BACKGROUND Major depressive disorder(MDD)with comorbid anxiety is an intricate psychiatric condition,but limited research is available on the degree centrality(DC)between anxious MDD and nonanxious MDD patients.AIM To...BACKGROUND Major depressive disorder(MDD)with comorbid anxiety is an intricate psychiatric condition,but limited research is available on the degree centrality(DC)between anxious MDD and nonanxious MDD patients.AIM To examine changes in DC values and their use as neuroimaging biomarkers in anxious and non-anxious MDD patients.METHODS We examined 23 anxious MDD patients,30 nonanxious MDD patients,and 28 healthy controls(HCs)using the DC for data analysis.RESULTS Compared with HCs,the anxious MDD group reported markedly reduced DC values in the right fusiform gyrus(FFG)and inferior occipital gyrus,whereas elevated DC values in the left middle frontal gyrus and left inferior parietal angular gyrus.The nonanxious MDD group exhibited surged DC values in the bilateral cerebellum IX,right precuneus,and opercular part of the inferior frontal gyrus.Unlike the nonanxious MDD group,the anxious MDD group exhibited declined DC values in the right FFG and bilateral calcarine(CAL).Besides,declined DC values in the right FFG and bilateral CAL negatively correlated with anxiety scores in the MDD group.CONCLUSION This study shows that abnormal DC patterns in MDD,especially in the left CAL,can distinguish MDD from its anxiety subtype,indicating a potential neuroimaging biomarker.展开更多
Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’...Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.展开更多
The mature central nervous system(CNS,composed of the brain,spinal cord,olfactory and optic nerves)is unable to regenerate spontaneously after an insult,both in the cases of neurodegenerative diseases(for example Alzh...The mature central nervous system(CNS,composed of the brain,spinal cord,olfactory and optic nerves)is unable to regenerate spontaneously after an insult,both in the cases of neurodegenerative diseases(for example Alzheimer's or Parkinson's disease)or traumatic injuries(such as spinal cord lesions).In the last 20 years,the field has made significant progress in unlocking axon regrowth.展开更多
AIM:To compare the intravitreal brolucizumab and bevacizumab injections for chronic central serous chorioretinopathy(cCSC).METHODS:Patients with cCSC were classified into bevacizumab and brolucizumab group.The proport...AIM:To compare the intravitreal brolucizumab and bevacizumab injections for chronic central serous chorioretinopathy(cCSC).METHODS:Patients with cCSC were classified into bevacizumab and brolucizumab group.The proportion of complete resolution of subretinal fluid(SRF),best-corrected visual acuity(BCVA),central macular thickness(CMT),and subfoveal choroidal thickness(SFCT)were compared between the two groups.RESULTS:A total of 40 eyes from 40 patients with aged 34-59y were enrolled in the study.Twenty eyes in bevacizumab group(17 males)and 20 eyes(18 males)in brolucizumab group.Comparing the proportion of complete resolution of SRF,the brolucizumab group was statistically significantly higher than the bevacizumab group(P<0.05).In 1mo,CMT was significantly reduced in the brolucizumab group compared to the bevacizumab group(265±69 vs 319±70μm;P=0.021).However,there was no significant difference in CMT between the two groups at 2 and 3mo(P>0.05).CONCLUSION:Brolucizumab is anatomically and functionally superior to bevacizumab in the treatment of patients with cCSC.展开更多
China’s 2025 Central Economic Work Conference,held in Beijing from December 10 to 11,2025,is one of the most consequential policy-setting meetings of the year.Chaired by Xi Jinping,general secretary of the Communist ...China’s 2025 Central Economic Work Conference,held in Beijing from December 10 to 11,2025,is one of the most consequential policy-setting meetings of the year.Chaired by Xi Jinping,general secretary of the Communist Party of China Central Committee and Chinese president,this year's meeting coincided with the final year of the 14th Five-Year Plan,serving as an assessment of accom-plishments while setting the policy direction for the first year of the 15th Five-Year Plan(2026-2030).展开更多
Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery...Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery.We rst derive the projection formulas for a vector onto the feasible sets.The centralized circumcentered-reection method is designed to solve the convex feasibility problem.Some numerical experiments demonstrate the feasibility and e ectiveness of the proposed algorithm,showing superior performance compared to conventional alternating projection methods.展开更多
AIM:To evaluate the therapeutic effects of ranibizumab on optic disc and macular microvascular perfusion in central retinal vein occlusion(CRVO)with macular edema(ME).METHODS:Optical coherence tomography angiology(OCT...AIM:To evaluate the therapeutic effects of ranibizumab on optic disc and macular microvascular perfusion in central retinal vein occlusion(CRVO)with macular edema(ME).METHODS:Optical coherence tomography angiology(OCTA)parameters,including optic disc vessel density(VD;including whole-disc VD,intra-disc VD,and peripapillary VD),superficial/deep capillary plexus(SCP/DCP)VD,and central macular thickness(CMT)were analyzed.Additional assessments included best-corrected visual acuity(BCVA)via Early Treatment Diabetic Retinopathy Study(ETDRS)chart and hemorheological profiling.CRVO patients received monthly intravitreal ranibizumab injections for three consecutive months.Pre-and post-treatment parameters were statistically compared.RESULTS:The study comprised 60 CRVO-ME patients(28 males;32 females),aged 50-78y(mean 63.3±7.6y)and 60 age-/sex-matched healthy controls.As compared with participants exhibiting normal funduscopic findings,CRVO patients demonstrated significantly elevated levels of low-shear-rate whole blood viscosity(LSR-WBV),high-shearrate whole blood viscosity(HSR-WBV),and aggregation index(AI,all P<0.05).In CRVO-affected eyes,vertical cupto-disc(C/D)ratio and optic cup volume were significantly smaller,whereas retinal nerve fiber layer(RNFL)thickness was significantly greater,compared to both unaffected contralateral eyes and normal control eyes(all P<0.05).Following treatment,VD of the entire optic disc(P<0.05),intra-disc VD(P<0.05),and peripapillary VD(P<0.05)all increased significantly relative to baseline.CMT decreased significantly(P<0.05),whereas macular SCP-VD and macular DCP-VD showed non-significant slight reductions(P>0.05).At baseline,BCVA of CRVO eyes correlated with whole-disc VD(r=-0.276,P=0.033),intra-disc VD(r=-0.342,P=0.009),and peripapillary VD(r=-0.335,P=0.007),with intra-disc VD demonstrating the strongest association.Besides,BCVA improvement,after the treatment,correlated positively with whole-disc VD(r=0.342,P=0.008)and intradisc VD(r=0.396,P=0.002).CONCLUSION:Optic disc blood perfusion is more closely associated with visual acuity than macular perfusion,suggesting intra-disc VD may serve as a potential biomarker for monitoring visual acuity changes in CRVO.Multiple ranibizumab injections significantly improve optic disc perfusion but may have exerted detrimental effects on the macula.CRVO patients shows higher hemorheological parameters than those with normal fundi.Reduced vertical C/D ratio and optic cup volume may be linked to CRVO incidence,potentially acting as susceptibility factors.展开更多
In this paper, we propose a new centrality algorithm that can simultaneously rank the nodes and layers of multilayer networks, referred to as the MRFNL centrality. The centrality of nodes and layers are obtained by de...In this paper, we propose a new centrality algorithm that can simultaneously rank the nodes and layers of multilayer networks, referred to as the MRFNL centrality. The centrality of nodes and layers are obtained by developing a novel iterative algorithm for computing a set of tensor equations. Under some conditions, the existence and uniqueness of this centrality were proven by applying the Brouwer fixed point theorem. Furthermore, the convergence of the proposed iterative algorithm was established. Finally, numerical experiments on a simple multilayer network and two real-world multilayer networks(i.e., Pierre Auger Collaboration and European Air Transportation Networks) are proposed to illustrate the effectiveness of the proposed algorithm and to compare it to other existing centrality measures.展开更多
In this work we propose a centrality measure for networks, which we refer to as Laplacian centrality, that provides a general framework for the centrality of a vertex based on the idea that the importance (or centrali...In this work we propose a centrality measure for networks, which we refer to as Laplacian centrality, that provides a general framework for the centrality of a vertex based on the idea that the importance (or centrality) of a vertex is related to the ability of the network to respond to the deactivation or removal of that vertex from the network. In particular, the Laplacian centrality of a vertex is defined as the relative drop of Laplacian energy caused by the deactivation of this vertex. The Laplacian energy of network G with?n?vertices is defined as , where ?is the eigenvalue of the Laplacian matrix of G. Other dynamics based measures such as that of Masuda and Kori and PageRank compute the importance of a node by analyzing the way paths pass through a node while our measure captures this information as well as the way these paths are “redistributed” when the node is deleted. The validity and robustness of this new measure are illustrated on two different terrorist social network data sets and 84 networks in James Moody’s Add Health in school friendship nomination data, and is compared with other standard centrality measures.展开更多
AIM： To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality（DC） method.METHODS： In total, 38 patients with high myopia（HM...AIM： To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality（DC） method.METHODS： In total, 38 patients with high myopia（HM）（17 males and 21 females）, whose binocular refractive diopter were-6.00 to-7.00 D, and 38 healthy controls（17 males and 21 females）, closely matched in age, sex, and education levels, participated in the study. Spontaneous brain activities were evaluated using the voxel-wise DC method. The receiver operating characteristic curve was measured to distinguish patients with HM from healthy controls. Correlation analysis was used to explore the relationship between the observed mean DC values of the different brain areas and the behavioral performance.RESULTS： Compared with healthy controls, HM patients had significantly decreased DC values in the right inferior frontal gyrus/insula, right middle frontal gyrus, and right supramarginal/inferior parietal lobule（P〈0.05）. In contrast, HM patients had significantly increased DC values in the right cerebellum posterior lobe, left precentral gyrus/postcentral gyrus, and right middle cingulate gyrus（P〈0.05）. However, no relationship was found between the observed mean DC values of the different brain areas and the behavioral performance（P〉0.05）.CONCLUSION： HM is associated with abnormalities in many brain regions, which may indicate the neural mechanisms of HM. The altered DC values may be used as a useful biomarker for the brain activity changes in HM patients.展开更多
Based on statistical data and population flow data for 2016,and using entropy weight TOPSIS and the obstacle degree model,the centrality of cities in the Yangtze River Economic Belt(YREB)together with the factors infl...Based on statistical data and population flow data for 2016,and using entropy weight TOPSIS and the obstacle degree model,the centrality of cities in the Yangtze River Economic Belt(YREB)together with the factors influencing centrality were measured.In addition,data for the population flow were used to analyze the relationships between cities and to verify centrality.The results showed that:(1)The pattern of centrality conforms closely to the pole-axis theory and the central geography theory.Two axes,corresponding to the Yangtze River and the Shanghai-Kunming railway line,interconnect cities of different classes.On the whole,the downstream cities have higher centrality,well-defined gradients and better development of city infrastructure compared with cities in the middle and upper reaches.(2)The economic scale and size of the population play a fundamental role in the centrality of cities,and other factors reflect differences due to different city classes.For most of the coastal cities or the capital cities in the central and western regions,factors that require long-term development such as industrial facilities,consumption,research and education provide the main competitive advantages.For cities that are lagging behind in development,transportation facilities,construction of infrastructure and fixed asset investment have become the main methods to achieve development and enhance competitiveness.(3)The mobility of city populations has a significant correlation with the centrality score,the correlation coefficients for the relationships between population mobility and centrality are all greater than 0.86(P<0.01).The population flow is mainly between high-class cities,or high-class and low-class cities,reflecting the high centrality and huge radiating effects of high-class cities.Furthermore,the cities in the YREB are closely linked to Guangdong and Beijing,reflecting the dominant economic status of Guangdong with its geographical proximity to the YREB and Beijing's enormous influence as the national political and cultural center,respectively.展开更多
In many cases randomness in community detection algorithms has been avoided due to issues with stability. Indeed replacing random ordering with centrality rankings has improved the performance of some techniques such ...In many cases randomness in community detection algorithms has been avoided due to issues with stability. Indeed replacing random ordering with centrality rankings has improved the performance of some techniques such as Label Propagation Algorithms. This study evaluates the effects of such orderings on the Speaker-listener Label Propagation Algorithm or SLPA, a modification of LPA which has already been stabilized through alternate means. This study demonstrates that in cases where stability has been achieved without eliminating randomness, the result of removing random ordering is over fitting and bias. The results of testing seven various measures of centrality in conjunction with SLPA across five social network graphs indicate that while certain measures outperform random orderings on certain graphs, random orderings have the highest overall accuracy. This is particularly true when strict orderings are used in each run. These results indicate that the more evenly distributed solution space which results from complete random ordering is more valuable than the more targeted search that results from centrality orderings.展开更多
The zero-degree calorimeter(ZDC)plays a crucial role toward determining the centrality in the Cooling-Storage-Ring External-target Experiment(CEE)at the Heavy Ion Research Facility in Lanzhou.A boosted decision tree(B...The zero-degree calorimeter(ZDC)plays a crucial role toward determining the centrality in the Cooling-Storage-Ring External-target Experiment(CEE)at the Heavy Ion Research Facility in Lanzhou.A boosted decision tree(BDT)multi-classification algorithm was employed to classify the centrality of the collision events based on the raw features from ZDC such as the number of fired channels and deposited energy.The data from simulated^(238)U+^(238)U collisions at 500 MeV∕u,generated by the IQMD event generator and subsequently modeled using the GEANT4 package,were employed to train and test the BDT model.The results showed the high accuracy of the multi-classification model adopted in ZDC for centrality determination,which is robust against variations in different factors of detector geometry and response.This study demon-strates the good performance of CEE-ZDC in determining the centrality in nucleus-nucleus collisions.展开更多
Road network is a corridor system that interacts with surrounding landscapes,and understanding their interaction helps to develop an optimal plan for sustainable transportation and land use.This study investigates the...Road network is a corridor system that interacts with surrounding landscapes,and understanding their interaction helps to develop an optimal plan for sustainable transportation and land use.This study investigates the relationships between road centrality and landscape patterns in the Wuhan Metropolitan Area,China.The densities of centrality measures,including closeness,betweenness,and straightness,are calculated by kernel density estimation(KDE).The landscape patterns are characterized by four landscape metrics,including percentage of landscape(PLAND),Shannon′s diversity index(SHDI),mean patch size(MPS),and mean shape index(MSI).Spearman rank correlation analysis is then used to quantify their relationships at both landscape and class levels.The results show that the centrality measures can reflect the hierarchy of road network as they associate with road grade.Further analysis exhibit that as centrality densities increase,the whole landscape becomes more fragmented and regular.At the class level,the forest gradually decreases and becomes fragmented,while the construction land increases and turns to more compact.Therefore,these findings indicate that the ability and potential applications of centrality densities estimated by KDE in quantifying the relationships between roads and landscapes,can provide detailed information and valuable guidance for transportation and land-use planning as well as a new insight into ecological effects of roads.展开更多
AIM:To explore the intrinsic brain activity variations in retinal vein occlusion(RVO)subjects by using the voxel-wise degree centrality(DC)technique.METHODS:Twenty-one subjects with RVO and twentyone healthy controls(...AIM:To explore the intrinsic brain activity variations in retinal vein occlusion(RVO)subjects by using the voxel-wise degree centrality(DC)technique.METHODS:Twenty-one subjects with RVO and twentyone healthy controls(HCs)were enlisted and underwent the resting-state functional magnetic resonance imaging(rs-f MRI)examination.The spontaneous cerebrum activity variations were inspected using the DC technology.The receiver operating characteristic(ROC)curve was implemented to distinguish the DC values of RVOs from HCs.The relationships between DC signal of definite regions of interest and the clinical characteristics in RVO group were evaluated by Pearson’s correlation analysis.RESULTS:RVOs showed notably higher DC signals in right superior parietal lobule,middle frontal gyrus and left precuneus,but decreased DC signals in left middle temporal gyrus and bilateral anterior cingulated(BAC)when comparing with HCs.The mean DC value of RVOs in the BAC were negatively correlated with the anxiety and depression scale.CONCLUSION:RVO is associated aberrant intrinsic brain activity patterns in several brain areas including painrelated as well as visual-related regions,which might assist to reveal the latent neural mechanisms.展开更多
By using the recent spatially dependent nuclear PDF set EPS09 s, we investigated the centrality-dependent Cold Nuclear Matter(CNM) effects for neutral π, η mesons and inclusive jets at RHIC in d+Au collisions and at...By using the recent spatially dependent nuclear PDF set EPS09 s, we investigated the centrality-dependent Cold Nuclear Matter(CNM) effects for neutral π, η mesons and inclusive jets at RHIC in d+Au collisions and at LHC in p+Pb collisions. The nuclear modification factors as functions of transverse momentum are plotted at different centralities bins respectively. At all fixed centralities, the nuclear modification factors show no significant suppressions,contrast to the strong suppressions observed for central Au+Au collisions. Our results are consistent with the PHENIX preliminary Data in minimum bias and central d+Au collisions. The LHC experimental Data also support our predictions for both single inclusive hadron and inclusive jets productions in central p+Pb collisions. And the centrality dependence of the nuclear suppressions for all the observations in our calculations are lower than the RHIC and LHC Data.展开更多
A new centrality measure for complex networks, called resource flow centrality, is pro- posed in this paper. This centrality measure is based on the concept of the resource flow in net- works. It not only can be appli...A new centrality measure for complex networks, called resource flow centrality, is pro- posed in this paper. This centrality measure is based on the concept of the resource flow in net- works. It not only can be applied to the connected networks, but also the disconnected networks. Moreover, it overcomes some disadvantages of several common centrality measures. The perform- ance of the proposed measure is compared with some standard centrality measures using a classic dataset and the results indicate the proposed measure performs more reasonably. The statistical dis- tribution of the proposed centrality is investigated by experiments on large scale computer generated graphs and two networks from the real world.展开更多
Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central ne...Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central nervous system.Central copper dysregulations have been evidenced in two genetic disorders characterized by mutations in the copper-ATPases ATP7A and ATP7B,Menkes disease and Wilson’s disease,respectively,and also in multifactorial neurological disorders such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and multiple sclerosis.This review summarizes current knowledge about the role of copper in central nervous system physiology and pathology,reports about unbalances in copper levels and/or distribution under disease,describes relevant animal models for human disorders where copper metabolism genes are dysregulated,and discusses relevant therapeutic approaches modulating copper availability.Overall,alterations in copper metabolism may contribute to the etiology of central nervous system disorders and represent relevant therapeutic targets to restore tissue homeostasis.展开更多
Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain met...Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.展开更多
基金Supported by Hubei Provincial Department of Science and Technology Natural Fund,No.2024AFC056the Open Fund of the Mental Health Research Institute at Three Gorges University,No.YCXL-23-11.
文摘BACKGROUND Major depressive disorder(MDD)with comorbid anxiety is an intricate psychiatric condition,but limited research is available on the degree centrality(DC)between anxious MDD and nonanxious MDD patients.AIM To examine changes in DC values and their use as neuroimaging biomarkers in anxious and non-anxious MDD patients.METHODS We examined 23 anxious MDD patients,30 nonanxious MDD patients,and 28 healthy controls(HCs)using the DC for data analysis.RESULTS Compared with HCs,the anxious MDD group reported markedly reduced DC values in the right fusiform gyrus(FFG)and inferior occipital gyrus,whereas elevated DC values in the left middle frontal gyrus and left inferior parietal angular gyrus.The nonanxious MDD group exhibited surged DC values in the bilateral cerebellum IX,right precuneus,and opercular part of the inferior frontal gyrus.Unlike the nonanxious MDD group,the anxious MDD group exhibited declined DC values in the right FFG and bilateral calcarine(CAL).Besides,declined DC values in the right FFG and bilateral CAL negatively correlated with anxiety scores in the MDD group.CONCLUSION This study shows that abnormal DC patterns in MDD,especially in the left CAL,can distinguish MDD from its anxiety subtype,indicating a potential neuroimaging biomarker.
基金supported by the National Key R&D Program of China,No.2021YFC2501200(to PC).
文摘Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.
基金supported by ANR(ANR-21CE16-0008-01)ANR(ANR-21-CE16-0008-02 and ANR-23CE52-0007)+1 种基金UNADEV(A22018CS)(to HN)UNADEV(A22020CS)(to SB)。
文摘The mature central nervous system(CNS,composed of the brain,spinal cord,olfactory and optic nerves)is unable to regenerate spontaneously after an insult,both in the cases of neurodegenerative diseases(for example Alzheimer's or Parkinson's disease)or traumatic injuries(such as spinal cord lesions).In the last 20 years,the field has made significant progress in unlocking axon regrowth.
基金Supported by research fund from Chosun University Hospital,2022.
文摘AIM:To compare the intravitreal brolucizumab and bevacizumab injections for chronic central serous chorioretinopathy(cCSC).METHODS:Patients with cCSC were classified into bevacizumab and brolucizumab group.The proportion of complete resolution of subretinal fluid(SRF),best-corrected visual acuity(BCVA),central macular thickness(CMT),and subfoveal choroidal thickness(SFCT)were compared between the two groups.RESULTS:A total of 40 eyes from 40 patients with aged 34-59y were enrolled in the study.Twenty eyes in bevacizumab group(17 males)and 20 eyes(18 males)in brolucizumab group.Comparing the proportion of complete resolution of SRF,the brolucizumab group was statistically significantly higher than the bevacizumab group(P<0.05).In 1mo,CMT was significantly reduced in the brolucizumab group compared to the bevacizumab group(265±69 vs 319±70μm;P=0.021).However,there was no significant difference in CMT between the two groups at 2 and 3mo(P>0.05).CONCLUSION:Brolucizumab is anatomically and functionally superior to bevacizumab in the treatment of patients with cCSC.
文摘China’s 2025 Central Economic Work Conference,held in Beijing from December 10 to 11,2025,is one of the most consequential policy-setting meetings of the year.Chaired by Xi Jinping,general secretary of the Communist Party of China Central Committee and Chinese president,this year's meeting coincided with the final year of the 14th Five-Year Plan,serving as an assessment of accom-plishments while setting the policy direction for the first year of the 15th Five-Year Plan(2026-2030).
基金Supported by the Natural Science Foundation of Guangxi Province(Grant Nos.2023GXNSFAA026067,2024GXN SFAA010521)the National Natural Science Foundation of China(Nos.12361079,12201149,12261026).
文摘Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery.We rst derive the projection formulas for a vector onto the feasible sets.The centralized circumcentered-reection method is designed to solve the convex feasibility problem.Some numerical experiments demonstrate the feasibility and e ectiveness of the proposed algorithm,showing superior performance compared to conventional alternating projection methods.
基金Central High-Level Traditional Chinese Medicine Hospital Project of Eye Hospital China Academy of Chinese Medical Science(No.GSP5-83,No.GSP4-02No.GSP5-06)+1 种基金Supported by National Natural Science Foundation of China(General ProgramNo.82474582).
文摘AIM:To evaluate the therapeutic effects of ranibizumab on optic disc and macular microvascular perfusion in central retinal vein occlusion(CRVO)with macular edema(ME).METHODS:Optical coherence tomography angiology(OCTA)parameters,including optic disc vessel density(VD;including whole-disc VD,intra-disc VD,and peripapillary VD),superficial/deep capillary plexus(SCP/DCP)VD,and central macular thickness(CMT)were analyzed.Additional assessments included best-corrected visual acuity(BCVA)via Early Treatment Diabetic Retinopathy Study(ETDRS)chart and hemorheological profiling.CRVO patients received monthly intravitreal ranibizumab injections for three consecutive months.Pre-and post-treatment parameters were statistically compared.RESULTS:The study comprised 60 CRVO-ME patients(28 males;32 females),aged 50-78y(mean 63.3±7.6y)and 60 age-/sex-matched healthy controls.As compared with participants exhibiting normal funduscopic findings,CRVO patients demonstrated significantly elevated levels of low-shear-rate whole blood viscosity(LSR-WBV),high-shearrate whole blood viscosity(HSR-WBV),and aggregation index(AI,all P<0.05).In CRVO-affected eyes,vertical cupto-disc(C/D)ratio and optic cup volume were significantly smaller,whereas retinal nerve fiber layer(RNFL)thickness was significantly greater,compared to both unaffected contralateral eyes and normal control eyes(all P<0.05).Following treatment,VD of the entire optic disc(P<0.05),intra-disc VD(P<0.05),and peripapillary VD(P<0.05)all increased significantly relative to baseline.CMT decreased significantly(P<0.05),whereas macular SCP-VD and macular DCP-VD showed non-significant slight reductions(P>0.05).At baseline,BCVA of CRVO eyes correlated with whole-disc VD(r=-0.276,P=0.033),intra-disc VD(r=-0.342,P=0.009),and peripapillary VD(r=-0.335,P=0.007),with intra-disc VD demonstrating the strongest association.Besides,BCVA improvement,after the treatment,correlated positively with whole-disc VD(r=0.342,P=0.008)and intradisc VD(r=0.396,P=0.002).CONCLUSION:Optic disc blood perfusion is more closely associated with visual acuity than macular perfusion,suggesting intra-disc VD may serve as a potential biomarker for monitoring visual acuity changes in CRVO.Multiple ranibizumab injections significantly improve optic disc perfusion but may have exerted detrimental effects on the macula.CRVO patients shows higher hemorheological parameters than those with normal fundi.Reduced vertical C/D ratio and optic cup volume may be linked to CRVO incidence,potentially acting as susceptibility factors.
基金Project supported by the Postgraduate Research and Practice Innovation Program of Jiangsu Province,China(Grant No.AE91313/001/016)the National Natural Science Foundation of China(Grant No.11701097)the Natural Science Foundation of Jiangxi Province,China(Grant No.20161BAB212055)
文摘In this paper, we propose a new centrality algorithm that can simultaneously rank the nodes and layers of multilayer networks, referred to as the MRFNL centrality. The centrality of nodes and layers are obtained by developing a novel iterative algorithm for computing a set of tensor equations. Under some conditions, the existence and uniqueness of this centrality were proven by applying the Brouwer fixed point theorem. Furthermore, the convergence of the proposed iterative algorithm was established. Finally, numerical experiments on a simple multilayer network and two real-world multilayer networks(i.e., Pierre Auger Collaboration and European Air Transportation Networks) are proposed to illustrate the effectiveness of the proposed algorithm and to compare it to other existing centrality measures.
文摘In this work we propose a centrality measure for networks, which we refer to as Laplacian centrality, that provides a general framework for the centrality of a vertex based on the idea that the importance (or centrality) of a vertex is related to the ability of the network to respond to the deactivation or removal of that vertex from the network. In particular, the Laplacian centrality of a vertex is defined as the relative drop of Laplacian energy caused by the deactivation of this vertex. The Laplacian energy of network G with?n?vertices is defined as , where ?is the eigenvalue of the Laplacian matrix of G. Other dynamics based measures such as that of Masuda and Kori and PageRank compute the importance of a node by analyzing the way paths pass through a node while our measure captures this information as well as the way these paths are “redistributed” when the node is deleted. The validity and robustness of this new measure are illustrated on two different terrorist social network data sets and 84 networks in James Moody’s Add Health in school friendship nomination data, and is compared with other standard centrality measures.
基金Supported by National Natural Science Foundation of China (No.81760179 No.81360151)+2 种基金Natural Science Foundation of Jiangxi Province (No.20171BAB205046)Jiangxi Province Education Department Key Foundation (No. GJJ160033)Health Development Planning Commission Science Foundation of Jiangxi Province (No.20185118)
文摘AIM： To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality（DC） method.METHODS： In total, 38 patients with high myopia（HM）（17 males and 21 females）, whose binocular refractive diopter were-6.00 to-7.00 D, and 38 healthy controls（17 males and 21 females）, closely matched in age, sex, and education levels, participated in the study. Spontaneous brain activities were evaluated using the voxel-wise DC method. The receiver operating characteristic curve was measured to distinguish patients with HM from healthy controls. Correlation analysis was used to explore the relationship between the observed mean DC values of the different brain areas and the behavioral performance.RESULTS： Compared with healthy controls, HM patients had significantly decreased DC values in the right inferior frontal gyrus/insula, right middle frontal gyrus, and right supramarginal/inferior parietal lobule（P〈0.05）. In contrast, HM patients had significantly increased DC values in the right cerebellum posterior lobe, left precentral gyrus/postcentral gyrus, and right middle cingulate gyrus（P〈0.05）. However, no relationship was found between the observed mean DC values of the different brain areas and the behavioral performance（P〉0.05）.CONCLUSION： HM is associated with abnormalities in many brain regions, which may indicate the neural mechanisms of HM. The altered DC values may be used as a useful biomarker for the brain activity changes in HM patients.
基金National Natural Science Foundation of China,No.41871176The“Hua Bo”Plan of Central China Normal UniversityPostgraduate Education Innovation Subsidy Project of Central China Normal University,No.2018CXZZ004。
文摘Based on statistical data and population flow data for 2016,and using entropy weight TOPSIS and the obstacle degree model,the centrality of cities in the Yangtze River Economic Belt(YREB)together with the factors influencing centrality were measured.In addition,data for the population flow were used to analyze the relationships between cities and to verify centrality.The results showed that:(1)The pattern of centrality conforms closely to the pole-axis theory and the central geography theory.Two axes,corresponding to the Yangtze River and the Shanghai-Kunming railway line,interconnect cities of different classes.On the whole,the downstream cities have higher centrality,well-defined gradients and better development of city infrastructure compared with cities in the middle and upper reaches.(2)The economic scale and size of the population play a fundamental role in the centrality of cities,and other factors reflect differences due to different city classes.For most of the coastal cities or the capital cities in the central and western regions,factors that require long-term development such as industrial facilities,consumption,research and education provide the main competitive advantages.For cities that are lagging behind in development,transportation facilities,construction of infrastructure and fixed asset investment have become the main methods to achieve development and enhance competitiveness.(3)The mobility of city populations has a significant correlation with the centrality score,the correlation coefficients for the relationships between population mobility and centrality are all greater than 0.86(P<0.01).The population flow is mainly between high-class cities,or high-class and low-class cities,reflecting the high centrality and huge radiating effects of high-class cities.Furthermore,the cities in the YREB are closely linked to Guangdong and Beijing,reflecting the dominant economic status of Guangdong with its geographical proximity to the YREB and Beijing's enormous influence as the national political and cultural center,respectively.
文摘In many cases randomness in community detection algorithms has been avoided due to issues with stability. Indeed replacing random ordering with centrality rankings has improved the performance of some techniques such as Label Propagation Algorithms. This study evaluates the effects of such orderings on the Speaker-listener Label Propagation Algorithm or SLPA, a modification of LPA which has already been stabilized through alternate means. This study demonstrates that in cases where stability has been achieved without eliminating randomness, the result of removing random ordering is over fitting and bias. The results of testing seven various measures of centrality in conjunction with SLPA across five social network graphs indicate that while certain measures outperform random orderings on certain graphs, random orderings have the highest overall accuracy. This is particularly true when strict orderings are used in each run. These results indicate that the more evenly distributed solution space which results from complete random ordering is more valuable than the more targeted search that results from centrality orderings.
基金This work was supported in part by the National Nature Science Foundation of China(NSFC)(Nos.11927901 and 12175084)the National Key Research and Development Program of China(Nos.2020YFE0202002 and 2022YFA1604900)the Fundamental Research Funds for the Central Universities(No.CCNU22QN005).
文摘The zero-degree calorimeter(ZDC)plays a crucial role toward determining the centrality in the Cooling-Storage-Ring External-target Experiment(CEE)at the Heavy Ion Research Facility in Lanzhou.A boosted decision tree(BDT)multi-classification algorithm was employed to classify the centrality of the collision events based on the raw features from ZDC such as the number of fired channels and deposited energy.The data from simulated^(238)U+^(238)U collisions at 500 MeV∕u,generated by the IQMD event generator and subsequently modeled using the GEANT4 package,were employed to train and test the BDT model.The results showed the high accuracy of the multi-classification model adopted in ZDC for centrality determination,which is robust against variations in different factors of detector geometry and response.This study demon-strates the good performance of CEE-ZDC in determining the centrality in nucleus-nucleus collisions.
基金Under the auspices of National Key Technology Research and Development Program of China(No.2012BAH28B02)
文摘Road network is a corridor system that interacts with surrounding landscapes,and understanding their interaction helps to develop an optimal plan for sustainable transportation and land use.This study investigates the relationships between road centrality and landscape patterns in the Wuhan Metropolitan Area,China.The densities of centrality measures,including closeness,betweenness,and straightness,are calculated by kernel density estimation(KDE).The landscape patterns are characterized by four landscape metrics,including percentage of landscape(PLAND),Shannon′s diversity index(SHDI),mean patch size(MPS),and mean shape index(MSI).Spearman rank correlation analysis is then used to quantify their relationships at both landscape and class levels.The results show that the centrality measures can reflect the hierarchy of road network as they associate with road grade.Further analysis exhibit that as centrality densities increase,the whole landscape becomes more fragmented and regular.At the class level,the forest gradually decreases and becomes fragmented,while the construction land increases and turns to more compact.Therefore,these findings indicate that the ability and potential applications of centrality densities estimated by KDE in quantifying the relationships between roads and landscapes,can provide detailed information and valuable guidance for transportation and land-use planning as well as a new insight into ecological effects of roads.
文摘AIM:To explore the intrinsic brain activity variations in retinal vein occlusion(RVO)subjects by using the voxel-wise degree centrality(DC)technique.METHODS:Twenty-one subjects with RVO and twentyone healthy controls(HCs)were enlisted and underwent the resting-state functional magnetic resonance imaging(rs-f MRI)examination.The spontaneous cerebrum activity variations were inspected using the DC technology.The receiver operating characteristic(ROC)curve was implemented to distinguish the DC values of RVOs from HCs.The relationships between DC signal of definite regions of interest and the clinical characteristics in RVO group were evaluated by Pearson’s correlation analysis.RESULTS:RVOs showed notably higher DC signals in right superior parietal lobule,middle frontal gyrus and left precuneus,but decreased DC signals in left middle temporal gyrus and bilateral anterior cingulated(BAC)when comparing with HCs.The mean DC value of RVOs in the BAC were negatively correlated with the anxiety and depression scale.CONCLUSION:RVO is associated aberrant intrinsic brain activity patterns in several brain areas including painrelated as well as visual-related regions,which might assist to reveal the latent neural mechanisms.
基金Supported by Ministry of Science and Technology in China under Grant Nos.2014CB845404,2014DFG02050by Natural Science Foundation of China under Grant Nos.11322546,11435004,11221504
文摘By using the recent spatially dependent nuclear PDF set EPS09 s, we investigated the centrality-dependent Cold Nuclear Matter(CNM) effects for neutral π, η mesons and inclusive jets at RHIC in d+Au collisions and at LHC in p+Pb collisions. The nuclear modification factors as functions of transverse momentum are plotted at different centralities bins respectively. At all fixed centralities, the nuclear modification factors show no significant suppressions,contrast to the strong suppressions observed for central Au+Au collisions. Our results are consistent with the PHENIX preliminary Data in minimum bias and central d+Au collisions. The LHC experimental Data also support our predictions for both single inclusive hadron and inclusive jets productions in central p+Pb collisions. And the centrality dependence of the nuclear suppressions for all the observations in our calculations are lower than the RHIC and LHC Data.
基金Supported by the National Natural Science Foundation of China(61272119,61203372)
文摘A new centrality measure for complex networks, called resource flow centrality, is pro- posed in this paper. This centrality measure is based on the concept of the resource flow in net- works. It not only can be applied to the connected networks, but also the disconnected networks. Moreover, it overcomes some disadvantages of several common centrality measures. The perform- ance of the proposed measure is compared with some standard centrality measures using a classic dataset and the results indicate the proposed measure performs more reasonably. The statistical dis- tribution of the proposed centrality is investigated by experiments on large scale computer generated graphs and two networks from the real world.
文摘Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central nervous system.Central copper dysregulations have been evidenced in two genetic disorders characterized by mutations in the copper-ATPases ATP7A and ATP7B,Menkes disease and Wilson’s disease,respectively,and also in multifactorial neurological disorders such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and multiple sclerosis.This review summarizes current knowledge about the role of copper in central nervous system physiology and pathology,reports about unbalances in copper levels and/or distribution under disease,describes relevant animal models for human disorders where copper metabolism genes are dysregulated,and discusses relevant therapeutic approaches modulating copper availability.Overall,alterations in copper metabolism may contribute to the etiology of central nervous system disorders and represent relevant therapeutic targets to restore tissue homeostasis.
基金supported by the National Natural Science Foundation of China, No.82274616the Key Laboratory Project for General Universities in Guangdong Province, No.2019KSYS005Guangdong Province Science and Technology Plan International Cooperation Project, No.2020A0505100052 (all to QW)。
文摘Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.
