目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论...目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论量、保存量、被引频次、推荐量与Altmetrics评分、h指数、学术迹T之间的相关性以及对单篇论文的评价效果。结果:阅览量、下载量、讨论量与被引频次、h指数有正相关性,推荐量与h指数、学术迹无关。Altmetrics评分与阅览量、下载量和讨论量呈中度相关性,与被引频次呈弱相关。结论:PLo S ALMs是一个多维评价,应该应用多指标测度,才能体现研究成果的综合实力。展开更多
Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovar...Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.展开更多
介绍了一个基于覆盖网(Overlay Network)技术的应用层组播视频直播系统,它在IPv6网络上实现,提出了用IP地址最大匹配法与时延来寻找最优父结点。系统采用代理的结构和三级的服务模型,此外本系统基于当前流行Windows Media Technology技...介绍了一个基于覆盖网(Overlay Network)技术的应用层组播视频直播系统,它在IPv6网络上实现,提出了用IP地址最大匹配法与时延来寻找最优父结点。系统采用代理的结构和三级的服务模型,此外本系统基于当前流行Windows Media Technology技术,对流媒体数据进行处理。展开更多
文摘目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论量、保存量、被引频次、推荐量与Altmetrics评分、h指数、学术迹T之间的相关性以及对单篇论文的评价效果。结果:阅览量、下载量、讨论量与被引频次、h指数有正相关性,推荐量与h指数、学术迹无关。Altmetrics评分与阅览量、下载量和讨论量呈中度相关性,与被引频次呈弱相关。结论:PLo S ALMs是一个多维评价,应该应用多指标测度,才能体现研究成果的综合实力。
基金jointly supported by the National Key Research and Development Program of China(2018YFC1002104 to L.W.,2018YFC1004904 to B.-L.W.and J.F.,2016YFC1000500 to H.Y.W.and W.F.T.)the National Natural Science Foundation of China([81930036,31521003,31771669]to H.Y.W.)+1 种基金the Commission for Science and Technology of Shanghai Municipality(17JC1400902to H.Y.W.)the MDA-CHB Research Grant to B.-L.W。
文摘Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.
