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Motion Performance Analysis of Offshore Lifting for Wind-Fishery Integrated Aquaculture Net Cage Considering Multi-Body Coupling Effects
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作者 WANG Wanqi YU Tongshun +2 位作者 LU Peng ZHAO Hui TAO Wei 《南方能源建设》 2026年第1期1-15,共15页
[Objective]This study aims to investigate the multi-body hydrodynamic interaction mechanisms during offshore lifting operations of aquaculture net cages in wind-fishery integration systems.By integrating numerical sim... [Objective]This study aims to investigate the multi-body hydrodynamic interaction mechanisms during offshore lifting operations of aquaculture net cages in wind-fishery integration systems.By integrating numerical simulations and dynamic analysis methods,this study systematically investigates the coupled dynamic response characteristics during the cage-carrier vessel separation process to reveal its dynamic evolution patterns and key influence mechanisms.[Method]Based on potential flow theory,a fully coupled dynamic analysis model of crane vessel-net cage-semi-submersible barge was established for a marine ranch project in Guangdong.The complete lifting process was dynamically simulated using SESAM software.Five typical operating sea states were configured to investigate the influence of wave parameters on the system's motion response under combined wave-current-wind actions.[Result]The results demonstrate that wave period dominates the system stability.Under short-period conditions,the system maintains stable motion with relatively small horizontal relative displacements,while long-period conditions excite low-frequency resonance,leading to significant slow-drift motions.Vertical response analysis reveals that long-period waves cause severe relative displacement fluctuations between the cage and semi-submersible vessel,with actual displacement amplitudes doubling the preset safety target of 2.045 m.Quantitative analysis further indicates that when significant wave height increases from 1.0 m to 1.5 m,the actual displacement amplitude increases by approximately 20%relative to the target displacement of 2.045 m,demonstrating that its influence is significantly weaker than the displacement variations induced by wave period changes.The complete dynamic simulation successfully captures the continuous dynamic response characteristics during the lifting process.[Conclusion]This research clarifies the influence mechanisms of wave parameters on the cage lifting process,identifying wave period as the crucial factor for operational safety.An operation window assessment method incorporating multi-body coupling effects is established,proposing a safety criterion with peak period not exceeding six seconds as the core requirement.The findings provide theoretical foundation for safe installation of marine ranch net cages and offer valuable references for similar offshore lifting operations. 展开更多
关键词 wind-fishery integration offshore lifting hydrodynamic analysis multi-body coupling analysis motion response safe operation window
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Micropolar homogenization constitutive modeling and size effect analysis of lattice materials
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作者 Tingrui CHEN Fan YANG +2 位作者 Jingchun ZHANG Dong HAN Qingcheng YANG 《Applied Mathematics and Mechanics(English Edition)》 2026年第1期39-60,共22页
Lattice materials have demonstrated promising potential in engineering applications owing to their exceptional lightweight,high specific strength,and tunable mechanical properties.However,the traditional homogenizatio... Lattice materials have demonstrated promising potential in engineering applications owing to their exceptional lightweight,high specific strength,and tunable mechanical properties.However,the traditional homogenization methods based on the classical elasticity theory struggle to accurately describe the non-classical mechanical behaviors of lattice materials,especially when dealing with complex unit-cell geometries featured by non-symmetric configurations or non-single central node connections.In response to this limitation,this study establishes a generalized homogenization model based on the micropolar theory framework,employing Hill's boundary conditions to precisely predict the equivalent moduli of complex lattice materials.By introducing the independent rotational degree of freedom(DOF)characteristic of the micropolar theory,the proposed model successfully overcomes the limitation of conventional methods in accurately describing the asymmetric deformation and scale effects.We initially calculate the constitutive relations of two-dimensional(2D)cross-shaped multi-node chiral lattices and subsequently extend the method to three-dimensional(3D)lattices,successfully predicting the mechanical properties of both traditional and eccentric body-centered cubic(BCC)lattices.The theoretical model is validated through the finite element numerical verification which shows excellent consistency with the theoretical predictions.A further parametric study investigates the influence of geometric parameters,revealing the underlying size-effect mechanism.This paper provides a reliable theoretical tool for the design and property optimization of complex lattice materials. 展开更多
关键词 lattice material size effect micropolar theory homogenization method constitutive relationship
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From ancient herb to modern miracle:an in-depth analysis of the cardioprotective effects of artemisinin and its derivatives
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作者 Hao-Shuang LI Shu-Rong LI +6 位作者 Wen-Jue LIU Yuan ZHANG Rui WU Xu-Yang CUI Jia-Zheng SUN You-Wei MA Ying ZHAO 《Journal of Geriatric Cardiology》 2026年第1期45-64,共20页
Significant progress has been recently made in studying artemisinin and its derivatives for treating cardiovascular diseases,making this area a prominent research focus.Artemisinin,discovered with great acclaim,was in... Significant progress has been recently made in studying artemisinin and its derivatives for treating cardiovascular diseases,making this area a prominent research focus.Artemisinin,discovered with great acclaim,was initially and widely adopted in antimalarial treatments.As scientific research steadily progressed,its latent potential role in the cardiovascular system gradually captured the attention of the global scientific community.Artemisinin and its derivatives can reportedly play a protective role in the cardiovascular system through various mechanisms,including anti-inflammatory,anti-angiogenic,antioxidant,and anti-fibrotic effects,as well as the regulation of blood lipids and blood pressure.In particular,they have shown promising therapeutic effects in models of cardiovascular diseases such as atherosclerosis,myocardial ischaemia,and cardiac hypertrophy.In addition,artemisinin and its derivatives can improve cardiovascular function and prevent cardiovascular injury by regulating signalling pathways closely related to cardiovascular disease,such as AMPK and NF-kB.Although numerous ex vivo and in vivo experiments have verified the potential role of artemisinin in treating cardiovascular diseases,systematic studies to comprehensively elucidate its specific mechanism of action remain scarce.Further exploration of the precise roles of artemisinin and its derivatives in cardiovascular disease therapy,along with their potential clinical applications,could offer valuable insights for future research and treatment strategies. 展开更多
关键词 antimalarial treatmentsas ARTEMISININ cardiovascular diseasesmaking myocardial ischemia cardiac hypertrophy cardiovascular system cardioprotective effects ATHEROSCLEROSIS
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Evaluation of the protective effects of Crocus sativus L.against cypermethrin induced reproductive toxicity in male rats through the Nrf2 pathway and in silico ADMET analysis
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作者 Fareena Tariq Farah Ijaz +9 位作者 Yasameen Hameed Jasim Farah Naz Channa Sohail Ahmed Ahmed Shandookh Hameed Sobia Alyas Ahmed Raheem Rayshan Tahira Bibi Nazima Yousaf Khan Sadia Bibi Jameel Ahmed Buzdar 《Traditional Medicine Research》 2026年第3期12-25,共14页
Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to i... Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice. 展开更多
关键词 Crocus sativus L. CYPERMETHRIN male reproductive toxicity Nrf2 pathway in silico ADMET analysis
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Effects of Healthcare Failure Mode and Effect Analysis on the Prevention of Deep Venous Thrombosis in Elderly Patients Undergoing Femoral Fracture Surgery
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作者 Qiuxia He Maoping Fan +2 位作者 Yuhui Zeng Xixi Ge Jiehua Zhao 《Journal of Clinical and Nursing Research》 2025年第6期17-23,共7页
Purpose:To evaluate the effects of healthcare failure mode and effect analysis(FMEA)on the prevention of deep venous thrombosis(DVT)in elderly patients undergoing femoral fracture surgery.Methods:Eighty elderly patien... Purpose:To evaluate the effects of healthcare failure mode and effect analysis(FMEA)on the prevention of deep venous thrombosis(DVT)in elderly patients undergoing femoral fracture surgery.Methods:Eighty elderly patients undergoing femoral fracture surgery who did not apply FMEA in Suzhou BenQ Medical Center from June 1,2022 to May 31,2023 were selected as the control group.According to the equal group experiment method,80 elderly patients who were managed using FMEA from June 1,2023 to May 31,2024 were selected as the FMEA group.The control group received traditional nursing management,while the FMEA group applied FMEA to analyze failure causes,calculate Risk Priority Numbers(RPNs),identify failure modes with higher RPNs,analyze the influencing factors,develop improvement measures,and optimize processes.The RPN values and the incidence of DVT,as well as nursing satisfaction scores,were compared in the two groups.Results:Compared with the control group,the total RPN values of the FEMA group decreased significantly,with a reduction rate of 87.0%.Besides,the incidence of DVT was 1.3%in the FMEA group,lower than 10.0%in the control group(8/80).What’s more,the patients in the FMEA group were more satisfied with the nursing service compared with the patients in the control group.Conclusion:The application of the FMEA in elderly patients undergoing femoral fracture surgery has demonstrated its potential to prevent the incidence of DVT,lower RPN values,and improve nursing satisfaction. 展开更多
关键词 Healthcare failure mode and effect analysis Venous thrombosis Femoral fracture
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Sensitivity analysis of the lithospheric magnetic field at satellite altitude:the effects of the inducing field and the shape of the magnetic lithosphere 被引量:1
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作者 JinSong Du YuKun Li +5 位作者 HouPu Li ChangQing Yuan KangAn Zhao JiangSong Gui Pan Zhang ShaoFeng Bian 《Earth and Planetary Physics》 2025年第3期642-652,共11页
As a means of quantitative interpretation,forward calculations of the global lithospheric magnetic field in the Spherical Harmonic(SH)domain have been widely used to reveal geophysical,lithological,and geothermal vari... As a means of quantitative interpretation,forward calculations of the global lithospheric magnetic field in the Spherical Harmonic(SH)domain have been widely used to reveal geophysical,lithological,and geothermal variations in the lithosphere.Traditional approaches either do not consider the non-axial dipolar terms of the inducing field and its radial variation or do so by means of complicated formulae.Moreover,existing methods treat the magnetic lithosphere either as an infinitesimally thin layer or as a radially uniform spherical shell of constant thickness.Here,we present alternative forward formulae that account for an arbitrarily high maximum degree of the inducing field and for a magnetic lithosphere of variable thickness.Our simulations based on these formulae suggest that the satellite magnetic anomaly field is sensitive to the non-axial dipolar terms of the inducing field but not to its radial variation.Therefore,in forward and inverse calculations of satellite magnetic anomaly data,the non-axial dipolar terms of the inducing field should not be ignored.Furthermore,our results show that the satellite magnetic anomaly field is sensitive to variability in the lateral thickness of the magnetized shell.In particular,we show that for a given vertically integrated susceptibility distribution,underestimating the thickness of the magnetic layer overestimates the induced magnetic field.This discovery bridges the greatest part of the alleged gap between the susceptibility values measured from rock samples and the susceptibility values required to match the observed magnetic field signal.We expect the formulae and conclusions of this study to be a valuable tool for the quantitative interpretation of the Earth's global lithospheric magnetic field,through an inverse or forward modelling approach. 展开更多
关键词 lithospheric magnetic field forward calculation spherical harmonic analysis sensitivity analysis satellite magnetism
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Gene Expression Data Analysis Based on Mixed Effects Model
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作者 Yuanbo Dai 《Journal of Computer and Communications》 2025年第2期223-235,共13页
DNA microarray technology is an extremely effective technique for studying gene expression patterns in cells, and the main challenge currently faced by this technology is how to analyze the large amount of gene expres... DNA microarray technology is an extremely effective technique for studying gene expression patterns in cells, and the main challenge currently faced by this technology is how to analyze the large amount of gene expression data generated. To address this, this paper employs a mixed-effects model to analyze gene expression data. In terms of data selection, 1176 genes from the white mouse gene expression dataset under two experimental conditions were chosen, setting up two conditions: pneumococcal infection and no infection, and constructing a mixed-effects model. After preprocessing the gene chip information, the data were imported into the model, preliminary results were calculated, and permutation tests were performed to biologically validate the preliminary results using GSEA. The final dataset consists of 20 groups of gene expression data from pneumococcal infection, which categorizes functionally related genes based on the similarity of their expression profiles, facilitating the study of genes with unknown functions. 展开更多
关键词 Mixed effects Model Gene Expression Data analysis Gene analysis Gene Chip
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Biological activity analysis of baicalin nanodrugs:Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia 被引量:1
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作者 Chenqi Chang Chang Lu +5 位作者 Yu Zheng Lili Lin XiuZhen Chen Linwei Chen Zhipeng Chen Rui Chen 《Journal of Pharmaceutical Analysis》 2025年第7期1619-1633,共15页
Respiratory syncytial virus(RSV)is a ubiquitous respiratory virus that affects individuals of all ages;however,there is a notable lack of targeted treatments.RSV infection is associated with a range of respiratory sym... Respiratory syncytial virus(RSV)is a ubiquitous respiratory virus that affects individuals of all ages;however,there is a notable lack of targeted treatments.RSV infection is associated with a range of respiratory symptoms,including bronchiolitis and pneumonia.Baicalin(BA)exhibits significant therapeutic effects against RSV infection through mechanisms of viral inhibition and anti-inflammatory action.Nonetheless,the clinical application of BA is constrained by its low solubility and bioavailability.In this study,we prepared BA nanodrugs(BA NDs)with enhanced water solubility utilizing the supramolecular self-assembled strategy,and we further conducted a comparative analysis of this pharmacological activity between free drugs and NDs of BA.Both in vitro and in vivo results demonstrated that BA NDs significantly enhanced the dual effects of viral inhibition and inflammation relief compared to free BA,attributed to prolonged lung retention,improved cellular uptake,and increased targeting affinity.Our study confirms that the nanosizing strategy,a straightforward approach to enhance drug solubility,can also increase biological activity compared to free drugs with the same content,thereby providing a potential ND for RSV treatment.This correlation analysis between the existing forms of drugs and their biological activity offers a novel perspective for research on the active ingredients of traditional Chinese medicine. 展开更多
关键词 Respiratory syncytial virus BAICALIN Nanodrugs Biological activity analysis ANTIVIRAL ANTI-INFLAMMATORY
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SCS-Net:A DNN-based electromagnetic shielding effectiveness analysis method for slotted composite structures 被引量:1
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作者 Wanli DU Guangzhi CHEN +4 位作者 Ziang ZHANG Xinsong WANG Shunchuan YANG Xingye CHEN Donglin SU 《Chinese Journal of Aeronautics》 2025年第3期505-520,共16页
As the proportion of composite materials used in aircraft continues to increase, the electromagnetic Shielding Effectiveness (SE) of these materials becomes a critical factor in the electromagnetic safety design of ai... As the proportion of composite materials used in aircraft continues to increase, the electromagnetic Shielding Effectiveness (SE) of these materials becomes a critical factor in the electromagnetic safety design of aircraft structures. The assessment of electromagnetic SE for Slotted Composite Structures(SCSs) is particularly challenging due to their complex geometries and there remains a lack of suitable models for accurately predicting the SE performance of these intricate configurations. To address this issue, this paper introduces SCS-Net, a Deep Neural Network (DNN) method designed to accurately predict the SE of SCS. This method considers the impacts of various structural parameters, material properties and incident wave parameters on the SE of SCSs. In order to better model the SCS, an improved Nicolson-Ross-Weir (NRW) method is introduced in this paper to provide an equivalent flat structure for the SCS and to calculate the electromagnetic parameters of the equivalent structure. Additionally, the prediction of SE via DNNs is limited by insufficient test data, which hinders support for large-sample training. To address the issue of limited measured data, this paper develops a Measurement-Computation Fusion (MCF) dataset construction method. The predictions based on the simulation results show that the proposed method maintains an error of less than 0.07 dB within the 8–10 GHz frequency range. Furthermore, a new loss function based on the weighted L1-norm is established to improve the prediction accuracy for these parameters. Compared with traditional loss functions, the new loss function reduces the maximum prediction error for equivalent electromagnetic parameters by 47%. This method significantly improves the prediction accuracy of SCS-Net for measured data, with a maximum improvement of 23.88%. These findings demonstrate that the proposed method enables precise SE prediction and design for composite structures while reducing the number of test samples needed. 展开更多
关键词 Deep neural networkcs Measurement-computation fusion Electromagnetic shielding effectiveness Slotted composite structures Structural paranmeters
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Effects of advancing tunnel on a loaded pile:Numerical analysis and field measurements
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作者 Cheemin Khoo Hisham Mohamad +3 位作者 Aizat Akmal A.Mohamad Beddelee Phromphat Thansirichaisree Muhammad Farid Ghazali Muhammad Yusoff Mohd Nasir 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第10期6145-6158,共14页
A full-scale research study was conducted during the bored tunnelling of the Klang Valley Mass Rapid Transit-Putrajaya Line beneath an existing building structure in Kuala Lumpur,Malaysia.The primary objective was to ... A full-scale research study was conducted during the bored tunnelling of the Klang Valley Mass Rapid Transit-Putrajaya Line beneath an existing building structure in Kuala Lumpur,Malaysia.The primary objective was to investigate the tunnel-soil-pile interaction at various stages of tunnel excavation.This study combined field measurements and three-dimensional(3D)numerical analysis to understand the transient effects of TBM tunnelling on a loaded pile.An experimental pile was instrumented with vibrating wire strain gauges,an inclinometer,and distributed fibre optic sensors using Brillouin optical time domain analysis.The pile was pre-loaded and continuously monitored in real-time throughout the tunnel construction process.The 3D finite element modelling was used to simulate the pile’s transient responses based on actual tunnel boring machine(TBM)driving data.The study revealed that the zone of influence due to tunnelling effects extended from y¼2D to y¼4D,with the peak effect observed at y¼1D to 1.5D,where D represents the tunnel diameter.The analysis of axial load patterns highlighted transient responses,including tensile loads below the tunnel invert,which propagated upward and subsided due to negative skin friction.The maximum downdrag load observed reached 56%e71%of the pile’s working load.Additionally,pile movement patterns indicated outward deflections as the TBM approached and a return toward the tunnel post-passage,aligning with the predicted behaviour in a negative face loss scenario.This validated numerical framework provides a solid foundation for further parametric studies and enhances the understanding of tunnel-soil-pile interactions. 展开更多
关键词 Field measurement Numerical analysis Tunnel-soil-pile interaction Transient effects Pile responses
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An Analysis of Improving the Effectiveness of Chinese Classroom Teaching in Junior Middle School
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作者 Cengjie Yang 《Journal of Contemporary Educational Research》 2025年第2期90-95,共6页
With the evolution of society,education reform continues to progress,and increasing attention is being paid to the learning outcomes and overall academic quality of junior high school students.As a core subject at thi... With the evolution of society,education reform continues to progress,and increasing attention is being paid to the learning outcomes and overall academic quality of junior high school students.As a core subject at this stage,the effectiveness of Chinese language teaching directly influences students’overall academic performance.Therefore,enhancing the effectiveness of junior high school Chinese classroom teaching has become a key focus for educators.Against this backdrop,this paper explores the significance of building an effective classroom environment in junior high school Chinese teaching and provides an in-depth analysis of strategies to improve teaching effectiveness.The goal is to assist teachers in creating efficient classrooms,fostering students’interest in learning,enhancing their overall competence in Chinese,and ultimately improving teaching quality to contribute to the overall advancement of Chinese language education. 展开更多
关键词 Junior high school Chinese classroom Teaching effectiveness Strategy analysis
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Nonlinear effect analysis and compensation based on improved friction observer for torque rotating stage
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作者 Yingjie Jia Bo Liu +1 位作者 Hui Tang Yuzhang Wei 《Nanotechnology and Precision Engineering》 2025年第3期138-148,共11页
In semiconductor precision packaging and other applications involving alignment of automated equipment,the nonlinear motion caused by structural characteristics and friction effects on torque-type rotating motion stag... In semiconductor precision packaging and other applications involving alignment of automated equipment,the nonlinear motion caused by structural characteristics and friction effects on torque-type rotating motion stages seriously affects output accuracy and stability.To solve this problem,the motion characteristics of a rotating stage and the mechanism by which friction nonlinearity influences accuracy are analyzed in detail.In addition,a compound control strategy based on a kinematic model and the Stribeck friction model is designed.A friction disturbance observer based on output position feedback is improved for simple parameter tuning.Finally,an experimental system is constructed to carry out validation tests,including identification of nonlinear characteristics and performance comparisons.The experimental results show that the linear tracking error of the torque-type rotating stage is less than 1.47µm after adoption of the proposed model-based composite control strategy,and the corresponding rotary angle deviation is less than 0.0153°.The linearity of output motion is increased to 97.59%and the error compensation effect is improved by 51.6%compared with the PID control method.The experimental results confirm that the analysis method adopted here and the proposed compensation strategy can effectively reduce frictional nonlinearity and improve motion accuracy.The proposed method can also be applied to other precision electromechanical systems. 展开更多
关键词 Rotating stage Mechanical analysis Frictional nonlinear effect Disturbance observation
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Cavitation Effects and Flow Field Analysis of a Jet Impingement-Negative Pressure Ammonia Removal Reactor
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作者 Dong Hu Lingxing Hu Facheng Qiu 《Frontiers in Heat and Mass Transfer》 2025年第6期1865-1882,共18页
With the acceleration of industrialization and urbanization,ammonia nitrogen pollution in water bodies has become increasingly severe,making the development of efficient and low-consumption wastewater treatment tech-n... With the acceleration of industrialization and urbanization,ammonia nitrogen pollution in water bodies has become increasingly severe,making the development of efficient and low-consumption wastewater treatment tech-nologies highly significant.This study employs three-dimensional computational fluid dynamics(CFD)to investigate the cavitation mechanisms and flow field characteristics in a novel jet impingement-negative pressure ammonia removal reactor.The simulation,validated by experimental pressure data with a high degree of consistency,utilizes the Mixture model,the Realizable k-εturbulence model,and the Schnerr-Sauer cavitation model.The results demonstrate that the flow velocity undergoes a substantial acceleration within the orifice nozzle,triggering a dramatic pressure drop from an inlet value of approximately 1.17 MPa to below the saturated vapor pressure,reaching as low as−109 kPa,which induces intense cavitation.Cavitation bubbles primarily originate on the inner wall of the nozzle,with the vapor volume fraction peaking at about 0.42 within the orifice.A strong positive correlation was observed between the local vapor fraction and the flow velocity,indicating that cavitation enhances jet intensity.Furthermore,vortex structures near the wall and within the jacket sustain low-pressure zones,facilitating continuous cavitation and efficient mixing.This study quantitatively elucidates the cavitation dynamics and its interplay with the flow field,providing a solid theoretical and numerical basis for optimizing the reactor design to enhance ammonia removal efficiency. 展开更多
关键词 Jet impingement negative-pressure ammonia removal numerical simulation cavitation effects gas phase volume distribution flow field analysis
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Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis
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作者 Zhi-Wei Fu Yue-Jing Li +3 位作者 Ran Yu Rui-Qing Guo Li-Xia Gao Sheng-Xia Zhao 《World Journal of Psychiatry》 SCIE 2025年第1期128-136,共9页
BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current statu... BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children. 展开更多
关键词 Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect
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A Cost-Effectiveness Analysis of Magnetic Resonance Imaging Contrast Agent for Early Diagnosis of Hepatocellular Carcinoma Based on Decision Tree+Partitioned Survival Model
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作者 Shang Yumeng Zhang Fang Dong Li 《Asian Journal of Social Pharmacy》 2025年第2期184-194,共11页
Objective To evaluate the cost-effectiveness of gadopentetate dimeglumine(Gd-DTPA)and gadobenate dimeglumine(Gd-BOPTA)magnetic resonance imaging(MRI)contrast agents for the early diagnosis of hepatocellular carcinoma(... Objective To evaluate the cost-effectiveness of gadopentetate dimeglumine(Gd-DTPA)and gadobenate dimeglumine(Gd-BOPTA)magnetic resonance imaging(MRI)contrast agents for the early diagnosis of hepatocellular carcinoma(HCC)from the perspective of China’s healthcare system.Methods A decision tree+partitioned survival model was constructed for early diagnosis of HCC based on literature data.Taking quality-adjusted life year(QALY)as the main health outcome measure for incremental cost-effectiveness ratio(ICER)analysis,the sensitivity analysis by Monte Carlo simulation was constructed to generate corresponding tornado diagram,incremental cost-effectiveness scatter plot,and cost-effectiveness acceptability curve.Results and Conclusion The basic analysis results showed that the ICER value of Gd-BOPTA diagnostic scheme compared with Gd-DTPA diagnostic scheme was 17302.46 yuan/QALY,which is less than 1 times of China’s gross domestic product(GDP)per capita.The sensitivity analysis results showed that the cost of delayed treatment and timely treatment had a significant impact on the results.When the willingness to pay(WTP)was 1 time of GDP per capita,the probability of cost-effectiveness advantage of Gd-BOPTA diagnostic scheme was 65.30%.When the WTP value is set at 1 times of GDP per capita,Gd-BOPTA MRI has cost-effectiveness advantages for the early diagnosis of HCC. 展开更多
关键词 early HCC GD-DTPA GD-BOPTA cost-effectiveness analysis sensitivity analysis
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Reverse-normal immunopurification:An effective approach for purifying recombinant erythropoietin from its analogues in doping analysis
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作者 Sen He Die Wu +7 位作者 Chengshuai Niu Xinchao Liu Jie Zhang Liangzhi Xie Laurent Martin Kaifeng Liu Xinmiao Zhou Lisi Zhang 《Journal of Sport and Health Science》 2025年第6期107-116,共10页
Background Recombinant erythropoietin(rEPO)is commonly used in therapy but may be abused in sports to enhance endurance.In doping analysis,rEPO can be detected in human urine or blood samples at picogram(pg)levels bas... Background Recombinant erythropoietin(rEPO)is commonly used in therapy but may be abused in sports to enhance endurance.In doping analysis,rEPO can be detected in human urine or blood samples at picogram(pg)levels based on its slightly higher molecular weight(MW)than that of endogenous EPO using western blotting(WB).However,a type of variant erythropoietin(VAR-EPO)encoded by the EPO c.577del variant has a similar MW to rEPO,and these 2 molecules cannot be distinguished using conventional analytical methods.A fit-for-purpose method needs to be developed immediately.Methods In this study,we introduced a reverse–normal immunopurification technique for sample pretreatment to remove VAR-EPO from samples to eliminate its interference with rEPO detection.Firstly,a rabbit monoclonal antibody(mAb)that can specifically recognize trace amounts of VAR-EPO with high affinity was generated.Then,using this antibody to enrich VAR-EPO,we developed reverse–normal immunopurification coupled with WB on the purpose of analyzing rEPO in urine and serum samples.Next,the method was fully validated and evaluated using blank samples,spiked samples and rEPO excreted samples.Finally,the identification criteria of rEPO was established.Results A specific anti-VAR mAb with high affinity was developed.Using it,we developed the doping analytical method for rEPO.Our method effectively detects and removes VAR-EPO,enabling accurate rEPO detection.Conclusion A method has already been applied for rEPO confirmation in routine doping analyses. 展开更多
关键词 ERYTHROPOIETIN Doping analysis IMMUNOPURIFICATION Western blotting
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Theoretical Study and Slip Effect Analysis of Elastic Calculation Methods for Steel-Concrete Composite Beams
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作者 Shaohui Chu Xiangkai Zeng Zhixin Guo 《Journal of World Architecture》 2025年第5期67-74,共8页
Steel-concrete composite beams,due to their superior mechanical properties,are widely utilized in engineering structures.This study systematically investigates the calculation methods for internal forces and load-bear... Steel-concrete composite beams,due to their superior mechanical properties,are widely utilized in engineering structures.This study systematically investigates the calculation methods for internal forces and load-bearing capacity of composite beams based on elastic theory,with a focus on the transformed section method and its application under varying neutral axis positions.By deriving the geometric characteristics of the transformed section and incorporating a reduction factor accounting for slip effects,a computational model for sectional stress and ultimate load-bearing capacity is established.The results demonstrate that the slip effect significantly influences the flexural load-bearing capacity of composite beams.The proposed reduction factor,which considers the influence of the steel beam’s top flange thickness,offers higher accuracy compared to traditional methods.These findings provide a theoretical foundation for the design and analysis of composite beams,with significant practical engineering value. 展开更多
关键词 Composite beam Elastic calculation Slip effect Theoretical study
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Statistics and Analysis on the Learning Effect of Virtual Reality Technology Course
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作者 Liangquan He Nan Chen 《Journal of Contemporary Educational Research》 2025年第8期328-336,共9页
With the rapid development of artificial intelligence technology,the development of virtual reality technology has received increasing attention in various fields.Based on the difficulties in the course construction o... With the rapid development of artificial intelligence technology,the development of virtual reality technology has received increasing attention in various fields.Based on the difficulties in the course construction of“Virtual Reality Technology”,this paper adopts a questionnaire survey method to study the learning effects of students majoring in digital media technology at Guangxi University of Finance and Economics regarding the“Virtual Reality Technology”course.The research mainly involves four aspects:learning content,teaching effectiveness,learning experience,and future development needs.The research analysis in this paper not only provides strong support for the construction of a first-class course in“Virtual Reality Technology”but also offers references for the course construction of digital media technology majors in other universities. 展开更多
关键词 Virtual Reality Technology Course construction Learning effect
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Analysis of Effective Countermeasures of Value-Added Evaluation in Primary School Chinese
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作者 Sisi Chen 《Journal of Contemporary Educational Research》 2025年第11期28-33,共6页
As the enlightenment stage of students’Chinese learning,primary school Chinese education plays a key role in cultivating students’language ability,thinking development,and humanistic literacy.Value-added evaluation,... As the enlightenment stage of students’Chinese learning,primary school Chinese education plays a key role in cultivating students’language ability,thinking development,and humanistic literacy.Value-added evaluation,as an evaluation method that focuses on the changes in students’individual development and attaches importance to the learning process,has gradually attracted attention in the application of primary school Chinese education.This paper first analyzes the problems existing in the current implementation of value-added evaluation in primary school Chinese,and then explores the countermeasures to improve the effectiveness of value-added evaluation in primary school Chinese from the aspects of evaluation concept,evaluation content,evaluation method,evaluation subject,and application of evaluation results.The purpose is to provide strong support for the improvement of primary school Chinese teaching quality and the all-round development of students. 展开更多
关键词 Primary school Chinese Value-added evaluation effectIVENESS Countermeasure research
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