paper. The spatial trusses are taken as an example for the solution of the analytical expressions of the explicit displacements which are proved mathematically; then some conclusions are reached that are useful to structural sensitivity analysis and optimization. In the third part of the paper, a generalized geometric programming method is sugviped for the optimal model with the explicit displacement. Finally, the analytical solutions of the displacements of three trusses are given as examples.
基金supported by the Science Foundation of Heilongjiang Administration of Traditional Chinese Medicine(No.2018-21).
文摘Over the past decade,the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry,nuclear magnetic resonance,and multivariate statistics.Currently,metabolomics garners widespread application across diverse fields including drug research and development,early disease detection,toxicology,food and nutrition science,biology,prescription,and chinmedomics,among others.Metabolomics serves as an effective characterization technique,offering insights into physiological process alterations in vivo.These changes may result from various exogenous factors like environmental conditions,stress,medications,as well as endogenous elements including genetic and protein-based influences.The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods,poised to further broaden the scope of this domain.Today,metabolomics has evolved into a valuable and widely accepted instrument in the life sciences.However,comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant.This review aims to fill that gap,providing an overview of current trends and recent advancements in metabolomics.Particular emphasis is placed on sample preparation,sophisticated analytical techniques,and their applications in life science research.
基金supported by the National Natural Science Foundation of China(Grant Nos.:81603182 and 81703607)the Fundamental Research Funds for the Central Universities,China(Grant Nos.:DUT24MS018,DUT23YG228,DUT21RC(3)057)+1 种基金the Open funding of Cancer Hospital of Dalian University of Technology,China(Grant No.:2024-ZLKF-33)the Natural Science Foundation of Liaoning Province,China(Grant No.:2023-MSBA-018).
文摘Green analytical chemistry(GAC)focuses on mitigating the adverse effects of analytical activities on human safety,human health,and environment.In addition to the 12 principles of GAC,proper GAC tools should be developed and employed to assess the greenness of different analytical assays.The 15 widely used GAC metrics,i.e.,national environmental methods index(NEMI),advanced NEMI,assessment of green profile(AGP),chloroform-oriented toxicity estimation scale(ChlorTox Scale),Analytical Eco-Scale,Green Certificate Modified Eco-Scale,analytical method greenness score(AMGS),green analytical procedure index(GAPI),ComplexGAPI,red-green-blue(RGB)additive color model,RGB 12 algorithm,analytical greenness calculator(AGREE),AGREE preparation(AGREEprep),HEXAGON,and blue applicability grade index(BAGI),are selected as the typical tools.This article comprehensively presents and elucidates the principles,characteristics,merits,and demerits of 15 widely used GAC tools.This review is helpful for researchers to use the current GAC metrics to assess the environmental sustainability of analytical assays.
文摘Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely used“generic”(absolute intensity)cut-point approach has limited generalisability to population-level free-living data.Further,current methods generally fail to account for differences in people's physical capacity.
文摘This special issue focuses on simulation optimization(SO),which combines stochastic simulation with optimization techniques to address complex decisionmaking problems under uncertainty.SO has gained increasing importance in areas such as transportation,supply chain and manufacturing,providing solutions where traditional analytical methods may fail.Recent advances in computing,data analytics,and artificial intelligence have significantly enhanced the efficiency and capability of SO methods,enabling the development of innovative techniques.This special issue aims to highlight recent theoretical and practical advancements in SO,showcasing its potential to solve real-world problems and inspiring further research and application in this dynamic field.
