A new photocatalytic annulative acylative difunctionalization of 1,6-enynes is reported,enabling stereoselective access to acylated 1-indanones with cyclic quaternary centers in moderate to good yields.This photocatal...A new photocatalytic annulative acylative difunctionalization of 1,6-enynes is reported,enabling stereoselective access to acylated 1-indanones with cyclic quaternary centers in moderate to good yields.This photocatalysis enables two types of acylation of unsaturated hydrocarbons by adjusting the categories of acyl radical precursors.Aroyl chlorides as bifunctional reagents react with 1,6-enynes to realize annulative chloroacylation,while acyl oxime esters are used as acyl radical precursors,which undergo a three-component annulative alkoxyacylation by treatment with 1,6-enynes and alcohols.The current method demonstrates good functional group compatibility,a broad substrate scope and mild reaction conditions.展开更多
文摘A new photocatalytic annulative acylative difunctionalization of 1,6-enynes is reported,enabling stereoselective access to acylated 1-indanones with cyclic quaternary centers in moderate to good yields.This photocatalysis enables two types of acylation of unsaturated hydrocarbons by adjusting the categories of acyl radical precursors.Aroyl chlorides as bifunctional reagents react with 1,6-enynes to realize annulative chloroacylation,while acyl oxime esters are used as acyl radical precursors,which undergo a three-component annulative alkoxyacylation by treatment with 1,6-enynes and alcohols.The current method demonstrates good functional group compatibility,a broad substrate scope and mild reaction conditions.
