Interferon regulatory factors(IRFs)are transcription factors with a conserved N-terminal helix-loop-helix DNA-binding domain 1.IRF family plays a pivotal role in regulating interferon transcription,immune cell develop...Interferon regulatory factors(IRFs)are transcription factors with a conserved N-terminal helix-loop-helix DNA-binding domain 1.IRF family plays a pivotal role in regulating interferon transcription,immune cell development,cell growth,apoptosis,and oncogenesis.2 Despite considerable research,the roles of IRFs in cancer development,metastasis,drug resistance,and prognosis remain unclear.Through multidimensional correlation analysis,we examined the association between IRFs and various cancer characteristics,including clinical and immune subtype analysis,stemness,tumor microenvironment(TME),and drug sensitivity,by utilizing The Cancer Genome Atlas(TCGA)data.Moreover,the classification and prognostic role of IRF1 were further validated through immunohistochemistry staining of kidney renal papillary cell carcinoma(KIRP)clinical tissues.This research enriches our understanding of the IRFs’roles in cancer and their clinical applications.展开更多
The enigmatic phenomenon of colossal volumetric and uniaxial negative thermal expansion(NTE)in Ca_(2)RuO_(4)has long challenged understanding due to its intertwined electronic,structural,and magnetic degrees of freedo...The enigmatic phenomenon of colossal volumetric and uniaxial negative thermal expansion(NTE)in Ca_(2)RuO_(4)has long challenged understanding due to its intertwined electronic,structural,and magnetic degrees of freedom.Through ab initio molecular dynamics(AIMD),normal-mode decomposition techniques,and anharmonic Grüneisen analysis,we reveal the microscopic origin of its anisotropic expansion.The uniaxial NTE near the metal-to-insulator transition(MIT)arises from phonons with negative Grüneisen parameters coupled to pronounced elastic anisotropy.Octahedral tilts are central yet non-rigid,involving intrinsic shape changes rather than rigid unit modes.AIMD captures the thermal evolution of RuO_(6)rotations,tilts,and antipolar Ca displacements,which modify local tetragonal distortions of the RuO_(6)octahedra and drive the MIT.Our findings provide microscopic insight into NTE in Ca_(2)RuO_(4)and highlight strategies to engineer phase transitions and thermal responses in A_(2)BO_(4)oxides via tailored octahedral distortions.展开更多
基金supported in part by the National Natural Science Foundation of China(No.82002923,82203505).
文摘Interferon regulatory factors(IRFs)are transcription factors with a conserved N-terminal helix-loop-helix DNA-binding domain 1.IRF family plays a pivotal role in regulating interferon transcription,immune cell development,cell growth,apoptosis,and oncogenesis.2 Despite considerable research,the roles of IRFs in cancer development,metastasis,drug resistance,and prognosis remain unclear.Through multidimensional correlation analysis,we examined the association between IRFs and various cancer characteristics,including clinical and immune subtype analysis,stemness,tumor microenvironment(TME),and drug sensitivity,by utilizing The Cancer Genome Atlas(TCGA)data.Moreover,the classification and prognostic role of IRF1 were further validated through immunohistochemistry staining of kidney renal papillary cell carcinoma(KIRP)clinical tissues.This research enriches our understanding of the IRFs’roles in cancer and their clinical applications.
基金supported by JSPS KAKENHI JP24H00374,JST-CREST(JPMJCR22O1)the Kanagawa Institute of Industrial Science and Technology and Design and Engineering by Joint Inverse Innovation for Materials Architecture of the Ministry of Education,Culture,Sports,Science and Technology.The numerical calculations partially were carried out on the TSUBAME4.0 supercomputer at the Institute of Science Tokyo.
文摘The enigmatic phenomenon of colossal volumetric and uniaxial negative thermal expansion(NTE)in Ca_(2)RuO_(4)has long challenged understanding due to its intertwined electronic,structural,and magnetic degrees of freedom.Through ab initio molecular dynamics(AIMD),normal-mode decomposition techniques,and anharmonic Grüneisen analysis,we reveal the microscopic origin of its anisotropic expansion.The uniaxial NTE near the metal-to-insulator transition(MIT)arises from phonons with negative Grüneisen parameters coupled to pronounced elastic anisotropy.Octahedral tilts are central yet non-rigid,involving intrinsic shape changes rather than rigid unit modes.AIMD captures the thermal evolution of RuO_(6)rotations,tilts,and antipolar Ca displacements,which modify local tetragonal distortions of the RuO_(6)octahedra and drive the MIT.Our findings provide microscopic insight into NTE in Ca_(2)RuO_(4)and highlight strategies to engineer phase transitions and thermal responses in A_(2)BO_(4)oxides via tailored octahedral distortions.
