Magnesium (Mg)-based biometals are promising candidates for next-generation biodegradable implants in bone regeneration.However,their rapid biocorrosion in physiological environments necessitates protective coatings t...Magnesium (Mg)-based biometals are promising candidates for next-generation biodegradable implants in bone regeneration.However,their rapid biocorrosion in physiological environments necessitates protective coatings to enhance corrosion resistance and osteogenesis.Conventional hydrophobic modifications,while effective in mitigating corrosion,often impair biological responses,hindering tissue integration and bone regeneration.Inspired by the architecture of cell membranes,we developed a novel layered octacalcium phosphate (OCP) coatingintercalated with a hydrophobic alkyl-phosphate-surfactant bilayer,imparting Mg biometals with enhanced bioactivity and resistance to biocorrosion.Additionally,an MgF2transition layer with a mechanically interlocking architecture is fabricated via an in situ growth approach,ensuring the long-term structural integrity and interface stability of the hybrid coating.Compared with conventional coatings,the resulting intercalated organic/inorganic hybrid coatings exhibit exceptional mechanical robustness,remarkable corrosion resistance,and bioactivities conducive to cellular adhesion and proliferation.In vivo implantation tests further revealed a significantly reduced corrosion depth(~1.1μm),minimal inflammatory response,and reduced fibrous encapsulation (~65.2μm),demonstrating its clinical potential.This work pioneers a bioinspired strategy for multifunctional inorganic/organic hybrid coatings,advancing the clinical application of Mg-based implants in osteogenesis.展开更多
基金financially supported by the National Natural Science Foundation of China(No.52171234)the National Key Research and Development Project(No.2021YFC2400703)
文摘Magnesium (Mg)-based biometals are promising candidates for next-generation biodegradable implants in bone regeneration.However,their rapid biocorrosion in physiological environments necessitates protective coatings to enhance corrosion resistance and osteogenesis.Conventional hydrophobic modifications,while effective in mitigating corrosion,often impair biological responses,hindering tissue integration and bone regeneration.Inspired by the architecture of cell membranes,we developed a novel layered octacalcium phosphate (OCP) coatingintercalated with a hydrophobic alkyl-phosphate-surfactant bilayer,imparting Mg biometals with enhanced bioactivity and resistance to biocorrosion.Additionally,an MgF2transition layer with a mechanically interlocking architecture is fabricated via an in situ growth approach,ensuring the long-term structural integrity and interface stability of the hybrid coating.Compared with conventional coatings,the resulting intercalated organic/inorganic hybrid coatings exhibit exceptional mechanical robustness,remarkable corrosion resistance,and bioactivities conducive to cellular adhesion and proliferation.In vivo implantation tests further revealed a significantly reduced corrosion depth(~1.1μm),minimal inflammatory response,and reduced fibrous encapsulation (~65.2μm),demonstrating its clinical potential.This work pioneers a bioinspired strategy for multifunctional inorganic/organic hybrid coatings,advancing the clinical application of Mg-based implants in osteogenesis.
