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Simulation Analysis of the Extrusion Process for Complex Cross-Sectional Profiles of Ultra-High Strength AluminumAlloy
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作者 Tianxia Zou Yilin Sun +3 位作者 Fuhao Fan Zhen Zheng Yanjin Xu Baoshuai Han 《Computers, Materials & Continua》 2026年第4期471-491,共21页
Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentrat... Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentration,and forming defects are prone to occur during their extrusion.This study focuses on an Al-Zn-Mg-Cu ultra-high-strength aluminum alloy profile with a double-U,multi-cavity thin-walled structure.Firstly,hot compression experiments were conducted at temperatures of 350○C,400○C,and 450○C,with strain rates of 0.01 and 1.0 s^(−1),to investigate the plastic deformation behavior of the material.Subsequently,a 3D coupled thermo-mechanical extrusion simulation model was established using Deform-3D to systematically analyze the influence of die structure and process parameters on metal flow velocity,effective stress/strain,and temperature distribution.The simulation revealed significant velocity differences,stress concentration,and uneven temperature distribution.Key parameters,including mesh density,extrusion ratio,die fillet,and bearing length,were optimized through full-factorial experiments.This optimization,combined with a stepped flow-guiding die design,effectively improved the metal flow pattern during extrusion.Trial production based on both the initial and optimized parameters were carried out.A comparative analysis demonstrates that the optimized scheme results in a final profile whose cross-section matches the target design closely,with complete filling of complex features and no obvious forming defects.This research provides a valuable reference for the extrusion process optimization and die design of complex-section profiles made from ultra-high-strength aluminum alloys. 展开更多
关键词 Ultra-high-strength aluminum alloy EXTRUSION complex cross-section die optimization process optimization
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Coupled Dynamic Analysis of Offshore Wind Substation Hoisting Process Considering Variation of Hoisting Speed
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作者 REN Junqi LE Conghuan +2 位作者 WANG Kai ZHANG Puyang DING Hongyan 《Journal of Ocean University of China》 2026年第1期91-105,共15页
During the hoisting process of the offshore substation,changes in the hoisting speed can affect the hoisting system.Therefore,this study set four different speed conditions for the lifting and lowering stages of the i... During the hoisting process of the offshore substation,changes in the hoisting speed can affect the hoisting system.Therefore,this study set four different speed conditions for the lifting and lowering stages of the installation process,and studied the impact of different lifting and lowering speeds on the hoisting system under the same environmental conditions through numerical simulation.The results show that during the lifting operation,as the lifting speed increases,the swing motion of the substation and the installation vessel tends to decrease,and the faster the hoisting speed,the more obvious the swing suppression of the substation and the installation vessel,and the smaller the fluctuation in the tension amplitude of the slings and mooring lines.In contrast,during the lowering operation,as the lowering speed increases,the swing motion of the substation and the installation vessel tends to increase,and the faster the lowering speed,the more obvious the swing amplification effect of the substation and the installation vessel.Therefore,during hoisting operations,increasing the lifting speed and reducing the lowering speed can mitigate the motion performance of the hoisting coupling system,reduce the tension amplitude variation of the sling and mooring,and ensure the smooth progress of the hoisting operation. 展开更多
关键词 offshore substation floating installation vessel hoisting process hoisting speed dynamic characteristics
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Cost-Benefit Analysis of Continuous Manufacturing vs. Batch Processing in Biopharmaceutical Engineering Design: A Project Management Perspective
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作者 Yang Ge 《Science International Innovative Medicine》 2025年第3期1-4,共4页
This paper investigates the economic and operational trade-offs between continuous manufacturing and batch processing in the context of biopharmaceutical engineering design,through the lens of project management.The s... This paper investigates the economic and operational trade-offs between continuous manufacturing and batch processing in the context of biopharmaceutical engineering design,through the lens of project management.The study explores the fundamental principles of both manufacturing modes,assesses their implications on capital and operational expenditures,and evaluates their performance against key project management metrics such as cost,time,quality,and risk.Drawing on current regulatory guidance,industrial practices,and technological advances,the paper concludes that while continuous manufacturing offers significant benefits in process efficiency and quality control,its implementation requires substantial upfront investment,risk management,and stakeholder alignment.The study aims to support informed decision-making in early-stage biopharmaceutical facility and process design. 展开更多
关键词 Continuous Manufacturing Batch processing Biopharmaceutical Engineering Cost-Benefit analysis Project Management Facility Design Operational Efficiency Regulatory Compliance
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The power of ChatGPT in processing text:Evidence from analysis and prediction in the exchange rate markets
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作者 Kun Yang Ruxin Deng +1 位作者 Yunjie Wei Shouyang Wang 《Financial Innovation》 2025年第1期3419-3451,共33页
This study investigates the application of large language models in analyzing sentiment features within the exchange rate markets.Traditional natural language processing methods,such as LDA and BERT,are effective in e... This study investigates the application of large language models in analyzing sentiment features within the exchange rate markets.Traditional natural language processing methods,such as LDA and BERT,are effective in extracting topics from text;however,they fail to assess the relative importance of these topics in relation to target exchange rates.To bridge this gap,this paper employs ChatGPT to extract topics from texts and evaluate their importance scores,further enhancing exchange rate forecasting by integrating topic importance into the sentiment analysis framework.Through empirical analysis,the superiority of ChatGPT over LDA and BERT in both topic extraction and importance assessment is demonstrated.Furthermore,this study utilizes the topic importance scores generated by ChatGPT to develop a novel interval-valued sentiment index(TIS index).This index not only accounts for the relative importance of various events influencing exchange rate fluctuations but also captures the dynamic evolution of market sentiment within an interval.Empirical results highlight that the TIS Index significantly enhances the forecasting accuracy of interval models such as TARI and IMLP for exchange rates.These findings further demonstrate the advantages of ChatGPT in sentiment analysis within the foreign exchange market.These findings offer new insights into the application of ChatGPT in financial text research. 展开更多
关键词 ChatGPT Sentiment analysis Exchange rate Topic analysis INTERVAL
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Natural Language Processing for Sentiment Analysis in Social Media Marketing
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作者 Murat Başal 《Economics World》 2025年第1期39-51,共13页
Organizations often use sentiment analysis-based systems or even resort to simple manual analysis to try to extract useful meaning from their customers’general digital“chatter”.Driven by the need for a more accurat... Organizations often use sentiment analysis-based systems or even resort to simple manual analysis to try to extract useful meaning from their customers’general digital“chatter”.Driven by the need for a more accurate way to qualitatively extract valuable product and brand-oriented consumer-generated texts,this paper experimentally tests the ability of an NLP-based analytics approach to extract information from highly unstructured texts.The results show that natural language processing outperforms sentiment analysis for detecting issues from social media data.Surprisingly,the experiment shows that sentiment analysis is not only better than manual analysis of social media data for the goal of supporting organizational decision-making,but may also be disadvantageous for such efforts. 展开更多
关键词 social media marketing emotion analysis natural language
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Enhancing Heart Sound Classification with Iterative Clustering and Silhouette Analysis:An Effective Preprocessing Selective Method to Diagnose Rare and Difficult Cardiovascular Cases
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作者 Sami Alrabie Ahmed Barnawi 《Computer Modeling in Engineering & Sciences》 2025年第8期2481-2519,共39页
In the effort to enhance cardiovascular diagnostics,deep learning-based heart sound classification presents a promising solution.This research introduces a novel preprocessing method:iterative k-means clustering combi... In the effort to enhance cardiovascular diagnostics,deep learning-based heart sound classification presents a promising solution.This research introduces a novel preprocessing method:iterative k-means clustering combined with silhouette score analysis,aimed at downsampling.This approach ensures optimal cluster formation and improves data quality for deep learning models.The process involves applying k-means clustering to the dataset,calculating the average silhouette score for each cluster,and selecting the clusterwith the highest score.We evaluated this method using 10-fold cross-validation across various transfer learningmodels fromdifferent families and architectures.The evaluation was conducted on four datasets:a binary dataset,an augmented binary dataset,amulticlass dataset,and an augmentedmulticlass dataset.All datasets were derived from the Heart Wave heart sounds dataset,a novelmulticlass dataset introduced by our research group.To increase dataset sizes and improve model training,data augmentation was performed using heartbeat cycle segmentation.Our findings highlight the significant impact of the proposed preprocessing approach on the HeartWave datasets.Across all datasets,model performance improved notably with the application of our method.In augmented multiclass classification,the MobileNetV2 model showed an average weighted F1-score improvement of 27.10%.In binary classification,ResNet50 demonstrated an average accuracy improvement of 8.70%,reaching 92.40%compared to its baseline performance.These results underscore the effectiveness of clustering with silhouette score analysis as a preprocessing step,significantly enhancing model accuracy and robustness.They also emphasize the critical role of preprocessing in addressing class imbalance and advancing precision medicine in cardiovascular diagnostics. 展开更多
关键词 Heart sound MURMURS cardiovascular diseases(CVDs) transfer learning convolutional neural network(CNN) deep learning K-means silhouette analysis
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Analysis of the influence of processing of bran stir-baking on the main components of Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair by high-performance liquid chromatography 被引量:5
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作者 方新华 吴鑫 +2 位作者 曹岗 蔡皓 蔡宝昌 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2015年第4期231-235,共5页
The crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pairs, originated from Bai-zhu-shao-yao-san, are used to treat different diseases clinically. In order to evaluate the crude and pr... The crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pairs, originated from Bai-zhu-shao-yao-san, are used to treat different diseases clinically. In order to evaluate the crude and processed Paeoniae Radix-Atractylodis Macrocephalae Rhizoma herbal pairs, a simple, easy, and sensitive high-performance liquid chromatography coupled with diode array detectors was developed for simultaneous determination of nine bioactive components in the herbal pairs. The calibration curve exhibited good linearity(r2≥0.9992). The LODs and LOQs were ≤7.30 and 11.53 μg/m L, respectively. The intra-, inter-day and repeatability RSD values of the nine compounds were less than 3.86%, 2.71%, and 4.29%, respectively. The RSD stability values were less than 3.64%. The recovery of the method was in the range of 96.70%–102.10%, with RSD values less than 3.52%. The developed method can be applied to the intrinsic quality control of crude and processed Paeoniae Radix-Atractylodis Macrocephalae Rhizoma herbal pairs. 展开更多
关键词 High-performance liquid chromatography processing Quantification Paeoniae Radix Alba Atractylodis Macrocephalae Rhizoma
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Call for Papers from Agricultural Products Processing and Storage
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《肉类研究》 北大核心 2026年第4期I0011-I0011,共1页
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ... Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of significant,novel,and high-impact research in the fields of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics. 展开更多
关键词 processing Agricultural Products Consumer Demand
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Changes in border-associated macrophages after stroke: Single-cell sequencing analysis 被引量:2
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作者 Ning Yu Yang Zhao +3 位作者 Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 《Neural Regeneration Research》 2026年第1期346-356,共11页
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro... Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment. 展开更多
关键词 border-associated macrophages CLODRONATE hypoxia ISCHEMIA-REPERFUSION ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor
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Hot Compression Deformation Behavior and Processing Maps of Mg-Zn-Mn(-Sn)-Ca Alloy
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作者 Chen Xia Zhu Yulong +2 位作者 Liu Quanyi Zhang Dingfei Pan Fusheng 《稀有金属材料与工程》 北大核心 2026年第3期627-635,共9页
The hot compression deformation behavior of Mg-6Zn-1Mn-0.5Ca(ZM61-0.5Ca)and Mg-6Zn-1Mn-2Sn-0.5Ca(ZMT612-0.5Ca)alloys was investigated at deformation temperatures ranging from 250℃to 400℃and strain rates varying from... The hot compression deformation behavior of Mg-6Zn-1Mn-0.5Ca(ZM61-0.5Ca)and Mg-6Zn-1Mn-2Sn-0.5Ca(ZMT612-0.5Ca)alloys was investigated at deformation temperatures ranging from 250℃to 400℃and strain rates varying from 0.001 s^(-1) to 1 s^(-1).The results show that the addition of Sn promotes dynamic recrystallization(DRX),and CaMgSn phases can act as nucleation sites during the compression deformation.Flow stress increases with increasing the strain rate and decreasing the temperature.Both the ZM61-0.5Ca and ZMT612-0.5Ca alloys exhibit obvious DRX characteristics.CaMgSn phases can effectively inhibit dislocation motion with the addition of Sn,thus increasing the peak fl ow stress of the alloy.The addition of Sn increases the hot deformation activation energy of the ZM61-0.5Ca alloy from 199.654 kJ/mol to 276.649 kJ/mol,thus improving the thermal stability of the alloy.For the ZMT612-0.5Ca alloy,the optimal hot deformation parameters are determined to be a deformation temperature range of 350–400℃and a strain rate range of 0.001–0.01 s^(-1). 展开更多
关键词 hot deformation constitutive equation processing map deformation activation energy magnesium alloy
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Statistics and Development Analysis of Urban Rail Transit in China by the End of 2025
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作者 WANG Fuwen LIANG Shuaiwen FENG Aijun 《隧道建设(中英文)》 北大核心 2026年第2期437-444,I0005-I0012,共16页
First,statistics on the operational lines and mileage of urban rail transit in China are conducted.The results show that,as of Dec.31,2025,there were 60 cities with urban rail transit in operation nationwide,with a to... First,statistics on the operational lines and mileage of urban rail transit in China are conducted.The results show that,as of Dec.31,2025,there were 60 cities with urban rail transit in operation nationwide,with a total operational mileage of approximately 12837.8 km(excluding the electronic guideway rubber-tired system,there were 57 cities,with a total operational mileage of 12651.6 km).The metro system dominates,while low-capacity systems exhibit a multi-modal development pattern.Subsequently,the characteristics of China′s urban rail transit industry development are analyzed,indicating that:(1)It should closely align with the theme of urban intensive development,promote quality improvement and efficiency enhancement of existing lines,and focus on the supporting role of initial passenger flow for new line construction,multi-network integration,and economic and financial sustainability.(2)Significant innovative achievements have been made in safety resilience,green and low-carbon development,intelligent construction,and digital transformation.Finally,development recommendations for the"15th Five-Year Plan"period are proposed:promoting cost reduction and efficiency improvement in the rail transit industry,enhancing the operational efficiency of existing networks,continuously exploring railway services for urban commuting,strengthening external exchanges,and driving the"going global"strategy of the urban rail transit industry. 展开更多
关键词 rail transit operational lines data statistics development analysis
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Crystal structure,thermal analysis,and luminescence properties of six heterocyclic lanthanide complexes
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作者 SONG Zihe ZHAO Jinjin +1 位作者 REN Ning ZHANG Jianjun 《无机化学学报》 北大核心 2026年第1期181-192,共12页
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'... Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6. 展开更多
关键词 lanthanide complexes fluorescence property crystal structure thermal analysis
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Call for Papers from Agricultural Products Processing and Storage
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《肉类研究》 北大核心 2026年第1期I0017-I0017,共1页
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ... Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics. 展开更多
关键词 NUTRITION SCIENCE open access journal agricultural products processing STORAGE technology ENGINEERING agricultural product
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Cavity ring-down spectroscopy CO gas sensor integrating principal component analysis with savitzky-golay filtering
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作者 GUO Zi-long SHI Cheng-rui +4 位作者 DONG Yuan-yuan ZHANG Lei SUN Xiao-yuan SUN Jing-jing ZHOU Sheng 《中国光学(中英文)》 北大核心 2026年第1期179-189,共11页
The Savitzky-Golay(SG)filter,which employs polynomial least-squares approximations to smooth data and estimate derivatives,is widely used for processing noisy data.However,noise suppression by the SG filter is recogni... The Savitzky-Golay(SG)filter,which employs polynomial least-squares approximations to smooth data and estimate derivatives,is widely used for processing noisy data.However,noise suppression by the SG filter is recognized to be limited at data boundaries and high frequencies,which can significantly reduce the signal-to-noise ratio(SNR).To solve this problem,a novel method synergistically integrating Principal Component Analysis(PCA)with SG filtering is proposed in this paper.This approach avoids the is-sue of excessive smoothing associated with larger window sizes.The proposed PCA-SG filtering algorithm was applied to a CO gas sensing system based on Cavity Ring-Down Spectroscopy(CRDS).The perform-ance of the PCA-SG filtering algorithm is demonstrated through comparison with Moving Average Filtering(MAF),Wavelet Transformation(WT),Kalman Filtering(KF),and the SG filter.The results demonstrate that the proposed algorithm exhibits superior noise reduction capabilities compared to the other algorithms evaluated.The SNR of the ring-down signal was improved from 11.8612 dB to 29.0913 dB,and the stand-ard deviation of the extracted ring-down time constant was reduced from 0.037μs to 0.018μs.These results confirm that the proposed PCA-SG filtering algorithm effectively improves the smoothness of the ring-down curve data,demonstrating its feasibility. 展开更多
关键词 cavity ring-down spectroscopy CO gas sensor principal component analysis Savitzky-Golay filter
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Artificial intelligence-assisted non-metallic inclusion particle analysis in advanced steels using machine learning:A review
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作者 Gonghao Lian Xiaoming Liu +3 位作者 Qiang Wang Chunguang Shen Yi Wang Wangzhong Mu 《International Journal of Minerals,Metallurgy and Materials》 2026年第2期401-416,共16页
The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial in... The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial intelligence(AI)-based machine learning(ML)has developed rapidly.This technique has achieved impressive results in the field of inclusion classification in process metallurgy.The present study surveys the ML modeling of inclusion prediction in advanced steels,including the detection,classification,and feature prediction of inclusions in different steel grades.Studies on clean steel with different features based on data and image analysis via ML are summarized.Regarding the data analysis,the inclusion prediction methodology based on ML establishes a connection between the experimental parameters and inclusion characteristics and analyzes the importance of the experimental parameters.Regarding the image analysis,the focus is placed on the classification of different types of inclusions via deep learning,in comparison with data analysis.Finally,further development of inclusion analyses using ML-based methods is recommended.This work paves the way for the application of AIbased methodologies for ultraclean-steel studies from a sustainable metallurgy perspective. 展开更多
关键词 machine learning inclusion classification image analysis data analysis clean steel
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Comprehensive pan-cancer analysis of the receptor-interacting protein kinase family expression,genomic alterations,and functional implications
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作者 Wan-Rong Li Xin Li Jian Wang 《Life Research》 2026年第1期35-44,共10页
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations... Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications. 展开更多
关键词 RIPK family pan-cancer analysis tumor mutation burden microsatellite instability gene set enrichment analysis
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Motion Performance Analysis of Offshore Lifting for Wind-Fishery Integrated Aquaculture Net Cage Considering Multi-Body Coupling Effects
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作者 WANG Wanqi YU Tongshun +2 位作者 LU Peng ZHAO Hui TAO Wei 《南方能源建设》 2026年第1期1-15,共15页
[Objective]This study aims to investigate the multi-body hydrodynamic interaction mechanisms during offshore lifting operations of aquaculture net cages in wind-fishery integration systems.By integrating numerical sim... [Objective]This study aims to investigate the multi-body hydrodynamic interaction mechanisms during offshore lifting operations of aquaculture net cages in wind-fishery integration systems.By integrating numerical simulations and dynamic analysis methods,this study systematically investigates the coupled dynamic response characteristics during the cage-carrier vessel separation process to reveal its dynamic evolution patterns and key influence mechanisms.[Method]Based on potential flow theory,a fully coupled dynamic analysis model of crane vessel-net cage-semi-submersible barge was established for a marine ranch project in Guangdong.The complete lifting process was dynamically simulated using SESAM software.Five typical operating sea states were configured to investigate the influence of wave parameters on the system's motion response under combined wave-current-wind actions.[Result]The results demonstrate that wave period dominates the system stability.Under short-period conditions,the system maintains stable motion with relatively small horizontal relative displacements,while long-period conditions excite low-frequency resonance,leading to significant slow-drift motions.Vertical response analysis reveals that long-period waves cause severe relative displacement fluctuations between the cage and semi-submersible vessel,with actual displacement amplitudes doubling the preset safety target of 2.045 m.Quantitative analysis further indicates that when significant wave height increases from 1.0 m to 1.5 m,the actual displacement amplitude increases by approximately 20%relative to the target displacement of 2.045 m,demonstrating that its influence is significantly weaker than the displacement variations induced by wave period changes.The complete dynamic simulation successfully captures the continuous dynamic response characteristics during the lifting process.[Conclusion]This research clarifies the influence mechanisms of wave parameters on the cage lifting process,identifying wave period as the crucial factor for operational safety.An operation window assessment method incorporating multi-body coupling effects is established,proposing a safety criterion with peak period not exceeding six seconds as the core requirement.The findings provide theoretical foundation for safe installation of marine ranch net cages and offer valuable references for similar offshore lifting operations. 展开更多
关键词 wind-fishery integration offshore lifting hydrodynamic analysis multi-body coupling analysis motion response safe operation window
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Source-Text Processing in Xu-Argument-Based Continuation Writing:An Eye-Tracking Study
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作者 Wei Gao Jinyang Li Duanhui Yuan 《Chinese Journal of Applied Linguistics》 2026年第1期21-37,159,共18页
This study investigated the effects of xu-argument-based continuation writing on learners’processing of source texts.Seventy-five participants were randomly assigned to three conditions:(1)continuation writing,(2)sum... This study investigated the effects of xu-argument-based continuation writing on learners’processing of source texts.Seventy-five participants were randomly assigned to three conditions:(1)continuation writing,(2)summary writing,or(3)reading comprehension.Eye-tracking data were collected during reading,measuring early(first fixation duration,first pass duration)and late(go-past time,total fixation duration)eye movements.During writing,source-text rereading was tracked via fixation counts and durations.Results showed that task type did not affect initial lexical access,as first fixation duration showed no group differences.However,both production groups exhibited significantly longer first pass durations than the reading comprehension group.Late measures revealed a gradient pattern:the continuation writing group spent significantly longer gopast time and total fixation duration than the summary writing group,which exceeded the reading comprehension group.This indicates that continuation tasks promoted deeper cognitive engagement during reading.During writing,the continuation writing group spent more time rereading the source text with higher fixation counts than the summary writing group.These findings suggest that continuation writing triggers more intensive reader-text interaction during pre-writing and enhances comprehension-production coupling through sustained attention to input during writing.This study sheds light on the cognitive mechanisms underlying the theoretical and pedagogical value of xu-argument. 展开更多
关键词 xu-argument continuation writing source-text processing EYE-TRACKING
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Basic research and industrial development status of suancai in Northeast China:history,microflora diversity,processing technology,nutrition and safety
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作者 Qianqian Wang Jingbo Yang +7 位作者 Yuqi Wang Meiru Xie Xiaoxi Qi Ramnarain Ramakrishna Libo Liu Wenkui Guo Guofang Zhanga Chun Li 《Food Science and Human Wellness》 2026年第1期13-27,共15页
Suancai has a lengthy history and a wide range of categories,which has some influence on the pickled diet culture around the world.Suancai production is transitioning to a large-scale,standardized production due to th... Suancai has a lengthy history and a wide range of categories,which has some influence on the pickled diet culture around the world.Suancai production is transitioning to a large-scale,standardized production due to the growth of the market.It has a unique flavor and is rich in nutrients,and its abundance of free amino acids,vitamins and phenolics has many positive effects on the human body.This review gives the types and history of suancai,as well as its impact on the world’s pickled culture.The changes in nutritional composition and flavor of suancai during fermentation are summarized.It presented the production technology and influencing factors of the northeast suancai,examined the quality and safety issues in suancai,and put forth some ideas and opinions on the standardization development of the suancai industry.It also summarized the geographic distribution and flora diversity of pickles around the world.In order to provide some knowledge and guidance for the promotion of modern industrial production in the suancai industry. 展开更多
关键词 Fermented vegetables Microbial community process NUTRITION SAFETY
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Advanced isoconversional kinetic analysis of lepidolite sulfation product decomposition reactions for selectively extracting lithium
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作者 Yubo Liu Baozhong Ma +4 位作者 Jiahui Cheng Xiang Li Hui Yang Chengyan Wang Yongqiang Chen 《International Journal of Minerals,Metallurgy and Materials》 2026年第1期217-227,共11页
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A... The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium. 展开更多
关键词 LITHIUM LEPIDOLITE decomposition reactions KINETICS isoconversional analysis
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