In bone tissue engineering microstructure design,adjusting the structural design of biomimetic bone scaffolds can provide distinct differentiation stimuli to cells on the scaffold surface.This study explored the biome...In bone tissue engineering microstructure design,adjusting the structural design of biomimetic bone scaffolds can provide distinct differentiation stimuli to cells on the scaffold surface.This study explored the biomechanical impacts of different biomimetic microstructures on advanced bone tissue engineering scaffolds.Two irregular bone scaffolds(homogeneous/radial gradient)based on the Voronoi tesselation algorithm and eight regular lattice scaffolds involving pillar body centered cubic,vintiles,diamond,and cube(homogeneous/radial gradient)with constant 80%porosity were constructed.Mechanical stimulation differentiation algorithms,finite element analysis,and computational fluid dynamics were used to investigate the effects of different pore structures on the octahedral shear strain and fluid flow shear stress within the scaffolds,thereby elucidating the differentiation capabilities of the five structural bone/cartilage cell types.The findings demonstrated that irregular structures and radial-gradient designs promoted osteogenic differentiation,whereas regular structures and homogeneous designs facilitated chondrogenic differentiation.The highest percentages of osteoblast and chondrocyte differentiation were observed in radial-gradient irregular scaffolds.This research provides insights into the microstructure design of bone tissue engineering implants.展开更多
Aging of secondary organic aerosol（SOA） particles formed from OH– initiated oxidation of ethylbenzene in the presence of high mass（100–300 μg/m^3） concentrations of（NH_4）_2SO_4seed aerosol was investigated in...Aging of secondary organic aerosol（SOA） particles formed from OH– initiated oxidation of ethylbenzene in the presence of high mass（100–300 μg/m^3） concentrations of（NH_4）_2SO_4seed aerosol was investigated in a home-made smog chamber in this study.The chemical composition of aged ethylbenzene SOA particles was measured using an aerosol laser time-of-flight mass spectrometer（ALTOFMS） coupled with a Fuzzy C-Means（FCM） clustering algorithm.Experimental results showed that nitrophenol,ethyl-nitrophenol,2,4-dinitrophenol,methyl glyoxylic acid,5-ethyl-6-oxo-2,4-hexadienoic acid,2-ethyl-2,4-hexadiendioic acid,2,3-dihydroxy-5-ethyl-6-oxo-4-hexenoic acid,1H-imidazole,hydrated N-glyoxal substituted1H-imidazole,hydrated glyoxal dimer substituted imidazole,1H-imidazole-2-carbaldehyde,N-glyoxal substituted hydrated 1H-imidazole-2-carbaldehyde and high-molecular-weight（HMW） components were the predominant products in the aged particles.Compared to the previous aromatic SOA aging studies,imidazole compounds,which can absorb solar radiation effectively,were newly detected in aged ethylbenzene SOA in the presence of high concentrations of（NH_4）_2SO_4seed aerosol.These findings provide new information for discussing aromatic SOA aging mechanisms.展开更多
The scaled boundary finite element method （SBFEM） is a recently developed numerical method combining advantages of both finite element methods （FEM） and boundary element methods （BEM） and with its own special fe...The scaled boundary finite element method （SBFEM） is a recently developed numerical method combining advantages of both finite element methods （FEM） and boundary element methods （BEM） and with its own special features as well. One of the most prominent advantages is its capability of calculating stress intensity factors （SIFs） directly from the stress solutions whose singularities at crack tips are analytically represented. This advantage is taken in this study to model static and dynamic fracture problems. For static problems, a remeshing algorithm as simple as used in the BEM is developed while retaining the generality and flexibility of the FEM. Fully-automatic modelling of the mixed-mode crack propagation is then realised by combining the remeshing algorithm with a propagation criterion. For dynamic fracture problems, a newly developed series-increasing solution to the SBFEM governing equations in the frequency domain is applied to calculate dynamic SIFs. Three plane problems are modelled. The numerical results show that the SBFEM can accurately predict static and dynamic SIFs, cracking paths and load-displacement curves, using only a fraction of degrees of freedom generally needed by the traditional finite element methods.展开更多
In this Paper we have proven the general solution to the equations of linear operatorsAu=f as u=Cv+e . where v satisfies the equation Dv=g and D is adiagonal matrix. Basing on the consstructive proof of Hilbert Nulls...In this Paper we have proven the general solution to the equations of linear operatorsAu=f as u=Cv+e . where v satisfies the equation Dv=g and D is adiagonal matrix. Basing on the consstructive proof of Hilbert Nullstellensat=. we haregiven the mechanical method of constucting C. D and e.and some of the mechanicalalgorithm displacement functions in elasticity are given by this method also .展开更多
基金the National Natural Science Foundation of China(No.52165026)。
文摘In bone tissue engineering microstructure design,adjusting the structural design of biomimetic bone scaffolds can provide distinct differentiation stimuli to cells on the scaffold surface.This study explored the biomechanical impacts of different biomimetic microstructures on advanced bone tissue engineering scaffolds.Two irregular bone scaffolds(homogeneous/radial gradient)based on the Voronoi tesselation algorithm and eight regular lattice scaffolds involving pillar body centered cubic,vintiles,diamond,and cube(homogeneous/radial gradient)with constant 80%porosity were constructed.Mechanical stimulation differentiation algorithms,finite element analysis,and computational fluid dynamics were used to investigate the effects of different pore structures on the octahedral shear strain and fluid flow shear stress within the scaffolds,thereby elucidating the differentiation capabilities of the five structural bone/cartilage cell types.The findings demonstrated that irregular structures and radial-gradient designs promoted osteogenic differentiation,whereas regular structures and homogeneous designs facilitated chondrogenic differentiation.The highest percentages of osteoblast and chondrocyte differentiation were observed in radial-gradient irregular scaffolds.This research provides insights into the microstructure design of bone tissue engineering implants.
基金supported by the National Natural Science Foundation of China (Nos.41575118,41305109,21502086,41575126)the Outstanding Youth Science Foundation of Fujian Province of China (No.2015J06009)the Natural Science Foundation of Fujian Province of China (No.2015J05028)
文摘Aging of secondary organic aerosol（SOA） particles formed from OH– initiated oxidation of ethylbenzene in the presence of high mass（100–300 μg/m^3） concentrations of（NH_4）_2SO_4seed aerosol was investigated in a home-made smog chamber in this study.The chemical composition of aged ethylbenzene SOA particles was measured using an aerosol laser time-of-flight mass spectrometer（ALTOFMS） coupled with a Fuzzy C-Means（FCM） clustering algorithm.Experimental results showed that nitrophenol,ethyl-nitrophenol,2,4-dinitrophenol,methyl glyoxylic acid,5-ethyl-6-oxo-2,4-hexadienoic acid,2-ethyl-2,4-hexadiendioic acid,2,3-dihydroxy-5-ethyl-6-oxo-4-hexenoic acid,1H-imidazole,hydrated N-glyoxal substituted1H-imidazole,hydrated glyoxal dimer substituted imidazole,1H-imidazole-2-carbaldehyde,N-glyoxal substituted hydrated 1H-imidazole-2-carbaldehyde and high-molecular-weight（HMW） components were the predominant products in the aged particles.Compared to the previous aromatic SOA aging studies,imidazole compounds,which can absorb solar radiation effectively,were newly detected in aged ethylbenzene SOA in the presence of high concentrations of（NH_4）_2SO_4seed aerosol.These findings provide new information for discussing aromatic SOA aging mechanisms.
基金The project supported by the National Natural Science Foundation of China (50579081)the Australian Research Council (DP0452681)The English text was polished by Keren Wang
文摘The scaled boundary finite element method （SBFEM） is a recently developed numerical method combining advantages of both finite element methods （FEM） and boundary element methods （BEM） and with its own special features as well. One of the most prominent advantages is its capability of calculating stress intensity factors （SIFs） directly from the stress solutions whose singularities at crack tips are analytically represented. This advantage is taken in this study to model static and dynamic fracture problems. For static problems, a remeshing algorithm as simple as used in the BEM is developed while retaining the generality and flexibility of the FEM. Fully-automatic modelling of the mixed-mode crack propagation is then realised by combining the remeshing algorithm with a propagation criterion. For dynamic fracture problems, a newly developed series-increasing solution to the SBFEM governing equations in the frequency domain is applied to calculate dynamic SIFs. Three plane problems are modelled. The numerical results show that the SBFEM can accurately predict static and dynamic SIFs, cracking paths and load-displacement curves, using only a fraction of degrees of freedom generally needed by the traditional finite element methods.
文摘In this Paper we have proven the general solution to the equations of linear operatorsAu=f as u=Cv+e . where v satisfies the equation Dv=g and D is adiagonal matrix. Basing on the consstructive proof of Hilbert Nullstellensat=. we haregiven the mechanical method of constucting C. D and e.and some of the mechanicalalgorithm displacement functions in elasticity are given by this method also .
