To the Editor:Synthetic lethality(SL)occurs when the simultaneous perturbation of two genes results in cellular death,whereas the perturbation of an individual gene alone is compatible.Colorectal cancer(CRC)is one of ...To the Editor:Synthetic lethality(SL)occurs when the simultaneous perturbation of two genes results in cellular death,whereas the perturbation of an individual gene alone is compatible.Colorectal cancer(CRC)is one of the leading malignancy,ranking third in global incidence and second in mortality.It is widely believed that most CRCs arise from the accumulations of genetic and epigenetic changes.This tumorigenic process,from normal to dysplastic epithelium to carcinoma,along with multiple genetic alterations,is referred to as the adenoma–carcinoma sequence.展开更多
基金The study was supported by grants from the Project of Science and Technology Department of Sichuan Province(No.2023NSFSC1928)the Project of State Administration of Traditional Chinese Medicine of China(No.ZYYCXTD-D-202209)the Fundamental Research Funds for the Central Universities,and the Project of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2022C001).
文摘To the Editor:Synthetic lethality(SL)occurs when the simultaneous perturbation of two genes results in cellular death,whereas the perturbation of an individual gene alone is compatible.Colorectal cancer(CRC)is one of the leading malignancy,ranking third in global incidence and second in mortality.It is widely believed that most CRCs arise from the accumulations of genetic and epigenetic changes.This tumorigenic process,from normal to dysplastic epithelium to carcinoma,along with multiple genetic alterations,is referred to as the adenoma–carcinoma sequence.
